Research Topics
Genomes and Genes | P DvorakSummaryAffiliation: Mendel University of Agriculture and Forestry Country: Czech Republic Publications
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Publications
Embryoglycan ectodomains regulate biological activity of FGF-2 to embryonic stem cellsP Dvorak
Laboratory of Molecular Embryology, Mendel University Brno, Czech Republic
J Cell Sci 111:2945-52. 1998..These findings demonstrate that embryoglycan ectodomains may act as negative regulators of FGF-2-induced ES cell proliferation, most likely through the FGFR-1-independent signaling pathway...- Basic fibroblast growth factor and its receptors in human embryonic stem cellsPetr Dvorak
Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Folia Histochem Cytobiol 43:203-8. 2005.... - Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cellsPetr Dvorak
Laboratory of Molecular Embryology, Mendel University, Brno Zemedelska 1, 613 00 Brno, Czech Republic
Stem Cells 23:1200-11. 2005..In conclusion from our data, we propose that this endogenous FGF signaling pathway can be implicated in self-renewal or differentiation of hESCs... - Modulation of protein synthesis in rabbit inner cell mass-derived cells by FGF-2P Dvorak
Laboratory of Molecular Embryology, Mendel University Brno, Czech Republic
Reprod Nutr Dev 41:197-205. 2001..Thus, the readiness of ICM-derived cells to accept and respond to the FGF-2 signals may be of limited duration... 
Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic originV Bryja
Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
Cell Prolif 41:875-93. 2008..This article is to study the role of G(1)/S regulators in differentiation of pluripotent embryonic cells...- Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factorJ Pachernik
Laboratory of Molecular Embryology, Mendel University Brno, Zemedelska 1, 61300 Brno, Czech Republic
Physiol Res 54:257-62. 2005..Moreover, LIF also slows growth and increases the level of apoptosis in differentiating cells... - High molecular weight FGF2: the biology of a nuclear growth factorK Chlebova
Institute of Experimental Biology, Masaryk University, Kotlarska 2, 61137, Brno, Czech Republic
Cell Mol Life Sci 66:225-35. 2009..In this review, we summarize the current knowledge about the biology of HMW FGF2, its role in disease and areas for future investigation... - Levels and interactions of p27, cyclin D3, and CDK4 during the formation and maintenance of the corpus luteum in miceA Hampl
Laboratory of Molecular Embryology, Mendel University Brno, 613 00 Brno, Czech Republic
Biol Reprod 62:1393-401. 2000.... - FGF-2 abnormalities in B cell chronic lymphocytic and chronic myeloid leukemiasP Krejci
Laboratory of Molecular Embryology, Mendel University Brno, Czech Republic
Leukemia 15:228-37. 2001..We conclude that B-CLL WBCs secrete FGF-2 with no apparent autocrine actions. In contrast, WBCs in CML bind FGF-2 provided by other FGF-2-hyperproducing cells and activate the MEK/ERK kinase cascade, possibly to modulate cell growth... - Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemiaP Dvorak
Department of Molecular Embryology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Brno, Czech Republic
Leukemia 17:2418-25. 2003..These findings have implications for the involvement of FGFR-3 in malignant hematopoiesis and depict FGFR-3 tyrosine kinase in CD34+ leukemic cells as a possible target for tyrosine kinase inhibitors... - In vitro labelling of mouse embryonic stem cells with SPIO nanoparticlesJ Krejci
Institute of Biophysics, Academy of Sciences of the Czech Republic, v v i, Kralovopolska 135, Brno, Czech Republic
Gen Physiol Biophys 27:164-73. 2008..Thus for the first time we documented the effects of SPIO nanoparticles on ES cells and their differentiation... - A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cellsLivia Eiselleova
Department of Biology, Faculty of Medicine University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
Stem Cells 27:1847-57. 2009..This stimulation of self-renewal, cell survival, and adhesion by exogenous and endogenous FGF-2 may synergize to maintain the undifferentiated growth of hESCs... - Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cellsJ Pachernik
Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Faculty of Science, Brno, Czech Republic
Folia Biol (Praha) 53:157-63. 2007..These results suggest that in neurogenic regions, cooperative action of LIF and other neuro-differentiation-inducing factors, such as retinoic acid, may be mediated by the STAT3 signalling pathway... - Temporal distribution of CDK4, CDK6, D-type cyclins, and p27 in developing mouse oocytesJ Kohoutek
Laboratory of Molecular Embryology, Mendel University Brno, 613 00 Brno, Czech Republic
Biol Reprod 70:139-45. 2004..These data distinguish G1/S regulators as the potential players in molecular processes that are important for oocytes to function normally... 
Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse originI Kubikova
Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Cytotherapy 11:330-40, 1 p following 340. 2009..However, they may also contain immunogenic membrane domains and infectious particles acquired from xenogenic components of the culture milieu. Therefore, MV represent a potential risk for clinical application of cell therapy...- Comparative study of mouse and human feeder cells for human embryonic stem cellsLivia Eiselleova
Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Int J Dev Biol 52:353-63. 2008..Cumulatively, these results suggest that the ability of a feeder layer to promote the undifferentiated growth of hESCs is attributable to its characteristic growth factor production... - Fibroblast growth factor signaling in embryonic and cancer stem cellsPetr Dvorak
Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
FEBS Lett 580:2869-74. 2006..Here we summarize recent data on the effects of FGF-2 and its receptors on hESCs and leukemic stem/progenitor cells. Also, we discuss the similarities of these findings with stem cell renewal and differentiation phenotypes... - The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cellsMartin Anger
Department of Biology, University of Pennsylvania, USA
Biochem Biophys Res Commun 302:825-30. 2003.... - Targeted disruption of fibroblast growth factor receptor-1 blocks maturation of visceral endoderm and cavitation in mouse embryoid bodiesMilan Esner
Department of Molecular Embryology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague
Int J Dev Biol 46:817-25. 2002..Our results indicate that FGFR-1 may play a vital role in endoderm formation... - Characterization of human embryonic stem cell lines by the International Stem Cell InitiativeOluseun Adewumi
UK Stem Cell Bank, Division of Cell Biology and Imaging, National Institute for Biological Standards and Control, South Mimms, Herts, EN6 3QG, UK
Nat Biotechnol 25:803-16. 2007..Also, some female lines expressed readily detectable levels of XIST whereas others did not. No significant contamination of the lines with mycoplasma, bacteria or cytopathic viruses was detected... - The reverse tetracycline-controlled transactivator rtTA2s-S2 is toxic in mouse embryonic stem cellsVitezslav Bryja
Center for Cell Therapy and Tissue Repair, Charles University, Department of Molecular Embryology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Reprod Nutr Dev 43:477-86. 2003..Our results indicate that this transactivator is toxic to ES cells and raise the need for the development of other strategies for stable and inducible expression of genes in ES cells...