P Dvorak

Summary

Affiliation: Mendel University of Agriculture and Forestry
Country: Czech Republic

Publications

  1. ncbi Embryoglycan ectodomains regulate biological activity of FGF-2 to embryonic stem cells
    P Dvorak
    Laboratory of Molecular Embryology, Mendel University Brno, Czech Republic
    J Cell Sci 111:2945-52. 1998
  2. ncbi Basic fibroblast growth factor and its receptors in human embryonic stem cells
    Petr Dvorak
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Folia Histochem Cytobiol 43:203-8. 2005
  3. ncbi Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells
    Petr Dvorak
    Laboratory of Molecular Embryology, Mendel University, Brno Zemedelska 1, 613 00 Brno, Czech Republic
    Stem Cells 23:1200-11. 2005
  4. ncbi Modulation of protein synthesis in rabbit inner cell mass-derived cells by FGF-2
    P Dvorak
    Laboratory of Molecular Embryology, Mendel University Brno, Czech Republic
    Reprod Nutr Dev 41:197-205. 2001
  5. pmc Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin
    V Bryja
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Cell Prolif 41:875-93. 2008
  6. ncbi Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor
    J Pachernik
    Laboratory of Molecular Embryology, Mendel University Brno, Zemedelska 1, 61300 Brno, Czech Republic
    Physiol Res 54:257-62. 2005
  7. pmc High molecular weight FGF2: the biology of a nuclear growth factor
    K Chlebova
    Institute of Experimental Biology, Masaryk University, Kotlarska 2, 61137, Brno, Czech Republic
    Cell Mol Life Sci 66:225-35. 2009
  8. ncbi Levels and interactions of p27, cyclin D3, and CDK4 during the formation and maintenance of the corpus luteum in mice
    A Hampl
    Laboratory of Molecular Embryology, Mendel University Brno, 613 00 Brno, Czech Republic
    Biol Reprod 62:1393-401. 2000
  9. ncbi FGF-2 abnormalities in B cell chronic lymphocytic and chronic myeloid leukemias
    P Krejci
    Laboratory of Molecular Embryology, Mendel University Brno, Czech Republic
    Leukemia 15:228-37. 2001
  10. ncbi Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia
    P Dvorak
    Department of Molecular Embryology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Leukemia 17:2418-25. 2003

Collaborators

Detail Information

Publications21

  1. ncbi Embryoglycan ectodomains regulate biological activity of FGF-2 to embryonic stem cells
    P Dvorak
    Laboratory of Molecular Embryology, Mendel University Brno, Czech Republic
    J Cell Sci 111:2945-52. 1998
    ..These findings demonstrate that embryoglycan ectodomains may act as negative regulators of FGF-2-induced ES cell proliferation, most likely through the FGFR-1-independent signaling pathway...
  2. ncbi Basic fibroblast growth factor and its receptors in human embryonic stem cells
    Petr Dvorak
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Folia Histochem Cytobiol 43:203-8. 2005
    ....
  3. ncbi Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells
    Petr Dvorak
    Laboratory of Molecular Embryology, Mendel University, Brno Zemedelska 1, 613 00 Brno, Czech Republic
    Stem Cells 23:1200-11. 2005
    ..In conclusion from our data, we propose that this endogenous FGF signaling pathway can be implicated in self-renewal or differentiation of hESCs...
  4. ncbi Modulation of protein synthesis in rabbit inner cell mass-derived cells by FGF-2
    P Dvorak
    Laboratory of Molecular Embryology, Mendel University Brno, Czech Republic
    Reprod Nutr Dev 41:197-205. 2001
    ..Thus, the readiness of ICM-derived cells to accept and respond to the FGF-2 signals may be of limited duration...
  5. pmc Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin
    V Bryja
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Cell Prolif 41:875-93. 2008
    ..This article is to study the role of G(1)/S regulators in differentiation of pluripotent embryonic cells...
  6. ncbi Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor
    J Pachernik
    Laboratory of Molecular Embryology, Mendel University Brno, Zemedelska 1, 61300 Brno, Czech Republic
    Physiol Res 54:257-62. 2005
    ..Moreover, LIF also slows growth and increases the level of apoptosis in differentiating cells...
  7. pmc High molecular weight FGF2: the biology of a nuclear growth factor
    K Chlebova
    Institute of Experimental Biology, Masaryk University, Kotlarska 2, 61137, Brno, Czech Republic
    Cell Mol Life Sci 66:225-35. 2009
    ..In this review, we summarize the current knowledge about the biology of HMW FGF2, its role in disease and areas for future investigation...
  8. ncbi Levels and interactions of p27, cyclin D3, and CDK4 during the formation and maintenance of the corpus luteum in mice
    A Hampl
    Laboratory of Molecular Embryology, Mendel University Brno, 613 00 Brno, Czech Republic
    Biol Reprod 62:1393-401. 2000
    ....
  9. ncbi FGF-2 abnormalities in B cell chronic lymphocytic and chronic myeloid leukemias
    P Krejci
    Laboratory of Molecular Embryology, Mendel University Brno, Czech Republic
    Leukemia 15:228-37. 2001
    ..We conclude that B-CLL WBCs secrete FGF-2 with no apparent autocrine actions. In contrast, WBCs in CML bind FGF-2 provided by other FGF-2-hyperproducing cells and activate the MEK/ERK kinase cascade, possibly to modulate cell growth...
  10. ncbi Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia
    P Dvorak
    Department of Molecular Embryology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Leukemia 17:2418-25. 2003
    ..These findings have implications for the involvement of FGFR-3 in malignant hematopoiesis and depict FGFR-3 tyrosine kinase in CD34+ leukemic cells as a possible target for tyrosine kinase inhibitors...
  11. ncbi In vitro labelling of mouse embryonic stem cells with SPIO nanoparticles
    J Krejci
    Institute of Biophysics, Academy of Sciences of the Czech Republic, v v i, Kralovopolska 135, Brno, Czech Republic
    Gen Physiol Biophys 27:164-73. 2008
    ..Thus for the first time we documented the effects of SPIO nanoparticles on ES cells and their differentiation...
  12. pmc A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells
    Livia Eiselleova
    Department of Biology, Faculty of Medicine University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Stem Cells 27:1847-57. 2009
    ..This stimulation of self-renewal, cell survival, and adhesion by exogenous and endogenous FGF-2 may synergize to maintain the undifferentiated growth of hESCs...
  13. ncbi Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells
    J Pachernik
    Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Faculty of Science, Brno, Czech Republic
    Folia Biol (Praha) 53:157-63. 2007
    ..These results suggest that in neurogenic regions, cooperative action of LIF and other neuro-differentiation-inducing factors, such as retinoic acid, may be mediated by the STAT3 signalling pathway...
  14. ncbi Temporal distribution of CDK4, CDK6, D-type cyclins, and p27 in developing mouse oocytes
    J Kohoutek
    Laboratory of Molecular Embryology, Mendel University Brno, 613 00 Brno, Czech Republic
    Biol Reprod 70:139-45. 2004
    ..These data distinguish G1/S regulators as the potential players in molecular processes that are important for oocytes to function normally...
  15. doi Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin
    I Kubikova
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Cytotherapy 11:330-40, 1 p following 340. 2009
    ..However, they may also contain immunogenic membrane domains and infectious particles acquired from xenogenic components of the culture milieu. Therefore, MV represent a potential risk for clinical application of cell therapy...
  16. doi Comparative study of mouse and human feeder cells for human embryonic stem cells
    Livia Eiselleova
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Int J Dev Biol 52:353-63. 2008
    ..Cumulatively, these results suggest that the ability of a feeder layer to promote the undifferentiated growth of hESCs is attributable to its characteristic growth factor production...
  17. ncbi Fibroblast growth factor signaling in embryonic and cancer stem cells
    Petr Dvorak
    Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
    FEBS Lett 580:2869-74. 2006
    ..Here we summarize recent data on the effects of FGF-2 and its receptors on hESCs and leukemic stem/progenitor cells. Also, we discuss the similarities of these findings with stem cell renewal and differentiation phenotypes...
  18. ncbi The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells
    Martin Anger
    Department of Biology, University of Pennsylvania, USA
    Biochem Biophys Res Commun 302:825-30. 2003
    ....
  19. ncbi Targeted disruption of fibroblast growth factor receptor-1 blocks maturation of visceral endoderm and cavitation in mouse embryoid bodies
    Milan Esner
    Department of Molecular Embryology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague
    Int J Dev Biol 46:817-25. 2002
    ..Our results indicate that FGFR-1 may play a vital role in endoderm formation...
  20. ncbi Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
    Oluseun Adewumi
    UK Stem Cell Bank, Division of Cell Biology and Imaging, National Institute for Biological Standards and Control, South Mimms, Herts, EN6 3QG, UK
    Nat Biotechnol 25:803-16. 2007
    ..Also, some female lines expressed readily detectable levels of XIST whereas others did not. No significant contamination of the lines with mycoplasma, bacteria or cytopathic viruses was detected...
  21. ncbi The reverse tetracycline-controlled transactivator rtTA2s-S2 is toxic in mouse embryonic stem cells
    Vitezslav Bryja
    Center for Cell Therapy and Tissue Repair, Charles University, Department of Molecular Embryology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Reprod Nutr Dev 43:477-86. 2003
    ..Our results indicate that this transactivator is toxic to ES cells and raise the need for the development of other strategies for stable and inducible expression of genes in ES cells...