Lumir Krejci

Summary

Affiliation: Masaryk University
Country: Czech Republic

Publications

  1. pmc Homologous recombination and its regulation
    Lumir Krejci
    Department of Biology, Masaryk University, Brno, Czech Republic
    Nucleic Acids Res 40:5795-818. 2012
  2. pmc Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis
    Peter Burkovics
    National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic
    EMBO J 32:742-55. 2013
  3. pmc Strand invasion by HLTF as a mechanism for template switch in fork rescue
    Peter Burkovics
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, HU 6726 Szeged, Hungary, Department of Biology, Masaryk University, Brno, Czech Republic, National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic and International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St Anne s University Hospital Brno, CZ 62500 Brno, Czech Republic
    Nucleic Acids Res 42:1711-20. 2014
  4. pmc Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans
    Marek Sebesta
    National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic
    DNA Repair (Amst) 12:691-8. 2013
  5. pmc Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation
    Peter Kolesar
    Department of Biology, National Centre for Biomolecular Research, Masaryk University, 62500 Brno, Czech Republic
    Nucleic Acids Res 40:7831-43. 2012
  6. pmc Unwinding of synthetic replication and recombination substrates by Srs2
    Victoria Marini
    Department of Biology, Masaryk University, Kamenice, Brno, Czech Republic
    DNA Repair (Amst) 11:789-98. 2012
  7. pmc Rad52 SUMOylation affects the efficiency of the DNA repair
    Veronika Altmannova
    Department of Biology, Masaryk University, Brno, Czech Republic
    Nucleic Acids Res 38:4708-21. 2010
  8. pmc Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities
    Marek Sebesta
    Department of Biology, Masaryk University, Kamenice 5 A7, 625 00 Brno, Czech Republic
    DNA Repair (Amst) 10:567-76. 2011

Collaborators

  • Lajos Haracska
  • Xiaolan Zhao
  • Nadine Eckert-Boulet
  • Michael Lisby
  • Peter Burkovics
  • Marek Sebesta
  • Peter Kolesar
  • Victoria Marini
  • Veronika Altmannova
  • David Balogh
  • Thomas Robert
  • Szilvia Juhasz
  • Valeria Szukacsov
  • Nicolas Plault
  • Judit E Szabó
  • Sufang Zhang
  • Serge Gangloff
  • Marietta Y W T Lee
  • Lajos Pintér
  • Alexandra Sisakova
  • Prabha Sarangi
  • Milica Arneric
  • Patrick Sung
  • Jiri Damborsky
  • Radka Chaloupkova

Detail Information

Publications8

  1. pmc Homologous recombination and its regulation
    Lumir Krejci
    Department of Biology, Masaryk University, Brno, Czech Republic
    Nucleic Acids Res 40:5795-818. 2012
    ....
  2. pmc Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis
    Peter Burkovics
    National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic
    EMBO J 32:742-55. 2013
    ..Our results suggest that cycling cells use the Siz1-dependent SUMOylation of PCNA to limit the extension of repair synthesis during template switch or HR and attenuate reciprocal DNA strand exchanges to maintain genome stability...
  3. pmc Strand invasion by HLTF as a mechanism for template switch in fork rescue
    Peter Burkovics
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, HU 6726 Szeged, Hungary, Department of Biology, Masaryk University, Brno, Czech Republic, National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic and International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St Anne s University Hospital Brno, CZ 62500 Brno, Czech Republic
    Nucleic Acids Res 42:1711-20. 2014
    ..Our data indicate that HLTF is involved in a RAD51-independent D-loop branch of template switch pathway that can promote repair of gaps formed during replication of damaged DNA. ..
  4. pmc Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans
    Marek Sebesta
    National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic
    DNA Repair (Amst) 12:691-8. 2013
    ..In addition, the presence of PCNA on the D-loop regulates the length of the extension tracks by recruiting various polymerases and might present a regulatory point for the various recombination outcomes. ..
  5. pmc Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation
    Peter Kolesar
    Department of Biology, National Centre for Biomolecular Research, Masaryk University, 62500 Brno, Czech Republic
    Nucleic Acids Res 40:7831-43. 2012
    ..Our findings suggest a potential mechanism for the equilibrium of sumoylated and PCNA-bound pools of Srs2 in cells...
  6. pmc Unwinding of synthetic replication and recombination substrates by Srs2
    Victoria Marini
    Department of Biology, Masaryk University, Kamenice, Brno, Czech Republic
    DNA Repair (Amst) 11:789-98. 2012
    ..These biochemical results help us understand the possible role of Srs2 in the processing of stalled or blocked replication forks as a part of post-replication repair as well as homologous recombination (HR)...
  7. pmc Rad52 SUMOylation affects the efficiency of the DNA repair
    Veronika Altmannova
    Department of Biology, Masaryk University, Brno, Czech Republic
    Nucleic Acids Res 38:4708-21. 2010
    ..Taken together, our results highlight the importance of Rad52 SUMOylation as part of a 'quality control' mechanism regulating the efficiency of recombination and DNA repair...
  8. pmc Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities
    Marek Sebesta
    Department of Biology, Masaryk University, Kamenice 5 A7, 625 00 Brno, Czech Republic
    DNA Repair (Amst) 10:567-76. 2011
    ..The experimental system described here can be employed to increase our understanding of HR events following D-loop formation, as well as the regulatory mechanisms involved...