L Izakovicova Holla

Summary

Affiliation: Masaryk University
Country: Czech Republic

Publications

  1. pmc Haplotype analysis of interleukin-8 gene polymorphisms in chronic and aggressive periodontitis
    Petra Borilova Linhartova
    Department of Pathophysiology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
    Mediators Inflamm 2013:342351. 2013
  2. doi request reprint Haplotypes of the IL-1 gene cluster are associated with gastroesophageal reflux disease and Barrett's esophagus
    Lydie Izakovicova Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Czech Republic
    Hum Immunol 74:1161-9. 2013
  3. doi request reprint Matrix metalloproteinase 8 (MMP8) gene polymorphisms in chronic periodontitis
    L Izakovicova Holla
    Clinic of Stomatology, Masaryk University Brno, Czech Republic
    Arch Oral Biol 57:188-96. 2012
  4. ncbi request reprint Lack of association between chronic periodontitis and the Toll-like receptor 4 gene polymorphisms in a Czech population
    L Izakovicova Holla
    Department of Pathological Physiology and Clinic of Stomatology, Medical Faculty, Masaryk University Brno, Czech Republic
    J Periodontal Res 42:340-4. 2007
  5. doi request reprint Association of interleukin-6 (IL-6) haplotypes with plaque-induced gingivitis in children
    Lydie Izakovicova Holla
    Clinics of Stomatology, St Anne s University Hospital and Faculty of Medicine, Masaryk University Brno, Czech Republic
    Acta Odontol Scand 66:105-12. 2008
  6. doi request reprint Haplotype analysis of the endothelial nitric oxide synthase gene in asthma
    Lydie Izakovicova Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Brno, Czech Republic
    Hum Immunol 69:306-13. 2008
  7. doi request reprint Haplotype analysis of the NADPH oxidase p22 phox gene in patients with bronchial asthma
    Lydie Izakovicova Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Brno, Czech Republic
    Int Arch Allergy Immunol 148:73-80. 2009
  8. ncbi request reprint The association of interleukin-4 haplotypes with chronic periodontitis in a Czech population
    Lydie Izakovicova Holla
    Department of Pathophysiology, Masaryk University, Brno, Czech Republic
    J Periodontol 79:1927-33. 2008
  9. doi request reprint MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders
    L Izakovicova Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University, Brno, Czech Republic
    Int J Immunogenet 36:69-72. 2009
  10. doi request reprint Association of Toll-like receptor 9 haplotypes with chronic periodontitis in Czech population
    Lydie Izakovicova Holla
    Clinic of Stomatology, Faculty of Medicine, Masaryk University Brno and St Anne s University Hospital Brno, Brno, Czech Republic
    J Clin Periodontol 37:152-9. 2010

Collaborators

Detail Information

Publications28

  1. pmc Haplotype analysis of interleukin-8 gene polymorphisms in chronic and aggressive periodontitis
    Petra Borilova Linhartova
    Department of Pathophysiology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
    Mediators Inflamm 2013:342351. 2013
    ..Interleukin-8 (IL8) is important in the regulation of the immune response. The aim of this study was to analyze four polymorphisms in the IL8 gene in relation to chronic (CP) and aggressive (AgP) periodontitis...
  2. doi request reprint Haplotypes of the IL-1 gene cluster are associated with gastroesophageal reflux disease and Barrett's esophagus
    Lydie Izakovicova Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Czech Republic
    Hum Immunol 74:1161-9. 2013
    ..The aim of our study was to determine the impact of IL-1 gene polymorphisms on the development of GERD, RE and BE...
  3. doi request reprint Matrix metalloproteinase 8 (MMP8) gene polymorphisms in chronic periodontitis
    L Izakovicova Holla
    Clinic of Stomatology, Masaryk University Brno, Czech Republic
    Arch Oral Biol 57:188-96. 2012
    ..The aim of this study was to analyse polymorphisms in the MMP8 gene and their associations with microbial composition and clinical manifestation of CP...
  4. ncbi request reprint Lack of association between chronic periodontitis and the Toll-like receptor 4 gene polymorphisms in a Czech population
    L Izakovicova Holla
    Department of Pathological Physiology and Clinic of Stomatology, Medical Faculty, Masaryk University Brno, Czech Republic
    J Periodontal Res 42:340-4. 2007
    ..Toll-like receptors are signal molecules essential for the cellular response to bacterial cell wall components. The aim of this study was to investigate relationships between chronic periodontitis and variations in the TLR4 gene...
  5. doi request reprint Association of interleukin-6 (IL-6) haplotypes with plaque-induced gingivitis in children
    Lydie Izakovicova Holla
    Clinics of Stomatology, St Anne s University Hospital and Faculty of Medicine, Masaryk University Brno, Czech Republic
    Acta Odontol Scand 66:105-12. 2008
    ..The aim of this case-control study was to test differences between children with and without gingivitis in the distribution of IL-6 alleles at positions -174, -572, and -597 and their haplotypes...
  6. doi request reprint Haplotype analysis of the endothelial nitric oxide synthase gene in asthma
    Lydie Izakovicova Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Brno, Czech Republic
    Hum Immunol 69:306-13. 2008
    ..001, p(corr) < 0.05, odds ratio = 0.58, 95% confidence interval = 0.46-0.73). These findings suggest that endothelial NOS variants may be one of the factors participating in protection or susceptibility to asthma in our population...
  7. doi request reprint Haplotype analysis of the NADPH oxidase p22 phox gene in patients with bronchial asthma
    Lydie Izakovicova Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Brno, Czech Republic
    Int Arch Allergy Immunol 148:73-80. 2009
    ..3) in asthma susceptibility by means of an association study of haplotypes based on 3 common single nucleotide polymorphisms (SNPs), -930A/G, 242C/T (H72Y) and 640A/G...
  8. ncbi request reprint The association of interleukin-4 haplotypes with chronic periodontitis in a Czech population
    Lydie Izakovicova Holla
    Department of Pathophysiology, Masaryk University, Brno, Czech Republic
    J Periodontol 79:1927-33. 2008
    ..The aim of this study was to test differences in the distribution of the IL-4 alleles, genotypes, and haplotypes between patients with chronic periodontitis (CP) and healthy controls in a Czech population...
  9. doi request reprint MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders
    L Izakovicova Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University, Brno, Czech Republic
    Int J Immunogenet 36:69-72. 2009
    ..Nevertheless, MCP-1 variants were associated with allergen sensitization. The results suggest that MCP-1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population...
  10. doi request reprint Association of Toll-like receptor 9 haplotypes with chronic periodontitis in Czech population
    Lydie Izakovicova Holla
    Clinic of Stomatology, Faculty of Medicine, Masaryk University Brno and St Anne s University Hospital Brno, Brno, Czech Republic
    J Clin Periodontol 37:152-9. 2010
    ..The aim of this study was to analyse polymorphisms in the TLR genes and their association with chronic periodontitis (CP)...
  11. doi request reprint Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders
    Lydie Izakovicova Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University, Brno, Czech Republic
    Hum Immunol 71:592-7. 2010
    ..59-7.14). In contrast, there was no relationship among the IL-18 variants and total serum IgE level. Our results indicate that promoter polymorphisms in the IL-18 gene act in interaction and could play a role in allergic disorders...
  12. doi request reprint Interferon-γ +874A/T polymorphism in relation to generalized chronic periodontitis and the presence of periodontopathic bacteria
    L Izakovicova Holla
    Clinic of Stomatology, Faculty of Medicine, Masaryk University Brno and St Anne s University Hospital Brno, Czech Republic
    Arch Oral Biol 56:153-8. 2011
    ..The aim of this study was to analyze +874A/T polymorphism in the IFN-γ gene and its associations with the presence of periodontopathic bacteria and susceptibility to generalized chronic periodontitis (CP)...
  13. ncbi request reprint Functional polymorphisms in the matrix metalloproteinase-9 gene in relation to severity of chronic periodontitis
    Lydie Izakovicova Holla
    Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    J Periodontol 77:1850-5. 2006
    ..Therefore, we performed a case-control study to investigate a plausible association between susceptibility to chronic periodontitis (CP) and the polymorphisms in the MMP-9 (gelatinase B) gene...
  14. ncbi request reprint Interactions of lymphotoxin alpha (TNF-beta), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis
    L I Holla
    Institute of Pathological Physiology, Medical Faculty, Masaryk University Brno, Czech Republic
    J Periodontol 72:85-9. 2001
    ..To investigate whether the genes encoded within the HLA class III region may confer susceptibility to periodontitis, polymorphisms in the ET-1 and TNF-beta genes were analyzed together with the I/D polymorphism of the ACE gene...
  15. ncbi request reprint Variants of endothelin-1 gene in atopic diseases
    L L Hollá
    Institute of Pathological Physiology, Medical Faculty Masaryk University Brno, Czech Republic
    J Investig Allergol Clin Immunol 11:193-8. 2001
    ..However, a possible involvement of polymorphisms of the corresponding gene in the origin of these conditions has so far not been subjected to a more comprehensive study...
  16. ncbi request reprint 5 polymorphisms in the transforming growth factor-beta 1 gene (TGF-beta 1) in adult periodontitis
    Lydie Izakovicova Holla
    Institute of Pathological Physiology, Medical Faculty, Masaryk University Brno, Czech Republic
    J Clin Periodontol 29:336-41. 2002
    ..The purpose of this study was to determine whether polymorphisms in the TGF-beta 1 gene may confer susceptibility to adult periodontitis...
  17. ncbi request reprint Plasminogen-activator-inhibitor-1 promoter polymorphism as a risk factor for adult periodontitis in non-smokers
    L Izakovicova Holla
    Department of Pathological Physiology, Medical Faculty, Masaryk University Brno, Czech Republic
    Genes Immun 3:292-4. 2002
    ..05). A stronger association occurred in non-smokers (P = 0.00021, P(corr) < 0.01; P = 0.0024, P(corr) < 0.05) where the presence of the PAI-1 gene 4G allele appears to be one of the risk factors for periodontitis...
  18. ncbi request reprint Prevalence of endothelial nitric oxide synthase gene polymorphisms in patients with atopic asthma
    L I Holla
    Institute of Pathological Physiology, Masaryk University Brn Czch Republic
    Clin Exp Allergy 32:1193-8. 2002
    ..Asthma is a common multifactorial disease, the aetiology of which is attributable to both environmental and genetic factors. The endothelial nitric oxide synthase (NOS3) gene has been implicated in asthma pathogenesis...
  19. ncbi request reprint The interaction of the polymorphisms in transporter of antigen peptides (TAP) and lymphotoxin alpha (LT-alpha) genes and atopic diseases in the Czech population
    L Izakovicova Holla
    Institute of Pathological Physiology, Medical Faculty, Masaryk University Brno, Czech Republic
    Clin Exp Allergy 31:1418-23. 2001
    ..These genes, inducible by interferon gamma, as well as lymphotoxin alpha (LT-alpha), are located in the HLA region. Their involvement in immune response regulation makes them candidate atopy susceptibility genes...
  20. ncbi request reprint Distribution of the receptor for advanced glycation end products gene polymorphisms in patients with chronic periodontitis: a preliminary study
    L I Holla
    Institute of Pathological Physiology, Medical Faculty, Masaryk University Brno, Czech Republic
    J Periodontol 72:1742-6. 2001
    ..The aim of this study was to investigate a possible association of 3 common polymorphisms in the RAGE gene with chronic periodontitis...
  21. ncbi request reprint Analysis of the interleukin-6 gene promoter polymorphisms in Czech patients with chronic periodontitis
    Lydie Izakovicova Holla
    Department of Pathological Physiology, Medical Faculty, Masaryk University, Brno, Czech Republic
    J Periodontol 75:30-6. 2004
    ..The purpose of this study was to investigate the associations of chronic periodontitis with IL-6 gene polymorphisms (at positions -597 [G/A], -572 [G/C], and -174 [G/C])...
  22. ncbi request reprint Genetic variations in the matrix metalloproteinase-1 promoter and risk of susceptibility and/or severity of chronic periodontitis in the Czech population
    L Izakovicova Holla
    Department of Pathological Physiology, Medical Faculty, Masaryk University Brno, Czech Republic
    J Clin Periodontol 31:685-90. 2004
    ..Therefore, the aim of our study was to examine the association between three promoter polymorphisms of the MMP-1 gene and chronic periodontitis susceptibility and/or severity in a Czech population...
  23. ncbi request reprint Genetic variations in the human gelatinase A (matrix metalloproteinase-2) promoter are not associated with susceptibility to, and severity of, chronic periodontitis
    Lydie Izakovicova Holla
    Department of Pathological Physiology, Medical Faculty, Masaryk University Brno, Komenskeho nam 2, 662 43 Brno, Czech Republic
    J Periodontol 76:1056-60. 2005
    ..In this study, we test the hypothesis that variations in this gene influence the development and severity of chronic periodontitis...
  24. ncbi request reprint Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma
    Lydie Izakovicova Holla
    Department of Pathophysiology, Faculty of Medicine, Masaryk University Brno, Komenskeho nam 2, 662 43 Brno, Czech Republic
    Clin Biochem 39:299-302. 2006
    ..To investigate the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects...
  25. ncbi request reprint Association study of promoter polymorphisms within the NOS3 gene and allergic diseases
    Lydie Izakovicova Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Brno, Czech Republic
    Int Arch Allergy Immunol 141:103-9. 2006
    ..Nitric oxide (NO) is an important mediator of physiologic and pathologic processes in the airways. On this basis, we hypothesized that polymorphisms in the NOS3 gene could be associated with the disease process...
  26. ncbi request reprint Polymorphisms in the +252(A/G) lymphotoxin-alpha and the -308(A/G) tumor necrosis factor-alpha genes and susceptibility to chronic periodontitis in a Czech population
    Antonin Fassmann
    Department of Pathological Physiology, Clinic of Stomatology, Medical Faculty and Centre for Mathematical Modelling, Masaryk University Brno, Czech Republic
    J Periodontal Res 38:394-9. 2003
    ..Tumor necrosis factor (TNF), a pluripotent proinflammatory cytokine that is able to induce tissue destruction and bone resorption, has been implicated in the pathogenesis of periodontal disease...
  27. doi request reprint The association of MMP-9 and IL-18 gene promoter polymorphisms with gingivitis in adolescents
    Jan Vokurka
    Faculty of Medicine, Masaryk University Brno, Czech Republic
    Arch Oral Biol 54:172-8. 2009
    ..The aim of this study was to test for differences between Czech adolescents with and without gingivitis in relation to MMP-9 and IL-18 polymorphisms...
  28. ncbi request reprint Polymorphisms of the CD14 gene and atopic phenotypes in Czech patients with IgE-mediated allergy
    Dana Buckova
    Institute of Pathological Physiology LF MU Medical Faculty, Masaryk University, Komenskeho nam 2, Brno 662 43, Czech Republic
    J Hum Genet 51:977-83. 2006
    ..0008-0.0035). Our study supports the idea that CD14 plays a role in IgE-mediated allergic diseases, and its gene polymorphisms can be important for manifestation of these disorders...