Petr Dubovy

Summary

Affiliation: Masaryk University
Country: Czech Republic

Publications

  1. ncbi request reprint Role of inflammation and cytokines in peripheral nerve regeneration
    Petr Dubovy
    Central European Institute of Technology CEITEC, Masaryk University, Brno, Czech Republic Department of Anatomy, Division of Neuroanatomy, Medical Faculty, Masaryk University, Brno, Czech Republic Electronic address
    Int Rev Neurobiol 108:173-206. 2013
  2. pmc Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve
    Petr Dubovy
    Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic
    J Neuroinflammation 10:55. 2013
  3. pmc Enhancement of musculocutaneous nerve reinnervation after vascular endothelial growth factor (VEGF) gene therapy
    Pavel Haninec
    Department of Neurosurgery, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    BMC Neurosci 13:57. 2012
  4. ncbi request reprint Laminin molecules in freeze-treated nerve segments are associated with migrating Schwann cells that display the corresponding alpha6beta1 integrin receptor
    P Dubovy
    Department of Anatomy, Division of Neuroanatomy, Medical Faculty, Masaryk University, Brno, Czech Republic
    Glia 33:36-44. 2001
  5. doi request reprint Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic nerve injury as a model of neuropathic pain
    Petr Dubovy
    Division of Neuroanatomy, Department of Anatomy, Faculty of Medicine, Masaryk University, Kamenice 3, 625 00, Brno, Czech Republic
    Histochem Cell Biol 133:323-37. 2010
  6. doi request reprint Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Neuron Glia Biol 6:73-83. 2010
  7. doi request reprint Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine and Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, Czech Republic
    Ann Anat 193:267-75. 2011
  8. ncbi request reprint Restoration of lamellar structures in adult rat Pacinian corpuscles following their simultaneous freezing injury and denervation
    P Dubovy
    Department of Anatomy, School of Medicine, Masaryk University Brno, Czech Republic
    Anat Embryol (Berl) 202:235-45. 2000
  9. ncbi request reprint Increased invasion of ED-1 positive macrophages in both ipsi- and contralateral dorsal root ganglia following unilateral nerve injuries
    P Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Kamenice 3, Brno 625 00, Czech Republic
    Neurosci Lett 427:88-93. 2007
  10. ncbi request reprint Intra- and extraneuronal changes of immunofluorescence staining for TNF-alpha and TNFR1 in the dorsal root ganglia of rat peripheral neuropathic pain models
    P Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Kamenice 3, CZ 625 00, Brno, Czech Republic
    Cell Mol Neurobiol 26:1205-17. 2006

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Role of inflammation and cytokines in peripheral nerve regeneration
    Petr Dubovy
    Central European Institute of Technology CEITEC, Masaryk University, Brno, Czech Republic Department of Anatomy, Division of Neuroanatomy, Medical Faculty, Masaryk University, Brno, Czech Republic Electronic address
    Int Rev Neurobiol 108:173-206. 2013
    ..Understanding of the cellular and molecular interactions between the immune system and peripheral nerve injury opens new possibilities for targeting inflammatory mediators to improve functional reinnervation. ..
  2. pmc Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve
    Petr Dubovy
    Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic
    J Neuroinflammation 10:55. 2013
    ..Current research implicates interleukin (IL)-6 as a key component of the nervous-system response to injury with various effects...
  3. pmc Enhancement of musculocutaneous nerve reinnervation after vascular endothelial growth factor (VEGF) gene therapy
    Pavel Haninec
    Department of Neurosurgery, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    BMC Neurosci 13:57. 2012
    ..Reinnervation of the MCN stumps was assessed based on density, diameter and myelin sheath thickness of regenerated axons, grooming test and the wet weight index of the biceps brachii muscles...
  4. ncbi request reprint Laminin molecules in freeze-treated nerve segments are associated with migrating Schwann cells that display the corresponding alpha6beta1 integrin receptor
    P Dubovy
    Department of Anatomy, Division of Neuroanatomy, Medical Faculty, Masaryk University, Brno, Czech Republic
    Glia 33:36-44. 2001
    ..The immunostaining for laminins and integrin chains, which constitute one of integrin receptor, suggests an autocrine and/or paracrine utilization of laminin molecules in the promotion of Schwann cell migration...
  5. doi request reprint Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic nerve injury as a model of neuropathic pain
    Petr Dubovy
    Division of Neuroanatomy, Department of Anatomy, Faculty of Medicine, Masaryk University, Kamenice 3, 625 00, Brno, Czech Republic
    Histochem Cell Biol 133:323-37. 2010
    ..Functional involvement of these alterations in DRG non-associated with injured nerve in neuropathic pain remains to be elucidated...
  6. doi request reprint Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Neuron Glia Biol 6:73-83. 2010
    ..The results may suggest that unilateral CCI of the sciatic nerve induces bilateral activation of SGC in L4-L5 DRG to transduce IL-6 signalling during neuroinflammation...
  7. doi request reprint Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine and Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, Czech Republic
    Ann Anat 193:267-75. 2011
    ..Understanding the pleiotropic effects of cytokines/chemokines, however, requires investigating their highly specific pathways and precise points of action...
  8. ncbi request reprint Restoration of lamellar structures in adult rat Pacinian corpuscles following their simultaneous freezing injury and denervation
    P Dubovy
    Department of Anatomy, School of Medicine, Masaryk University Brno, Czech Republic
    Anat Embryol (Berl) 202:235-45. 2000
    ..The molecules deposited into the extracellular matrix are able to influence the redifferentiation of multilamellar auxiliary structures from immature cells...
  9. ncbi request reprint Increased invasion of ED-1 positive macrophages in both ipsi- and contralateral dorsal root ganglia following unilateral nerve injuries
    P Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Kamenice 3, Brno 625 00, Czech Republic
    Neurosci Lett 427:88-93. 2007
    ..Signaling for macrophage invasion into DRG contralateral to nerve injury may be mediated by lost motoneurons or by interneurones...
  10. ncbi request reprint Intra- and extraneuronal changes of immunofluorescence staining for TNF-alpha and TNFR1 in the dorsal root ganglia of rat peripheral neuropathic pain models
    P Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Kamenice 3, CZ 625 00, Brno, Czech Republic
    Cell Mol Neurobiol 26:1205-17. 2006
    ..Moreover, the different cellular distribution of TNFR1 in the ipsi- and contralateral DRG may reflect different pathways by which TNF-alpha effect on the primary sensory neurons can be mediated following nerve injury...
  11. ncbi request reprint A heterogeneous immunofluorescence staining for laminin-1 and related basal lamina molecules in the dorsal root ganglia following constriction nerve injury
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Kamenice 3, CZ 625 00, Brno, Czech Republic
    Histochem Cell Biol 125:671-80. 2006
    ..A modulation of the basal laminae may be related with other cellular and molecular alterations related with peripheral neuropathic pain, for example, expansion of sympathetic sprouts...
  12. ncbi request reprint Schwann cells and endoneurial extracellular matrix molecules as potential cues for sorting of regenerated axons: a review
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Medical Faculty, Masaryk University Brno, Czech Republic
    Anat Sci Int 79:198-208. 2004
    ..Knowledge of the sorting mechanisms of regenerated motor and sensory axons is needed not only for improvement of functional recovery, but also for the development of biocompatible nerve prostheses...
  13. pmc Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, and Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, CZ 625 00 Brno, Czech Republic
    BMC Neurosci 12:58. 2011
    ..Reinnervation of biceps brachii muscles was assessed by electromyography, behavioral test, and diameter and myelin sheath thickness of regenerated axons...
  14. ncbi request reprint Computer-assisted quantitative analysis of immunofluorescence staining of the extracellular matrix in rat dorsal and ventral spinal roots
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Acta Histochem 104:371-4. 2002
    ..The ECM composition of the endoneurium in dorsal and ventral roots may be related with the creation of extrinsic conditions that support differential regeneration of afferent and motor axons after injury...
  15. ncbi request reprint A quantitative immunohistochemical study of the endoneurium in the rat dorsal and ventral spinal roots
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Kamenice 3, 62500 Brno, Czech Republic
    Histochem Cell Biol 117:473-80. 2002
    ....
  16. ncbi request reprint Immunohistochemical labelling of components of the endoneurial extracellular matrix of intact and rhizotomized dorsal and ventral spinal roots of the rat--a quantitative evaluation using image analysis
    Jancalek Radim
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Kamenice 3, CZ 625 00 Brno, Czech Republic
    Acta Histochem 107:453-62. 2006
    ....
  17. pmc Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve
    Radim Jancálek
    Department of Anatomy, Division of Neuroanatomy, Medical Faculty, Masaryk University, Brno, Czech Republic
    J Neuroinflammation 7:11. 2010
    ..Because cytokines act as crucial signaling molecules for response of peripheral nerves to injury, they may be induced to mediate the reaction in remote structures...
  18. doi request reprint Alterations in the vascular architecture of the dorsal root ganglia in a rat neuropathic pain model
    Lubos Kubícek
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Kamenice 3, CZ 625 00 Brno, Czech Republic
    Ann Anat 192:101-6. 2010
    ..Fractal analysis confirmed a higher degree of vascular branching, irregularity, and tortuosity in L4-DRG related with sciatic nerve injury. The results suggest that nerve injury induces changes in vascular architecture in associated DRG...
  19. ncbi request reprint Quantitative assessment of the ability of collateral sprouting of the motor and primary sensory neurons after the end-to-side neurorrhaphy of the rat musculocutaneous nerve with the ulnar nerve
    Filip Samal
    Department of Neurosurgery, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    Ann Anat 188:337-44. 2006
    ..The present experimental study confirms end-to-side neurorrhaphy as a suitable method of nerve reconstruction...
  20. doi request reprint Bilateral changes in IL-6 protein, but not in its receptor gp130, in rat dorsal root ganglia following sciatic nerve ligature
    Vaclav Brazda
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic
    Cell Mol Neurobiol 29:1053-62. 2009
    ..The data provide evidence for changes in IL-6 levels not only in the DRG associated with the damaged nerve but also in those unassociated with nerve injury during the experimental neuropathic pain model...
  21. doi request reprint Experimental models of peripheral neuropathic pain based on traumatic nerve injuries - an anatomical perspective
    Ilona Klusáková
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic
    Ann Anat 191:248-59. 2009
    ..e., in the contralateral DRG or at different spinal segments). Generally, all experimental PNP models based on a partial injury of peripheral nerve segments contain mechanisms initiated by signal molecules of Wallerian degeneration...
  22. doi request reprint A Comparison of collateral sprouting of sensory and motor axons after end-to-side neurorrhaphy with and without the perineurial window
    Pavel Haninec
    Department of Neurosurgery, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    Plast Reconstr Surg 130:609-14. 2012
    ..The aim of the present study was to quantitatively evaluate collateral sprouting of motor and sensory axons after end-to-side neurorrhaphy with and without the perineurial window...
  23. doi request reprint Prediabetes/early diabetes-associated neuropathy predominantly involves sensory small fibres
    Sarka Divisova
    Department of Neurology, University Hospital, University Hospital, Masaryk University Brno, Czech Republic
    J Peripher Nerv Syst 17:341-50. 2012
    ..The absolute IENFD values from distal leg were significantly lower in both eDM2 (p < 0.0001) and preDM patients (p = 0.005) compared to controls. Neuropathy associated with preDM/eDM2 predominantly involves sensory small fibres...
  24. ncbi request reprint Morphological evidence of collateral sprouting of intact afferent and motor axons of the rat ulnar nerve demonstrated by one type of tracer molecule
    T Kubek
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Kamenice 3, CZ 62500 Brno, Czech Republic
    Ann Anat 186:231-4. 2004
    ..Our results unequivocally demonstrate that a nerve stump attached to an intact nerve can induce collateral sprouting of both afferent and motor axons...
  25. pmc Bilateral changes of cannabinoid receptor type 2 protein and mRNA in the dorsal root ganglia of a rat neuropathic pain model
    Ivana Hradilová Svízenská
    Central European Institute of Technology, Brno, Czech Republic
    J Histochem Cytochem 61:529-47. 2013
    ..The fact that changes appear bilaterally and (albeit at a lower level) even in the remote cervical DRG can be related to propagation of neuroinflammation alongside the neuraxis and to the neuroprotective effects of CB2R...
  26. ncbi request reprint Morphometric analysis of early regeneration of motor axons through motor and cutaneous nerve grafts
    N Ghalib
    Department of Anatomy, Faculty of Medicine, Masaryk University, Brno, Czech Republik
    Ann Anat 183:363-8. 2001
    ..Morphometric analysis of early regeneration of myelinated motor axons suggests that the cutaneous and motor branches of the femoral nerve provide different conditions not for the growth but for the maturation of motor axons...
  27. doi request reprint Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus
    Sarka Bursova
    Department of Neurology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
    J Neurol Sci 315:60-3. 2012
    ..1%. In conclusion, these results show that impaired regeneration of intra-epidermal C fibers in the early stages of type 2 diabetes mellitus, as indicated by GAP-43, might be a marker of incipient diabetic neuropathy...
  28. ncbi request reprint Recovery of non-specific cholinesterase activity in sensory corpuscles of mouse toe skin after irreversible inhibition of this enzyme and cold injury
    P Dubovy
    Department of Anatomy, Medical Faculty, Purkyne University, Brno, Czechoslovakia
    Acta Histochem 88:77-91. 1990
    ..These findings suggest certain trophic independence of inner core cells upon sensory terminals in the sensory corpuscles of adult animals...
  29. ncbi request reprint Inflammatory profiling of schwann cells in contact with growing axons distal to nerve injury
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Medical Faculty and Central European Institute of Technology CEITEC, Masaryk University, 625 00 Brno, Czech Republic
    Biomed Res Int 2014:691041. 2014
    ....
  30. pmc Dynamic response to peripheral nerve injury detected by in situ hybridization of IL-6 and its receptor mRNAs in the dorsal root ganglia is not strictly correlated with signs of neuropathic pain
    Vaclav Brazda
    Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, 62500, Brno, Czech Republic
    Mol Pain 9:42. 2013
    ....
  31. doi request reprint Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures--a short review
    Ivana Svízenská
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Kamenice 3, CZ 625 00 Brno, Czech Republic
    Pharmacol Biochem Behav 90:501-11. 2008
    ..The aim of this review is to highlight distribution of the CB1 and CB2 receptor subtypes in the nervous system and functional involvement of their specific ligands...