Dalibor Blazek

Summary

Affiliation: Masaryk University
Country: Czech Republic

Publications

  1. ncbi Cyclin K goes with Cdk12 and Cdk13
    Jiri Kohoutek
    Central European Institute of Technology CEITEC, Masaryk University, 62500 Brno, Czech Republic
    Cell Div 7:12. 2012
  2. ncbi The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
    Dalibor Blazek
    Department of Medicine, Microbiology, and Immunology, Rosalind Russell Medical Research Center, University of California at San Francisco UCSF, USA
    Genes Dev 25:2158-72. 2011
  3. ncbi Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb
    Dalibor Blazek
    Department of Medicine, Rosalind Russell Medical Research Center, University of California at San Francisco, San Francisco, CA 94143-0703, USA
    Nucleic Acids Res 33:7000-10. 2005
  4. ncbi Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters
    Jiri Kohoutek
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143-0703, USA
    Proc Natl Acad Sci U S A 103:17349-54. 2006
  5. ncbi Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb
    Matjaz Barboric
    Department of Medicine, Rosalind Russell Medical Research Center, University of California at San Francisco, San Francisco, CA 94143 0703, USA
    EMBO J 24:4291-303. 2005
  6. ncbi Tat-SIRT1 tango
    Dalibor Blazek
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, San Francisco, CA 94143 0703, USA
    Mol Cell 29:539-40. 2008

Detail Information

Publications6

  1. ncbi Cyclin K goes with Cdk12 and Cdk13
    Jiri Kohoutek
    Central European Institute of Technology CEITEC, Masaryk University, 62500 Brno, Czech Republic
    Cell Div 7:12. 2012
    ....
  2. ncbi The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
    Dalibor Blazek
    Department of Medicine, Microbiology, and Immunology, Rosalind Russell Medical Research Center, University of California at San Francisco UCSF, USA
    Genes Dev 25:2158-72. 2011
    ..The essential role of CycK for organisms in vivo is further supported by the result that genetic inactivation of CycK in mice causes early embryonic lethality...
  3. ncbi Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb
    Dalibor Blazek
    Department of Medicine, Rosalind Russell Medical Research Center, University of California at San Francisco, San Francisco, CA 94143-0703, USA
    Nucleic Acids Res 33:7000-10. 2005
    ..Our results suggest that two independent regions in HEXIM1 form oligomers to incorporate P-TEFb into the large complex and determine the inhibition of transcriptional elongation...
  4. ncbi Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters
    Jiri Kohoutek
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143-0703, USA
    Proc Natl Acad Sci U S A 103:17349-54. 2006
    ..Thus, modulating ratios between active and inactive P-TEFb complexes is an additional mechanism of regulating transcriptional activators such as CIITA...
  5. ncbi Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb
    Matjaz Barboric
    Department of Medicine, Rosalind Russell Medical Research Center, University of California at San Francisco, San Francisco, CA 94143 0703, USA
    EMBO J 24:4291-303. 2005
    ..We propose a model where the interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct its binding to P-TEFb and subcellular localization that culminates in the inhibition of transcription...
  6. ncbi Tat-SIRT1 tango
    Dalibor Blazek
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, San Francisco, CA 94143 0703, USA
    Mol Cell 29:539-40. 2008
    ..2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation...