Country: Czech Republic
- Importance of thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicityMichal Kolorz
Department of Human Pharmacology and Toxicology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
Neuro Endocrinol Lett 30:137-42. 2009..We focused on patients who experienced leucopenia caused by high blood levels of active azathioprine metabolites...
- Gene polymorphisms involved in manifestation of leucopenia, digestive intolerance, and pancreatitis in azathioprine-treated patientsKaterina Wroblova
Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1 3, 612 42 Brno, Czech Republic
Dig Dis Sci 57:2394-401. 2012..Other adverse drug reactions that often accompany thiopurine therapy are pancreatitis, hepatotoxicity, allergic reactions, digestive intolerance, arthralgia, febrile conditions, and rash...
- Frequencies of HLA-DQ2 and HLA-DQ8 haplotypes in Czech and Slovak coeliac patients and the healthy populationKaterina Wroblova
Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic
Acta Biochim Pol 61:191-3. 2014..0494; OR3.5; CI 1.0428-11.7468). At least one of the studied HLA-variants was found more often in patients than in healthy individuals (P=0.0001; OR58.8; CI 7.6856-449.8602). ..
- Polymorphism G-308A in the promoter of the tumor necrosis factor-α gene and its association with the risk of venous thromboembolismKristyna Horakova
Department of Human Pharmacology and Toxicology, University of Veterinary and Pharmaceutical Sciences Brno, The Czech Republic
Blood Coagul Fibrinolysis 23:316-9. 2012..02). The results of this work imply possible association between the variant allele -308A and the development of DVT...