Jana Vrbikova

Summary

Affiliation: Institute of Endocrinology
Country: Czech Republic

Publications

  1. ncbi request reprint [A recommended approach to evaluate cardiovascular risk and to prevent cardiovascular diseases and type 2 diabetes mellitus in women with polycystic ovary syndrome]
    J Vrbikova
    Endokrinologický ustav Praha, Reditelka RNDr Bela Bendlová, CSc
    Vnitr Lek 58:56-7. 2012
  2. ncbi request reprint Metabolic syndrome in young Czech women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Narodni 8, Prague 1, 116 94 Czech Republic, Department of Obstetrics and Gynecology, Charles University, Apolinárská 28, Prague 2, 120 00 Czech Republic
    Hum Reprod 20:3328-32. 2005
  3. ncbi request reprint [Incretins]
    J Vrbikova
    Endokrinologický ustav, Praha
    Vnitr Lek 52:919-25. 2006
  4. ncbi request reprint Weight change and androgen levels during contraceptive treatment of women affected by polycystic ovary
    J Vrbikova
    Institute of Endocrinology, Prague, 116 94 Czech Republic
    Endocr Regul 40:119-23. 2006
  5. ncbi request reprint [Polycystic ovary syndrome in 2006]
    J Vrbikova
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:218-22. 2007
  6. ncbi request reprint Prevalence of insulin resistance and prediction of glucose intolerance and type 2 diabetes mellitus in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 45:639-44. 2007
  7. ncbi request reprint Family history of diabetes mellitus determines insulin sensitivity and beta cell function in polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:547-53. 2008
  8. doi request reprint Incretin levels in polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Narodni 8, Prague 111694, Czech Republic
    Eur J Endocrinol 159:121-7. 2008
  9. doi request reprint Beta cell function and insulin sensitivity in women with polycystic ovary syndrome: influence of the family history of type 2 diabetes mellitus
    Jana Vrbikova
    Institute of Endocrinology, Narodni 8 Prague 1, Czech Republic
    Gynecol Endocrinol 25:597-602. 2009
  10. doi request reprint Impaired glucose metabolism in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, General Faculty Hospital, Charles University, Prague, Czech Republic
    Gynecol Obstet Invest 68:186-90. 2009

Detail Information

Publications37

  1. ncbi request reprint [A recommended approach to evaluate cardiovascular risk and to prevent cardiovascular diseases and type 2 diabetes mellitus in women with polycystic ovary syndrome]
    J Vrbikova
    Endokrinologický ustav Praha, Reditelka RNDr Bela Bendlová, CSc
    Vnitr Lek 58:56-7. 2012
    ..We present the recommendations of Czech Endocrine and Czech Diabetological Societies for the screening and primary prevention of cardiovascular diseases and diabetes mellitus...
  2. ncbi request reprint Metabolic syndrome in young Czech women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Narodni 8, Prague 1, 116 94 Czech Republic, Department of Obstetrics and Gynecology, Charles University, Apolinárská 28, Prague 2, 120 00 Czech Republic
    Hum Reprod 20:3328-32. 2005
    ..3 +/- 4.8 kg/m2; mean 6 SD] and 73 age-matched healthy females (BMI 22.3 +/- 3.3 kg/m2; mean +/- SD) were evaluated for the occurrence of features of metabolic syndrome according to the Adult Treatment Panel III...
  3. ncbi request reprint [Incretins]
    J Vrbikova
    Endokrinologický ustav, Praha
    Vnitr Lek 52:919-25. 2006
    ..Physiology, pathophysiology and therapeutic implications of incretins in diabetes, neurodegenerative disorders and stress-induced hyperglycemia are concerned...
  4. ncbi request reprint Weight change and androgen levels during contraceptive treatment of women affected by polycystic ovary
    J Vrbikova
    Institute of Endocrinology, Prague, 116 94 Czech Republic
    Endocr Regul 40:119-23. 2006
    ....
  5. ncbi request reprint [Polycystic ovary syndrome in 2006]
    J Vrbikova
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:218-22. 2007
    ..Metformin and glitazones improve anovulation however the studies conducted till now were not representative concerning the point of successful pregnancy...
  6. ncbi request reprint Prevalence of insulin resistance and prediction of glucose intolerance and type 2 diabetes mellitus in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 45:639-44. 2007
    ..We evaluated the sensitivity and specificity of clinical and fasting biochemical parameters in screening for impaired glucose tolerance (IGT) and DM2...
  7. ncbi request reprint Family history of diabetes mellitus determines insulin sensitivity and beta cell function in polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:547-53. 2008
    ..Thus, women with PCOS with the concomitant family history of DM 2 have lower insulin sensitivity than healthy control women. Insulin resistance observed in these women with PCOS is compensated by increased insulin secretion...
  8. doi request reprint Incretin levels in polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Narodni 8, Prague 111694, Czech Republic
    Eur J Endocrinol 159:121-7. 2008
    ..This paper considers the secretion of GIP and GLP-1 after oral glucose load in a group of lean, glucose-tolerant PCOS women in comparison with age- and body mass index (BMI)-matched healthy women...
  9. doi request reprint Beta cell function and insulin sensitivity in women with polycystic ovary syndrome: influence of the family history of type 2 diabetes mellitus
    Jana Vrbikova
    Institute of Endocrinology, Narodni 8 Prague 1, Czech Republic
    Gynecol Endocrinol 25:597-602. 2009
    ..To study the impact of family history (FH) of type 2 diabetes mellitus on beta-cell compensatory mechanism in women with polycystic ovary syndrome (PCOS)...
  10. doi request reprint Impaired glucose metabolism in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, General Faculty Hospital, Charles University, Prague, Czech Republic
    Gynecol Obstet Invest 68:186-90. 2009
    ..To compare the prevalence of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in lean and overweight/obese women with polycystic ovary syndrome (PCOS), with the data from a normal population sample...
  11. doi request reprint Obesity and polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Obesity Management Centre, Prague, Czech Republic
    Obes Facts 2:26-35. 2009
    ..However, the best treatment approach in obese PCOS patients remains to be defined. Studies concerning different weight loss regimens, antiobesity drugs, bariatric surgery, insulin sensitizers, and hormonal therapy are reviewed...
  12. doi request reprint Metabolic syndrome in adolescents with polycystic ovary syndrome
    Jana Vrbikova
    Department of Clinical Endocrinology, Institute of Endocrinology, Narodni 8, Prague 1, 116 94 Czech Republic
    Gynecol Endocrinol 27:820-2. 2011
    ....
  13. ncbi request reprint [The prevalence of metabolic syndrome in women with polycystic ovary syndrome]
    Jana Vrbikova
    Endokrinologický ustav, Praha
    Cas Lek Cesk 149:337-9. 2010
    ..We aimed to ascertain the prevalence of metabolic syndrome in Czech women with PCOS and to describe relations of different features of metabolic syndrome with insulin sensitivity...
  14. ncbi request reprint Determinants of circulating adiponectin in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Gynecol Obstet Invest 60:155-61. 2005
    ..Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome...
  15. ncbi request reprint An analysis of the relationship between insulin resistance and the activity of steroid C17,20-lyase and 3beta-hydroxysteroid dehydrogenase in ovaries and adrenals in women with polycystic ovary syndrome
    J Vrbíklová
    Institute of Endocrinology, Prague, Czech Republic
    Exp Clin Endocrinol Diabetes 108:455-62. 2000
    ..The authors conclude that insulin resistance and/or hyperinsulinemia is probably not the primary factor responsible for the exaggerated adrenal androgen secretion found in a great number of patients with PCOS...
  16. ncbi request reprint Prediction of the effect of metformin treatment in patients with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Gynecol Obstet Invest 53:100-4. 2002
    ..7% of the subjects...
  17. ncbi request reprint Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Exp Clin Endocrinol Diabetes 110:74-6. 2002
    ..Homocysteine (Hcy) is one of the independent risk factors for ischemic heart disease. We examined the effect of metformin (M) treatment on Hcy levels, steroids and glycide tolerance in PCOS...
  18. ncbi request reprint Plasma thiols and androgen levels in polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague 1, Prague, Czech Republic
    Clin Chem Lab Med 41:216-21. 2003
    ..469; p < 0.05). We conclude that homocysteine is increased in women with polycystic ovary syndrome and is probably linked to androgen levels but not to markers of insulin resistance or with lipid metabolism...
  19. ncbi request reprint Cardiovascular risk factors in young Czech females with polycystic ovary syndrome
    J Vrbikova
    Department of Clinical Endocrinology, Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Hum Reprod 18:980-4. 2003
    ..The aim of our study was to compare the cardiovascular risk factors in PCOS women and in a control group selected from a random population sample...
  20. ncbi request reprint Metabolic and endocrine effects of treatment with peroral or transdermal oestrogens in conjunction with peroral cyproterone acetate in women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Eur J Endocrinol 150:215-23. 2004
    ..To compare the influence of transdermal and peroral oestrogen treatments in conjunction with cyproterone acetate (CPA) on metabolic and hormonal parameters in women with polycystic ovary syndrome (PCOS)...
  21. ncbi request reprint [Effect of long-term treatment with metformin on steroid levels and parameters of insulin resistance in women with polycystic ovary syndrome]
    J Vrbikova
    Gynekologicko porodnická klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 140:688-94. 2001
    ..We also tried to find predictors of the successful therapy (in terms of improvement of menstrual cyclicity)...
  22. ncbi request reprint Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Gynecol Obstet Invest 58:36-41. 2004
    ..Flutamide is effective in reducing adrenal androgen production in overweight women, but has no effect on lipid spectrum or on insulin resistance...
  23. ncbi request reprint Insulin sensitivity in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Charles University in Prague, 116 94 Czech Republic
    J Clin Endocrinol Metab 89:2942-5. 2004
    ..000008). We conclude that lean PCOS women are not more insulin resistant than healthy controls. Insulin hypersecretion, on the other hand, is present even in lean PCOS women...
  24. ncbi request reprint The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Eur J Endocrinol 144:619-28. 2001
    ..To evaluate adrenal and ovarian steroidogenesis before and after long-term treatment with metformin in women with polycystic ovary syndrome (PCOS)...
  25. ncbi request reprint Insulin sensitivity and beta-cell function in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Diabetes Care 25:1217-22. 2002
    ..To evaluate insulin sensitivity (IS) and beta-cell function (beta F) in lean and obese women with polycystic ovary syndrome (PCOS), either separately or by using a disposition index (DI)...
  26. ncbi request reprint Reinstatement of serum pregnanolone isomers and progesterone during alcohol detoxification therapy in premenopausal women
    Martin Hill
    Institute of EndocrinologyCharles University, Prague, Czech Republic
    Alcohol Clin Exp Res 29:1010-7. 2005
    ....
  27. ncbi request reprint Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age
    Helena Havlikova
    Institute of Endocrinology, Narodni trida 8, CZ 116 94 Prague 1, Czech Republic
    J Clin Endocrinol Metab 91:3092-9. 2006
    ..The 3beta-PI and sulfates of PI and pregnenolone exert the opposite effect. In addition to the brain's in situ synthesis, some circulating steroids can penetrate the blood-brain barrier...
  28. ncbi request reprint The identification and simultaneous quantification of 7-hydroxylated metabolites of pregnenolone, dehydroepiandrosterone, 3beta,17beta-androstenediol, and testosterone in human serum using gas chromatography-mass spectrometry
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94 Prague, Czech Republic
    J Steroid Biochem Mol Biol 96:187-200. 2005
    ..Despite the three times lower concentration of AD-metabolites, their antiglucocorticoid, immunomodulatory, and neuroprotective effects may be comparable to that of DHEA based on their reported greater biological activity...
  29. doi request reprint The steroid metabolome in lamotrigine-treated women with epilepsy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Praha 1, CZ 116 94, Czech Republic
    Steroids 76:1351-7. 2011
    ....
  30. ncbi request reprint Low-density lipoprotein receptor-related protein-5 C/T polymorphism in exon 18 is associated with C peptide and proinsulin levels in control women and patients with polycystic ovary syndrome
    Bela Bendlova
    Institute of Endocrinology, Charles University, Prague, Czech Republic
    Fertil Steril 90:699-708. 2008
    ..The low-density lipoprotein receptor-related protein-5 gene has been found to play a role in determining insulin secretion in animal models...
  31. ncbi request reprint Relationships of circulating pregnanolone isomers and their polar conjugates to the status of sex, menstrual cycle, and pregnancy
    Radmila Kancheva
    Institute of Endocrinology, Národnítrída 8, CZ 116 94 Prague 1, Czech Republic
    J Endocrinol 195:67-78. 2007
    ....
  32. ncbi request reprint Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome
    Bela Bendlova
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    J Steroid Biochem Mol Biol 104:68-74. 2007
    ..In conclusion, the D327N polymorphism of the SHBG gene does not influence susceptibility to PCOS...
  33. ncbi request reprint Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, CZ 11694 Prague 1, Czech Republic
    Steroids 70:515-24. 2005
    ..The reinstatement of serum estradiol, progesterone, and PI during the therapy demonstrates its favorable effect on both reproductive functions and the psychosomatic stability of the patients...
  34. doi request reprint Effect of telmisartan on selected adipokines, insulin sensitivity, and substrate utilization during insulin-stimulated conditions in patients with metabolic syndrome and impaired fasting glucose
    Petr Wohl
    Diabetes Center, Institute for Clinical and Experimental Medicine, Vídenská 1958 4, Prague, Czech Republic
    Eur J Endocrinol 163:573-83. 2010
    ..This study evaluated the effect of telmisartan on insulin sensitivity, substrate utilization, selected plasma adipokines and their expressions in subcutaneous adipose tissue (SAT) in metabolic syndrome...
  35. doi request reprint Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Prague 1 CZ 116 94, Czech Republic
    J Steroid Biochem Mol Biol 122:239-52. 2010
    ..Reduced steroid 20α-hydroxy-metabolites and cortisol were connected with epilepsy without an effect of AEDs. Carbamazepine induced only slight decrease in isopregnanolone, 5α,20α-tetrahydroprogesterone, and androstanediol levels...
  36. doi request reprint Adrenocortical function in young adults with diabetes mellitus type 1
    Katerina Simunkova
    Institute of Endocrinology, Narodni trida 8, 116 94 Prague, Czech Republic
    J Steroid Biochem Mol Biol 122:35-41. 2010
    ....
  37. ncbi request reprint Association of insulin gene VNTR polymorphism with polycystic ovary syndrome
    Marketa Vankova
    Institute of Endocrinology, Prague, Czech Republic
    Ann N Y Acad Sci 967:558-65. 2002
    ....