K Vondra

Summary

Affiliation: Institute of Endocrinology
Country: Czech Republic

Publications

  1. ncbi request reprint [Will vitamin D become a new antidiabetic?]
    Karel Vondra
    Endokrinologický ustav Praha
    Vnitr Lek 58:411-6. 2012
  2. pmc A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis stud
    Kvido Smitka
    Institute of Endocrinology, Laboratory of Clinical and Experimental Neuroendocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Nutr Metab (Lond) 8:81. 2011
  3. ncbi request reprint Thyroid autoantibodies and their clinical relevance in young adults with type 1 diabetes during the first 12 yr after diabetes onset
    K Vondra
    Institute of Endocrinology, Prague, Czech Republic
    J Endocrinol Invest 27:728-32. 2004
  4. ncbi request reprint [Autoimmune polyglandular syndromes: clinical aspects]
    K Vondra
    Endokrinologický ustav Praha
    Vnitr Lek 53:804-6. 2007
  5. ncbi request reprint Differences in type I diabetes mellitus of young adults with and without thyroid autoimmunity
    K Vondra
    Institute of Endocrinology, Narodni 8, 116 94 Prague I, Czech Republic
    Exp Clin Endocrinol Diabetes 113:404-8. 2005
  6. ncbi request reprint Thyroid gland diseases in adult patients with diabetes mellitus
    K Vondra
    Institute of Endocrinology, Prague, Czech Republic
    Minerva Endocrinol 30:217-36. 2005
  7. ncbi request reprint Somatostatin: beneficial effects on remission in young adult patients with newly diagnosed diabetes mellitus type 1
    K Vondra
    Institute of Endocrinology, Prague 1, Czech Republic
    Physiol Res 53:115-7. 2004
  8. ncbi request reprint [Glucocorticoids and diabetes mellitus]
    K Vondra
    Endokrinologický ustav, Praha
    Vnitr Lek 52:493-7. 2006
  9. ncbi request reprint [Metformin has a positive effect on disorders of carbohydrate metabolism in long-term care with low doses of prednisone]
    K Vondra
    Klinika detského a dorostového lékarství 1 LF UK a VFN, Praha
    Cas Lek Cesk 141:255-60. 2002
  10. ncbi request reprint [Role of the steroids, SHBG, IGF-1, IGF BP-3 and growth hormone in glucose metabolism disorders during long-term treatment with low doses of glucocorticoids]
    K Vondra
    Endokrinologický ustav, Praha
    Cas Lek Cesk 141:89-95. 2002

Collaborators

Detail Information

Publications43

  1. ncbi request reprint [Will vitamin D become a new antidiabetic?]
    Karel Vondra
    Endokrinologický ustav Praha
    Vnitr Lek 58:411-6. 2012
    ....
  2. pmc A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis stud
    Kvido Smitka
    Institute of Endocrinology, Laboratory of Clinical and Experimental Neuroendocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Nutr Metab (Lond) 8:81. 2011
    ..abstract:..
  3. ncbi request reprint Thyroid autoantibodies and their clinical relevance in young adults with type 1 diabetes during the first 12 yr after diabetes onset
    K Vondra
    Institute of Endocrinology, Prague, Czech Republic
    J Endocrinol Invest 27:728-32. 2004
    ..001). The data shed new light on the relative diagnostic value of thyroid antibodies, ultrasonography and functional examination for an early detection of thyroid autoimmunity of adult diabetic patients...
  4. ncbi request reprint [Autoimmune polyglandular syndromes: clinical aspects]
    K Vondra
    Endokrinologický ustav Praha
    Vnitr Lek 53:804-6. 2007
    ..In some cases the combination of various disease conditions can make these patients completely disabled...
  5. ncbi request reprint Differences in type I diabetes mellitus of young adults with and without thyroid autoimmunity
    K Vondra
    Institute of Endocrinology, Narodni 8, 116 94 Prague I, Czech Republic
    Exp Clin Endocrinol Diabetes 113:404-8. 2005
    ....
  6. ncbi request reprint Thyroid gland diseases in adult patients with diabetes mellitus
    K Vondra
    Institute of Endocrinology, Prague, Czech Republic
    Minerva Endocrinol 30:217-36. 2005
    ..At the end, we provide recommendations for the thyroid disease screening and diagnosis in patients with diabetes mellitus based on our experience...
  7. ncbi request reprint Somatostatin: beneficial effects on remission in young adult patients with newly diagnosed diabetes mellitus type 1
    K Vondra
    Institute of Endocrinology, Prague 1, Czech Republic
    Physiol Res 53:115-7. 2004
    ..It can thus be concluded that octreotide administration in adults with newly diagnosed diabetes mellitus type 1 positively influences both the onset and duration of remission...
  8. ncbi request reprint [Glucocorticoids and diabetes mellitus]
    K Vondra
    Endokrinologický ustav, Praha
    Vnitr Lek 52:493-7. 2006
    ..Application of insulin in type 2 diabetics is justified by the effort to prevent nonketotic hyperosmolar coma. In type 1 diabetes, it is usually necessary to increase the overall insulin dose and change its dosage during the day...
  9. ncbi request reprint [Metformin has a positive effect on disorders of carbohydrate metabolism in long-term care with low doses of prednisone]
    K Vondra
    Klinika detského a dorostového lékarství 1 LF UK a VFN, Praha
    Cas Lek Cesk 141:255-60. 2002
    ..3 mg/kg/day) on glucoregulation and glucose tolerance was studied in 20 female patients (15-20 yrs), including verification of possibility to correct the impairment of glucose tolerance (IGT) by metformin (M)...
  10. ncbi request reprint [Role of the steroids, SHBG, IGF-1, IGF BP-3 and growth hormone in glucose metabolism disorders during long-term treatment with low doses of glucocorticoids]
    K Vondra
    Endokrinologický ustav, Praha
    Cas Lek Cesk 141:89-95. 2002
    ..3 mg/kg/day) (baseline phase) and after adding 1000 mg of metformin per day for following 6 months to improve impaired glucose metabolism (control phase)...
  11. ncbi request reprint [Diabetes mellitus in adult patients with type I diabetes shows immunological, functional and clinical differences depending on the presence of autoimmune thyroiditis]
    K Vondra
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:267-72. 2007
    ..Autoimmune diabetes is usually accompanied by other autoimmune endocrinopathies, most often by autoimmune thyroiditis (AIT), but it is not clear whether diabetes in these patients differs from diabetes without AIT...
  12. ncbi request reprint [Thyroid autoimmunity in adults with diabetes mellitus type 1. Own experience gained by 11-year monitoring]
    K Vondra
    Endokrinologický ustav, Praha
    Vnitr Lek 52:864-72. 2006
    ..For clinical practice, determination of TSH once a year in all DM1 subjects, and of anti-TPO in DM1 women in fertile age is recommended. Ultrasonographic examination should be carried out in case of pathologic results of these tests...
  13. ncbi request reprint Dehydroepiandrosterone in relation to adiposity, glucose tolerance and lipid spectra in Czech non-diabetic population
    B Bendlova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S67-76. 2008
    ..In this respect, the benefit of DHEA(S) supplementation seems -- at least in terms of its alleged antiobesity and antidiabetogenic effects -- to be more than controversial...
  14. ncbi request reprint An analysis of the relationship between insulin resistance and the activity of steroid C17,20-lyase and 3beta-hydroxysteroid dehydrogenase in ovaries and adrenals in women with polycystic ovary syndrome
    J Vrbíklová
    Institute of Endocrinology, Prague, Czech Republic
    Exp Clin Endocrinol Diabetes 108:455-62. 2000
    ..The authors conclude that insulin resistance and/or hyperinsulinemia is probably not the primary factor responsible for the exaggerated adrenal androgen secretion found in a great number of patients with PCOS...
  15. ncbi request reprint PPARgamma2 Pro12Ala polymorphism in relation to free fatty acids concentration and composition in lean healthy Czech individuals with and without family history of diabetes type 2
    B Bendlova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S77-90. 2008
    ....
  16. ncbi request reprint The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Eur J Endocrinol 144:619-28. 2001
    ..To evaluate adrenal and ovarian steroidogenesis before and after long-term treatment with metformin in women with polycystic ovary syndrome (PCOS)...
  17. ncbi request reprint Effects of smoking cessation on hormonal levels in men
    H Hruskovicova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 62:67-73. 2013
    ..The decrease in total testosterone was non-significant. Changes in SHBG and testosterone did not correlate with BMI, presumably due to the direct effect of smoking cessation...
  18. ncbi request reprint Metabolic profile and sex hormone binding globulin (SHBG) in different reproductive phases of Czech women and their relations to weight, body composition and fat distribution
    I KOSKOVA
    Faculty of Science, Charles University, Prague, Czech Republic
    Physiol Res 58:393-402. 2009
    ..Markers of lipid and carbohydrate metabolism are not only age-related, but they are also related to BMI, total fat mass and central fat indices. Therefore, preventive programs should be focused above all on menopausal women...
  19. ncbi request reprint Family history of diabetes mellitus determines insulin sensitivity and beta cell function in polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:547-53. 2008
    ..Thus, women with PCOS with the concomitant family history of DM 2 have lower insulin sensitivity than healthy control women. Insulin resistance observed in these women with PCOS is compensated by increased insulin secretion...
  20. ncbi request reprint Fasting insulin pulsatile secretion in lean women with polycystic ovary syndrome
    T Grimmichova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S91-8. 2008
    ..Prolactin, androgens and cortisol might participate in alteration of insulin secretion in PCOS-affected women. Body weight and prolactin levels could influence insulin secretion regularity...
  21. ncbi request reprint The UCP1 gene polymorphism A-3826G in relation to DM2 and body composition in Czech population
    D Sramkova
    Institute of Endocrinology, Prague, Czech Republic
    Exp Clin Endocrinol Diabetes 115:303-7. 2007
    ..The A-3826G polymorphism in the UCP1 gene promoter region was found to be associated with reduced mRNA expression indicating that the polymorphism is of functional importance...
  22. ncbi request reprint Evaluation of hepatic 11 beta-hydroxysteroid dehydrogenase activity by cortisone acetate test in young adults with diabetes mellitus type 1
    K Simunkova
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 60:263-70. 2011
    ....
  23. ncbi request reprint T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition
    J Vcelak
    Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 61:229-40. 2012
    ..59, p=0.036. The association of TCF7L2 haplotypes with T2D and gestational diabetes but not with PCOS was confirmed. Novel association of TCF7L2 with FFAs composition was found...
  24. ncbi request reprint Metabolic and endocrine effects of treatment with peroral or transdermal oestrogens in conjunction with peroral cyproterone acetate in women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Eur J Endocrinol 150:215-23. 2004
    ..To compare the influence of transdermal and peroral oestrogen treatments in conjunction with cyproterone acetate (CPA) on metabolic and hormonal parameters in women with polycystic ovary syndrome (PCOS)...
  25. ncbi request reprint Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Gynecol Obstet Invest 58:36-41. 2004
    ..Flutamide is effective in reducing adrenal androgen production in overweight women, but has no effect on lipid spectrum or on insulin resistance...
  26. ncbi request reprint Autoimmune thyroiditis in non-obese subjects with initial diagnosis of Type 2 diabetes mellitus
    M Matejkova-Behanova
    Institute of Endocrinology, Prague, Czech Republic
    J Endocrinol Invest 25:779-84. 2002
    ..8 nmol/l compared to the group with post-breakfast C-peptide levels > 0.8 nmol/l (37% vs 16%), however the group with post-breakfast C-peptide levels < or = 0.8 nmol/l had longer duration of diabetes...
  27. ncbi request reprint TRH test in patients with diabetes mellitus type 1 and/or autoimmune thyroiditis. Changes in the pituitary-thyroid axis, reverse T3, prolactin and growth hormone levels
    E Orlická
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S109-17. 2008
    ..AT was associated with impairment of TRH stimulated fT3, fT4, fT3/fT4 response and changes in rT3 levels, in spite of preserved TRH-stimulated TSH secretion. GH response in AT patients was also altered...
  28. ncbi request reprint Metabolic syndrome in young Czech women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Narodni 8, Prague 1, 116 94 Czech Republic, Department of Obstetrics and Gynecology, Charles University, Apolinárská 28, Prague 2, 120 00 Czech Republic
    Hum Reprod 20:3328-32. 2005
    ..3 +/- 4.8 kg/m2; mean 6 SD] and 73 age-matched healthy females (BMI 22.3 +/- 3.3 kg/m2; mean +/- SD) were evaluated for the occurrence of features of metabolic syndrome according to the Adult Treatment Panel III...
  29. ncbi request reprint Comparison of total and salivary cortisol in a low-dose ACTH (Synacthen) test: influence of three-month oral contraceptives administration to healthy women
    K Simunkova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S193-9. 2008
    ..Therefore, salivary cortisol can be used for assessment of adrenal function in women regularly using COC...
  30. ncbi request reprint How smoking cessation influence hormonal levels in postmenopausal women?
    Hana Jandíková
    Institute of Endocrinology, Prague, Czech Republic
    Prague Med Rep 115:60-6. 2014
    ..Women successful in smoking cessation, compared to the non-successful ones, have lower androgen levels initially and also after smoking discontinuation. ..
  31. ncbi request reprint Anti-GAD-positive patients with type 1 diabetes mellitus have higher prevalence of autoimmune thyroiditis than anti-GAD-negative patients with type 1 and type 2 diabetes mellitus
    H Bárová
    Third Department of Medicine, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 53:279-86. 2004
    ..Patients with or without thyroid antibodies do not differ in age, DM onset and duration, BMI or HbA1c. Thyroid antibodies-positive patients have higher levels of thyroid stimulating hormone (TSH)...
  32. ncbi request reprint Decrease in serum dehydroepiandrosterone level after fenofibrate treatment in males with hyperlipidemia
    J Sulcova
    Institute of Endocrinology, First Faculty of Medicine, Charles University, Narodni 8, 11694 Prague 1, Czech Republic
    Physiol Res 54:151-7. 2005
    ..Taking together, the most important is the finding of decrease DHEA levels after fenofibrate therapy. It could be explained, at least in part, by the effect of the fenofibrateon on the biosynthesis of DHEA and its regulation...
  33. ncbi request reprint [Study of the genetic causes of polygeneticallv determined endocrinopathies--patience can bring success]
    B Bendlova
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:198-204. 2007
    ..The article gives a short review of the recent knowledge together with our own experience in the field of study of the genetic background of polygenic diseases...
  34. ncbi request reprint Salivary cortisol in low dose (1 microg) ACTH test in healthy women: comparison with serum cortisol
    K Simunkova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 56:449-53. 2007
    ..5183, p=0.0525); correlations after stimulation were not significant. Low-dose ACTH administration appeared as a sufficient stimulus for increasing salivary cortisol to a range considered as a normal adrenal functional reserve...
  35. ncbi request reprint Prediction of the effect of metformin treatment in patients with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Gynecol Obstet Invest 53:100-4. 2002
    ..7% of the subjects...
  36. ncbi request reprint [Effect of long-term treatment with metformin on steroid levels and parameters of insulin resistance in women with polycystic ovary syndrome]
    J Vrbikova
    Gynekologicko porodnická klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 140:688-94. 2001
    ..We also tried to find predictors of the successful therapy (in terms of improvement of menstrual cyclicity)...
  37. ncbi request reprint [Polyglandular activation of autoimmnunity as a manifestation of subclinical endocrinopathies]
    I Sterzl
    Ustav imunologie a mikrobiologie 1 LF UK a VFN, Praha
    Cas Lek Cesk 146:256-61. 2007
    ..Autoimmune thyropathies belong to the most frequently occurring autoimmune endocrinopathies. Autoimmune thyropathies occur either independently or linked to known polyglandular syndromes of type I-III...
  38. ncbi request reprint [Natural antiglucocorticoids]
    R Hampl
    Endokrinologický ustav, Praha
    Vnitr Lek 52:973-8. 2006
    ..Where known, the molecular mechanisms are mentioned, staying behind these events...
  39. ncbi request reprint [Incretins]
    J Vrbikova
    Endokrinologický ustav, Praha
    Vnitr Lek 52:919-25. 2006
    ..Physiology, pathophysiology and therapeutic implications of incretins in diabetes, neurodegenerative disorders and stress-induced hyperglycemia are concerned...
  40. ncbi request reprint Weight, body composition and fat distribution of Czech women in relation with reproductive phase: a cross-sectional study
    Irena Kosková
    Department of Anthropology of the Faculty of Science, Charles University, Prague, Czech Republic
    Prague Med Rep 108:13-26. 2007
    ..The mean values of 14 skinfolds thickness are shown, the skinfold at the abdomen shows the strongest correlation to the age (r = 0.49, p < 0.001). The results are consistent with the hypothesis of progressive fat centralisation...
  41. ncbi request reprint Weight, body composition and fat distribution changes of Czech women in the different reproductive phases: a longitudinal study
    I KOSKOVA
    Department of Anthropology, Charles University in Prague, Faculty of Science, Czech Republic
    Prague Med Rep 108:226-42. 2007
    ....
  42. ncbi request reprint [The Endocrinology Institute celebrates its 50th anniversary. How is the Institute poised for the next 50 years?]
    V Hainer
    Cas Lek Cesk 146:183-8. 2007
    ..In the forthcoming years closer cooperation with Charles University and the Academy of Sciences is highly likely and should be reflected by a new legislative status of the Institute...
  43. ncbi request reprint [Osteopenia and osteoporosis in diabetic women over 40 years of age]
    V Bartos
    , Praha
    Cas Lek Cesk 140:299-301. 2001
    ..CONCLUSION: The prevalence of osteoporosis and osteopenia in postmenopausal diabetic women is similar to those in the common population of the respective age...