M Stros

Summary

Affiliation: Institute of Biophysics
Country: Czech Republic

Publications

  1. ncbi request reprint HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter
    Michal Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    J Biol Chem 277:7157-64. 2002
  2. pmc HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha
    Michal Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, Brno, Czech Republic
    Nucleic Acids Res 37:2070-86. 2009
  3. doi request reprint HMGB proteins: interactions with DNA and chromatin
    Michal Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, Kralovopolska 135, 612 65 Brno, Czech Republic
    Biochim Biophys Acta 1799:101-13. 2010
  4. pmc Binding of histone H1 to DNA is differentially modulated by redox state of HMGB1
    Eva Polanská
    Laboratory of Analysis of Chromosomal Proteins, Institute of Biophysics, Academy of Science of the Czech Republic, Brno, Czech Republic
    PLoS ONE 9:e89070. 2014
  5. pmc HMGB1 interacts with human topoisomerase IIalpha and stimulates its catalytic activity
    Michal Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, Brno, Czech Republic
    Nucleic Acids Res 35:5001-13. 2007
  6. ncbi request reprint The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins
    M Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, Kralovopolska 135, 612 65, Brno, Czech Republic
    Cell Mol Life Sci 64:2590-606. 2007
  7. ncbi request reprint Formation of large nucleoprotein complexes upon binding of the high-mobility-group (HMG) box B-domain of HMG1 protein to supercoiled DNA
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno
    Eur J Biochem 251:427-34. 1998
  8. ncbi request reprint High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops
    Michal Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, 612 65 Brno, Czech Republic
    Biochemistry 43:7215-25. 2004
  9. ncbi request reprint Two mutations of basic residues within the N-terminus of HMG-1 B domain with different effects on DNA supercoiling and binding to bent DNA
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Biochemistry 40:4769-79. 2001
  10. ncbi request reprint A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, CZ 612 65 Brno, Czech Republic
    J Biol Chem 275:35699-707. 2000

Collaborators

Detail Information

Publications14

  1. ncbi request reprint HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter
    Michal Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    J Biol Chem 277:7157-64. 2002
    ..A possible mechanism of HMGB1-mediated modulation of p73- and p53-dependent transactivation is discussed...
  2. pmc HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha
    Michal Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, Brno, Czech Republic
    Nucleic Acids Res 37:2070-86. 2009
    ....
  3. doi request reprint HMGB proteins: interactions with DNA and chromatin
    Michal Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, Kralovopolska 135, 612 65 Brno, Czech Republic
    Biochim Biophys Acta 1799:101-13. 2010
    ....
  4. pmc Binding of histone H1 to DNA is differentially modulated by redox state of HMGB1
    Eva Polanská
    Laboratory of Analysis of Chromosomal Proteins, Institute of Biophysics, Academy of Science of the Czech Republic, Brno, Czech Republic
    PLoS ONE 9:e89070. 2014
    ..Our results suggested a novel mechanism for the HMGB1-mediated modulation of histone H1 binding to DNA. Possible biological consequences of linker histones H1 replacement by HMGB1 for the functioning of chromatin are discussed. ..
  5. pmc HMGB1 interacts with human topoisomerase IIalpha and stimulates its catalytic activity
    Michal Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, Brno, Czech Republic
    Nucleic Acids Res 35:5001-13. 2007
    ..The observed abilities of HMGB1 to interact with topo IIalpha and promote topo IIalpha binding to DNA suggest a mechanism by which HMGB1 stimulates the catalytic activity of the enzyme via enhancement of DNA cleavage...
  6. ncbi request reprint The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins
    M Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, Kralovopolska 135, 612 65, Brno, Czech Republic
    Cell Mol Life Sci 64:2590-606. 2007
    ..Compared to plants, human cells contain a larger variety of HMG-box proteins. Whereas in humans transcription factors are the most divergent group of HMG-box proteins, in plants the chromosomal HMGB-type proteins are most variable...
  7. ncbi request reprint Formation of large nucleoprotein complexes upon binding of the high-mobility-group (HMG) box B-domain of HMG1 protein to supercoiled DNA
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno
    Eur J Biochem 251:427-34. 1998
    ..A model for the interaction of the B-domain of HMG 1 with supercoiled DNA is presented and discussed...
  8. ncbi request reprint High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops
    Michal Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, 612 65 Brno, Czech Republic
    Biochemistry 43:7215-25. 2004
    ..Only the full-length p53 can form stable ternary complexes with hcDNA and HMGB1. The possible biological relevance of p53 and HMGB1 binding to hemicatenanes is discussed...
  9. ncbi request reprint Two mutations of basic residues within the N-terminus of HMG-1 B domain with different effects on DNA supercoiling and binding to bent DNA
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Biochemistry 40:4769-79. 2001
    ..We propose that binding of the A/B linker region within the major DNA groove helps the two HMG-1 domains to anchor to the minor DNA groove to facilitate their DNA binding and other activities...
  10. ncbi request reprint A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, CZ 612 65 Brno, Czech Republic
    J Biol Chem 275:35699-707. 2000
    ....
  11. ncbi request reprint HMG1 protein stimulates DNA end joining by promoting association of DNA molecules via their ends
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Eur J Biochem 267:4088-97. 2000
    ..We propose that HMG1 protein may be involved in the rejoining of DNA breaks by different DNA ligases due to its ability to bring DNA duplexes and their termini into a close proximity while leaving the ends accessible for ligation...
  12. ncbi request reprint Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein
    Jana Kasparkova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, CZ 61265 Brno, Czech Republic
    Biochemistry 42:1234-44. 2003
    ..The model structure is consistent with the hypothesis that the enhancement of binding affinity afforded by the basic lysine-rich A/B linker is a consequence of its tight binding to the sugar-phosphate backbone of both DNA strands...
  13. ncbi request reprint Cloning the genes and DNA binding properties of High Mobility Group B1 (HMGB1) proteins from the human blood flukes Schistosoma mansoni and Schistosoma japonicum
    Francisco Meirelles Bastos de Oliveira
    Instituto de Bioquimica Medica, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Ilha do Fundao, Brazil
    Gene 377:33-45. 2006
    ....
  14. ncbi request reprint Determinants of specific binding of HMGB1 protein to hemicatenated DNA loops
    Sandrine Jaouen
    Institut Jacques Monod, 2 place Jussieu, F 75251 Paris 05, France
    J Mol Biol 353:822-37. 2005
    ..Our results point to a tight structural fit between HMGB1 and DNA hemicatenanes under physiological conditions, and suggest that one of the nuclear functions of HMGB1 could be linked to the possible presence of hemicatenanes in the cell...