Luboslav Starka

Summary

Affiliation: Institute of Endocrinology
Country: Czech Republic

Publications

  1. ncbi request reprint [Male hypogonadism and civilization diseases]
    Lubomír Stárka
    Endokrinologický ustav, Praha
    Cas Lek Cesk 151:69-72. 2012
  2. ncbi request reprint Steroid hormones in the development of postpartum depression
    A Pařízek
    Department of Obstetrics and Gynecology of the First Faculty of Medicine, Charles University in Prague and General Teaching Hospital, Prague, Czech Republic Steroid Hormone Department, Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 63:S277-82. 2014
  3. ncbi request reprint Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome?
    L Starka
    Institute of Endocrinology, Narodni 8, CZ 116 94 Prague 1, Czech Republic
    Endocr Regul 39:127-31. 2005
  4. ncbi request reprint [Metamorphosis of endocrinology]
    L Starka
    Endokrinologický ustav, Praha
    Cas Lek Cesk 145:597-8. 2006
  5. ncbi request reprint [Testosterone treatment of sarcopenia]
    L Starka
    Endokrinologický ustav, Praha
    Vnitr Lek 52:909-11. 2006
  6. ncbi request reprint Antiandrogenic activity of epitestosterone in male mice in vivo
    L Starka
    Inst Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Sb Lek 102:7-11. 2001
  7. ncbi request reprint [Half century of the continuation of the Endocrinology Institute in Prague]
    L Starka
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:189-92. 2007
  8. ncbi request reprint Melatonin negatively correlates with C-peptide after food intake
    L Starka
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S187-92. 2008
  9. ncbi request reprint Dihydrotestosterone and testosterone throughout the life span of Czech men
    Luboslav Starka
    Institute of Endocrinology, Prague, Czech Republic
    Neuro Endocrinol Lett 29:201-4. 2008
  10. ncbi request reprint Endocrine factors of pair bonding
    L Starka
    Institute of Endocrinology, Prague, Czech Republic
    Prague Med Rep 108:297-305. 2007

Detail Information

Publications38

  1. ncbi request reprint [Male hypogonadism and civilization diseases]
    Lubomír Stárka
    Endokrinologický ustav, Praha
    Cas Lek Cesk 151:69-72. 2012
    ..Testosterone has a beneficial effect on cardiovascular risk factors, but it is not clear whether it can reduce mortality...
  2. ncbi request reprint Steroid hormones in the development of postpartum depression
    A Pařízek
    Department of Obstetrics and Gynecology of the First Faculty of Medicine, Charles University in Prague and General Teaching Hospital, Prague, Czech Republic Steroid Hormone Department, Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 63:S277-82. 2014
    ..Descriptions of changes in steroidogenesis in relation to postpartum depression could help clarify the causes of this disease, and changes in some steroid hormones are a promising marker of mental changes in the postpartum period. ..
  3. ncbi request reprint Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome?
    L Starka
    Institute of Endocrinology, Narodni 8, CZ 116 94 Prague 1, Czech Republic
    Endocr Regul 39:127-31. 2005
    ..The complexity of symptoms and genetic base started up the hypothesis on the existence of male equivalent of PCOS. Precocious loss of hair before 30 years of age was suggested as one of the male symptoms of this syndrome...
  4. ncbi request reprint [Metamorphosis of endocrinology]
    L Starka
    Endokrinologický ustav, Praha
    Cas Lek Cesk 145:597-8. 2006
    ..Besides the present type of care of the patients with endocrinopathies it is necessary to envision a new type of patient requesting "comfort therapy", as e.g. improvement of signs of aging, declining sexuality, or body height or weight...
  5. ncbi request reprint [Testosterone treatment of sarcopenia]
    L Starka
    Endokrinologický ustav, Praha
    Vnitr Lek 52:909-11. 2006
    ..The most frequent adverse effects of testosterone treatment in aging men are an increase of hematocrit and increased risk of prostate events...
  6. ncbi request reprint Antiandrogenic activity of epitestosterone in male mice in vivo
    L Starka
    Inst Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Sb Lek 102:7-11. 2001
    ..Thus in mice epitestosterone effects could be classified as antiandrogenic...
  7. ncbi request reprint [Half century of the continuation of the Endocrinology Institute in Prague]
    L Starka
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:189-92. 2007
    ..Silink introduced also endocrine immunology, paediatric endocrinology, molecular biology, neuroendocrinology and obesitology into the normal program of research and health care, which is now-a-days applied to over 150,000 patients...
  8. ncbi request reprint Melatonin negatively correlates with C-peptide after food intake
    L Starka
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S187-92. 2008
    ..However, the physiological role of melatonin association with food intake in daytime remains in question and should be further investigated...
  9. ncbi request reprint Dihydrotestosterone and testosterone throughout the life span of Czech men
    Luboslav Starka
    Institute of Endocrinology, Prague, Czech Republic
    Neuro Endocrinol Lett 29:201-4. 2008
    ..Data from the database of the Institute of Endocrinology served as the basis for the definition of the life span curve for the ratio dihydrotestosterone : testosterone...
  10. ncbi request reprint Endocrine factors of pair bonding
    L Starka
    Institute of Endocrinology, Prague, Czech Republic
    Prague Med Rep 108:297-305. 2007
    ..Endorphins, oxytocin and vasopressin may play a role during the later phases of love. However, proof of hormonal events associated with love in humans has, until recently, been lacking...
  11. ncbi request reprint Free testosterone and free dihydrotestosterone throughout the life span of men
    Luboslav Starka
    Steroid Hormones Dept, Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 116:118-20. 2009
    ..Hormonal values from our database served for the construction of the life span curve of free dihydrotestosterone/free testosterone ratio...
  12. ncbi request reprint 7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid
    Luboslav Starka
    Institute of Endocrinology, Prague, Czech Republic
    Neuro Endocrinol Lett 30:368-72. 2009
    ..Dehydroepiandrosterone is a long established neuroactive steroid. Some authors documented that 7-oxygenated derivatives of this steroid may be responsive at least by part for its physiological activity...
  13. ncbi request reprint Circulating neuroactive C21- and C19-steroids in young men before and after ejaculation
    L Starka
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 55:429-36. 2006
    ..This fact speaks against the hypothesis that a drop in the level of neuroactive steroids, e.g. allopregnanolone may trigger the orgasm-related increase of oxytocin, reported by other authors...
  14. ncbi request reprint Plasma levels of 7-hydroxymetabolites of dehydroepiandrosterone in healthy Central European aging men
    Luboslav Starka
    Institute of Endocrinology, Praha, Czech Republic
    Clin Chem Lab Med 43:1218-22. 2005
    ..The curves for age dependence of 7-hydroxy metabolite levels in males resembled those previously determined for unconjugated dehydroepiandrosterone. The levels of both 7-hydroxylated epimers correlated excellently with each other...
  15. ncbi request reprint Hormonal profile of men with premature balding
    L Starka
    Institute of Endocrinology, Prague, Czech Republic
    Exp Clin Endocrinol Diabetes 112:24-8. 2004
    ..However, the hormonal pattern of men with premature balding has been investigated in only a few studies with inconsistent results...
  16. ncbi request reprint Epitestosterone
    L Starka
    Institute of Endocrinology, Národni tr 8, CZ 116 94 Prague 1, Czech Republic
    J Steroid Biochem Mol Biol 87:27-34. 2003
    ..It can be presumed that epitestosterone as a natural hormone can contribute to the regulation of such androgen dependent events as, e.g. the control of prostate growth or body hair distribution...
  17. ncbi request reprint Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age
    Helena Havlikova
    Institute of Endocrinology, Narodni trida 8, CZ 116 94 Prague 1, Czech Republic
    J Clin Endocrinol Metab 91:3092-9. 2006
    ..The 3beta-PI and sulfates of PI and pregnenolone exert the opposite effect. In addition to the brain's in situ synthesis, some circulating steroids can penetrate the blood-brain barrier...
  18. ncbi request reprint Reinstatement of serum pregnanolone isomers and progesterone during alcohol detoxification therapy in premenopausal women
    Martin Hill
    Institute of EndocrinologyCharles University, Prague, Czech Republic
    Alcohol Clin Exp Res 29:1010-7. 2005
    ....
  19. ncbi request reprint Prevalence of insulin resistance and prediction of glucose intolerance and type 2 diabetes mellitus in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 45:639-44. 2007
    ..We evaluated the sensitivity and specificity of clinical and fasting biochemical parameters in screening for impaired glucose tolerance (IGT) and DM2...
  20. ncbi request reprint Determinants of circulating adiponectin in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Gynecol Obstet Invest 60:155-61. 2005
    ..Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome...
  21. doi request reprint The steroid metabolome in lamotrigine-treated women with epilepsy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Praha 1, CZ 116 94, Czech Republic
    Steroids 76:1351-7. 2011
    ....
  22. ncbi request reprint Relationships of circulating pregnanolone isomers and their polar conjugates to the status of sex, menstrual cycle, and pregnancy
    Radmila Kancheva
    Institute of Endocrinology, Národnítrída 8, CZ 116 94 Prague 1, Czech Republic
    J Endocrinol 195:67-78. 2007
    ....
  23. ncbi request reprint Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, CZ 11694 Prague 1, Czech Republic
    Steroids 70:515-24. 2005
    ..The reinstatement of serum estradiol, progesterone, and PI during the therapy demonstrates its favorable effect on both reproductive functions and the psychosomatic stability of the patients...
  24. ncbi request reprint The identification and simultaneous quantification of 7-hydroxylated metabolites of pregnenolone, dehydroepiandrosterone, 3beta,17beta-androstenediol, and testosterone in human serum using gas chromatography-mass spectrometry
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94 Prague, Czech Republic
    J Steroid Biochem Mol Biol 96:187-200. 2005
    ..Despite the three times lower concentration of AD-metabolites, their antiglucocorticoid, immunomodulatory, and neuroprotective effects may be comparable to that of DHEA based on their reported greater biological activity...
  25. doi request reprint Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Prague 1 CZ 116 94, Czech Republic
    J Steroid Biochem Mol Biol 122:239-52. 2010
    ..Reduced steroid 20α-hydroxy-metabolites and cortisol were connected with epilepsy without an effect of AEDs. Carbamazepine induced only slight decrease in isopregnanolone, 5α,20α-tetrahydroprogesterone, and androstanediol levels...
  26. doi request reprint Steroid metabolome in plasma from the umbilical artery, umbilical vein, maternal cubital vein and in amniotic fluid in normal and preterm labor
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Prague 116 94, Czech Republic
    J Steroid Biochem Mol Biol 121:594-610. 2010
    ..950), UA (R=0.945), MV (R=0.895), and AF (R=0.891). Although the predictivity of steroids in maternal blood was slightly less effective when compared with the UV and UA, it was the best solution for further practice...
  27. ncbi request reprint Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome
    Bela Bendlova
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    J Steroid Biochem Mol Biol 104:68-74. 2007
    ..In conclusion, the D327N polymorphism of the SHBG gene does not influence susceptibility to PCOS...
  28. ncbi request reprint Delayed effects of short-term transdermal application of 7-oxo-dehydroepiandrosterone on its metabolites, some hormonal steroids and relevant proteohormones in healthy male volunteers
    Jarmila Sulcová
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 43:221-7. 2005
    ..The study points to an immediate as well as delayed effect of the short-term transdermal application of 7-oxo-dehydroepiandrosterone on relevant hormonal parameters...
  29. ncbi request reprint [The prevalence of metabolic syndrome in women with polycystic ovary syndrome]
    Jana Vrbikova
    Endokrinologický ustav, Praha
    Cas Lek Cesk 149:337-9. 2010
    ..We aimed to ascertain the prevalence of metabolic syndrome in Czech women with PCOS and to describe relations of different features of metabolic syndrome with insulin sensitivity...
  30. ncbi request reprint Plasma thiols and androgen levels in polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague 1, Prague, Czech Republic
    Clin Chem Lab Med 41:216-21. 2003
    ..469; p < 0.05). We conclude that homocysteine is increased in women with polycystic ovary syndrome and is probably linked to androgen levels but not to markers of insulin resistance or with lipid metabolism...
  31. doi request reprint Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances
    Radmila Kancheva
    Institute of Endocrinology, Narodni trida 8, Prague CZ 116 94, Czech Republic
    J Steroid Biochem Mol Biol 119:35-44. 2010
    ..The CNS in situ synthesis and transport from periphery might be complementary in some cases, i.e. brain synthesis might provide minimum level of steroids, which are indispensable for the CNS functions...
  32. ncbi request reprint The content of four immunomodulatory steroids and major androgens in human semen
    Richard Hampl
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Czech Republic
    J Steroid Biochem Mol Biol 84:307-16. 2003
    ..In addition, the steroids were measured in serum and the concentrations in both fluids were compared. The concentrations of 7-OH-DHEA in seminal fluid varied from 1.8 to 15.7 nmol/l, while those of DHEA were about five times higher...
  33. ncbi request reprint Circulating levels of pregnanolone isomers during the third trimester of human pregnancy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94 Prague 1, Czech Republic
    J Steroid Biochem Mol Biol 105:166-75. 2007
    ....
  34. ncbi request reprint Relationship of dehydroepiandrosterone and its 7-hydroxylated metabolites to thyroid parameters and sex hormone-binding globulin (SHBG) in healthy subjects
    Richard Hampl
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 41:1081-6. 2003
    ..The results should serve for further investigation of changes in the thyroid hormone concentrations, together with SHBG and dehydroepiandrosterone metabolites, under various pathological situations...
  35. ncbi request reprint Steroid hormones in human semen with particular respect to dehydroepiandrosterone and its immunomodulatory metabolites
    Michal Pohanka
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Czech Republic
    Endocr Regul 36:79-86. 2002
    ..Occurrence of steroids in seminal fluid and their possible role is reviewed in the first part of the article...
  36. doi request reprint Steroid metabolome in fetal and maternal body fluids in human late pregnancy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Prague CZ 116 94, Czech Republic
    J Steroid Biochem Mol Biol 122:114-32. 2010
    ....
  37. ncbi request reprint How smoking cessation influence hormonal levels in postmenopausal women?
    Hana Jandíková
    Institute of Endocrinology, Prague, Czech Republic
    Prague Med Rep 115:60-6. 2014
    ..Women successful in smoking cessation, compared to the non-successful ones, have lower androgen levels initially and also after smoking discontinuation. ..
  38. ncbi request reprint Insulin sensitivity and beta-cell function in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Diabetes Care 25:1217-22. 2002
    ..To evaluate insulin sensitivity (IS) and beta-cell function (beta F) in lean and obese women with polycystic ovary syndrome (PCOS), either separately or by using a disposition index (DI)...