Luboslav Starka

..Testosterone has a beneficial effect on cardiovascular risk factors, but it is not clear whether it can reduce mortality...

..This fact speaks against the hypothesis that a drop in the level of neuroactive steroids, e.g. allopregnanolone may trigger the orgasm-related increase of oxytocin, reported by other authors...

..The complexity of symptoms and genetic base started up the hypothesis on the existence of male equivalent of PCOS. Precocious loss of hair before 30 years of age was suggested as one of the male symptoms of this syndrome...

..g. improvement of signs of aging, declining sexuality, or body height or weight...

..The most frequent adverse effects of testosterone treatment in aging men are an increase of hematocrit and increased risk of prostate events...

..Silink introduced also endocrine immunology, paediatric endocrinology, molecular biology, neuroendocrinology and obesitology into the normal program of research and health care, which is now-a-days applied to over 150,000 patients...

..However, the physiological role of melatonin association with food intake in daytime remains in question and should be further investigated...

..Data from the database of the Institute of Endocrinology served as the basis for the definition of the life span curve for the ratio dihydrotestosterone : testosterone...

..Endorphins, oxytocin and vasopressin may play a role during the later phases of love. However, proof of hormonal events associated with love in humans has, until recently, been lacking...

..Hormonal values from our database served for the construction of the life span curve of free dihydrotestosterone/free testosterone ratio...

..Dehydroepiandrosterone is a long established neuroactive steroid. Some authors documented that 7-oxygenated derivatives of this steroid may be responsive at least by part for its physiological activity...

..The curves for age dependence of 7-hydroxy metabolite levels in males resembled those previously determined for unconjugated dehydroepiandrosterone. The levels of both 7-hydroxylated epimers correlated excellently with each other...

..Thus in mice epitestosterone effects could be classified as antiandrogenic...

..It can be presumed that epitestosterone as a natural hormone can contribute to the regulation of such androgen dependent events as, e.g. the control of prostate growth or body hair distribution...

..However, the hormonal pattern of men with premature balding has been investigated in only a few studies with inconsistent results...

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..The 3beta-PI and sulfates of PI and pregnenolone exert the opposite effect. In addition to the brain's in situ synthesis, some circulating steroids can penetrate the blood-brain barrier...

..Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome...

..We evaluated the sensitivity and specificity of clinical and fasting biochemical parameters in screening for impaired glucose tolerance (IGT) and DM2...

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..Despite the three times lower concentration of AD-metabolites, their antiglucocorticoid, immunomodulatory, and neuroprotective effects may be comparable to that of DHEA based on their reported greater biological activity...

..The reinstatement of serum estradiol, progesterone, and PI during the therapy demonstrates its favorable effect on both reproductive functions and the psychosomatic stability of the patients...

..Reduced steroid 20α-hydroxy-metabolites and cortisol were connected with epilepsy without an effect of AEDs. Carbamazepine induced only slight decrease in isopregnanolone, 5α,20α-tetrahydroprogesterone, and androstanediol levels...

..In conclusion, the D327N polymorphism of the SHBG gene does not influence susceptibility to PCOS...

..The study points to an immediate as well as delayed effect of the short-term transdermal application of 7-oxo-dehydroepiandrosterone on relevant hormonal parameters...

..950), UA (R=0.945), MV (R=0.895), and AF (R=0.891). Although the predictivity of steroids in maternal blood was slightly less effective when compared with the UV and UA, it was the best solution for further practice...

..We aimed to ascertain the prevalence of metabolic syndrome in Czech women with PCOS and to describe relations of different features of metabolic syndrome with insulin sensitivity...

..The CNS in situ synthesis and transport from periphery might be complementary in some cases, i.e. brain synthesis might provide minimum level of steroids, which are indispensable for the CNS functions...

..469; p < 0.05). We conclude that homocysteine is increased in women with polycystic ovary syndrome and is probably linked to androgen levels but not to markers of insulin resistance or with lipid metabolism...

..In addition, the steroids were measured in serum and the concentrations in both fluids were compared. The concentrations of 7-OH-DHEA in seminal fluid varied from 1.8 to 15.7 nmol/l, while those of DHEA were about five times higher...

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..The results should serve for further investigation of changes in the thyroid hormone concentrations, together with SHBG and dehydroepiandrosterone metabolites, under various pathological situations...

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..To evaluate insulin sensitivity (IS) and beta-cell function (beta F) in lean and obese women with polycystic ovary syndrome (PCOS), either separately or by using a disposition index (DI)...

..CONCLUSION: The presence of steroids derived from dehydroepiandrosterone by 7-hydroxylation with recently reported immunomodulatory activity was for the first time demonstrated in seminal fluid of normal men...