M Pokorny


Affiliation: Institute for Clinical and Experimental Medicine
Country: Czech Republic


  1. Pokorny M, Mrázová I, Sochman J, Melenovsky V, Maly J, Pirk J, et al. Isovolumic loading of the failing heart by intraventricular placement of a spring expander attenuates cardiac atrophy after heterotopic heart transplantation. Biosci Rep. 2018;38: pubmed publisher
    ..05 in each case). We conclude that the enhanced isovolumic heart loading obtained by implantation of the spring expander attenuates the development of unloading-induced cardiac atrophy in the failing rat heart. ..
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    Koblihová E, Lukšan O, Mrázová I, Ryska M, Červenka L. Hepatocyte transplantation attenuates the course of acute liver failure induced by thioacetamide in Lewis rats. Physiol Res. 2015;64:689-700 pubmed
    ..This information should be considered in attempts to develop new therapeutic approaches to the treatment of ALF. ..
  3. Alánová P, Husková Z, Kopkan L, Sporková A, Jíchová Å, Neckář J, et al. Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats. Vascul Pharmacol. 2015;73:45-56 pubmed publisher
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    Kala P, Sedláková L, Skaroupkova P, Kopkan L, Vanourková Z, Taborsky M, et al. Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistu. Physiol Res. 2018;67:401-415 pubmed
    ..Thus, combined treatment with sEHi and ACEi is not a promising approach to further attenuate renal dysfunction and retard progression of CHF. ..
  5. Červenka L, Melenovský V, Husková Z, Sporková A, Bürgelová M, Škaroupková P, et al. Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula. Physiol Res. 2015;64:857-73 pubmed
    ..Strong protective actions of ACEi were associated with suppression of the vasoconstrictor/sodium retaining axis and activation of vasodilatory/natriuretic axis of the renin-angiotensin system in the circulating blood and kidney tissue. ..
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    Sporkova A, Husková Z, Skaroupkova P, Rami Reddy N, Falck J, Sadowski J, et al. Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experi. Physiol Res. 2017;66:29-39 pubmed
    ..Hence, reduced renal vasodilatory responsiveness cannot be responsible for the lack of beneficial effects of chronic sEH inhibition on the development of renal dysfunction and progression of CHF in ACF HanSD rats. ..
  7. Jíchová S, Doleželová Š, Kopkan L, Kompanowska Jezierska E, Sadowski J, Cervenka L. Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats. Am J Med Sci. 2016;352:618-630 pubmed publisher
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    Cervenka L, Horacek V, Vaneckova I, Hubacek J, Oliverio M, Coffman T, et al. Essential role of AT1A receptor in the development of 2K1C hypertension. Hypertension. 2002;40:735-41 pubmed
    ..These results support the essential role of AT1A receptors in mediating 2K1C hypertension and support the hypothesis that augmented NO production serves as a counteracting system in this model of hypertension. ..
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    Cervenka L, Vaneckova I, Maly J, Horacek V, El Dahr S. Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor. J Hypertens. 2003;21:1531-8 pubmed
    ..Therefore, the role of AT2 receptors in B2R-mediated protection against ANG II-dependent hypertension remains uncertain. ..

More Information


  1. Cervenka L, Vaneckova I, Husková Z, Vanourková Z, Erbanova M, Thumová M, et al. Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: study in angiotensin II receptor subtype 1A knockout mice. J Hypertens. 2008;26:1379-89 pubmed publisher
    ..Finally, enhanced nitric oxide synthase activity plays a protective role by counteracting the vasoconstrictor influences of angiotensin II in 2K1C hypertensive mice. ..
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    Červenka L, Bíbová J, Husková Z, Vaňourková Z, Kramer H, Herget J, et al. Combined suppression of the intrarenal and circulating vasoconstrictor renin-ACE-ANG II axis and augmentation of the vasodilator ACE2-ANG 1-7-Mas axis attenuates the systemic hypertension in Ren-2 transgenic rats exposed to chronic hypoxia. Physiol Res. 2015;64:11-24 pubmed
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    Hampl V, Herget J, Bíbová J, Baňasová A, Husková Z, Vaňourková Z, et al. Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia. Physiol Res. 2015;64:25-38 pubmed
  4. Sporková A, ÄŒertíková Chábová V, Doleželová Å, Jíchová Å, Kopkan L, Vaňourková Z, et al. Fenofibrate Attenuates Hypertension in Goldblatt Hypertensive Rats: Role of 20-Hydroxyeicosatetraenoic Acid in the Nonclipped Kidney. Am J Med Sci. 2017;353:568-579 pubmed publisher
    ..Therefore, fenofibrate treatment effectively attenuated hypertension, probably via stimulation of 20-HETE formation in the nonclipped kidney. ..
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    Pokorny M, Mrázová I, Maly J, Pirk J, Netuka I, Vanourková Z, et al. Effects of increased myocardial tissue concentration of myristic, palmitic and palmitoleic acids on the course of cardiac atrophy of the failing heart unloaded by heterotopic transplantation. Physiol Res. 2018;67:13-30 pubmed
    ..We conclude that increasing heart tissue concentrations of the fatty acids allegedly involved in heart growth does not attenuate the unloading-induced cardiac atrophy. ..