K Pavelka

Summary

Affiliation: Institute of Rheumatology
Country: Czech Republic

Publications

  1. ncbi [Early diagnosis of ankylosing spondylitis]
    K Pavelka
    Revmatologický ústav, Praha
    Vnitr Lek 52:726-9. 2006
  2. ncbi The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period
    Karel Pavelka
    Institute of Rheumatology and Charles University Prague, Prague, Czech Republic
    Arthritis Rheum 56:4055-64. 2007
  3. ncbi Increasing the infliximab dose in rheumatoid arthritis patients: a randomised, double blind study failed to confirm its efficacy
    K Pavelka
    Institute of Rheumatology, Department of Rheumatology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Ann Rheum Dis 68:1285-9. 2009
  4. ncbi Optimizing outcomes in rheumatoid arthritis patients with inadequate responses to disease-modifying anti-rheumatic drugs
    Karel Pavelka
    Institute and Cliníc of Rheumatology, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic
    Rheumatology (Oxford) 51:v12-21. 2012
  5. ncbi A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials
    K Pavelka
    Institute of Rheumatology and Clinic of Rheumatology, Charles University, Prague, Czech Republic
    Curr Med Res Opin 28:163-78. 2012
  6. ncbi Transdermal fentanyl for the treatment of pain caused by osteoarthritis of the knee or hip: an open, multicentre study
    Xavier Le Loet
    Centre Hospitalier Universitaire de Rouen, Hôpitaux Rouen, Rouen, France
    BMC Musculoskelet Disord 6:31. 2005
  7. ncbi Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis
    Lucie Andrés Cerezo
    Institute of Rheumatology, First Medical Faculty, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic
    Arthritis Res Ther 13:R122. 2011
  8. ncbi Efficacy evaluation of highly purified intra-articular hyaluronic acid (Sinovial(®)) vs hylan G-F20 (Synvisc(®)) in the treatment of symptomatic knee osteoarthritis. A double-blind, controlled, randomized, parallel-group non-inferiority study
    K Pavelka
    Institute of Rheumatology, Praha, Czech Republic
    Osteoarthritis Cartilage 19:1294-300. 2011
  9. ncbi Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis
    K Pavelka
    Institute of Rheumatology Prague and Clinic of Rheumatology, Charles University Ist Medical School, Prague, Czech Republic
    Osteoarthritis Cartilage 12:277-83. 2004
  10. ncbi Anti-TNF therapy of ankylosing spondylitis in clinical practice. Results from the Czech national registry ATTRA
    K Pavelka
    Institute of Rheumatology, 1st Faculty of Medicine, Charles University Prague, Czech Republic
    Clin Exp Rheumatol 27:958-63. 2009

Detail Information

Publications59

  1. ncbi [Early diagnosis of ankylosing spondylitis]
    K Pavelka
    Revmatologický ústav, Praha
    Vnitr Lek 52:726-9. 2006
    ..The overall concept requires verification of new samples in a prospective study. After certification of such study, it will be possible to use biological medications for much more efficient therapy of patients in early AS stages...
  2. ncbi The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period
    Karel Pavelka
    Institute of Rheumatology and Charles University Prague, Prague, Czech Republic
    Arthritis Rheum 56:4055-64. 2007
    ..To determine whether the efficacy of diacerein persists at 2 months after the end of a 3-month treatment period, compared with placebo, in patients with painful knee osteoarthritis (OA)...
  3. ncbi Increasing the infliximab dose in rheumatoid arthritis patients: a randomised, double blind study failed to confirm its efficacy
    K Pavelka
    Institute of Rheumatology, Department of Rheumatology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Ann Rheum Dis 68:1285-9. 2009
    ..To evaluate the effect of infliximab dose escalation in incomplete responders in a randomised controlled trial...
  4. ncbi Optimizing outcomes in rheumatoid arthritis patients with inadequate responses to disease-modifying anti-rheumatic drugs
    Karel Pavelka
    Institute and Cliníc of Rheumatology, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic
    Rheumatology (Oxford) 51:v12-21. 2012
    ....
  5. ncbi A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials
    K Pavelka
    Institute of Rheumatology and Clinic of Rheumatology, Charles University, Prague, Czech Republic
    Curr Med Res Opin 28:163-78. 2012
    ..g., alternative NSAIDs, cyclooxygenase type 2 [COX-2] inhibitors) is uncertain. The objective of this systematic review is to compare the current evidence on efficacy of diclofenac versus other pain relief medications...
  6. ncbi Transdermal fentanyl for the treatment of pain caused by osteoarthritis of the knee or hip: an open, multicentre study
    Xavier Le Loet
    Centre Hospitalier Universitaire de Rouen, Hôpitaux Rouen, Rouen, France
    BMC Musculoskelet Disord 6:31. 2005
    ..The second part of the trial, investigating TDF in patients with rheumatoid arthritis (RA) is reported separately...
  7. ncbi Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis
    Lucie Andrés Cerezo
    Institute of Rheumatology, First Medical Faculty, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic
    Arthritis Res Ther 13:R122. 2011
    ..The aim of this study was to examine the serum levels of S100 proteins and to evaluate their role in patients with recent-onset rheumatoid arthritis (RA)...
  8. ncbi Efficacy evaluation of highly purified intra-articular hyaluronic acid (Sinovial(®)) vs hylan G-F20 (Synvisc(®)) in the treatment of symptomatic knee osteoarthritis. A double-blind, controlled, randomized, parallel-group non-inferiority study
    K Pavelka
    Institute of Rheumatology, Praha, Czech Republic
    Osteoarthritis Cartilage 19:1294-300. 2011
    ....
  9. ncbi Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis
    K Pavelka
    Institute of Rheumatology Prague and Clinic of Rheumatology, Charles University Ist Medical School, Prague, Czech Republic
    Osteoarthritis Cartilage 12:277-83. 2004
    ..To study prognostic value of different biochemical markers for morphological progression of early knee osteoarthritis...
  10. ncbi Anti-TNF therapy of ankylosing spondylitis in clinical practice. Results from the Czech national registry ATTRA
    K Pavelka
    Institute of Rheumatology, 1st Faculty of Medicine, Charles University Prague, Czech Republic
    Clin Exp Rheumatol 27:958-63. 2009
    ..To estimate efficacy, safety and adherence to therapy of ankylosing spondlitis (AS) patients included in the Czech National Registry ATTRA, and to look for predictive factors for therapy discontinuation...
  11. ncbi [Is retardation of radiologic progression of ankylosing spondylitis possible?]
    K Pavelka
    Revmatologický ústav Praha
    Vnitr Lek 57:923-9. 2011
    ..Combination therapy of AS with anti-TNF and continuous celecoxib therapy could be very interesting...
  12. ncbi [Diffuse idiopathic skeletal hyperostosis and its relation to metabolic parameters]
    A Pavelkova
    Revmatologický ústav, Praha
    Vnitr Lek 52:477-80. 2006
    ..From the point of symptomatic therapy, patients should not be given medicaments that aggravate hyperinsulinemia...
  13. ncbi [Intra-articular treatment with Hyalgan in osteoarthrosis of the knee joint: experience in clinical practice in the Czech Republic]
    K Pavelka
    Revmatologický ústav, Praha
    Acta Chir Orthop Traumatol Cech 69:302-7. 2002
    ..To evaluate safety and efficacy of intraarticular (IA) hyaluronic acid (HA; Hyalgan in current medical practice...
  14. ncbi Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study
    Karel Pavelka
    Department of Medicine and Rheumatology, Charles University, Prague, Czech Republic
    Arch Intern Med 162:2113-23. 2002
    ....
  15. ncbi [Treatment of early arthritis--recommendations of EULAR]
    K Pavelka
    Revmatologický ústav, Praha
    Vnitr Lek 52:665-72. 2006
    ..This publication was made on the basis of analysis of previously published double-blind studies (the so-called evidence based procedure) and mutual consensus of the authors...
  16. ncbi [Therapy of osteoarthritis--from controlling the symptoms to preserving articular cartilage]
    K Pavelka
    Revmatologický ústav, Praha
    Cas Lek Cesk 139:487-93. 2000
    ..From the surgical approaches aimed to preserve the articular cartilage several methods are currently tested: joint debridment, transplantation of the soft components, transplantation of the cartilage grafts and some experimental methods...
  17. ncbi A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee
    K Pavelka
    Department of Medicine and Rheumatology, Charles University, Prague, Czech Republic
    Osteoarthritis Cartilage 8:335-42. 2000
    ..To determine the structure (disease) modifying effect of a glycosaminoglycan polypeptide association complex (GP-C; Rumalon) in patients with knee and hip osteoarthritis (OA)...
  18. ncbi Increased pentosidine, an advanced glycation end product, in serum and synovial fluid from patients with knee osteoarthritis and its relation with cartilage oligomeric matrix protein
    L Senolt
    Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic
    Ann Rheum Dis 64:886-90. 2005
    ....
  19. ncbi Advanced glycation end-product pentosidine is not a relevant marker of disease activity in patients with rheumatoid arthritis
    L Senolt
    Institute of Rheumatology, Charles University, First Medical Facility, Prague, Czech Republic
    Physiol Res 56:771-7. 2007
    ..However, AGEs can be suggested as important players participating in joint destruction rather than markers of disease activity...
  20. ncbi Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis
    V Vilim
    Institute of Rheumatology, Na Slupi 4, 128 50 Prague 2, Czech Republic
    Osteoarthritis Cartilage 9:612-8. 2001
    ..To assess the hypothesis that synovitis affects serum COMP levels in patients with knee OA, we collected sera for COMP simultaneous with a clinical examination for synovitis...
  21. ncbi Radiographic progression of rheumatoid arthritis in patients from the Czech National Registry receiving infliximab treatment
    K Pavelka
    Institute of Rheumatology and Department of Rheumatology, Charles University, Prague, Czech Republic
    Clin Exp Rheumatol 25:540-5. 2007
    ..To evaluate the clinical status and radiographic progression in patients with rheumatoid arthritis (RA) being followed by the Czech National Registry of biological treatments...
  22. ncbi Serum hyaluronic acid as a potential marker with a predictive value for further radiographic progression of hand osteoarthritis
    M Filková
    Institute of Rheumatology and Connective Tissue Research Laboratory, Department of Rheumatology of the First Faculty of Medicine, Charles University in Prague, Czech Republic
    Osteoarthritis Cartilage 17:1615-9. 2009
    ..To compare serum levels of hyaluronic acid (HA) between patients with erosive and non-erosive hand osteoarthritis (HOA), and investigate its association with morphological changes and radiographic progression over 2 years...
  23. ncbi The lack of correlation between the increased frequency of allele IL-1RN*2 of interleukin-1 receptor antagonist gene in Czech patients with knee osteoarthritis and the markers of cartilage degradation
    S Ruzickova
    Institute of Rheumatology, Prague, Czech Republic
    Folia Biol (Praha) 54:115-20. 2008
    ..0032, OR = 2.79; 95% CI 1.42-5.48). These results suggest that the IL-1RN*2 allele might represent a factor of susceptibility to OA; however, no correlation between this allele and the markers of cartilage degradation was found...
  24. ncbi Elevated prolactin levels in patients with rheumatoid arthritis: association with disease activity and structural damage
    M Fojtikova
    Institute of Rheumatology and Department of Clinical and Experimental Rheumatology, First Faculty of Medicine, Charles University in Prague, and General University Hospital in Prague, Prague, Czech Republic
    Clin Exp Rheumatol 28:849-54. 2010
    ..Therefore, the aim of this study was to evaluate the levels of PRL in serum and synovial fluid in patients with RA and osteoarthritis (OA) and examine whether PRL might be associated with laboratory and clinical disease activity of RA...
  25. ncbi Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis
    V Vilim
    Institute of Rheumatology, Prague, Czech Republic
    Osteoarthritis Cartilage 10:707-13. 2002
    ..To evaluate the prognostic utility of serum COMP level measured with a new sandwich ELISA, by correlating COMP level with outcome measures of osteoarthritis (OA) progression...
  26. ncbi Characterization of monoclonal antibodies recognizing different fragments of cartilage oligomeric matrix protein in human body fluids
    V Vilim
    Institute of Rheumatology, Praha, Czech Republic
    Arch Biochem Biophys 341:8-16. 1997
    ....
  27. ncbi Low circulating Dickkopf-1 and its link with severity of spinal involvement in diffuse idiopathic skeletal hyperostosis
    L Senolt
    Institute of Rheumatology, Department of Experimental and Clinical Rheumatology, First Faculty of Medicine, Charles University, Na Slupi 4, 12850 Prague 2, Czech Republic
    Ann Rheum Dis 71:71-4. 2012
    ..The aim of this study was therefore to explore serum levels of DKK-1 and to evaluate DKK-1's association with the severity of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH)...
  28. ncbi Factors influencing health status and disability of patients with ankylosing spondylitis in the Czech Republic
    S Forejtova
    Institute of Rheumatology, Prague, Czech Republic
    Clin Rheumatol 27:1005-13. 2008
    ..Seven hundred ninety one patients underwent spa treatment in the previous year; 96% of them experienced improvement of their health condition...
  29. ncbi Incidence and prevalence of psoriatic arthritis, ankylosing spondylitis, and reactive arthritis in the first descriptive population-based study in the Czech Republic
    P Hanova
    Institute of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Czech Republic
    Scand J Rheumatol 39:310-7. 2010
    ..To estimate the annual incidence and prevalence of psoriatic arthritis (PsA), ankylosing spondylitis (AS), and reactive arthritis (ReA) in a sample of the Czech population...
  30. ncbi Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum
    L Senolt
    Institute of Rheumatology, 1st Medical Faculty, Charles University, Na Slupi 4, 12850 Prague 2, Czech Republic, and University Hospital Giessen, Department of Internal Medicine and Rheumatology, Germany
    Ann Rheum Dis 66:458-63. 2007
    ..Resistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents. In humans, proinflammatory properties of resistin are superior to its insulin resistance-inducing effects...
  31. ncbi Novel adipokine fibroblast growth factor 21 is increased in rheumatoid arthritis
    H Hulejová
    Institute of Rheumatology, Prague, Czech Republic
    Physiol Res 61:489-94. 2012
    ..This work shows that patients with seropositive RA have increased levels of FGF-21. The results suggest that FGF-21 is related to BMI but not disease activity or lipid profiles in patients with RA...
  32. ncbi Relief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure-modifying drug trials
    K Pavelka
    Department of Medicine and Rheumatology, Charles University, Prague, Czech Republic
    Osteoarthritis Cartilage 11:730-7. 2003
    ....
  33. ncbi Increased adiponectin is negatively linked to the local inflammatory process in patients with rheumatoid arthritis
    L Senolt
    Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic
    Cytokine 35:247-52. 2006
    ..However, increased synovial fluid adiponectin in RA patients may counterpart the local inflammatory process...
  34. ncbi Seroprevalence and specificity of NMO-IgG (anti-aquaporin 4 antibodies) in patients with neuropsychiatric systemic lupus erythematosus
    Jakub Zavada
    Institute of Rheumatology and First Faculty of Medicine, Charles University in Prague, Na Slupi 4, 128 50, Praha 2, Czech Republic
    Rheumatol Int 33:259-63. 2013
    ..Testing for NMO-IgG/AQP4-Ab positivity should be considered in patients presenting with SLE and TM. Non-longitudinally extensive lesions do no not exclude NMO-IgG/AQP4-Ab in patients presenting with SLE and TM...
  35. ncbi Valdecoxib is as effective as diclofenac in the management of rheumatoid arthritis with a lower incidence of gastroduodenal ulcers: results of a 26-week trial
    K Pavelka
    Institute of Rheumatology, Prague, Czech Republic
    Rheumatology (Oxford) 42:1207-15. 2003
    ..035) compared with diclofenac. CONCLUSIONS: Single daily doses of valdecoxib 20 and 40 mg provided efficacy comparable to that of diclofenac, with a superior upper GI safety profile in the long-term treatment of RA patients...
  36. ncbi Collagen type I(alpha 1) and vitamin D receptor polymorphisms in diffuse idiopathic skeletal hyperostosis
    S Havelka
    Institute of Rheumatology, Prague, Czech Republic
    Clin Rheumatol 21:347-8. 2002
  37. ncbi [Recommendations of Czech Rheumatological Society for the treatment of rheumatoid arthritis. Efficacy and treatment strategies]
    R Becvar
    Revmatologický ústav Praha
    Vnitr Lek 54:84-99. 2008
    ..To the complex therapy of RA nonpharmacological means are usually implemented--different physical procedures and various surgeries...
  38. ncbi Monoclonal antibodies to human cartilage oligomeric matrix protein: epitope mapping and characterization of sandwich ELISA
    Vladimir Vilim
    Institute of Rheumatology, Na Slupi 4, 128 50 Prague 2, Czech Republic
    Clin Chim Acta 328:59-69. 2003
    ..Our aim was to map the epitopes of three monoclonal antibodies (mAb) to COMP and to develop and characterize a sandwich enzyme-linked immunosorbent assay (ELISA) for measuring COMP levels in human body fluids...
  39. ncbi Some principles of the development of a clinical database/national register of selected inflammatory rheumatic diseases in the Czech Republic
    Ctibor Dostal
    Institute of Rheumatology, Na Slupi 2, 128 50 Prague 2, Czech Republic
    Int J Med Inform 75:216-23. 2006
    ..Some first acquired information inclusive comparison with German database is demonstrated...
  40. ncbi Prospective new biological therapies for rheumatoid arthritis
    Ladislav Senolt
    Institute of Rheumatology and Connective Tissue Research Laboratory, Department of Rheumatology of the First Faculty of Medicine, Charles University in Prague, Czech Republic
    Autoimmun Rev 9:102-7. 2009
    ..In this review, we describe the cytokine inhibitors and modulators of the immune response currently in ongoing clinical trials, the results of which may further expand the spectrum of efficient therapies for chronic autoimmune diseases...
  41. ncbi Analysis of the reasons for DMARD therapy discontinuation in patients with rheumatoid arthritis in the Czech and Slovak republics
    K Pavelka
    Institute of Rheumatology, HA Slupi 4, 12850 Prague, Czech Republic
    Clin Rheumatol 21:220-6. 2002
    ..More education about modern strategies in the treatment of RA is probably necessary for practising rheumatologists...
  42. ncbi Association of systemic lupus erythematosus with low serum bilirubin levels
    L Vitek
    Institute of Clinical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University in Prague, Praha, Prague, Czech Republic
    Scand J Rheumatol 39:480-4. 2010
    ..Bilirubin has been reported as a strong negative predictor of oxidative stress-mediated diseases, such as atherosclerosis. The objective of our study was to evaluate the association between serum bilirubin levels and SLE manifestation...
  43. ncbi The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis
    J T Studýnková
    Institute of Rheumatology, Prague, Czech Republic
    Clin Exp Rheumatol 22:395-402. 2004
    ....
  44. ncbi Epidemiology of rheumatoid arthritis, juvenile idiopathic arthritis and gout in two regions of the Czech Republic in a descriptive population-based survey in 2002-2003
    P Hanova
    Institute of Rheumatology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Clin Exp Rheumatol 24:499-507. 2006
    ..To estimate the annual incidence and prevalence of rheumatoid arthritis (RA), juvenile arthritis (JIA) and gout in a population based study in two regions of the Czech Republic with total population of 186,000 inhabitants...
  45. ncbi Correlation of some MR findings in ankylosing spondylitis
    V Peterová
    Department of Radiodiagnostics of the First Faculty of Medicine, Charles University in Prague, Czech Republic
    Prague Med Rep 107:26-36. 2006
    ....
  46. ncbi Seronegative Lyme arthritis caused by Borrelia garinii
    H Dejmkova
    Institute of Rheumatology, Prague, Czech Republic
    Clin Rheumatol 21:330-4. 2002
    ..The patient was then repeatedly treated by antibiotics and synovectomy has been performed...
  47. ncbi [Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis). Case study and a literature review]
    M Olejarova
    Revmatologický ústav, Praha
    Vnitr Lek 50:786-92. 2004
    ..4 month after lowering the dose of prednisolon a temporary exacerbation of the disease appeared and again disappeared after increasing the dose of corticoid...
  48. ncbi Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee
    Karel Pavelka
    Institute of Rheumatology, Charles University Prague, Prague, Czech Republic
    Clin Rheumatol 29:659-70. 2010
    ..It can be assumed that the once daily intake of ASU will lead to a better compliance in routine therapy...
  49. ncbi Benefits of transdermal fentanyl in patients with rheumatoid arthritis or with osteoarthritis of the knee or hip: an open-label study to assess pain control
    Karel Pavelka
    Institute of Rheumatology, Prague, Czech Republic
    Curr Med Res Opin 20:1967-77. 2004
    ..Treatment could be discontinued without issues. Nausea and vomiting was usually mild during treatment initiation. Patients' well being could be further accommodated by optimising prophylactic treatment...
  50. ncbi Knowledge of osteoporosis correlated with hormone therapy use and health status
    Magda Vytrisalova
    Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
    Maturitas 56:21-9. 2007
    ....
  51. ncbi Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies
    Olivier Bruyere
    WHO Collaborating Center for Public Health Aspect of Osteoarticular Disorders, Liege, Belgium
    Menopause 11:138-43. 2004
    ....
  52. ncbi OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis
    Laure Gossec
    Medicine Faculty, Paris 5 René Descartes University AP HP, Cochin Hospital, Department of Rheumatology B, Paris, France
    J Rheumatol 34:1432-5. 2007
    ..quot;..
  53. ncbi The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previo
    Ferdinand C Breedveld
    Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, C4 R Postbox 9600, Leiden 2300 RC, The Netherlands
    Arthritis Rheum 54:26-37. 2006
    ..To compare the efficacy and safety of adalimumab plus methotrexate (MTX) versus MTX monotherapy or adalimumab monotherapy in patients with early, aggressive rheumatoid arthritis (RA) who had not previously received MTX treatment...
  54. ncbi S100A4 (Mts1): is there any relation to the pathogenesis of rheumatoid arthritis?
    Ladislav Senolt
    Center of Experimental Rheumatology, Univ Hosp Zürich, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Autoimmun Rev 5:129-31. 2006
    ..Since several phenomena are similar between rheumatoid arthritis and malignant tumors it can be hypothesized that S100A4 contributes to the invasive and tumor-like behavior of rheumatoid arthritis synovium...
  55. ncbi Upper gastrointestinal tract safety of daily oral risedronate in patients taking NSAIDs: a randomized, double-blind, placebo-controlled trial
    Silvano Adami
    Rheumatologic Rehabilitation Unit, University of Verona, Via Santa Maria Crocifissa di Rosa, 37067 Valeggio sul Mincio VR, Italy
    Mayo Clin Proc 80:1278-85. 2005
    ..To evaluate the frequency of upper gastrointestinal (GI) tract adverse events associated with risedronate during two (2-year) randomized, double-blind, parallel-group, placebo-controlled studies...
  56. ncbi Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institute Karolinska Hospital, Stockholm 17176, Sweden
    Lancet 363:675-81. 2004
    ..We aimed to assess combination treatment with etanercept and methotrexate versus the monotherapies in patients with rheumatoid arthritis...
  57. ncbi Up-regulation of metastasis-promoting S100A4 (Mts-1) in rheumatoid arthritis: putative involvement in the pathogenesis of rheumatoid arthritis
    Jorg Klingelhofer
    Danish Cancer Society, Copenhagen, Denmark
    Arthritis Rheum 56:779-89. 2007
    ..To examine the involvement of the metastasis-inducing protein S100A4 (Mts-1) in the pathogenesis of rheumatoid arthritis (RA)...
  58. ncbi COL6A1, the candidate gene for ossification of the posterior longitudinal ligament, is associated with diffuse idiopathic skeletal hyperostosis in Japanese
    So Tsukahara
    Division of Genetic Diagnosis, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 30:2321-4. 2005
    ..Genetic screening of collagen 6A1 gene (COL6A1) in patients with diffuse idiopathic skeletal hyperostosis (DISH) recruited in Japan and the Czech Republic...
  59. ncbi Clinical significance of the long-term symptom-modifying effects of glucosamine sulfate: comment on the article by Brandt and Mazzuca
    Olivier Bruyere
    Arthritis Rheum 54:2339-41; author reply 2341-3. 2006