Hana Kovarova

Summary

Affiliation: Institute of Animal Physiology and Genetics
Country: Czech Republic

Publications

  1. pmc Cancer cell response to anthracyclines effects: mysteries of the hidden proteins associated with these drugs
    Jirina Tyleckova
    Institute of Animal Physiology and Genetics AS CR, v v i, 277 21 Libechov, Czech Republic
    Int J Mol Sci 13:15536-64. 2012
  2. ncbi request reprint Analysis of state-specific phosphorylation of proteins by two-dimensional gel electrophoresis approach
    Hana Kovarova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska Str 89, CZ 277 21 Libechov, Czech Republic
    J Chromatogr B Analyt Technol Biomed Life Sci 787:53-61. 2003
  3. doi request reprint 1st Central and Eastern European Proteomic Conference and 3rd Czech Proteomic Conference
    Hana Kovarova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, 27721 Libechov, Czech Republic
    Expert Rev Proteomics 5:25-8. 2008
  4. doi request reprint Protein signaling pathways in differentiation of neural stem cells
    Helena Skalnikova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
    Proteomics 8:4547-59. 2008
  5. doi request reprint Development of ovarian hyperstimulation syndrome: interrogation of key proteins and biological processes in human follicular fluid of women undergoing in vitro fertilization
    Karla Jarkovska
    Department of Reproductive and Developmental Biology, Institute of Animal Physiology and Genetics AS CR, v v i, 277 21 Libechov, Czech Republic
    Mol Hum Reprod 17:679-92. 2011
  6. doi request reprint Cancer drug-resistance and a look at specific proteins: Rho GDP-dissociation inhibitor 2, Y-box binding protein 1, and HSP70/90 organizing protein in proteomics clinical application
    Helena Skalnikova
    Institute of Animal Physiology and Genetics AS CR, vvi, Libechov, Czech Republic
    J Proteome Res 10:404-15. 2011
  7. ncbi request reprint Protein fingerprints of anti-cancer effects of cyclin-dependent kinase inhibition: identification of candidate biomarkers using 2-D liquid phase separation coupled to mass spectrometry
    Helena Skalnikova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska 89, 27721 Libechov, Czech Republic
    Technol Cancer Res Treat 4:447-54. 2005
  8. doi request reprint The third Central and Eastern European Proteomic conference
    Suresh Jivan Gadher
    Millipore Bioscience, St Charles, MO, USA and Institute of Animal Physiology and Genetics, Academy of Sciences of Czech Republic, v v i, Rumburska 89, 27721 Libechov, Czech Republic
    Expert Rev Proteomics 7:15-7. 2010
  9. doi request reprint Regulation of cap-dependent translation initiation in the early stage porcine parthenotes
    Andrej Susor
    Institute of Animal Physiology and Genetics, Libechov, Czech Republic
    Mol Reprod Dev 75:1716-25. 2008
  10. ncbi request reprint Proteomic analysis of porcine oocytes during in vitro maturation reveals essential role for the ubiquitin C-terminal hydrolase-L1
    Andrej Susor
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska Str 89, 277 21 Libechov, Czech Republic
    Reproduction 134:559-68. 2007

Collaborators

Detail Information

Publications27

  1. pmc Cancer cell response to anthracyclines effects: mysteries of the hidden proteins associated with these drugs
    Jirina Tyleckova
    Institute of Animal Physiology and Genetics AS CR, v v i, 277 21 Libechov, Czech Republic
    Int J Mol Sci 13:15536-64. 2012
    ....
  2. ncbi request reprint Analysis of state-specific phosphorylation of proteins by two-dimensional gel electrophoresis approach
    Hana Kovarova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska Str 89, CZ 277 21 Libechov, Czech Republic
    J Chromatogr B Analyt Technol Biomed Life Sci 787:53-61. 2003
    ..Current findings demonstrate that this method represents a reasonable alternative to the use of other tools to study protein phosphorylation...
  3. doi request reprint 1st Central and Eastern European Proteomic Conference and 3rd Czech Proteomic Conference
    Hana Kovarova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, 27721 Libechov, Czech Republic
    Expert Rev Proteomics 5:25-8. 2008
    ....
  4. doi request reprint Protein signaling pathways in differentiation of neural stem cells
    Helena Skalnikova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
    Proteomics 8:4547-59. 2008
    ..Computer simulation of possible interaction network connecting regulated proteins, exposed additional relationships including direct interactions of HO2 with amyloid precursor protein or huntingtin-associated protein 1...
  5. doi request reprint Development of ovarian hyperstimulation syndrome: interrogation of key proteins and biological processes in human follicular fluid of women undergoing in vitro fertilization
    Karla Jarkovska
    Department of Reproductive and Developmental Biology, Institute of Animal Physiology and Genetics AS CR, v v i, 277 21 Libechov, Czech Republic
    Mol Hum Reprod 17:679-92. 2011
    ....
  6. doi request reprint Cancer drug-resistance and a look at specific proteins: Rho GDP-dissociation inhibitor 2, Y-box binding protein 1, and HSP70/90 organizing protein in proteomics clinical application
    Helena Skalnikova
    Institute of Animal Physiology and Genetics AS CR, vvi, Libechov, Czech Republic
    J Proteome Res 10:404-15. 2011
    ..Furthermore, these proteins were validated for their roles in drug resistance using different cell lines resistant to diverse representatives of anti-cancer drugs such as vincristine and daunorubicin...
  7. ncbi request reprint Protein fingerprints of anti-cancer effects of cyclin-dependent kinase inhibition: identification of candidate biomarkers using 2-D liquid phase separation coupled to mass spectrometry
    Helena Skalnikova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska 89, 27721 Libechov, Czech Republic
    Technol Cancer Res Treat 4:447-54. 2005
    ..This strategy is valuable for comprehensive proteomic analysis of cellular protein targets and pathways that are relevant to anticancer activity of cyclin-dependent kinase inhibition...
  8. doi request reprint The third Central and Eastern European Proteomic conference
    Suresh Jivan Gadher
    Millipore Bioscience, St Charles, MO, USA and Institute of Animal Physiology and Genetics, Academy of Sciences of Czech Republic, v v i, Rumburska 89, 27721 Libechov, Czech Republic
    Expert Rev Proteomics 7:15-7. 2010
    ....
  9. doi request reprint Regulation of cap-dependent translation initiation in the early stage porcine parthenotes
    Andrej Susor
    Institute of Animal Physiology and Genetics, Libechov, Czech Republic
    Mol Reprod Dev 75:1716-25. 2008
    ..Although the translation is gradually decreasing during early preimplantation development, the eIF4F complex, which is temporarily formed, might be a premise for the translation of a small subset of mRNAs at this period of development...
  10. ncbi request reprint Proteomic analysis of porcine oocytes during in vitro maturation reveals essential role for the ubiquitin C-terminal hydrolase-L1
    Andrej Susor
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska Str 89, 277 21 Libechov, Czech Republic
    Reproduction 134:559-68. 2007
    ..In summary, a proteomic approach coupled with protein verification study revealed an essential role of UCH-L1 in the completion of the first meiosis and its transition to anaphase...
  11. doi request reprint Proteomics of neural stem cells
    Helena Skalnikova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska 89, 277 21 Libechov, Czech Republic
    Expert Rev Proteomics 5:175-86. 2008
    ....
  12. doi request reprint Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy
    Rita Hrabakova
    Institute of Animal Physiology and Genetics, AS CR, vvi, Laboratory of Biochemistry and Molecular Biology of Germ Cells, Rumburska 89, 277 21 Libechov, Czech Republic
    J Proteome Res 12:455-69. 2013
    ..In addition, serpin B5 and calretinin appear to be candidate biomarkers that may be accessible in patients for monitoring of cancer therapy with ease...
  13. doi request reprint Proteome mining of human follicular fluid reveals a crucial role of complement cascade and key biological pathways in women undergoing in vitro fertilization
    Karla Jarkovska
    Institute of Animal Physiology and Genetics AS CR, v v i, Libechov, Czech Republic
    J Proteome Res 9:1289-301. 2010
    ..Several specific proteins were observed, many of which have not yet been associated with follicle/oocyte maturation. These proteins together with their regulatory pathways may play a vital role in the reproductive process...
  14. ncbi request reprint A proteomic approach to studying the differentiation of neural stem cells
    Helena Skalnikova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
    Proteomics 7:1825-38. 2007
    ..These findings represent a significant step towards understanding neural cell differentiation and identification of the regulatory proteins associated with this process...
  15. doi request reprint Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines
    Helena Skalnikova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
    Proteomics 11:691-708. 2011
    ..Recent advances and challenges of the stem cell and primary cell secretome analysis together with the most relevant results are discussed in this review...
  16. ncbi request reprint ERK1/2 map kinase metabolic pathway is responsible for phosphorylation of translation initiation factor eIF4E during in vitro maturation of pig oocytes
    Zdenka Ellederova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
    Mol Reprod Dev 75:309-17. 2008
    ..We also demonstrate that activation and phosphorylation of ERK1/2 MAP kinase and eIF4E is associated with the activating phosphorylation of Mnk1 kinase, one of the two main kinases phosphorylating eIF4E in somatic cells...
  17. ncbi request reprint Suppression of translation during in vitro maturation of pig oocytes despite enhanced formation of cap-binding protein complex eIF4F and 4E-BP1 hyperphosphorylation
    Zdenka Ellederova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
    Mol Reprod Dev 73:68-76. 2006
    ....
  18. doi request reprint Challenges of Huntington's disease and quest for therapeutic biomarkers
    Eva Kotrcova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic Research Center PIGMOD, Libechov, Czech Republic
    Proteomics Clin Appl 9:147-58. 2015
    ..Furthermore, brain, body fluids, and immune system are intensively studied in order to search for additional proteins with a view to their use as a biomarker(s) or set of biomarkers in clinical trials in HD translational research. ..
  19. doi request reprint Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies
    Martina Zizkova
    Laboratory of Applied Proteome Analyses, Institute of Animal Physiology and Genetics, AS CR, v v i, Libechov, Czech Republic
    Expert Rev Proteomics 12:83-95. 2015
    ....
  20. doi request reprint Challenges in cancer research and multifaceted approaches for cancer biomarker quest
    Jirina Martinkova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, v v i, Rumburska 89, 27721 Libechov, Czech Republic
    FEBS Lett 583:1772-84. 2009
    ..This review attempts to illustrate recent advances in the field of cancer biomarkers and multifaceted approaches undertaken in combating cancer...
  21. ncbi request reprint Relative quantitation of proteins fractionated by the ProteomeLab PF 2D system using isobaric tags for relative and absolute quantitation (iTRAQ)
    Helena Skalnikova
    Institute of Animal Physiology and Genetics, Academy of Sciences of Czech Republic, Rumburska 89, 277 21 Libechov, Czech Republic
    Anal Bioanal Chem 389:1639-45. 2007
    ..The overall outcome is the simplification in the data complexity and the ease of use of the labelling protocol...
  22. ncbi request reprint Protein patterns of pig oocytes during in vitro maturation
    Zdenka Ellederova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska Str 89, 277 21 Libechov, Czech Republic
    Biol Reprod 71:1533-9. 2004
    ..It is a useful inventory toward a deeper understanding of the mechanisms underlying reproduction and development...
  23. doi request reprint Signaling proteins in spinal parenchyma and dorsal root ganglion in rat with spinal injury-induced spasticity
    Helena Kupcova Skalnikova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, v v i, Laboratory of Biochemistry and Molecular Biology of Germ Cells, Libechov, Czech Republic
    J Proteomics 91:41-57. 2013
    ....
  24. doi request reprint Revelation of fibroblast protein commonalities and differences and their possible roles in wound healing and tumourigenesis using co-culture models of cells
    Karla Jarkovska
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
    Biol Cell 106:203-18. 2014
    ....
  25. ncbi request reprint The characterization of stem cell proteomes
    Petr Vodicka
    Laboratory of Cell Regeneration and Plasticity, Department of Reproductive and Developmental Biology, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Rumburska 89, Libechov 277 21, Czech Republic
    Curr Opin Mol Ther 8:232-9. 2006
    ..This review will discuss recent advances in the field of proteomic research that have initiated the characterization of stem cell proteomes...
  26. ncbi request reprint Application of proteomics in the search for novel proteins associated with the anti-cancer effect of the synthetic cyclin-dependent kinases inhibitor, bohemine
    Hana Kovarova
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, 277 21 Libechov, Czech Republic
    Technol Cancer Res Treat 1:247-56. 2002
    ..Our conclusions further underline the importance of cell cycle control in both the cellular signalling and metabolic pathways...
  27. doi request reprint Antibody microarray analyses of signal transduction protein expression and phosphorylation during porcine oocyte maturation
    Steven Pelech
    Kinexus Bioinformatics Corporation, Suite 1, 8755 Ash Street, Vancouver, BC, Canada V6P 6T3
    J Proteome Res 7:2860-71. 2008
    ....