Roman Kotlin

Summary

Affiliation: Institute of Hematology and Blood Transfusion
Country: Czech Republic

Publications

  1. ncbi Fibrinogen Šumperk II: dysfibrinogenemia in an individual with two coding mutations
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Am J Hematol 87:555-7. 2012
  2. ncbi Dysfibrinogenemia in childhood: two cases of congenital dysfibrinogens
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, Praha, Czech Republic
    Blood Coagul Fibrinolysis 21:640-8. 2010
  3. ncbi Two novel fibrinogen variants in the C-terminus of the Bβ-chain: fibrinogen Rokycany and fibrinogen Znojmo
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Praha 2, Czech Republic
    J Thromb Thrombolysis 30:311-8. 2010
  4. ncbi Two cases of congenital dysfibrinogenemia associated with thrombosis - Fibrinogen Praha III and Fibrinogen Plzen
    Roman Kotlin
    Institute of Haematology and Blood Transfusion, 128 20 Praha 2, Czech Republic
    Thromb Haemost 102:479-86. 2009
  5. ncbi A novel fibrinogen variant--Praha I: hypofibrinogenemia associated with gamma Gly351Ser substitution
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, Praha, Czech Republic
    Eur J Haematol 78:410-6. 2007
  6. ncbi Acquired dysfibrinogenemia secondary to multiple myeloma
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, Praha, Czech Republic
    Acta Haematol 120:75-81. 2008
  7. ncbi A novel fibrinogen variant--Liberec: dysfibrinogenaemia associated with gamma Tyr262Cys substitution
    Roman Kotlin
    Institute of Haematology and Blood Transfusion, Praha 2, Czech Republic
    Eur J Haematol 81:123-9. 2008
  8. ncbi Fibrinogen Nový Jicín and Praha II: cases of hereditary Aalpha 16 Arg-->Cys and Aalpha 16 Arg-->His dysfibrinogenemia
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Praha 2, Czech Republic
    Thromb Res 121:75-84. 2007
  9. ncbi Clinical manifestation and molecular genetic characterization of MYH9 disorders
    Dana Provaznikova
    Institute of Haematology and Blood Transfusion, Prague, Czech Republic
    Platelets 20:289-96. 2009
  10. ncbi Antioxidants change platelet responses to various stimulating events
    Alzbeta Sobotková
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 00 Prague 2, Czech Republic
    Free Radic Biol Med 47:1707-14. 2009

Collaborators

Detail Information

Publications12

  1. ncbi Fibrinogen Šumperk II: dysfibrinogenemia in an individual with two coding mutations
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Am J Hematol 87:555-7. 2012
    ..While mutation Aa Gly13Glu is responsible for abnormal fibrinopeptide release and prolonged thrombin time, the novel mutation Aa Ser314Cys seems to affect fibrin morphology and fibrinolysis...
  2. ncbi Dysfibrinogenemia in childhood: two cases of congenital dysfibrinogens
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, Praha, Czech Republic
    Blood Coagul Fibrinolysis 21:640-8. 2010
    ..Two cases of asymptomatic dysfibrinogenemias, found by routine coagulation testing, were genetically identified as new cases of fibrinogen variants Aα Arg16His and Aα Arg16Cys...
  3. ncbi Two novel fibrinogen variants in the C-terminus of the Bβ-chain: fibrinogen Rokycany and fibrinogen Znojmo
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Praha 2, Czech Republic
    J Thromb Thrombolysis 30:311-8. 2010
    ....
  4. ncbi Two cases of congenital dysfibrinogenemia associated with thrombosis - Fibrinogen Praha III and Fibrinogen Plzen
    Roman Kotlin
    Institute of Haematology and Blood Transfusion, 128 20 Praha 2, Czech Republic
    Thromb Haemost 102:479-86. 2009
    ..Although both mutations are situated in different regions of the molecule, both mutations have a very similar effect on fibrinogen functions and both are connected with thromboses...
  5. ncbi A novel fibrinogen variant--Praha I: hypofibrinogenemia associated with gamma Gly351Ser substitution
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, Praha, Czech Republic
    Eur J Haematol 78:410-6. 2007
    ..A 25-yr-old man from Prague had abnormal bleeding after several surgical operations with low fibrinogen level and hypofibrinogenemia was suspected...
  6. ncbi Acquired dysfibrinogenemia secondary to multiple myeloma
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, Praha, Czech Republic
    Acta Haematol 120:75-81. 2008
    ..It was found that the paraprotein interacts with the gamma-chain of fibrinogen. Acquired dysfibrinogenemia associated with multiple myeloma was diagnosed in the 72-year-old patient...
  7. ncbi A novel fibrinogen variant--Liberec: dysfibrinogenaemia associated with gamma Tyr262Cys substitution
    Roman Kotlin
    Institute of Haematology and Blood Transfusion, Praha 2, Czech Republic
    Eur J Haematol 81:123-9. 2008
    ..A 22-yr-old woman had abnormal preoperative coagulation test results and congenital dysfibrinogenaemia was suspected...
  8. ncbi Fibrinogen Nový Jicín and Praha II: cases of hereditary Aalpha 16 Arg-->Cys and Aalpha 16 Arg-->His dysfibrinogenemia
    Roman Kotlin
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Praha 2, Czech Republic
    Thromb Res 121:75-84. 2007
    ..Various dysfibrinogenemias have been described worldwide. This paper describes two new cases of dysfibrinogenemia identified in the Czech Republic...
  9. ncbi Clinical manifestation and molecular genetic characterization of MYH9 disorders
    Dana Provaznikova
    Institute of Haematology and Blood Transfusion, Prague, Czech Republic
    Platelets 20:289-96. 2009
    ..We also determined the number of glycoprotein sites on the surface of platelets. Most patients had an increased number of glycoproteins, which could be due to platelet size...
  10. ncbi Antioxidants change platelet responses to various stimulating events
    Alzbeta Sobotková
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 00 Prague 2, Czech Republic
    Free Radic Biol Med 47:1707-14. 2009
    ..The results also show the importance of studying platelet activation under conditions of real blood flow in contact with reactive surfaces, e.g., using dynamic adhesion experiments...
  11. ncbi High-resolution melting analysis for detection of MYH9 mutations
    Dana Provaznikova
    Institute of Haematology and Blood Transfusion, Coagulation Laboratory, Prague, Czech Republic
    Platelets 19:471-5. 2008
    ..Samples identified by HRMA as positive for the mutation were analysed by direct sequencing. HRMA saved us over 85% of redundant sequencing...
  12. ncbi Nature of frequent deletions in CEBPA
    Ota Fuchs
    Institute of Hematology and Blood Transfusion, Department of Cell Physiology, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Blood Cells Mol Dis 43:260-3. 2009
    ..NM_004364.2. A mechanism for deletion formation between two repetitive sequences can be recombination events in the repair process. Double-stranded cut in DNA can initiate these recombination events of adjacent DNA sequences...