Martin Hill

Summary

Affiliation: Institute of Endocrinology
Country: Czech Republic

Publications

  1. ncbi request reprint Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal and umbilical blood: 3.3beta-hydroxy-5-ene steroids
    M Hill
    Institute of Endocrinology, Narodni trida 8, Prague, Czech Republic
    J Steroid Biochem Mol Biol 82:241-50. 2002
  2. doi request reprint WITHDRAWN: Special issue on Pregnancy and Steroids
    Martin Hill
    Institute of Endocrinology, Prague, Czech Republic Electronic address
    J Steroid Biochem Mol Biol . 2013
  3. doi request reprint Dehydroepiandrosterone, its metabolites and ion channels
    M Hill
    Steroid Hormone Unit, Institute of Endocrinology, Narodni trida 8, Prague 116 94, Praha 1, CZ 116 94, Czech Republic Electronic address
    J Steroid Biochem Mol Biol 145:293-314. 2015
  4. doi request reprint Steroid profiling in pregnancy: a focus on the human fetus
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Prague CZ 116 94, Czech Republic Electronic address
    J Steroid Biochem Mol Biol 139:201-22. 2014
  5. pmc Comparison of a high-carbohydrate and high-protein breakfast effect on plasma ghrelin, obestatin, NPY and PYY levels in women with anorexia and bulimia nervosa
    Dana Sedlácková
    Institute of Endocrinology, Narodni 8, 116 94, Prague 1, Czech Republic
    Nutr Metab (Lond) 9:52. 2012
  6. ncbi request reprint Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, CZ 11694 Prague 1, Czech Republic
    Steroids 70:515-24. 2005
  7. ncbi request reprint Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal blood: 2. Time profiles of pregnanolone isomers
    M Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 78:51-7. 2001
  8. ncbi request reprint Reinstatement of serum pregnanolone isomers and progesterone during alcohol detoxification therapy in premenopausal women
    Martin Hill
    Institute of EndocrinologyCharles University, Prague, Czech Republic
    Alcohol Clin Exp Res 29:1010-7. 2005
  9. ncbi request reprint 7-Hydroxydehydroepiandrosterone epimers in human serum and saliva. Comparison of gas chromatography-mass spectrometry and radioimmunoassay
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    J Chromatogr A 935:297-307. 2001
  10. doi request reprint The steroid metabolome in lamotrigine-treated women with epilepsy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Praha 1, CZ 116 94, Czech Republic
    Steroids 76:1351-7. 2011

Detail Information

Publications167 found, 100 shown here

  1. ncbi request reprint Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal and umbilical blood: 3.3beta-hydroxy-5-ene steroids
    M Hill
    Institute of Endocrinology, Narodni trida 8, Prague, Czech Republic
    J Steroid Biochem Mol Biol 82:241-50. 2002
    ..On the basis of these data, a scheme of steroid biosynthesis in maternal organism during the critical stages around parturition is proposed...
  2. doi request reprint WITHDRAWN: Special issue on Pregnancy and Steroids
    Martin Hill
    Institute of Endocrinology, Prague, Czech Republic Electronic address
    J Steroid Biochem Mol Biol . 2013
    ..The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.jsbmb.2013.08.007. The duplicate article has therefore been withdrawn...
  3. doi request reprint Dehydroepiandrosterone, its metabolites and ion channels
    M Hill
    Steroid Hormone Unit, Institute of Endocrinology, Narodni trida 8, Prague 116 94, Praha 1, CZ 116 94, Czech Republic Electronic address
    J Steroid Biochem Mol Biol 145:293-314. 2015
    ..This article is part of a Special Issue entitled "Essential role of DHEA". ..
  4. doi request reprint Steroid profiling in pregnancy: a focus on the human fetus
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Prague CZ 116 94, Czech Republic Electronic address
    J Steroid Biochem Mol Biol 139:201-22. 2014
    ..This article is part of a Special Issue entitled 'Pregnancy and Steroids'. ..
  5. pmc Comparison of a high-carbohydrate and high-protein breakfast effect on plasma ghrelin, obestatin, NPY and PYY levels in women with anorexia and bulimia nervosa
    Dana Sedlácková
    Institute of Endocrinology, Narodni 8, 116 94, Prague 1, Czech Republic
    Nutr Metab (Lond) 9:52. 2012
    ..As various types of consumed macronutrients may induce different plasma hormone responses, so we examined these responses in women patients with eating disorders and compared them with those of healthy controls...
  6. ncbi request reprint Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, CZ 11694 Prague 1, Czech Republic
    Steroids 70:515-24. 2005
    ..The reinstatement of serum estradiol, progesterone, and PI during the therapy demonstrates its favorable effect on both reproductive functions and the psychosomatic stability of the patients...
  7. ncbi request reprint Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal blood: 2. Time profiles of pregnanolone isomers
    M Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 78:51-7. 2001
    ..A decrease was also observed in the ratio of 3 alpha/3 beta-isomers and 5 alpha/5 beta-isomers around parturition. The possible physiological consequences of the findings are indicated...
  8. ncbi request reprint Reinstatement of serum pregnanolone isomers and progesterone during alcohol detoxification therapy in premenopausal women
    Martin Hill
    Institute of EndocrinologyCharles University, Prague, Czech Republic
    Alcohol Clin Exp Res 29:1010-7. 2005
    ....
  9. ncbi request reprint 7-Hydroxydehydroepiandrosterone epimers in human serum and saliva. Comparison of gas chromatography-mass spectrometry and radioimmunoassay
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    J Chromatogr A 935:297-307. 2001
    ..Besides serum, these steroids were, for the first time, measured in saliva where their concentrations were about five times lower. 7alpha- and 7beta-epimer levels correlated well in both body fluids and they were larger in male...
  10. doi request reprint The steroid metabolome in lamotrigine-treated women with epilepsy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Praha 1, CZ 116 94, Czech Republic
    Steroids 76:1351-7. 2011
    ....
  11. ncbi request reprint The identification and simultaneous quantification of 7-hydroxylated metabolites of pregnenolone, dehydroepiandrosterone, 3beta,17beta-androstenediol, and testosterone in human serum using gas chromatography-mass spectrometry
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94 Prague, Czech Republic
    J Steroid Biochem Mol Biol 96:187-200. 2005
    ..Despite the three times lower concentration of AD-metabolites, their antiglucocorticoid, immunomodulatory, and neuroprotective effects may be comparable to that of DHEA based on their reported greater biological activity...
  12. ncbi request reprint Sulphates of 3beta-hydroxy-5-ene steroids in women with epilepsy
    M Hill
    Institute of Endocrinology, Prague, Czech Republic and Charles University in Prague, First Faculty of Medicine and General University Hospital, Department of Obstetrics and Gynaecology, Prague, Czech Republic
    Prague Med Rep 111:111-26. 2010
    ..10), while primidone decreased DHEAS in both FP and LP (both p=0.05) and did not significantly change the levels of PregS. In conclusion, carbamazepine and primidone therapies significantly suppressed the sulphated steroids in serum...
  13. ncbi request reprint Circulating levels of pregnanolone isomers during the third trimester of human pregnancy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94 Prague 1, Czech Republic
    J Steroid Biochem Mol Biol 105:166-75. 2007
    ....
  14. doi request reprint Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Prague 1 CZ 116 94, Czech Republic
    J Steroid Biochem Mol Biol 122:239-52. 2010
    ..Reduced steroid 20α-hydroxy-metabolites and cortisol were connected with epilepsy without an effect of AEDs. Carbamazepine induced only slight decrease in isopregnanolone, 5α,20α-tetrahydroprogesterone, and androstanediol levels...
  15. doi request reprint Steroid metabolome in plasma from the umbilical artery, umbilical vein, maternal cubital vein and in amniotic fluid in normal and preterm labor
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Prague 116 94, Czech Republic
    J Steroid Biochem Mol Biol 121:594-610. 2010
    ..950), UA (R=0.945), MV (R=0.895), and AF (R=0.891). Although the predictivity of steroids in maternal blood was slightly less effective when compared with the UV and UA, it was the best solution for further practice...
  16. ncbi request reprint Is maternal progesterone actually independent of the fetal steroids?
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 59:211-24. 2010
    ....
  17. doi request reprint Steroid metabolome in fetal and maternal body fluids in human late pregnancy
    Martin Hill
    Institute of Endocrinology, Narodni trida 8, Prague CZ 116 94, Czech Republic
    J Steroid Biochem Mol Biol 122:114-32. 2010
    ....
  18. ncbi request reprint Neuroactive steroids, their precursors, and polar conjugates during parturition and postpartum in maternal and umbilical blood: 1. Identification and simultaneous determination of pregnanolone isomers
    M Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 75:237-44. 2000
    ..The possible role of the sulfatation of pregnanolone isomers around parturition is discussed...
  19. ncbi request reprint Analysis of relations between serum levels of epitestosterone, estradiol, testosterone, IGF-1 and prostatic specific antigen in men with benign prostatic hyperplasia and carcinoma of the prostate
    M Hill
    Institute of Endocrinology, First Medical School, Charles University, Prague, Czech Republic
    Physiol Res 49:S113-8. 2000
    ..377, p<0.01) in partial correlations. PSA levels were higher in patients with prostate cancer (p<0.00001). Epitestosterone, which is negatively correlating with estradiol and IGF-1, may modulate the development of prostate diseases...
  20. ncbi request reprint Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age
    Helena Havlikova
    Institute of Endocrinology, Narodni trida 8, CZ 116 94 Prague 1, Czech Republic
    J Clin Endocrinol Metab 91:3092-9. 2006
    ..The 3beta-PI and sulfates of PI and pregnenolone exert the opposite effect. In addition to the brain's in situ synthesis, some circulating steroids can penetrate the blood-brain barrier...
  21. ncbi request reprint Determinants of circulating adiponectin in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Gynecol Obstet Invest 60:155-61. 2005
    ..Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome...
  22. ncbi request reprint Relationships of circulating pregnanolone isomers and their polar conjugates to the status of sex, menstrual cycle, and pregnancy
    Radmila Kancheva
    Institute of Endocrinology, Národnítrída 8, CZ 116 94 Prague 1, Czech Republic
    J Endocrinol 195:67-78. 2007
    ....
  23. ncbi request reprint Low-density lipoprotein receptor-related protein-5 C/T polymorphism in exon 18 is associated with C peptide and proinsulin levels in control women and patients with polycystic ovary syndrome
    Bela Bendlova
    Institute of Endocrinology, Charles University, Prague, Czech Republic
    Fertil Steril 90:699-708. 2008
    ..The low-density lipoprotein receptor-related protein-5 gene has been found to play a role in determining insulin secretion in animal models...
  24. ncbi request reprint Plasma thiols and androgen levels in polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague 1, Prague, Czech Republic
    Clin Chem Lab Med 41:216-21. 2003
    ..469; p < 0.05). We conclude that homocysteine is increased in women with polycystic ovary syndrome and is probably linked to androgen levels but not to markers of insulin resistance or with lipid metabolism...
  25. ncbi request reprint Plasma levels of 7-hydroxylated dehydroepiandrosterone (DHEA) metabolites and selected amino-thiols as discriminatory tools of Alzheimer's disease and vascular dementia
    Marie Bicíková
    Institute of Endocrinology, Praha, Czech Republic
    Clin Chem Lab Med 42:518-24. 2004
    ..The early differential diagnosis of Alzheimer's disease (AD) remains still problematic. We developed a laboratory test enabling us to distinguish patients with AD from those with vascular dementia (VD) and healthy subjects...
  26. ncbi request reprint Prevalence of insulin resistance and prediction of glucose intolerance and type 2 diabetes mellitus in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 45:639-44. 2007
    ..We evaluated the sensitivity and specificity of clinical and fasting biochemical parameters in screening for impaired glucose tolerance (IGT) and DM2...
  27. ncbi request reprint Interpretation of sex hormone-binding globulin levels in thyroid disorders
    Richard Hampl
    Institute of Endocrinology, Praha 1, Czech Republic
    Thyroid 13:755-60. 2003
    ..After adjustment for age, the only significant positive correlation was between SHBG and free triiodothyronine...
  28. ncbi request reprint Neuroactive pregnanolone isomers during pregnancy
    Antonín Pařízek
    Department of Gynecology and Obstetrics, First Medical Faculty, Charles University, Prague 1, Czech Republic
    J Clin Endocrinol Metab 90:395-403. 2005
    ..A pregnancy-stabilizing role of pregnanolone, counterbalancing the stimulating effect of estradiol on the onset of parturition, was suggested...
  29. doi request reprint Incretin levels in polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Narodni 8, Prague 111694, Czech Republic
    Eur J Endocrinol 159:121-7. 2008
    ..This paper considers the secretion of GIP and GLP-1 after oral glucose load in a group of lean, glucose-tolerant PCOS women in comparison with age- and body mass index (BMI)-matched healthy women...
  30. doi request reprint Adrenocortical function in young adults with diabetes mellitus type 1
    Katerina Simunkova
    Institute of Endocrinology, Narodni trida 8, 116 94 Prague, Czech Republic
    J Steroid Biochem Mol Biol 122:35-41. 2010
    ....
  31. ncbi request reprint Steroids, sex hormone-binding globulin, homocysteine, selected hormones and markers of lipid and carbohydrate metabolism in patients with severe hypothyroidism and their changes following thyroid hormone supplementation
    Marie Bicíková
    Institute of Endocrinology, Praha, Czech Republic
    Clin Chem Lab Med 41:284-92. 2003
    ..Similarly, in hypothyroidism only, dehydroepiandrosterone sulfate correlated positively with immunoglobulin F1 and homocysteine and negatively with thyroid hormones and SHBG...
  32. ncbi request reprint Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome
    Bela Bendlova
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    J Steroid Biochem Mol Biol 104:68-74. 2007
    ..In conclusion, the D327N polymorphism of the SHBG gene does not influence susceptibility to PCOS...
  33. ncbi request reprint Neuro- and immunomodulatory steroids and other biochemical markers in drug-naive schizophrenia patients and the effect of treatment with atypical antipsychotics
    Marie Bicíková
    Institute of Endocrinology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Neuro Endocrinol Lett 32:141-7. 2011
    ....
  34. ncbi request reprint Biochemical markers of bone remodeling correlate negatively with circulating TSH in postmenopausal women
    Ivana Zofkova
    Institute of Endocrinology, Prague, Czech Repulic
    Endocr Regul 42:121-7. 2008
    ..To evaluate the interrelations between circulating TSH and bone metabolism in postmenopausal women...
  35. ncbi request reprint Delayed effects of short-term transdermal application of 7-oxo-dehydroepiandrosterone on its metabolites, some hormonal steroids and relevant proteohormones in healthy male volunteers
    Jarmila Sulcová
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 43:221-7. 2005
    ..The study points to an immediate as well as delayed effect of the short-term transdermal application of 7-oxo-dehydroepiandrosterone on relevant hormonal parameters...
  36. ncbi request reprint Immunomodulatory cytokines in human seminal plasma correlate with immunomodulatory steroids
    Ivan Sterzl
    1st Faculty of Medicine, Institute of Immunology and Microbiology, Charles University, Prague, Czech Republic
    Steroids 68:725-31. 2003
    ..The results, however, are in agreement with our recent finding of an autonomous production of these steroids in the male reproductive tract...
  37. ncbi request reprint Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy
    Sona Stanicka
    Institute of Endocrinology, Faculty Teaching Hospital Motol, Prague, Czech Republic
    Clin Chem Lab Med 43:715-20. 2005
    ..The situation was restored by HRT, as manifested not only by normalisation of insulin sensitivity, secretion and levels of glucoregulatory hormones, but also by improvement of their relationships...
  38. ncbi request reprint Insulin sensitivity in non-obese women with polycystic ovary syndrome during treatment with oral contraceptives containing low-androgenic progestin
    D Cibula
    Department of Obstetrics and Gynecology, Charles University, Apolinarska 18, Prague 2, 120 00, Czech Republic
    Hum Reprod 17:76-82. 2002
    ..The study aim was to investigate insulin action and androgen production during treatment with COC containing low-androgenic progestin...
  39. ncbi request reprint How smoking cessation influence hormonal levels in postmenopausal women?
    Hana Jandíková
    Institute of Endocrinology, Prague, Czech Republic
    Prague Med Rep 115:60-6. 2014
    ..Women successful in smoking cessation, compared to the non-successful ones, have lower androgen levels initially and also after smoking discontinuation. ..
  40. ncbi request reprint Relationship of dehydroepiandrosterone and its 7-hydroxylated metabolites to thyroid parameters and sex hormone-binding globulin (SHBG) in healthy subjects
    Richard Hampl
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 41:1081-6. 2003
    ..The results should serve for further investigation of changes in the thyroid hormone concentrations, together with SHBG and dehydroepiandrosterone metabolites, under various pathological situations...
  41. ncbi request reprint The content of four immunomodulatory steroids and major androgens in human semen
    Richard Hampl
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Czech Republic
    J Steroid Biochem Mol Biol 84:307-16. 2003
    ..In addition, the steroids were measured in serum and the concentrations in both fluids were compared. The concentrations of 7-OH-DHEA in seminal fluid varied from 1.8 to 15.7 nmol/l, while those of DHEA were about five times higher...
  42. ncbi request reprint Dehydroepiandrosterone status in postmenopausal women is determined by the gene for the vitamin D receptor
    I Zofkova
    Institute of Endocrinology, Prague, Czech Republic
    Horm Metab Res 34:127-31. 2002
    ..The results indicate that DHEA production and bone mass share a common genetic control through VDR...
  43. pmc A Comprehensive Evaluation of Steroid Metabolism in Women with Intrahepatic Cholestasis of Pregnancy
    Antonín Pařízek
    Department of Obstetrics and Gynecology, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    PLoS ONE 11:e0159203. 2016
    ..3% specificity and 81.3% sensitivity (ROC analysis). These new data demonstrating altered steroidogenesis in ICP patients offer more detailed pathophysiological insights into the role of steroids in the development of ICP. ..
  44. pmc Differential acute postprandial effects of processed meat and isocaloric vegan meals on the gastrointestinal hormone response in subjects suffering from type 2 diabetes and healthy controls: a randomized crossover study
    Lenka Belinova
    Institute for Clinical and Experimental Medicine, Prague, Czech Republic First Faculty of Medicine, Charles University, Prague, Czech Republic
    PLoS ONE 9:e107561. 2014
    ..We hypothesized that the meat meal would lead to abnormal postprandial increases in plasma lipids and oxidative stress markers and impaired GIH responses...
  45. ncbi request reprint Determination of 17alpha-hydroxypregnenolone sulfate and its application in diagnostics
    Helena Vceláková
    Institute of Endocrinology, Narodni 8, 11694 Prague 1, Czech Republic
    Steroids 72:323-7. 2007
    ..These findings indicate that, the conversion of pregnenolone sulfate to 17-PregS is the major metabolic pathway for biosynthesis of 17-PregS...
  46. doi request reprint Factors affecting spontaneous voiding recovery after radical hysterectomy
    David Cibula
    Department of Obstetrics and Gynecology, General Teaching Hospital, First Medical School, Charles University, Prague, Czech Republic
    Int J Gynecol Cancer 20:685-90. 2010
    ..The impairment of spontaneous voiding is the most prominent type of morbidity in the early postoperative period after radical hysterectomy. The aim of our work was to evaluate the parameters affecting the recovery of spontaneous voiding...
  47. doi request reprint Free testosterone and free dihydrotestosterone throughout the life span of men
    Luboslav Starka
    Steroid Hormones Dept, Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 116:118-20. 2009
    ..Hormonal values from our database served for the construction of the life span curve of free dihydrotestosterone/free testosterone ratio...
  48. ncbi request reprint Does obesity diminish the positive effect of oral contraceptive treatment on hyperandrogenism in women with polycystic ovarian syndrome?
    D Cibula
    Department of Obstetrics and Gynecology, General Faculty Hospital, Charles University, Prague 2, Czech Republic
    Hum Reprod 16:940-4. 2001
    ..In conclusion, the positive effect of COC treatment on androgen production, serum androgen binding capacity, and clinical androgenic symptoms was negatively influenced by an increased BMI...
  49. ncbi request reprint Insulin Sensitivity and Secretion in Obese Type 2 Diabetic Women after Various Bariatric Operations
    Jana Vrbikova
    Institute of Endocrinology, Clinical Department, Prague, Czech Republic
    Obes Facts 9:410-423. 2016
    ..To compare the effects of biliopancreatic diversion (BPD) and laparoscopic gastric banding (LAGB) on insulin sensitivity and secretion with the effects of laparoscopic gastric plication (P)...
  50. doi request reprint Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic
    Jana Vitku
    Department of Steroids and Proteofactors, Institute of Endocrinology, Prague, Czech Republic Electronic address
    Environ Int 89:166-73. 2016
    ..As yet, however, no complex study has been conducted evaluating the relationships between EDs and the steroid spectrum in the plasma and seminal plasma...
  51. ncbi request reprint Derivatives of 16alpha-hydroxy-dehydroepiandrosterone with an additional 7-oxo or 7-hydroxy substituent: synthesis and gas chromatography/mass spectrometry analysis
    Vladimir Pouzar
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Steroids 70:739-49. 2005
    ..The target compounds were characterized by (1)H and (13)C NMR spectra and in the form of O-methyloxime-trimethylsilyl derivatives, by gas chromatography/mass spectrometry methods...
  52. doi request reprint Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women
    Kvido Smitka
    Institute of Endocrinology, Laboratory of Clinical and Experimental Neuroendocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Regul Pept 182:45-52. 2013
    ..Also leptin may be affected by exercise. Dysfunction of FFA-leptin-ACTH secretion might be involved in binge eating and subsequent purging as is the case in bulimia nervosa (BN)...
  53. doi request reprint Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia
    Marie Bicíková
    Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 133:77-83. 2013
    ..On the other hand, steroid metabolome model may be used as a diagnostic tool for further studies...
  54. ncbi request reprint A novel radioimmunoassay of 16alpha-hydroxy-dehydroepiandrosterone and its physiological levels
    Ludmila Zamrazilová
    Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 104:130-5. 2007
    ..Physiological levels of 16alpha-OH-DHEA in 316 sera (184 females and 132 males) analyzed so far varied between 0.0 and 1.86 nmol/l...
  55. ncbi request reprint Simultaneous determination of dehydroepiandrosterone, its 7-hydroxylated metabolites, and their sulfates in rat brain tissues
    Hana Kazihnitková
    Institute of Endocrinology, Narodni 8, 11694 Praha 1, Czech Republic
    Steroids 69:667-74. 2004
    ..The reproducibility of the method with respect to coefficients of variation varied from 12 to 25%. An age-related decrease of sulfated dehydroepiandrosterone in the cortex of animals was also observed...
  56. doi request reprint Low-dose estrogen combined oral contraceptives may negatively influence physiological bone mineral density acquisition during adolescence
    David Cibula
    Department of Obstetrics and Gynecology, Faculty of Medicine 1, Charles University, Prague, Czech Republic
    Eur J Endocrinol 166:1003-11. 2012
    ..The aim was to evaluate changes of bone mineral density (BMD) and markers of bone turnover in healthy adolescents, and in adolescent users of combined oral contraceptives (COCs) with different ethinylestradiol (EE) contents...
  57. ncbi request reprint Insulin sensitivity and beta-cell function in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Diabetes Care 25:1217-22. 2002
    ..To evaluate insulin sensitivity (IS) and beta-cell function (beta F) in lean and obese women with polycystic ovary syndrome (PCOS), either separately or by using a disposition index (DI)...
  58. ncbi request reprint Dihydrotestosterone and testosterone throughout the life span of Czech men
    Luboslav Starka
    Institute of Endocrinology, Prague, Czech Republic
    Neuro Endocrinol Lett 29:201-4. 2008
    ..Data from the database of the Institute of Endocrinology served as the basis for the definition of the life span curve for the ratio dihydrotestosterone : testosterone...
  59. doi request reprint Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances
    Radmila Kancheva
    Institute of Endocrinology, Narodni trida 8, Prague CZ 116 94, Czech Republic
    J Steroid Biochem Mol Biol 119:35-44. 2010
    ..The CNS in situ synthesis and transport from periphery might be complementary in some cases, i.e. brain synthesis might provide minimum level of steroids, which are indispensable for the CNS functions...
  60. ncbi request reprint Low-density lipoprotein receptor-related protein 5 and vitamin D receptor gene polymorphisms in relation to vitamin D levels in menopause
    Katerina Zajickova
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 44:1066-9. 2006
    ..4037C>T polymorphisms in a cohort of 165 perimenopausal women and to associate the genotypes with biochemical and densitometric bone parameters in a subset of 112 postmenopausal women...
  61. ncbi request reprint Vitamin D receptor polymorphisms, bone ultrasound and mineral density in post-menopausal women
    Katerina Zajickova
    Institute of Endocrinology, Prague, Czech Republic
    Aging Clin Exp Res 17:121-4. 2005
    ....
  62. doi request reprint Steroid sulfatase and sulfuryl transferase activities in human brain tumors
    Lubomir Kriz
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    J Steroid Biochem Mol Biol 109:31-9. 2008
    ..7% of pituitary adenomas. Astrocytomas, meningiomas and remaining 27.3% pituitary adenomas showed similarities in both enzymes' activities. Differences in STS and SULT activity did not depend on the sex or age of subjects...
  63. ncbi request reprint What may be the markers of the male equivalent of polycystic ovary syndrome?
    M Duskova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 53:287-94. 2004
    ..This frequency corresponds to the prevalence of PCOS in women. There was no significant difference between the two subgroups in the occurrence of allele 3 INS VNTR...
  64. ncbi request reprint The effect of combination therapy with metformin and combined oral contraceptives (COC) versus COC alone on insulin sensitivity, hyperandrogenaemia, SHBG and lipids in PCOS patients
    D Cibula
    Department of Obstetrics and Gynecology, Charles University, Apolinarska 18, Prague 2, 120 00, Czech Republic
    Hum Reprod 20:180-4. 2005
    ..Neither oral contraceptives (COC) nor metformin are an optimal modality for the long-term treatment of polycystic ovary syndrome (PCOS). The aim of this study was to evaluate whether a combination of both is beneficial over COC monotherapy...
  65. ncbi request reprint Polymorphism of INS VNTR is associated with glutamic acid decarboxylase antibodies and postprandial C-peptide in patients with onset of diabetes after 35 years of age
    M Matejkova-Behanova
    Institute of Endocrinology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 53:187-90. 2004
    ....
  66. ncbi request reprint TRH test in patients with diabetes mellitus type 1 and/or autoimmune thyroiditis. Changes in the pituitary-thyroid axis, reverse T3, prolactin and growth hormone levels
    E Orlická
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S109-17. 2008
    ..AT was associated with impairment of TRH stimulated fT3, fT4, fT3/fT4 response and changes in rT3 levels, in spite of preserved TRH-stimulated TSH secretion. GH response in AT patients was also altered...
  67. ncbi request reprint Neuromedin beta: P73T polymorphism in overweight and obese subjects
    J Spálová
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S39-48. 2008
    ..Nevertheless, only female non-carriers showed a significant decrease in the hunger score...
  68. ncbi request reprint Prediction of insulin sensitivity in nonobese women with polycystic ovary syndrome
    D Cibula
    Department of Obstetrics and Gynecology, Charles University, Praha 2, 120 00, Czech Republic
    J Clin Endocrinol Metab 87:5821-5. 2002
    ..The close relationship between insulin sensitivity and SHBG was documented by factor analysis and by its presence in all prediction models as the most significant (or even the single) predictor of the insulin sensitivity index...
  69. ncbi request reprint Immunoassay of 7-hydroxysteroids: 1. Radioimmunoassay of 7beta-hydroxy dehydroepiandrosterone
    O Lapcik
    Institute of Endocrinology, Praha, Czech Republic
    J Steroid Biochem Mol Biol 67:439-45. 1998
    ..05 +/- 1.02 nmol l(-1), the broad range of values from undetectable levels to 10.3 nmol l(-1) was found in the patients. Serum levels of free 7beta-OH-DHEA in the patients significantly correlated with DHEA and its sulfate...
  70. doi request reprint The Effect of Meal Frequency on the Fatty Acid Composition of Serum Phospholipids in Patients with Type 2 Diabetes
    Hana Kahleova
    a Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    J Am Coll Nutr 35:317-25. 2016
    ..The aim of this secondary analysis was to explore the effect of meal frequency on the fatty acid composition of serum phospholipids in subjects with type 2 diabetes (T2D)...
  71. doi request reprint Preliminary evidence of altered steroidogenesis in women with Alzheimer's disease: Have the patients "OLDER" adrenal zona reticularis?
    Marketa Vankova
    Institute of Endocrinology, Narodni 8, Prague 116 94, Czech Republic Electronic address
    J Steroid Biochem Mol Biol 158:157-77. 2016
    ..Our study suggested relationships between AD status in women based on the age of subjects and levels of 10 steroids measured by GC-MS. ..
  72. doi request reprint Endocrine disruptors and other inhibitors of 11β-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition
    Jana Vitku
    Institute of Endocrinology, Department of Steroids and Proteofactors, Prague, Czech Republic Electronic address
    J Steroid Biochem Mol Biol 155:207-16. 2016
    ..This review focuses on the effects of 11βHSD inhibitors in the testis, colon, adipose tissue, kidney, brain and placenta. ..
  73. doi request reprint Low maternal serum matrix metalloproteinase (MMP)-2 concentrations are associated with preterm labor and fetal inflammatory response
    Michal Koucký
    Department of Gynecology and Obstetrics of the First Faculty of Medicine and General Teaching Hospital, Charles University in Prague, Prague, Czech Republic
    J Perinat Med 38:589-96. 2010
    ....
  74. ncbi request reprint Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects
    Helena Havlikova
    Institute of Endocrinology, CZ 116 94 Prague, Czech Republic
    J Clin Endocrinol Metab 87:2225-31. 2002
    ....
  75. ncbi request reprint 7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid
    Luboslav Starka
    Institute of Endocrinology, Prague, Czech Republic
    Neuro Endocrinol Lett 30:368-72. 2009
    ..Dehydroepiandrosterone is a long established neuroactive steroid. Some authors documented that 7-oxygenated derivatives of this steroid may be responsive at least by part for its physiological activity...
  76. doi request reprint Effect of telmisartan on selected adipokines, insulin sensitivity, and substrate utilization during insulin-stimulated conditions in patients with metabolic syndrome and impaired fasting glucose
    Petr Wohl
    Diabetes Center, Institute for Clinical and Experimental Medicine, Vídenská 1958 4, Prague, Czech Republic
    Eur J Endocrinol 163:573-83. 2010
    ..This study evaluated the effect of telmisartan on insulin sensitivity, substrate utilization, selected plasma adipokines and their expressions in subcutaneous adipose tissue (SAT) in metabolic syndrome...
  77. ncbi request reprint Gas chromatographic-mass spectrometric identification of 16alpha-hydroxy-dehydroepiandrosterone in human seminal plasma
    Jakub Hert
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Czech Republic
    Steroids 69:773-7. 2004
    ..The concentration of 16alpha-hydroxydehydroepiandrosterone amounted in average 1.06 nmol/l, being lower but close to- the product of concurrent DHEA metabolism, 7-hydroxydehydroepiandrosterone isomers, found recently in seminal plasma...
  78. ncbi request reprint Genetic variant of luteinizing hormone: impact on gonadal steroid sex hormones in women
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 50:583-7. 2001
    ..No differences were detected in serum LH, FSH, epitestosterone and sex hormone binding globulin (SHBG)...
  79. ncbi request reprint The concentrations of the endogenous C19-steroids in hyperplastic prostatic tissue and the effect of finasteride treatment
    M Hill
    Institute of Endocrinology, Charles University, Prague, Czech Republic
    Horm Metab Res 28:562-4. 1996
    ..The prostatic tissue from the patients treated with finasteride for 8 weeks showed a significant decrease not only in DHT but also in androstenedione and epiT, whereas the concentration of testosterone increased significantly...
  80. ncbi request reprint Leptin levels in obese children: effects of gender, weight reduction and androgens
    R Pilcová
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 52:53-60. 2003
    ..0001 in girls). No significant correlation was found between leptin concentrations and total cholesterol or androgens. We confirmed that leptin is a sensitive parameter of body composition and weight reduction in obese children...
  81. ncbi request reprint Two neuroactive steroids in midpregnancy as measured in maternal and fetal sera and in amniotic fluid
    Marie Bicíková
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Praha, Czech Republic
    Steroids 67:399-402. 2002
    ..No correlation of pregnenolone sulfate levels between mother and fetus was found. This finding suggests the autonomous production of pregnenolone sulfate in mother and fetus...
  82. pmc A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis stud
    Kvido Smitka
    Institute of Endocrinology, Laboratory of Clinical and Experimental Neuroendocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Nutr Metab (Lond) 8:81. 2011
    ..Dysregulations of the AT-brain axis peptides might be involved in binge eating as is the case in BN...
  83. ncbi request reprint Plasma levels of 7-hydroxymetabolites of dehydroepiandrosterone in healthy Central European aging men
    Luboslav Starka
    Institute of Endocrinology, Praha, Czech Republic
    Clin Chem Lab Med 43:1218-22. 2005
    ..The curves for age dependence of 7-hydroxy metabolite levels in males resembled those previously determined for unconjugated dehydroepiandrosterone. The levels of both 7-hydroxylated epimers correlated excellently with each other...
  84. ncbi request reprint Oral but not transdermal estrogen replacement therapy reduced level of tissue factor pathway inhibitor: cross-over designed study
    Tomas Fait
    Department of Obstetrics and Gynaecology, General Faculty Hospital Prague and 1st Faculty of Medicine, Charles University, Czech Republic
    Neuro Endocrinol Lett 27:665-8. 2006
    ..The purpose of the present study was to determine changes of biochemical risk factors of thromboembolism especially of TFPI during the use of oral versus transdermal administration of early estrogen replacement therapy...
  85. ncbi request reprint Levels of testosterone, allopregnanolone and homocysteine in severe hypothyroidism
    Marie Bicíková
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 40:1024-7. 2002
    ..There was a positive correlation between testosterone and homocysteine in the euthyroid state which suggests that not only estrogens but also androgen state should be considered in future studies on homocysteine...
  86. ncbi request reprint Steroid sulfatase and sulfuryl transferase activity in monkey brain tissue
    Lubomir Kriz
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Steroids 70:960-9. 2005
    ..10 +/- 8.33 microM, V(max) 8.38 +/- 1.68 nmol/h/mg protein. These results will serve as a basis for further studies concerning the pathophysiology of human brain tumors...
  87. ncbi request reprint Apolipoprotein E 4 allele is associated with low bone density in postmenopausal women
    K Zajickova
    Institute of Endocrinology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    J Endocrinol Invest 26:312-5. 2003
    ..In contrast, there were no significant differences in BMD at the hip comparing women with or without the Apo E 4 allele. To conclude, these data may support the importance of Apo E 4 allele in determining postmenopausal spine bone mass...
  88. ncbi request reprint Calcium intake and the outcome of short-term weight management
    K Kabrnová-Hlavatá
    Institute of Endocrinology, Obesity Management Centre, Prague, Czech Republic
    Physiol Res 57:237-45. 2008
    ..Body composition measured by bioimpedance demonstrated that added calcium leads to preservation of fat-free mass. Nevertheless, a greater loss of fat-free mass in the placebo group might be partly due to a greater loss of water...
  89. ncbi request reprint Apolipoprotein E gene determines serum testosterone and dehydroepiandrosterone levels in postmenopausal women
    Ivana Zofkova
    Institute of Endocrinology, Narodni 8, Prague 1 116 94, Czech Republic
    Eur J Endocrinol 147:503-6. 2002
    ....
  90. doi request reprint Acipimox during exercise points to an inhibitory feedback of GH on ghrelin secretion in bulimic and healthy women
    Jara Nedvidkova
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Regul Pept 167:134-9. 2011
    ..The disruption of the gut-brain axis might be involved in bulimia nervosa (BN)...
  91. ncbi request reprint [Relation between dietary and physical activity patterns and obesity in seven year old children--current situation--WHO study]
    Radka Braunerova
    Endokrinologický ustav, Centrum pro diagnostiku a Ié6bu obezity, Narodni 8, 116 94 Praha 1
    Cas Lek Cesk 149:533-6. 2010
    ..This paper provides an overview of the situation in the Czech Republic with focus on diet and physical activity...
  92. ncbi request reprint Is a Pro12Ala polymorphism of the PPARgamma2 gene related to obesity and type 2 diabetes mellitus in the Czech population?
    Daniela Srámková
    Institute of Endocrinology, Prague, Czech Republic
    Ann N Y Acad Sci 967:265-73. 2002
    ....
  93. ncbi request reprint Insulin sensitivity in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Charles University in Prague, 116 94 Czech Republic
    J Clin Endocrinol Metab 89:2942-5. 2004
    ..000008). We conclude that lean PCOS women are not more insulin resistant than healthy controls. Insulin hypersecretion, on the other hand, is present even in lean PCOS women...
  94. ncbi request reprint [The prevalence of metabolic syndrome in women with polycystic ovary syndrome]
    Jana Vrbikova
    Endokrinologický ustav, Praha
    Cas Lek Cesk 149:337-9. 2010
    ..We aimed to ascertain the prevalence of metabolic syndrome in Czech women with PCOS and to describe relations of different features of metabolic syndrome with insulin sensitivity...
  95. ncbi request reprint Metabolic and endocrine effects of treatment with peroral or transdermal oestrogens in conjunction with peroral cyproterone acetate in women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Eur J Endocrinol 150:215-23. 2004
    ..To compare the influence of transdermal and peroral oestrogen treatments in conjunction with cyproterone acetate (CPA) on metabolic and hormonal parameters in women with polycystic ovary syndrome (PCOS)...
  96. ncbi request reprint Relationship between pituitary-thyroid axis hormones and anthropometric parameters in Czech adult population
    M Dvorakova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S127-34. 2008
    ..The fT3/fT4 ratio, reflecting deiodinase activity, was inversely related to age and positively related to BMI in both genders, while the highly significant negative correlation between CI and fT3/fT4 ratio was specific for women...
  97. ncbi request reprint Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Exp Clin Endocrinol Diabetes 110:74-6. 2002
    ..Homocysteine (Hcy) is one of the independent risk factors for ischemic heart disease. We examined the effect of metformin (M) treatment on Hcy levels, steroids and glycide tolerance in PCOS...
  98. ncbi request reprint [Role of the steroids, SHBG, IGF-1, IGF BP-3 and growth hormone in glucose metabolism disorders during long-term treatment with low doses of glucocorticoids]
    K Vondra
    Endokrinologický ustav, Praha
    Cas Lek Cesk 141:89-95. 2002
    ..3 mg/kg/day) (baseline phase) and after adding 1000 mg of metformin per day for following 6 months to improve impaired glucose metabolism (control phase)...
  99. ncbi request reprint Melatonin negatively correlates with C-peptide after food intake
    L Starka
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S187-92. 2008
    ..However, the physiological role of melatonin association with food intake in daytime remains in question and should be further investigated...
  100. ncbi request reprint [Effect of long-term treatment with metformin on steroid levels and parameters of insulin resistance in women with polycystic ovary syndrome]
    J Vrbikova
    Gynekologicko porodnická klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 140:688-94. 2001
    ..We also tried to find predictors of the successful therapy (in terms of improvement of menstrual cyclicity)...
  101. ncbi request reprint Effect of treatment of hypothyroidism on the plasma concentrations of neuroactive steroids and homocysteine
    M Bicikova
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 39:753-7. 2001
    ..Steroid concentrations correlated negatively with the level of thyroid antimicrosomal antibodies...