Richard Hampl

Summary

Affiliation: Institute of Endocrinology
Country: Czech Republic

Publications

  1. ncbi request reprint The content of four immunomodulatory steroids and major androgens in human semen
    Richard Hampl
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Czech Republic
    J Steroid Biochem Mol Biol 84:307-16. 2003
  2. ncbi request reprint The content of five sex steroids in human testis
    L Zamrazilová
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 61:221-5. 2012
  3. pmc Salivary testosterone levels in preadolescent children
    Daniela Ostatnikova
    Institute of Physiology, School of Medicine, Comenius University, Bratislava, Slovak Republic
    BMC Pediatr 2:5. 2002
  4. ncbi request reprint [Selected phytoestrogens with potential beneficial effects on risk of certain environmental diseases]
    R Hampl
    Endokrinologický ustav, Praha
    Cas Lek Cesk 139:31-3. 2000
  5. ncbi request reprint Relationship of dehydroepiandrosterone and its 7-hydroxylated metabolites to thyroid parameters and sex hormone-binding globulin (SHBG) in healthy subjects
    Richard Hampl
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 41:1081-6. 2003
  6. ncbi request reprint Immunomodulatory 7-hydroxylated metabolites of dehydroepiandrosterone are present in human semen
    R Hampl
    Institute of Endocrinology, Narodni 8, 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 75:273-6. 2000
  7. ncbi request reprint Sex hormone-binding globulin as a marker of the effect of hormonal treatment in Turner's syndrome
    R Hampl
    Institute of Endocrinology, 119 94 Praha, Czech Republic
    Endocr Regul 35:17-24. 2001
  8. ncbi request reprint [History, presence and trends of steroid endocrinology]
    R Hampl
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:193-7. 2007
  9. ncbi request reprint 7-Hydroxydehydroepiandrosterone epimers in the life span
    R Hampl
    Institute of Endocrinology, Narodni 8, 116 94 1, Praha, Czech Republic
    J Steroid Biochem Mol Biol 78:367-72. 2001
  10. ncbi request reprint [Natural antiglucocorticoids]
    R Hampl
    Endokrinologický ustav, Praha
    Vnitr Lek 52:973-8. 2006

Collaborators

Detail Information

Publications77

  1. ncbi request reprint The content of four immunomodulatory steroids and major androgens in human semen
    Richard Hampl
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Czech Republic
    J Steroid Biochem Mol Biol 84:307-16. 2003
    ..In addition, the steroids were measured in serum and the concentrations in both fluids were compared. The concentrations of 7-OH-DHEA in seminal fluid varied from 1.8 to 15.7 nmol/l, while those of DHEA were about five times higher...
  2. ncbi request reprint The content of five sex steroids in human testis
    L Zamrazilová
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 61:221-5. 2012
    ..The values varied considerably with means ± S.D. 2.43±2.47, 0.27±0.24, 0.080±0.13, 0.071±0.089 and 0.31±0.27 for testosterone, dihydrotestosterone, androstenedione, estradiol and epitestosterone, respectively...
  3. pmc Salivary testosterone levels in preadolescent children
    Daniela Ostatnikova
    Institute of Physiology, School of Medicine, Comenius University, Bratislava, Slovak Republic
    BMC Pediatr 2:5. 2002
    ..The study aimed to investigate salivary testosterone levels and their changes in preadolescent children and to study sexual dimorphism...
  4. ncbi request reprint [Selected phytoestrogens with potential beneficial effects on risk of certain environmental diseases]
    R Hampl
    Endokrinologický ustav, Praha
    Cas Lek Cesk 139:31-3. 2000
    ..The original detection and quantification of four above mentioned isoflavonoids in beer is an example...
  5. ncbi request reprint Relationship of dehydroepiandrosterone and its 7-hydroxylated metabolites to thyroid parameters and sex hormone-binding globulin (SHBG) in healthy subjects
    Richard Hampl
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 41:1081-6. 2003
    ..The results should serve for further investigation of changes in the thyroid hormone concentrations, together with SHBG and dehydroepiandrosterone metabolites, under various pathological situations...
  6. ncbi request reprint Immunomodulatory 7-hydroxylated metabolites of dehydroepiandrosterone are present in human semen
    R Hampl
    Institute of Endocrinology, Narodni 8, 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 75:273-6. 2000
    ..Mean concentrations of 7-OH-DHEA as measured by RIA amounted 5.75+/-1.29 and 5.39+/-0.75 nmol/l (mean+/-SEM) for 7alpha- and 7beta-OH-DHEA, respectively...
  7. ncbi request reprint Sex hormone-binding globulin as a marker of the effect of hormonal treatment in Turner's syndrome
    R Hampl
    Institute of Endocrinology, 119 94 Praha, Czech Republic
    Endocr Regul 35:17-24. 2001
    ..Limited data on SHBG levels in these patients and only scarce reports on other than gonadal steroids in these patients are available so far. The major aim of this study was to find out whether SHBG does respond to GH treatment...
  8. ncbi request reprint [History, presence and trends of steroid endocrinology]
    R Hampl
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:193-7. 2007
    ..After the brief historical survey the following chapters are devoted to steroid laboratory diagnostics, therapy and expected trends...
  9. ncbi request reprint 7-Hydroxydehydroepiandrosterone epimers in the life span
    R Hampl
    Institute of Endocrinology, Narodni 8, 116 94 1, Praha, Czech Republic
    J Steroid Biochem Mol Biol 78:367-72. 2001
    ..The levels of both 7-OH-DHEA epimers correlated excellently with each other...
  10. ncbi request reprint [Natural antiglucocorticoids]
    R Hampl
    Endokrinologický ustav, Praha
    Vnitr Lek 52:973-8. 2006
    ..Where known, the molecular mechanisms are mentioned, staying behind these events...
  11. ncbi request reprint Steroids and thermogenesis
    R Hampl
    Institute of Endocrinology, Narodni 8, 116 94 Prague l, Czech Republic
    Physiol Res 55:123-31. 2006
    ..Recent findings of various actions of these steroids support the view that they may also participate in modulating thermogenic effects...
  12. doi request reprint Neuroimmunomodulatory steroids in Alzheimer dementia
    Richard Hampl
    Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 119:97-104. 2010
    ..New findings may be anticipated when the mosaic describing the molecular mechanisms behind these events becomes more complete...
  13. ncbi request reprint 7-Hydroxydehydroepiandrosterone--a natural antiglucocorticoid and a candidate for steroid replacement therapy?
    R Hampl
    Institute of Endocrinology, Czech Academy of Sciences, Prague, Czech Republic
    Physiol Res 49:S107-12. 2000
    ..Application of 7-oxo-DHEA also led to a significant increase of both 7-hydroxyisomers of DHEA, with 7beta-OH-DHEA being the preferred metabolite the concentration of which was increased more than three times...
  14. ncbi request reprint How short-term transdermal treatment of men with 7-oxo-dehydroepiandrosterone influence thyroid function
    R Hampl
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Physiol Res 55:49-54. 2006
    ..It was concluded that treatment of 7-oxo-dehydroepiandrosterone affects the thyroid parameters only temporarily and that it provides a considerable persistent amount of 7beta-hydroxy-dehydroepiandrosterone...
  15. ncbi request reprint Minireview: 16alpha-hydroxylated metabolites of dehydroepiandrosterone and their biological significance
    R Hampl
    Institute of Endocrinology, 116 94 Prague 1, Czech Republic
    Endocr Regul 34:161-3. 2000
    ..The present knowledge on the latter metabolite was summarized and discussed...
  16. ncbi request reprint Neuro- and immunomodulatory steroids and other biochemical markers in drug-naive schizophrenia patients and the effect of treatment with atypical antipsychotics
    Marie Bicíková
    Institute of Endocrinology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Neuro Endocrinol Lett 32:141-7. 2011
    ....
  17. ncbi request reprint Antimüllerian hormone (AMH) not only a marker for prediction of ovarian reserve
    R Hampl
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 60:217-23. 2011
    ..The physiological changes of serum AMH leves in the life span in both sexes and their alterations under various pathological conditions are provided, too...
  18. ncbi request reprint Short-term effect of soy consumption on thyroid hormone levels and correlation with phytoestrogen level in healthy subjects
    Richard Hampl
    Institute of Endocrinology, Prague, Czech Republic
    Endocr Regul 42:53-61. 2008
    ..Since soy isoflavones may influence the thyroid hormone feedback system by interference with their biosynthesis, secretion and metabolism, we tested whether their controlled shortterm consumption affects thyroid function...
  19. ncbi request reprint Interpretation of sex hormone-binding globulin levels in thyroid disorders
    Richard Hampl
    Institute of Endocrinology, Praha 1, Czech Republic
    Thyroid 13:755-60. 2003
    ..After adjustment for age, the only significant positive correlation was between SHBG and free triiodothyronine...
  20. ncbi request reprint Plasma levels of 7-hydroxylated dehydroepiandrosterone (DHEA) metabolites and selected amino-thiols as discriminatory tools of Alzheimer's disease and vascular dementia
    Marie Bicíková
    Institute of Endocrinology, Praha, Czech Republic
    Clin Chem Lab Med 42:518-24. 2004
    ..The early differential diagnosis of Alzheimer's disease (AD) remains still problematic. We developed a laboratory test enabling us to distinguish patients with AD from those with vascular dementia (VD) and healthy subjects...
  21. ncbi request reprint Steroids, sex hormone-binding globulin, homocysteine, selected hormones and markers of lipid and carbohydrate metabolism in patients with severe hypothyroidism and their changes following thyroid hormone supplementation
    Marie Bicíková
    Institute of Endocrinology, Praha, Czech Republic
    Clin Chem Lab Med 41:284-92. 2003
    ..Similarly, in hypothyroidism only, dehydroepiandrosterone sulfate correlated positively with immunoglobulin F1 and homocysteine and negatively with thyroid hormones and SHBG...
  22. ncbi request reprint Delayed effects of short-term transdermal application of 7-oxo-dehydroepiandrosterone on its metabolites, some hormonal steroids and relevant proteohormones in healthy male volunteers
    Jarmila Sulcová
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 43:221-7. 2005
    ..The study points to an immediate as well as delayed effect of the short-term transdermal application of 7-oxo-dehydroepiandrosterone on relevant hormonal parameters...
  23. ncbi request reprint Immunomodulatory cytokines in human seminal plasma correlate with immunomodulatory steroids
    Ivan Sterzl
    1st Faculty of Medicine, Institute of Immunology and Microbiology, Charles University, Prague, Czech Republic
    Steroids 68:725-31. 2003
    ..The results, however, are in agreement with our recent finding of an autonomous production of these steroids in the male reproductive tract...
  24. ncbi request reprint Difference of neuro- and immunomodulatory steroids and selected hormone and lipid concentrations between Toxoplasma-free and Toxoplasma-infected but not CMV-free and CMV-infected schizophrenia patients
    Jaroslav Flegr
    Division of Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
    Neuro Endocrinol Lett 35:20-7. 2014
    ..Toxoplasma is known to change levels of certain neurotransmitters, cytokines and several hormones in both infected animals and humans. A common feature of toxoplasmosis and schizophrenia is a disorder of immune system...
  25. doi request reprint Adrenocortical function in young adults with diabetes mellitus type 1
    Katerina Simunkova
    Institute of Endocrinology, Narodni trida 8, 116 94 Prague, Czech Republic
    J Steroid Biochem Mol Biol 122:35-41. 2010
    ....
  26. ncbi request reprint Steroid hormones in human semen with particular respect to dehydroepiandrosterone and its immunomodulatory metabolites
    Michal Pohanka
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Czech Republic
    Endocr Regul 36:79-86. 2002
    ..Occurrence of steroids in seminal fluid and their possible role is reviewed in the first part of the article...
  27. ncbi request reprint Actual levels of soy phytoestrogens in children correlate with thyroid laboratory parameters
    Jana Milerová
    Institute of Endocrinology, Praha, Czech Republic
    Clin Chem Lab Med 44:171-4. 2006
    ..On the other hand, even small differences in soy phytoestrogen intake may influence thyroid function, which could be important when iodine intake is insufficient...
  28. ncbi request reprint Levels of testosterone, allopregnanolone and homocysteine in severe hypothyroidism
    Marie Bicíková
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 40:1024-7. 2002
    ..There was a positive correlation between testosterone and homocysteine in the euthyroid state which suggests that not only estrogens but also androgen state should be considered in future studies on homocysteine...
  29. doi request reprint Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia
    Marie Bicíková
    Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 133:77-83. 2013
    ..On the other hand, steroid metabolome model may be used as a diagnostic tool for further studies...
  30. doi request reprint Steroid sulfatase and sulfuryl transferase activities in human brain tumors
    Lubomir Kriz
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    J Steroid Biochem Mol Biol 109:31-9. 2008
    ..7% of pituitary adenomas. Astrocytomas, meningiomas and remaining 27.3% pituitary adenomas showed similarities in both enzymes' activities. Differences in STS and SULT activity did not depend on the sex or age of subjects...
  31. ncbi request reprint Simultaneous determination of dehydroepiandrosterone, its 7-hydroxylated metabolites, and their sulfates in rat brain tissues
    Hana Kazihnitková
    Institute of Endocrinology, Narodni 8, 11694 Praha 1, Czech Republic
    Steroids 69:667-74. 2004
    ..The reproducibility of the method with respect to coefficients of variation varied from 12 to 25%. An age-related decrease of sulfated dehydroepiandrosterone in the cortex of animals was also observed...
  32. ncbi request reprint Immunoassay of 7-hydroxysteroids: 1. Radioimmunoassay of 7beta-hydroxy dehydroepiandrosterone
    O Lapcik
    Institute of Endocrinology, Praha, Czech Republic
    J Steroid Biochem Mol Biol 67:439-45. 1998
    ..05 +/- 1.02 nmol l(-1), the broad range of values from undetectable levels to 10.3 nmol l(-1) was found in the patients. Serum levels of free 7beta-OH-DHEA in the patients significantly correlated with DHEA and its sulfate...
  33. ncbi request reprint A novel radioimmunoassay of 16alpha-hydroxy-dehydroepiandrosterone and its physiological levels
    Ludmila Zamrazilová
    Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 104:130-5. 2007
    ..Physiological levels of 16alpha-OH-DHEA in 316 sera (184 females and 132 males) analyzed so far varied between 0.0 and 1.86 nmol/l...
  34. ncbi request reprint Gas chromatographic-mass spectrometric identification of 16alpha-hydroxy-dehydroepiandrosterone in human seminal plasma
    Jakub Hert
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Czech Republic
    Steroids 69:773-7. 2004
    ..The concentration of 16alpha-hydroxydehydroepiandrosterone amounted in average 1.06 nmol/l, being lower but close to- the product of concurrent DHEA metabolism, 7-hydroxydehydroepiandrosterone isomers, found recently in seminal plasma...
  35. ncbi request reprint Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects
    Helena Havlikova
    Institute of Endocrinology, CZ 116 94 Prague, Czech Republic
    J Clin Endocrinol Metab 87:2225-31. 2002
    ....
  36. ncbi request reprint Derivatives of 16alpha-hydroxy-dehydroepiandrosterone with an additional 7-oxo or 7-hydroxy substituent: synthesis and gas chromatography/mass spectrometry analysis
    Vladimir Pouzar
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Steroids 70:739-49. 2005
    ..The target compounds were characterized by (1)H and (13)C NMR spectra and in the form of O-methyloxime-trimethylsilyl derivatives, by gas chromatography/mass spectrometry methods...
  37. ncbi request reprint Plasma levels of 7-hydroxymetabolites of dehydroepiandrosterone in healthy Central European aging men
    Luboslav Starka
    Institute of Endocrinology, Praha, Czech Republic
    Clin Chem Lab Med 43:1218-22. 2005
    ..The curves for age dependence of 7-hydroxy metabolite levels in males resembled those previously determined for unconjugated dehydroepiandrosterone. The levels of both 7-hydroxylated epimers correlated excellently with each other...
  38. ncbi request reprint The relation of cortisol and sex hormone levels to results of psychological, performance, IQ and memory tests in military men and women
    Jaroslav Flegr
    Faculty of Science, Charles University in Prague, Biology Dept, Prague, Czech Republic
    Neuro Endocrinol Lett 33:224-35. 2012
    ..Cortisol, along with other hormones of hypothalamo-pituitary-adrenal axis, belongs to one of the main factors influencing psychological and pathognomic factors, intelligence, and memory...
  39. ncbi request reprint Evaluation of hepatic 11 beta-hydroxysteroid dehydrogenase activity by cortisone acetate test in young adults with diabetes mellitus type 1
    K Simunkova
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 60:263-70. 2011
    ....
  40. ncbi request reprint Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal blood: 2. Time profiles of pregnanolone isomers
    M Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 78:51-7. 2001
    ..A decrease was also observed in the ratio of 3 alpha/3 beta-isomers and 5 alpha/5 beta-isomers around parturition. The possible physiological consequences of the findings are indicated...
  41. ncbi request reprint Dehydroepiandrosterone in relation to adiposity, glucose tolerance and lipid spectra in Czech non-diabetic population
    B Bendlova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S67-76. 2008
    ..In this respect, the benefit of DHEA(S) supplementation seems -- at least in terms of its alleged antiobesity and antidiabetogenic effects -- to be more than controversial...
  42. ncbi request reprint [Glucocorticoids and diabetes mellitus]
    K Vondra
    Endokrinologický ustav, Praha
    Vnitr Lek 52:493-7. 2006
    ..Application of insulin in type 2 diabetics is justified by the effort to prevent nonketotic hyperosmolar coma. In type 1 diabetes, it is usually necessary to increase the overall insulin dose and change its dosage during the day...
  43. ncbi request reprint Salivary cortisol in low dose (1 microg) ACTH test in healthy women: comparison with serum cortisol
    K Simunkova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 56:449-53. 2007
    ..5183, p=0.0525); correlations after stimulation were not significant. Low-dose ACTH administration appeared as a sufficient stimulus for increasing salivary cortisol to a range considered as a normal adrenal functional reserve...
  44. ncbi request reprint [Neurosteroids and their function]
    M Bicikova
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:223-6. 2007
    ..Future study targeted on regulation of their production and metabolism and understanding of the mechanism of their actions will help to use them therapeutically...
  45. ncbi request reprint Comparison of total and salivary cortisol in a low-dose ACTH (Synacthen) test: influence of three-month oral contraceptives administration to healthy women
    K Simunkova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S193-9. 2008
    ..Therefore, salivary cortisol can be used for assessment of adrenal function in women regularly using COC...
  46. ncbi request reprint A novel radioimmunoassay of 7-oxo-DHEA and its physiological levels
    H Kazihnitková
    Institute of Endocrinology, Narodni 8, 11694 Praha 1, Czech Republic
    Steroids 72:342-50. 2007
    ..The only group which differed significantly from all other ones were males below 10 years, significantly lower values than in other age groups were found also in the first two age groups of females...
  47. ncbi request reprint Decrease in serum dehydroepiandrosterone level after fenofibrate treatment in males with hyperlipidemia
    J Sulcova
    Institute of Endocrinology, First Faculty of Medicine, Charles University, Narodni 8, 11694 Prague 1, Czech Republic
    Physiol Res 54:151-7. 2005
    ..Taking together, the most important is the finding of decrease DHEA levels after fenofibrate therapy. It could be explained, at least in part, by the effect of the fenofibrateon on the biosynthesis of DHEA and its regulation...
  48. ncbi request reprint 7-Hydroxydehydroepiandrosterone epimers in human serum and saliva. Comparison of gas chromatography-mass spectrometry and radioimmunoassay
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    J Chromatogr A 935:297-307. 2001
    ..Besides serum, these steroids were, for the first time, measured in saliva where their concentrations were about five times lower. 7alpha- and 7beta-epimer levels correlated well in both body fluids and they were larger in male...
  49. ncbi request reprint Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men
    J Sulcova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 50:9-18. 2001
    ..The most expressive was the fall of the atherogenic index. We suggest that the gel containing 7-oxo-DHEA might be a suitable drug for improving the composition of the steroid and lipid parameters in elderly men...
  50. ncbi request reprint Neuroactive steroids, their precursors, and polar conjugates during parturition and postpartum in maternal and umbilical blood: 1. Identification and simultaneous determination of pregnanolone isomers
    M Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 75:237-44. 2000
    ..The possible role of the sulfatation of pregnanolone isomers around parturition is discussed...
  51. ncbi request reprint Genetic variant of luteinizing hormone: impact on gonadal steroid sex hormones in women
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 50:583-7. 2001
    ..No differences were detected in serum LH, FSH, epitestosterone and sex hormone binding globulin (SHBG)...
  52. ncbi request reprint [Role of the steroids, SHBG, IGF-1, IGF BP-3 and growth hormone in glucose metabolism disorders during long-term treatment with low doses of glucocorticoids]
    K Vondra
    Endokrinologický ustav, Praha
    Cas Lek Cesk 141:89-95. 2002
    ..3 mg/kg/day) (baseline phase) and after adding 1000 mg of metformin per day for following 6 months to improve impaired glucose metabolism (control phase)...
  53. ncbi request reprint [Metformin has a positive effect on disorders of carbohydrate metabolism in long-term care with low doses of prednisone]
    K Vondra
    Klinika detského a dorostového lékarství 1 LF UK a VFN, Praha
    Cas Lek Cesk 141:255-60. 2002
    ..3 mg/kg/day) on glucoregulation and glucose tolerance was studied in 20 female patients (15-20 yrs), including verification of possibility to correct the impairment of glucose tolerance (IGT) by metformin (M)...
  54. ncbi request reprint Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and lipids in men
    J Sulcova
    Institute of Endocrinology, AREKO, Ltd, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 49:685-93. 2000
    ..Using this application protocol, exogenous DHEA neither altered the lipid spectrum, nor did it influence the atherogenic index...
  55. ncbi request reprint Serum concentrations of some neuroactive steroids in women suffering from mixed anxiety-depressive disorder
    M Bicikova
    Institute of Endocrinology, Praha, Czech Republic
    Neurochem Res 25:1623-7. 2000
    ..01) levels in the patients group in the follicular phase. Our results indicate that imbalance in neuroactive steroids may play a negative role in origin and course of psychiatric and neurological disorders...
  56. ncbi request reprint Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal and umbilical blood: 3.3beta-hydroxy-5-ene steroids
    M Hill
    Institute of Endocrinology, Narodni trida 8, Prague, Czech Republic
    J Steroid Biochem Mol Biol 82:241-50. 2002
    ..On the basis of these data, a scheme of steroid biosynthesis in maternal organism during the critical stages around parturition is proposed...
  57. ncbi request reprint Pregnanolone isomers, pregnenolone and their polar conjugates around parturition
    J Klak
    Institute of Endocrinology, Prague, CZ 116 94, Czech Republic
    Physiol Res 52:211-21. 2003
    ..A decrease was also observed in the ratio of 3alpha/3beta-isomers and 5alpha/5beta-isomers around parturition. The possible physiological consequences of the findings are indicated...
  58. ncbi request reprint Immunoassay of 7-hydroxysteroids: 2. Radioimmunoassay of 7alpha-hydroxy-dehydroepiandrosterone
    O Lapcik
    Institute of Endocrinology, Národni tr 8, 116 94, Praha, Czech Republic
    J Steroid Biochem Mol Biol 71:231-7. 1999
    ..21 to 6.57 (mean 2.33+/-1.50) nM, while those of the patients from 0 to 5. 99 (mean 1.46+/-1.52) nM. The levels of 7alpha-OH-DHEA in patients significantly correlated with those of DHEA and its sulfate...
  59. ncbi request reprint Steroid sulfatase and sulfuryl transferase activity in monkey brain tissue
    Lubomir Kriz
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Steroids 70:960-9. 2005
    ..10 +/- 8.33 microM, V(max) 8.38 +/- 1.68 nmol/h/mg protein. These results will serve as a basis for further studies concerning the pathophysiology of human brain tumors...
  60. ncbi request reprint Division of lymphatic vessels at varicocelectomy leads to testicular oedema and decline in testicular function according to the LH-RH analogue stimulation test
    Radim Kocvara
    Department of Urology, General University Hospital and 1st Medical School, Charles University, Ke Karlovu 6, 128 08 2, Prague, Czech Republic
    Eur Urol 43:430-5. 2003
    ..To study the andrological outcome of the division of testicular lymphatic vessels at varicocelectomy in children and adolescents...
  61. ncbi request reprint Allopregnanolone in women with premenstrual syndrome
    M Bicikova
    Institute of Endocrinology, Praha, Czech Republic
    Horm Metab Res 30:227-30. 1998
    ..Significantly lower levels of both progesterone and allopregnanolone than in controls have been found in PMS patients in the follicular phase only...
  62. ncbi request reprint Two neuroactive steroids in midpregnancy as measured in maternal and fetal sera and in amniotic fluid
    Marie Bicíková
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Praha, Czech Republic
    Steroids 67:399-402. 2002
    ..No correlation of pregnenolone sulfate levels between mother and fetus was found. This finding suggests the autonomous production of pregnenolone sulfate in mother and fetus...
  63. ncbi request reprint Elimination of cross-reactivity by addition of an excess of cross-reactant for radioimmunoassay of 17alpha-hydroxypregnenolone
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    Steroids 64:341-55. 1999
    ..Mathematical analysis of the relations in equilibrium demonstrates that such a simple approach is an efficient way for improvement of immunoassay specificity using some polyclonal antisera...
  64. ncbi request reprint Radioimmunoassay of free genistein in human serum
    O Lapcik
    Institute of Endocrinology, Prague 1, Czech Republic
    J Steroid Biochem Mol Biol 64:261-8. 1998
    ..The values obtained in ether extracts from human sera were almost identical for both RIA systems, indicating that both RIAs measure the same entity...
  65. ncbi request reprint Immunoprotective steroids and SHBG in non-treated hypothyroidism and their relationship to autoimmune thyroid disorders
    K Drbalová
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S119-25. 2008
    ..The results point to a negative relationship between the above mentioned immunoprotective steroids and the extent of the autoimmune process in hypothyroidism...
  66. ncbi request reprint The concentrations of the endogenous C19-steroids in hyperplastic prostatic tissue and the effect of finasteride treatment
    M Hill
    Institute of Endocrinology, Charles University, Prague, Czech Republic
    Horm Metab Res 28:562-4. 1996
    ..The prostatic tissue from the patients treated with finasteride for 8 weeks showed a significant decrease not only in DHT but also in androstenedione and epiT, whereas the concentration of testosterone increased significantly...
  67. ncbi request reprint Roles of steroid sulfatase in brain and other tissues
    L Kriz
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:657-68. 2008
    ..In the past few years research into the enzyme properties and regulations has been strongly driven by the discovery of its putative role in the indirect stimulation of the growth of hormone-dependent tumors of the breast and prostate...
  68. ncbi request reprint Age relationships and sex differences in serum levels of pregnenolone and 17-hydroxypregnenolone in healthy subjects
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 37:439-47. 1999
    ..These results indicate that the increased metabolic activity in gonads in adolescence concerns not only dehydroepiandrosterone as the product of the 5-ene metabolic pathway but also its precursors...
  69. ncbi request reprint Epitestosterone--a potent competitive inhibitor of C21-steroid side chain cleavage in the testis
    M Bicikova
    Institute of Endocrinology, Praha, Czechoslovakia
    J Steroid Biochem Mol Biol 43:721-4. 1992
    ..The inhibitory activity in terms of the Ki is 2 and 1.5 times as high, respectively, as that of cyproterone acetate...
  70. ncbi request reprint Inhibition of rat renal and testicular 11 beta-hydroxysteroid dehydrogenase by some antihypertensive drugs, diuretics, and epitestosterone
    M Bicikova
    Institute of Endocrinology, Prague, Czech Republic
    Horm Metab Res 29:465-8. 1997
    ..min). The results represent further evidence for different substrate specificity of renal and testicular 11 beta-hydroxysteroid dehydrogenase...
  71. ncbi request reprint The endocrine profiles in men with localized and locally advanced prostate cancer treated with radical prostatectomy
    Jiri Heracek
    Department of Urology, 3rd Faculty of Medicine, Charles University in Prague, Czech Republic
    Neuro Endocrinol Lett 28:45-51. 2007
    ..The aim of this study was to find out whether serum hormone levels differ significantly in localized (pT2) and locally advanced (pT3-pT4 or N1) prostate cancer...
  72. ncbi request reprint Neurosteroids: Cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics
    Sae Bom Kim
    Biotechnologie, Conservatoire National des Arts et Metiers, 75003 Paris, France
    J Clin Endocrinol Metab 88:5199-206. 2003
    ....
  73. ncbi request reprint Synthesis of [19- 2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates
    Ivan Cerny
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
    Steroids 69:161-71. 2004
    ..3% yield. Corresponding sulfates were prepared via pyridinium salts in 53 and 57% yields, respectively. Fully assigned NMR data of selected pregnenolone derivatives were given...
  74. ncbi request reprint Syntheses of 19-[O-(carboxymethyl)oxime] haptens of epipregnanolone and pregnanolone
    Ivan Cerny
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
    Steroids 71:120-8. 2006
    ..Both haptens, i.e., (19E)-3beta- and -3alpha-hydroxy-20-oxo-5beta-pregnan-19-al 19-[O-(carboxymethyl)oxime], were designed for the development of immunoassays of the corresponding parent neuroactive steroids...
  75. ncbi request reprint Time-resolved fluoroimmunoassay for equol in plasma and urine
    Elke Brouwers
    Folkhalsan Research Center, Division of Clinical Chemistry, Institute for Preventive Medicine, Nutrition and Cancer, P O Box 63, University of Helsinki, FIN 00014 Helsinki, Finland
    J Steroid Biochem Mol Biol 84:577-88. 2003
    ..5-6.5 and 3.4-6.9, respectively. The inter-assay CV% varies between 5.4-9.7 and 7.4-7.7, respectively. The working ranges of the plasma and urine assay are 1.27-512 and 1.9-512nmol/l, respectively...
  76. ncbi request reprint Synthesis of two new haptens of 16alpha-hydroxydehydroepiandrosterone (3beta,16alpha-dihydroxyandrost-5-en-17-one)
    Vladimir Pouzar
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
    Steroids 68:149-58. 2003
    ..Final haptens were designed as components for immunoanalytical kits...
  77. ncbi request reprint Short-term soybean intake and its effect on steroid sex hormones and cognitive abilities
    Daniela Ostatnikova
    Institute of Physiology, Faculty of Medicine, Bratislava, Slovak Republic
    Fertil Steril 88:1632-6. 2007
    ..To observe the effects of short-term soybean consumption on cognitive spatial abilities and changes in sex endocrine net in both genders...