Vojtech Hainer

Summary

Affiliation: Institute of Endocrinology
Country: Czech Republic

Publications

  1. ncbi request reprint Role of hereditary factors in weight loss and its maintenance
    V Hainer
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S1-15. 2008
  2. ncbi request reprint [Role of infection in the pathogenesis of obesity]
    Vojtech Hainer
    Centrum pro diagnostiku a lécbu obezity, Endokrinologický ustav, Praha
    Cas Lek Cesk 151:563-7. 2012
  3. doi request reprint Do we need anti-obesity drugs?
    Vojtech Hainer
    Institute of Endocrinology, Prague, Czech Republic
    Diabetes Metab Res Rev 28:8-20. 2012
  4. ncbi request reprint The Eating Inventory, body adiposity and prevalence of diseases in a quota sample of Czech adults
    V Hainer
    Obesity Management Centre, Institute of Endocrinology, Prague, Czech Republic
    Int J Obes (Lond) 30:830-6. 2006
  5. ncbi request reprint [Drug treatment of obesity--current situation and perspectives]
    Vojtech Hainer
    Endokrinologický i ustav Praha, Centrum pro diagnostiku a lécbu obezity
    Cas Lek Cesk 149:513-9. 2010
  6. ncbi request reprint Hormonal and psychobehavioral predictors of weight loss in response to a short-term weight reduction program in obese women
    V Hainer
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S17-27. 2008
  7. ncbi request reprint Serum cortisol and sex hormone binding globulin (SHBG) levels, body fat distribution and the role of genetic factors in obese females
    V Hainer
    Obesity Management Centre, 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Czech Republic
    Sb Lek 103:471-5. 2002
  8. ncbi request reprint Psychobehavioral and nutritional predictors of weight loss in obese women treated with sibutramine
    V Hainer
    Institute of Endocrinology, Obesity Management Centre, Prague, Czech Republic
    Int J Obes (Lond) 29:208-16. 2005
  9. ncbi request reprint [The first Obesity Unit in Czechoslovakia was established twenty years ago]
    V Hainer
    Endokrinologický, Ustav, Praha
    Cas Lek Cesk 148:179-83. 2009
  10. doi request reprint Treatment modalities of obesity: what fits whom?
    Vojtech Hainer
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Diabetes Care 31:S269-77. 2008

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Role of hereditary factors in weight loss and its maintenance
    V Hainer
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S1-15. 2008
    ..It is believed that an elucidation of the genetic component in the prognosis of weight management could assist in the development of more effective and individually tailored therapeutic strategies...
  2. ncbi request reprint [Role of infection in the pathogenesis of obesity]
    Vojtech Hainer
    Centrum pro diagnostiku a lécbu obezity, Endokrinologický ustav, Praha
    Cas Lek Cesk 151:563-7. 2012
    ..Key words: obesity, infection, adenovirus AD-36, diabetes mellitus, lipid profile, insulin sensitivity...
  3. doi request reprint Do we need anti-obesity drugs?
    Vojtech Hainer
    Institute of Endocrinology, Prague, Czech Republic
    Diabetes Metab Res Rev 28:8-20. 2012
    ..However, recently developed anti-obesity medications such as gut hormone analogues and drug combinations provided encouraging results in terms of weight loss, safety and improvement of cardio-metabolic health risks...
  4. ncbi request reprint The Eating Inventory, body adiposity and prevalence of diseases in a quota sample of Czech adults
    V Hainer
    Obesity Management Centre, Institute of Endocrinology, Prague, Czech Republic
    Int J Obes (Lond) 30:830-6. 2006
    ..To study the relationships between the Eating Inventory (EI) factors (restraint, disinhibition and hunger), body adiposity and prevalence of selected diseases in a quota sample of Czech adults...
  5. ncbi request reprint [Drug treatment of obesity--current situation and perspectives]
    Vojtech Hainer
    Endokrinologický i ustav Praha, Centrum pro diagnostiku a lécbu obezity
    Cas Lek Cesk 149:513-9. 2010
    ..To confirm the strong role of antiobesity drugs in the treatment of obesity and its complications further long-term studies evaluating their effect on morbidity and mortality end points in appropriate target populations are needed...
  6. ncbi request reprint Hormonal and psychobehavioral predictors of weight loss in response to a short-term weight reduction program in obese women
    V Hainer
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S17-27. 2008
    ..8 % of the variability in weight loss. Psychobehavioral factors (items of the Eating Inventory, Beck Depression score) did not contribute to weight change induced by a well-controlled short-term weight reduction program...
  7. ncbi request reprint Serum cortisol and sex hormone binding globulin (SHBG) levels, body fat distribution and the role of genetic factors in obese females
    V Hainer
    Obesity Management Centre, 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Czech Republic
    Sb Lek 103:471-5. 2002
    ..The mechanisms controlling baseline levels of cortisol and SHBG apparently differ from those controlling their responses to energy restriction...
  8. ncbi request reprint Psychobehavioral and nutritional predictors of weight loss in obese women treated with sibutramine
    V Hainer
    Institute of Endocrinology, Obesity Management Centre, Prague, Czech Republic
    Int J Obes (Lond) 29:208-16. 2005
    ..The impact of changes in psychobehavioral and nutritional markers observed after 4 and 12 months of treatment on BMI changes was also investigated...
  9. ncbi request reprint [The first Obesity Unit in Czechoslovakia was established twenty years ago]
    V Hainer
    Endokrinologický, Ustav, Praha
    Cas Lek Cesk 148:179-83. 2009
    ..Since 2002 Obesity Unit has been a part of the Institute of Endocrinology which provided additional modern facilities for hormonal and molecular genetic examinations...
  10. doi request reprint Treatment modalities of obesity: what fits whom?
    Vojtech Hainer
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Diabetes Care 31:S269-77. 2008
    ..Centers of excellence in obesity management represented by multidisciplinary teams should provide comprehensive programs for the treatment of obesity derived from evidence-based medicine...
  11. ncbi request reprint Serotonin and norepinephrine reuptake inhibition and eating behavior
    Vojtech Hainer
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Ann N Y Acad Sci 1083:252-69. 2006
    ..In a 1-year sibutramine trial, only a decrease in the disinhibition score remained a significant correlate of weight loss among the psychobehavioral and nutritional factors which were taken into account...
  12. doi request reprint Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women
    Kvido Smitka
    Institute of Endocrinology, Laboratory of Clinical and Experimental Neuroendocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Regul Pept 182:45-52. 2013
    ..Also leptin may be affected by exercise. Dysfunction of FFA-leptin-ACTH secretion might be involved in binge eating and subsequent purging as is the case in bulimia nervosa (BN)...
  13. doi request reprint Hypogonadotropic hypogonadism in a homozygous MC4R mutation carrier and the effect of sibutramine treatment on body weight and obesity-related health risks
    Irena Aldhoon Hainerová
    Department of Paediatrics, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    Obes Facts 4:324-8. 2011
    ..The second aim of our study was to evaluate the effect of the anti-obesity drug sibutramine in this patient who failed to respond to an intensive lifestyle intervention and exhibited continuous weight gain...
  14. ncbi request reprint The within-pair resemblance in serum levels of androgens, sex-hormone binding globulin and cortisol in female obese identical twins - effect of negative energy balance induced by very low-calorie diet
    V Hainer
    Obesity Management Centre, 3rd Department of Internal Medicine, The First Medical Faculty, Charles University, Prague, Czech Republic
    Horm Metab Res 33:417-22. 2001
    ..Our results also suggest that the mechanisms controlling baseline levels of cortisol and SHBG differ from those influencing their responses to energy deficit induced by VLCD...
  15. ncbi request reprint Influence of vitamin A consumption on resting metabolic rate and fasting respiratory quotient in severely obese subjects
    Radka Mikulová-Braunerová
    Obesity Management Center, Third Department of Medicine, Charles University, Prague, Czech Republic
    Med Princ Pract 12:189-92. 2003
    ..To study whether or not the amount of vitamin A consumed affects the resting metabolic rate (RMR) and fat oxidation at rest in severely obese subjects...
  16. ncbi request reprint Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis
    Irena Hainerova
    Department of Pediatrics and Center for Research of Diabetes, Metabolism, and Nutrition, Third Faculty of Medicine, Charles University, 100 34 Prague 10, Czech Republic
    J Clin Endocrinol Metab 92:3689-96. 2007
    ..Mutations in the melanocortin 4 receptor gene (MC4R) represent the most common known cause of monogenic human obesity...
  17. ncbi request reprint Neuromedin beta: P73T polymorphism in overweight and obese subjects
    J Spálová
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S39-48. 2008
    ..Nevertheless, only female non-carriers showed a significant decrease in the hunger score...
  18. ncbi request reprint [Reduction of abdominal obesity and cardiometabolic health risks in obese adolescents in response to a short-term spa weight management program]
    Petr Hlavatý
    Oddelení obezitologie, Endokrinologický ustav, Narodni 8, 116 94 Praha 1
    Cas Lek Cesk 149:537-41. 2010
    ..The aim of this study was to follow changes in selected anthropometric parameters and cardiometabolic risks in overweight and obese adolescents in response to a 4-week spa weight management program...
  19. pmc A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis stud
    Kvido Smitka
    Institute of Endocrinology, Laboratory of Clinical and Experimental Neuroendocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Nutr Metab (Lond) 8:81. 2011
    ..abstract:..
  20. doi request reprint Obesity and polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Obesity Management Centre, Prague, Czech Republic
    Obes Facts 2:26-35. 2009
    ..However, the best treatment approach in obese PCOS patients remains to be defined. Studies concerning different weight loss regimens, antiobesity drugs, bariatric surgery, insulin sensitizers, and hormonal therapy are reviewed...
  21. ncbi request reprint Intrapair resemblance in very low calorie diet-induced weight loss in female obese identical twins
    V Hainer
    Obesity Unit, 3rd Department of Internal Medicine, The First Medical Faculty, Charles University, 128 08 Prague, Czech Republic
    Int J Obes Relat Metab Disord 24:1051-7. 2000
    ....
  22. pmc Comparison of a high-carbohydrate and high-protein breakfast effect on plasma ghrelin, obestatin, NPY and PYY levels in women with anorexia and bulimia nervosa
    Dana Sedlácková
    Institute of Endocrinology, Narodni 8, 116 94, Prague 1, Czech Republic
    Nutr Metab (Lond) 9:52. 2012
    ..abstract:..
  23. doi request reprint Lifestyle intervention discloses an association of the Eating Inventory-51 factors with cardiometabolic health risks
    Irena Aldhoon Hainerová
    Obesity Management Centre, Institute of Endocrinology, Narodni 8, Prague 1, 116 94, Czech Republic
    Eat Weight Disord 18:83-6. 2013
    ..An implementation of a standard dietary and lifestyle pattern for 3 weeks revealed significant associations between EI factors and metabolic risks in women...
  24. ncbi request reprint Is a Pro12Ala polymorphism of the PPARgamma2 gene related to obesity and type 2 diabetes mellitus in the Czech population?
    Daniela Srámková
    Institute of Endocrinology, Prague, Czech Republic
    Ann N Y Acad Sci 967:265-73. 2002
    ..However, the present data show that fasting insulin concentrations are lower in diabetics with the 12Ala allele than in those without it. This finding provides evidence that the polymorphism may influence glucose homeostasis...
  25. ncbi request reprint Assessment of dietary and genetic factors influencing serum and adipose fatty acid composition in obese female identical twins
    Marie Kunesova
    Obesity Management Centre, Third Medical Department, First Medical School, Charles University, Prague, Czech Republic
    Lipids 37:27-32. 2002
    ..The high level of IPR in the PC fraction in contrast to the other lipid fractions suggests strong genetic influence over selection of specific FA for this membrane fraction independent of diet...
  26. ncbi request reprint [A new simple method for estimating trunk and visceral fat by bioelectrical impedance: comparison with magnetic resonance imaging and dual X-ray absorptiometry in Czech adolescents]
    Hana Zamrazilová
    Endokrinologický ústav v Praze, Centrum pro diagnostiku a lécbu obezity
    Cas Lek Cesk 149:417-22. 2010
    ....
  27. ncbi request reprint [Relationships between the "eating inventory" factors, socioeconomic status, anthropometric body adiposity indexes and health risks in Czech population]
    M Wagenknecht
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:284-6, 287-91. 2007
    ....
  28. ncbi request reprint The UCP1 gene polymorphism A-3826G in relation to DM2 and body composition in Czech population
    D Sramkova
    Institute of Endocrinology, Prague, Czech Republic
    Exp Clin Endocrinol Diabetes 115:303-7. 2007
    ..The A-3826G polymorphism in the UCP1 gene promoter region was found to be associated with reduced mRNA expression indicating that the polymorphism is of functional importance...
  29. ncbi request reprint [Role of nutritional factors in the weight management]
    K Kabrnova
    Endokrinologický ustav Centrum pro diagnostiku a lécbu obezity, Praha
    Cas Lek Cesk 144:529-33; discussion 534. 2005
    ..Recently a role of consumption of calcium, phosphate and vitamin A in the body weight regulation and weight management has been also studied...
  30. ncbi request reprint Change in fatty acid composition of serum lipids in obese females after short-term weight-reducing regimen with the addition of n-3 long chain polyunsaturated fatty acids in comparison to controls
    P Hlavaty
    Obesity Management Centre, Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S57-65. 2008
    ..The results suggest that low doses of n-3 fatty acid enrichment can help to avoid unfavorable changes in fatty acid composition in serum lipids after a short-term weight-reducing regimen...
  31. ncbi request reprint [Study of the genetic causes of polygeneticallv determined endocrinopathies--patience can bring success]
    B Bendlova
    Endokrinologický ustav, Praha
    Cas Lek Cesk 146:198-204. 2007
    ..The article gives a short review of the recent knowledge together with our own experience in the field of study of the genetic background of polygenic diseases...
  32. ncbi request reprint The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women
    M Kunesova
    Obesity Management Centre, Institute of Endocrinology, Charles University, Prague 1, Czech Republic
    Physiol Res 55:63-72. 2006
    ..595, p<0.008). The results suggest that long chain n-3 PUFA enhance weight loss in obese females treated by VLCD. Docosahexaenoate (22:6n-3) seems to be the active component...
  33. ncbi request reprint Relationship between pituitary-thyroid axis hormones and anthropometric parameters in Czech adult population
    M Dvorakova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S127-34. 2008
    ..The fT3/fT4 ratio, reflecting deiodinase activity, was inversely related to age and positively related to BMI in both genders, while the highly significant negative correlation between CI and fT3/fT4 ratio was specific for women...
  34. ncbi request reprint Adiponectin, an adipocyte-derived protein
    J Nedvidkova
    Institute of Endocrinology, First Faculty of Medicine, Charles University, Narodni 8, 11694 Prague 1, Czech Republic
    Physiol Res 54:133-40. 2005
    ....
  35. ncbi request reprint [Influence of early postnatal nutrition in preterm infants on their anthropometric and hormonal characteristics at the age of 10 years]
    H Zamrazilová
    Ustav pro péci o matku a díte, Praha
    Cas Lek Cesk 146:278-83. 2007
    ..Several studies associated higher protein intake in postnatal period with the earlier "adiposity rebound" and the higher BMI in later life...
  36. doi request reprint Acipimox during exercise points to an inhibitory feedback of GH on ghrelin secretion in bulimic and healthy women
    Jara Nedvidkova
    Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic
    Regul Pept 167:134-9. 2011
    ..The disruption of the gut-brain axis might be involved in bulimia nervosa (BN)...
  37. ncbi request reprint Calcium intake and the outcome of short-term weight management
    K Kabrnová-Hlavatá
    Institute of Endocrinology, Obesity Management Centre, Prague, Czech Republic
    Physiol Res 57:237-45. 2008
    ..Body composition measured by bioimpedance demonstrated that added calcium leads to preservation of fat-free mass. Nevertheless, a greater loss of fat-free mass in the placebo group might be partly due to a greater loss of water...
  38. ncbi request reprint A twin study of weight loss and metabolic efficiency
    V Hainer
    Obesity Unit, 3rd Department of Internal Medicine, The First Medical Faculty, Charles University, Prague, Czech Republic
    Int J Obes Relat Metab Disord 25:533-7. 2001
    ..To assess the genetic contribution to determinants of therapeutic weight loss in obese female identical twins...
  39. ncbi request reprint The responses of serum and adipose Fatty acids to a one-year weight reduction regimen in female obese monozygotic twins
    M Kunesova
    Obesity Management Center, Third Department of Medicine, First Medical School, Charles University, Prague, Czech Republic
    Ann N Y Acad Sci 967:311-23. 2002
    ..Of particular note were the consistent IPRs for n-3 fatty acids despite dietary stress, indicating that the conservation and distribution of this EFA family are subject to considerable genetic variance in humans...
  40. ncbi request reprint Role of the PPARalpha Leu162Val and PPARgamma2 Pro12Ala gene polymorphisms in weight change after 2.5-year follow-up in Czech obese women
    B Aldhoon
    Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Folia Biol (Praha) 56:116-23. 2010
    ..5-year follow-up...
  41. ncbi request reprint Influence of some hereditary factors on weight loss following conservative and surgical treatment of obese female monozygotic twins
    M Fried
    1st Surgical Department, Charles University Teaching Hospital, Prague, Czech Republic
    Obes Surg 9:265-8. 1999
    ..The possible influence of some genetic factors on weight reduction or maintenance following conservative and/or surgical treatment was studied in 14 pairs of obese female monozygotic twins...
  42. ncbi request reprint Respiratory quotient in obesity: its association with an ability to retain weight loss and with parental obesity
    V Hainer
    IIIrd Department of Internal Medicine, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Sb Lek 101:99-104. 2000
    ..In contrast, parental history of obesity did not affect RMR in severely obese individuals...
  43. ncbi request reprint Plasma obestatin levels in normal weight, obese and anorectic women
    H Zamrazilová
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S49-55. 2008
    ..Lower plasma obestatin levels in obese women compared to normal weight and anorectic women as well as increased ghrelin to obestatin ratio in anorectic women might play a role in body weight regulation in these pathologies...
  44. ncbi request reprint Laparoscopic greater curvature plication in morbidly obese women with type 2 diabetes: effects on glucose homeostasis, postprandial triglyceridemia and selected gut hormones
    Olga Bradnová
    Institute of Endocrinology, Narodni 8, Prague 1, 116 94, Czech Republic
    Obes Surg 24:718-26. 2014
    ....
  45. ncbi request reprint Long-term treatment of obesity in the obesity unit
    M Kunesova
    IIIrd Department of Medicine, Charles University, Prague, Czech Republic
    Sb Lek 99:279-86. 1998
    ..In group A in-patient treatment was significantly more often used in men. The in-patient treatment promotes the compliance with the therapeutic regimen in women significantly more effectively than in men...
  46. ncbi request reprint Inter-disciplinary European guidelines on surgery of severe obesity
    M Fried
    Clinical Center for Minimally Invasive and Bariatric Surgery, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Int J Obes (Lond) 31:569-77. 2007
    ..There was a specific effort to develop clinical guidelines, which will reflect current knowledge, expertise and evidence based data on morbid obesity treatment...
  47. ncbi request reprint Simultaneous decrease of plasma obestatin and ghrelin levels after a high-carbohydrate breakfast in healthy women
    D Sedláčková
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S29-37. 2008
    ..05). In conclusion, we demonstrated in healthy young women that plasma obestatin concentrations decrease similarly to ghrelin after a high-carbohydrate breakfast...
  48. ncbi request reprint Activities of cytochrome c oxidase and citrate synthase in lymphocytes of obese and normal-weight subjects
    M Capková
    Department of Pediatrics and Centre for Integrated Genomics, Charles University, Prague, Czech Republic
    Int J Obes Relat Metab Disord 26:1110-7. 2002
    ..The aim of our study was to analyse activities of mitochondrial enzymes cytochrome c oxidase (COX) and citrate synthase (CS) in isolated lymphocytes of obese and normal-weight subjects...