Research Topics
Genomes and GenesSpecies | Jana BrezinovaSummaryAffiliation: Institute of Hematology and Blood Transfusion Country: Czech Republic Publications
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Detail Information
Publications
Structural aberrations of chromosome 7 revealed by a combination of molecular cytogenetic techniques in myeloid malignanciesJana Brezinova
Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
Cancer Genet Cytogenet 173:10-6. 2007..2 was most commonly deleted. Most of the deletions were cryptic, not detectable with conventional cytogenetics. Aberrations of chromosome 7 are associated with a very poor outcome; survival time in our cohort was short (median 7 months)...
A partial nontandem duplication of the MLL gene in four patients with acute myeloid leukemiaIveta Sárová
Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
Cancer Genet Cytogenet 195:150-6. 2009..The duplication, which included MLL exons 2 through 8-9, was interrupted by a cryptic insertion of one or two exons from the respective MLL partner gene: MLLT10, MLLT3, or MLLT1...- Prognostic significance of del(20q) in patients with hematological malignanciesJana Brezinova
Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
Cancer Genet Cytogenet 160:188-92. 2005..The survival time correlated with the type of chromosomal aberration; no significant differences in survival were found for sex, age, and diagnosis... - Nature of frequent deletions in CEBPAOta Fuchs
Institute of Hematology and Blood Transfusion, Department of Cell Physiology, U Nemocnice 1, 128 20 Prague 2, Czech Republic
Blood Cells Mol Dis 43:260-3. 2009..NM_004364.2. A mechanism for deletion formation between two repetitive sequences can be recombination events in the repair process. Double-stranded cut in DNA can initiate these recombination events of adjacent DNA sequences... - The presence of clonal cell subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with refractory anemia may reflect a multistep pathogenesis of myelodysplasiaJaroslav Cermak
Institute of Hematology and Blood Transfusion, Prague, Czech Republic
Leuk Res 29:371-9. 2005.... - Molecular cytogenetic analysis of complex karyotypes with derivative chromosome der(1)t(1;5) found in two patients with myeloid leukemiaJela Melichercíková
Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
Cancer Genet Cytogenet 176:150-5. 2007..The breakpoint on chromosome 1 was the same in both patients, in the 1p21 region. This region contains the colony stimulating factor 1 gene (CSF1), which may play a role in tumorigenesis of myeloid tissue... - From cryptic chromosomal lesions to pathologically relevant genes: integration of SNP-array with gene expression profiling in myelodysplastic syndrome with normal karyotypeMichaela Dostalova Merkerova
Department of Molecular Genetics, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
Genes Chromosomes Cancer 51:419-28. 2012..We showed that the genome-wide integrative approach is beneficial to the comprehension of molecular backgrounds of diseases with incompletely understood etiopathology... - A prognostic impact of separation of refractory cytopenia with multilineage dysplasia and 5q- syndrome from refractory anemia in primary myelodysplastic syndromeJaroslav Cermak
Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
Leuk Res 27:221-9. 2003..This definition enabled us to discriminate 5q- patients with favorable prognosis similar as in RA from those with poor outcome associated with 5q- combined with complex abnormalities involving either 5q or regions outside 5q... - Cytogenetic manifestation of chromosome 11 duplication/amplification in acute myeloid leukemiaIveta Sárová
Cytogenetic Department, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
Cancer Genet Cytogenet 199:121-7. 2010..In two cases, amplification involved parts of not only long arm but also of short arm of the chromosome 11: 11p15 and 11p11.1 to 11p13... - Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemiaJana Markova
Institute of Hematology and Blood Transfusion, Prague, Czech Republic
Eur J Haematol 88:128-35. 2012..Recently, mutations in DNMT3A gene have been described in about 25% acute myeloid leukemia (AML) cases, preferentially in monocytic AML. They were found to predict worse overall survival (OS) of mutated patients... - Variations in MLL amplification in a patient with acute myeloid leukemiaJana Brezinova
Institute of Hematology and Blood Transfusion, General Faculty Hospital and 1st Medical Faculty, Charles University, U Nemocnice 1, 128 20, Prague, Czech Republic
Leuk Lymphoma 43:2031-5. 2002..Complex karyotype rearrangements involving deletions del(5)(q31) and del(7)(q31) were verified by multicolor fluorescence in situ hybridization (mFISH)... - Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: a marker of disease prognosis?Zuzana Sieglova
Institute of Hematology and Blood Transfusion, U Nemocnice 1, Prague, Czech Republic
Leuk Res 28:1013-21. 2004..039) showed that telomere dynamics might serve as a useful prognostic factor for assessment of an individual MDS patient's risk and for decision of an optimal treatment strategy... - CEBPA polymorphisms and mutations in patients with acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma and non-Hodgkin's lymphomaOta Fuchs
Institute of Hematology and Blood Transfusion, Department of Cell Physiology, U Nemocnice 1, 128 20 Prague 2, Czech Republic
Blood Cells Mol Dis 40:401-5. 2008..1%) of multiple myeloma (MM) patients' samples. No C/EBPalpha mutations were detected in healthy donors (41 individuals). We discuss how these mutations can affect the cellular function of C/EBPalpha and block the myeloid differentiation... - Molecular monitoring of responses to DLI and DLI + IFN treatment of post-SCT relapses in patients with CMLJana Moravcova
Institute of Hematology and Blood Transfusion, Prague, Czech Republic
Leuk Res 27:719-29. 2003..Although the retrospective analyses did not confirm that IFN improved the response to DLI, our results based on sensitive molecular monitoring suggest that DLI effect, at least in some patients, is supported by IFN administration...