Jana Brezinova

Summary

Affiliation: Institute of Hematology and Blood Transfusion
Country: Czech Republic

Publications

  1. ncbi request reprint Structural aberrations of chromosome 7 revealed by a combination of molecular cytogenetic techniques in myeloid malignancies
    Jana Brezinova
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Cancer Genet Cytogenet 173:10-6. 2007
  2. doi request reprint A partial nontandem duplication of the MLL gene in four patients with acute myeloid leukemia
    Iveta Sárová
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Cancer Genet Cytogenet 195:150-6. 2009
  3. ncbi request reprint Prognostic significance of del(20q) in patients with hematological malignancies
    Jana Brezinova
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Cancer Genet Cytogenet 160:188-92. 2005
  4. doi request reprint Nature of frequent deletions in CEBPA
    Ota Fuchs
    Institute of Hematology and Blood Transfusion, Department of Cell Physiology, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Blood Cells Mol Dis 43:260-3. 2009
  5. ncbi request reprint The presence of clonal cell subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with refractory anemia may reflect a multistep pathogenesis of myelodysplasia
    Jaroslav Cermak
    Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Leuk Res 29:371-9. 2005
  6. ncbi request reprint Molecular cytogenetic analysis of complex karyotypes with derivative chromosome der(1)t(1;5) found in two patients with myeloid leukemia
    Jela Melichercíková
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Cancer Genet Cytogenet 176:150-5. 2007
  7. doi request reprint Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia
    Iveta Sárová
    Cytogenetic Department, Institute of Hematology and Blood Transfusion, Prague, Czech Republic Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General Faculty Hospital and 1st Faculty of Medicine of Charles University, Prague, Czech Republic
    Genes Chromosomes Cancer 52:619-35. 2013
  8. doi request reprint From cryptic chromosomal lesions to pathologically relevant genes: integration of SNP-array with gene expression profiling in myelodysplastic syndrome with normal karyotype
    Michaela Dostalova Merkerova
    Department of Molecular Genetics, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Genes Chromosomes Cancer 51:419-28. 2012
  9. ncbi request reprint A prognostic impact of separation of refractory cytopenia with multilineage dysplasia and 5q- syndrome from refractory anemia in primary myelodysplastic syndrome
    Jaroslav Cermak
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Leuk Res 27:221-9. 2003
  10. doi request reprint Cytogenetic manifestation of chromosome 11 duplication/amplification in acute myeloid leukemia
    Iveta Sárová
    Cytogenetic Department, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Cancer Genet Cytogenet 199:121-7. 2010

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Structural aberrations of chromosome 7 revealed by a combination of molecular cytogenetic techniques in myeloid malignancies
    Jana Brezinova
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Cancer Genet Cytogenet 173:10-6. 2007
    ..2 was most commonly deleted. Most of the deletions were cryptic, not detectable with conventional cytogenetics. Aberrations of chromosome 7 are associated with a very poor outcome; survival time in our cohort was short (median 7 months)...
  2. doi request reprint A partial nontandem duplication of the MLL gene in four patients with acute myeloid leukemia
    Iveta Sárová
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Cancer Genet Cytogenet 195:150-6. 2009
    ..The duplication, which included MLL exons 2 through 8-9, was interrupted by a cryptic insertion of one or two exons from the respective MLL partner gene: MLLT10, MLLT3, or MLLT1...
  3. ncbi request reprint Prognostic significance of del(20q) in patients with hematological malignancies
    Jana Brezinova
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Cancer Genet Cytogenet 160:188-92. 2005
    ..The survival time correlated with the type of chromosomal aberration; no significant differences in survival were found for sex, age, and diagnosis...
  4. doi request reprint Nature of frequent deletions in CEBPA
    Ota Fuchs
    Institute of Hematology and Blood Transfusion, Department of Cell Physiology, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Blood Cells Mol Dis 43:260-3. 2009
    ..NM_004364.2. A mechanism for deletion formation between two repetitive sequences can be recombination events in the repair process. Double-stranded cut in DNA can initiate these recombination events of adjacent DNA sequences...
  5. ncbi request reprint The presence of clonal cell subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with refractory anemia may reflect a multistep pathogenesis of myelodysplasia
    Jaroslav Cermak
    Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Leuk Res 29:371-9. 2005
    ....
  6. ncbi request reprint Molecular cytogenetic analysis of complex karyotypes with derivative chromosome der(1)t(1;5) found in two patients with myeloid leukemia
    Jela Melichercíková
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Cancer Genet Cytogenet 176:150-5. 2007
    ..The breakpoint on chromosome 1 was the same in both patients, in the 1p21 region. This region contains the colony stimulating factor 1 gene (CSF1), which may play a role in tumorigenesis of myeloid tissue...
  7. doi request reprint Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia
    Iveta Sárová
    Cytogenetic Department, Institute of Hematology and Blood Transfusion, Prague, Czech Republic Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General Faculty Hospital and 1st Faculty of Medicine of Charles University, Prague, Czech Republic
    Genes Chromosomes Cancer 52:619-35. 2013
    ..This study highlights several chromosome 11 loci that might be important for the leukemogeneic process in AML. © 2013 Wiley Periodicals ,Inc...
  8. doi request reprint From cryptic chromosomal lesions to pathologically relevant genes: integration of SNP-array with gene expression profiling in myelodysplastic syndrome with normal karyotype
    Michaela Dostalova Merkerova
    Department of Molecular Genetics, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Genes Chromosomes Cancer 51:419-28. 2012
    ..We showed that the genome-wide integrative approach is beneficial to the comprehension of molecular backgrounds of diseases with incompletely understood etiopathology...
  9. ncbi request reprint A prognostic impact of separation of refractory cytopenia with multilineage dysplasia and 5q- syndrome from refractory anemia in primary myelodysplastic syndrome
    Jaroslav Cermak
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Leuk Res 27:221-9. 2003
    ..This definition enabled us to discriminate 5q- patients with favorable prognosis similar as in RA from those with poor outcome associated with 5q- combined with complex abnormalities involving either 5q or regions outside 5q...
  10. doi request reprint Cytogenetic manifestation of chromosome 11 duplication/amplification in acute myeloid leukemia
    Iveta Sárová
    Cytogenetic Department, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Cancer Genet Cytogenet 199:121-7. 2010
    ..In two cases, amplification involved parts of not only long arm but also of short arm of the chromosome 11: 11p15 and 11p11.1 to 11p13...
  11. doi request reprint Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemia
    Jana Markova
    Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Eur J Haematol 88:128-35. 2012
    ..Recently, mutations in DNMT3A gene have been described in about 25% acute myeloid leukemia (AML) cases, preferentially in monocytic AML. They were found to predict worse overall survival (OS) of mutated patients...
  12. ncbi request reprint Variations in MLL amplification in a patient with acute myeloid leukemia
    Jana Brezinova
    Institute of Hematology and Blood Transfusion, General Faculty Hospital and 1st Medical Faculty, Charles University, U Nemocnice 1, 128 20, Prague, Czech Republic
    Leuk Lymphoma 43:2031-5. 2002
    ..Complex karyotype rearrangements involving deletions del(5)(q31) and del(7)(q31) were verified by multicolor fluorescence in situ hybridization (mFISH)...
  13. ncbi request reprint Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: a marker of disease prognosis?
    Zuzana Sieglova
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, Prague, Czech Republic
    Leuk Res 28:1013-21. 2004
    ..039) showed that telomere dynamics might serve as a useful prognostic factor for assessment of an individual MDS patient's risk and for decision of an optimal treatment strategy...
  14. doi request reprint CEBPA polymorphisms and mutations in patients with acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma and non-Hodgkin's lymphoma
    Ota Fuchs
    Institute of Hematology and Blood Transfusion, Department of Cell Physiology, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Blood Cells Mol Dis 40:401-5. 2008
    ..1%) of multiple myeloma (MM) patients' samples. No C/EBPalpha mutations were detected in healthy donors (41 individuals). We discuss how these mutations can affect the cellular function of C/EBPalpha and block the myeloid differentiation...
  15. ncbi request reprint Molecular monitoring of responses to DLI and DLI + IFN treatment of post-SCT relapses in patients with CML
    Jana Moravcova
    Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Leuk Res 27:719-29. 2003
    ..Although the retrospective analyses did not confirm that IFN improved the response to DLI, our results based on sensitive molecular monitoring suggest that DLI effect, at least in some patients, is supported by IFN administration...