Jakub Hort

Summary

Country: Czech Republic

Publications

  1. ncbi request reprint Effectiveness of open-label donepezil treatment in patients with Alzheimer's disease discontinuing memantine monotherapy
    Paraskevi Sakka
    Hygeia Diagnostic and Therapeutic Center of Athens, Athens, Greece
    Curr Med Res Opin 23:3153-65. 2007
  2. doi request reprint From Morris Water Maze to computer tests in the prediction of Alzheimer's disease
    J Laczó
    International Clinical Research Center, St Anne s University Hospital Brno, Brno, Czech Republic
    Neurodegener Dis 10:153-7. 2012
  3. pmc Spatial navigation deficit in amnestic mild cognitive impairment
    Jakub Hort
    Memory Disorders Clinic, Department of Neurology, Second Medical School, Charles University, 150 18 Prague 5, Czech Republic
    Proc Natl Acad Sci U S A 104:4042-7. 2007
  4. doi request reprint Use of cerebrospinal fluid biomarkers in diagnosis of dementia across Europe
    J Hort
    Department of Neurology, Memory Disorders Clinic, Charles University in Prague, Second Faculty of Medicinel, University Hospital Motol, Prague, Czech Republic
    Eur J Neurol 17:90-6. 2010
  5. doi request reprint EFNS guidelines for the diagnosis and management of Alzheimer's disease
    J Hort
    Memory Disorders Clinic, Deartment of Neurology, Charles University in Prague, Second Faculty of Medicine and Motol Hospital, Prague, Czech Republic
    Eur J Neurol 17:1236-48. 2010
  6. doi request reprint Spatial navigation and APOE in amnestic mild cognitive impairment
    Jan Laczó
    Memory Disorders Unit, Department of Neurology, 2nd Medical School, Charles University in Prague, Prague, Czech Republic
    Neurodegener Dis 8:169-77. 2011
  7. doi request reprint Spatial navigation testing discriminates two types of amnestic mild cognitive impairment
    Jan Laczó
    Memory Disorders Clinic, Department of Neurology, 2nd Medical School, Charles University in Prague, Prague, Czech Republic
    Behav Brain Res 202:252-9. 2009
  8. pmc Recognition of facial emotional expression in amnestic mild cognitive impairment
    Alexandra Varjassyová
    Memory Disorders Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
    J Alzheimers Dis 33:273-80. 2013
  9. pmc Famous landmark identification in amnestic mild cognitive impairment and Alzheimer's disease
    Katerina Sheardová
    International Clinical Research Center, St Anne s University Hospital Brno, Brno, Czech Republic
    PLoS ONE 9:e105623. 2014
  10. doi request reprint Olfactory identification in amnestic and non-amnestic mild cognitive impairment and its neuropsychological correlates
    Martin Vyhnálek
    International Clinical Research Center, St Anne s University Hospital Brno, Brno, Czech Republic Memory Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic Electronic address
    J Neurol Sci 349:179-84. 2015

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Effectiveness of open-label donepezil treatment in patients with Alzheimer's disease discontinuing memantine monotherapy
    Paraskevi Sakka
    Hygeia Diagnostic and Therapeutic Center of Athens, Athens, Greece
    Curr Med Res Opin 23:3153-65. 2007
    ..To evaluate the efficacy and safety of donepezil in patients with Alzheimer's disease (AD) who discontinue memantine due to a lack of efficacy or not being well tolerated...
  2. doi request reprint From Morris Water Maze to computer tests in the prediction of Alzheimer's disease
    J Laczó
    International Clinical Research Center, St Anne s University Hospital Brno, Brno, Czech Republic
    Neurodegener Dis 10:153-7. 2012
    ....
  3. pmc Spatial navigation deficit in amnestic mild cognitive impairment
    Jakub Hort
    Memory Disorders Clinic, Department of Neurology, Second Medical School, Charles University, 150 18 Prague 5, Czech Republic
    Proc Natl Acad Sci U S A 104:4042-7. 2007
    ..Our results suggest that spatial navigation impairment occurs early in the development of AD and can be used for monitoring of the disease progression or for evaluation of presymptomiatic AD...
  4. doi request reprint Use of cerebrospinal fluid biomarkers in diagnosis of dementia across Europe
    J Hort
    Department of Neurology, Memory Disorders Clinic, Charles University in Prague, Second Faculty of Medicinel, University Hospital Motol, Prague, Czech Republic
    Eur J Neurol 17:90-6. 2010
    ..Cerebrospinal fluid (CSF) biomarkers have been reported to be useful in dementia diagnosis. Not much is known about their use in clinical practice in Europe...
  5. doi request reprint EFNS guidelines for the diagnosis and management of Alzheimer's disease
    J Hort
    Memory Disorders Clinic, Deartment of Neurology, Charles University in Prague, Second Faculty of Medicine and Motol Hospital, Prague, Czech Republic
    Eur J Neurol 17:1236-48. 2010
    ..Mild cognitive impairment and non-Alzheimer dementias are not included in this guideline...
  6. doi request reprint Spatial navigation and APOE in amnestic mild cognitive impairment
    Jan Laczó
    Memory Disorders Unit, Department of Neurology, 2nd Medical School, Charles University in Prague, Prague, Czech Republic
    Neurodegener Dis 8:169-77. 2011
    ..The effect of APOE ε4 allele (ε4) on spatial navigation in amnestic mild cognitive impairment (aMCI) is unknown...
  7. doi request reprint Spatial navigation testing discriminates two types of amnestic mild cognitive impairment
    Jan Laczó
    Memory Disorders Clinic, Department of Neurology, 2nd Medical School, Charles University in Prague, Prague, Czech Republic
    Behav Brain Res 202:252-9. 2009
    ..Finally, the HaMCI group performed almost identically as the AD group. Spatial navigation deficit is particularly pronounced in individuals with hippocampus-related memory impairment and may signal preclinical AD...
  8. pmc Recognition of facial emotional expression in amnestic mild cognitive impairment
    Alexandra Varjassyová
    Memory Disorders Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
    J Alzheimers Dis 33:273-80. 2013
    ..13; 95% CI, 0.36-3.57; p = 0.836). Therefore, FER, but not FFI, may be impaired in MD-aMCI. This implies that in MD-aMCI, the tasks of FER and FFI may involve segregated neurocognitive networks...
  9. pmc Famous landmark identification in amnestic mild cognitive impairment and Alzheimer's disease
    Katerina Sheardová
    International Clinical Research Center, St Anne s University Hospital Brno, Brno, Czech Republic
    PLoS ONE 9:e105623. 2014
    ..However, the data on FFI and FER in MCI are controversial and FLI domain remains almost unexplored...
  10. doi request reprint Olfactory identification in amnestic and non-amnestic mild cognitive impairment and its neuropsychological correlates
    Martin Vyhnálek
    International Clinical Research Center, St Anne s University Hospital Brno, Brno, Czech Republic Memory Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic Electronic address
    J Neurol Sci 349:179-84. 2015
    ..The aim was to (a) compare the degree of olfactory identification dysfunction in aMCI, naMCI, controls and mild AD dementia and (b) assess the relation between olfactory identification and cognitive performance in aMCI compared to naMCI...
  11. ncbi request reprint Diffusion tensor imaging in Alzheimer disease and mild cognitive impairment
    Irena Stěpán-Buksakowska
    Department of Radiology, Charles University, 2nd Medical Faculty and University Hospital Motol Prague, Czech Republic, V Uvalu 84, 150 06, Prague, Czech Republic
    Neurol Neurochir Pol 46:462-71. 2012
    ....
  12. pmc Spatial navigation impairment is proportional to right hippocampal volume
    Zuzana Nedelska
    Memory Disorders Clinic, Department of Neurology, Charles University in Prague, 2 Faculty of Medicine and Motol University Hospital, 150 06 Prague 5, Czech Republic
    Proc Natl Acad Sci U S A 109:2590-4. 2012
    ..The respective real-space and virtual scores strongly correlated with each other. Our findings indicate that the right hippocampus plays a critical role in allocentric navigation, particularly when cognitive impairment is present...
  13. ncbi request reprint Cognitive changes in spinocerebellar ataxia type 2
    Martin Valis
    Department of Neurology, Charles University, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Neuro Endocrinol Lett 32:354-9. 2011
    ..Neuropsychological tests can reveal executive dysfunction, impaired visual and verbal memory, tongue and speech impairment, attention disorders and impaired verbal fluency...
  14. doi request reprint Clock Drawing Test and the diagnosis of amnestic mild cognitive impairment: can more detailed scoring systems do the work?
    Eva Rubínová
    a International Clinical Research Center, St Anne s University Hospital Brno, Brno, Czech Republic
    J Clin Exp Neuropsychol 36:1076-83. 2014
    ..We compare simple and complex scoring systems and evaluate the usefulness of the combination of the Clock Drawing Test with the Mini-Mental State Examination to detect patients with mild cognitive impairment...
  15. doi request reprint Odor identification in frontotemporal lobar degeneration subtypes
    Hana Magerová
    Department of Neurology, Memory Clinic, 2nd Faculty of Medicine and Motol University Hospital, Charles University in Prague, Prague, Czech Republic
    Am J Alzheimers Dis Other Demen 29:762-8. 2014
    ..Our data suggest that odor identification impairment is a symptom common to FTLD syndromes, and it seems to be based on olfactory structure damage rather than cognitive decline...
  16. doi request reprint Neuropsychological correlates of hippocampal atrophy in memory testing in nondemented older adults
    Martin Vyhnálek
    International Clinical Research Center, St Anne s University Hospital Brno, Brno, Czech Republic Memory Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
    J Alzheimers Dis 42:S81-90. 2014
    ..The objective of this study was to assess the relation between left and right hippocampal volumes and several frequently used memory tests...
  17. doi request reprint Disturbance of real space navigation in moderately advanced but not in early Huntington's disease
    Veronika Majerová
    Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital in Prague, Katerinska 30, 12800 Praha 2, Czech Republic
    J Neurol Sci 312:86-91. 2012
    ..Several studies have associated the allocentric navigation with the hippocampus and the egocentric navigation with the striatum. The striatum is predominantly impaired from the early stages of Huntington's disease...
  18. doi request reprint Perspective taking abilities in amnestic mild cognitive impairment and Alzheimer's disease
    Hana Marková
    Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic Department of Psychology, Faculty of Arts, Charles University in Prague, Prague, Czech Republic International Clinical Research Center, St Anne s University Hospital Brno, Brno, Czech Republic Electronic address
    Behav Brain Res 281:229-38. 2015
    ..The first-person view perspective taking is a potentially important candidate psychological marker for AD. ..
  19. doi request reprint Cortical and subcortical atrophy in Alzheimer disease: parallel atrophy of thalamus and hippocampus
    Irena Stěpán-Buksakowska
    Departments of Neurology, Memory Disorders Clinic Radiology, Charles University, 2nd Faculty of Medicine, University Hospital Motol Department of Neurosurgery, Charles University in Prague, 1st Faculty of Medicine, University Central Military Hospital Department of Radiodiagnostics, University Central Military Hospital, Prague International Clinical Research Center, St Anne s University Hospital, Brno, Czech Republic Department of Neurology, Albert Szent Gyorgyi Clinical Center, Faculty of Medicine Neuroscience Research Group of the Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary Department of Biomedical Engineering, Mayo Clinic, Rochester, MN
    Alzheimer Dis Assoc Disord 28:65-72. 2014
    ..Most importantly, our results raise the possibility that subcortical structure atrophy is not independent in AD patients. ..
  20. pmc Spatial navigation-a unique window into physiological and pathological aging
    Ivana Gazova
    Department of Neurology, Memory Disorders Clinic, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol Prague 5, Czech Republic
    Front Aging Neurosci 4:16. 2012
    ....
  21. doi request reprint Blood markers of oxidative stress in Alzheimer's disease
    Alice Skoumalová
    Department of Medical Chemistry and Biochemistry, Charles University in Prague, 2nd Faculty of Medicine, Prague, Czech Republic
    J Cell Mol Med 16:2291-300. 2012
    ..They are small lipophilic molecules and can diffuse into the blood stream, where they can then be detected. We propose that these fluorescent products are potential candidates for blood biomarkers of AD...
  22. doi request reprint Interactions between amyloid-β and tau in cerebrospinal fluid of people with mild cognitive impairment and Alzheimer's disease
    Zdena Kristofikova
    Prague Psychiatric Center, Prague, Czech Republic
    J Alzheimers Dis 42:S91-8. 2014
    ..A recent study reported increased Aβ-tau interactions in the neurons of AD patients...
  23. ncbi request reprint Magnetic resonance analysis of amygdalar volume in Alzheimer's disease
    Daniel Horinek
    Institute of Pathological Physiology, Department of Neurology, 2nd School of Medicine, Czech Republic cDepartment of Neurosurgery, 1st School of Medicine, Charles University, Prague, Czech Republic
    Curr Opin Psychiatry 20:273-7. 2007
    ..In the second part, the role of amygdalar volume in the assessment of clinical diagnosis is discussed. The third part encounters the relationship between the amygdalar atrophy and its neuropsychological correlates...
  24. ncbi request reprint Long lasting recurrent familiar transient global amnesia after betablocker treatment withdrawal: case report
    Martin Vyhnálek
    Memory Disorders Clinic, Dept of Neurology, Charles University, 2nd Medical School and Motol University hospital, Prague, Czech Republic
    Neuro Endocrinol Lett 29:44-6. 2008
    ..We suggest that familiar TGA could be caused by the mechanism of vasospasm rather than venous congestion and that the abnormal cerebral vasomotor control could be the hereditary substrate in this condition...
  25. doi request reprint Volumetry of the human amygdala - an anatomical study
    Jiri Brabec
    Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, Czech Republic
    Psychiatry Res 182:67-72. 2010
    ..Nevertheless, our results may have important implications for MRI studies because as of yet there is no gold standard for manual volumetry of the amygdala...
  26. pmc FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases
    Robert Rusina
    Department of Neurology, Thomayer Teaching Hospital and Institute for Postgraduate Education in Medicine, Prague, Czech Republic
    BMC Neurol 11:50. 2011
    ....