M Hill

Summary

Country: Czech Republic

Publications

  1. ncbi request reprint Age relationships and sex differences in serum levels of pregnenolone and 17-hydroxypregnenolone in healthy subjects
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 37:439-47. 1999
  2. ncbi request reprint Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and lipids in men
    J Sulcova
    Institute of Endocrinology, AREKO, Ltd, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 49:685-93. 2000
  3. ncbi request reprint An analysis of the relationship between insulin resistance and the activity of steroid C17,20-lyase and 3beta-hydroxysteroid dehydrogenase in ovaries and adrenals in women with polycystic ovary syndrome
    J Vrbíklová
    Institute of Endocrinology, Prague, Czech Republic
    Exp Clin Endocrinol Diabetes 108:455-62. 2000
  4. ncbi request reprint Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men
    J Sulcova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 50:9-18. 2001
  5. ncbi request reprint Sex hormone-binding globulin as a marker of the effect of hormonal treatment in Turner's syndrome
    R Hampl
    Institute of Endocrinology, 119 94 Praha, Czech Republic
    Endocr Regul 35:17-24. 2001
  6. ncbi request reprint Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Gynecol Obstet Invest 58:36-41. 2004
  7. ncbi request reprint Dehydroepiandrosterone in relation to adiposity, glucose tolerance and lipid spectra in Czech non-diabetic population
    B Bendlova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S67-76. 2008
  8. ncbi request reprint Hormonal and psychobehavioral predictors of weight loss in response to a short-term weight reduction program in obese women
    V Hainer
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S17-27. 2008
  9. ncbi request reprint Association of C/T polymorphism in the LRP5 gene with circulating follicle stimulating hormone in Caucasian postmenopausal women
    I Zofkova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 56:735-9. 2007
  10. ncbi request reprint Neuroactive steroids, their precursors, and polar conjugates during parturition and postpartum in maternal and umbilical blood: 1. Identification and simultaneous determination of pregnanolone isomers
    M Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 75:237-44. 2000

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Age relationships and sex differences in serum levels of pregnenolone and 17-hydroxypregnenolone in healthy subjects
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 37:439-47. 1999
    ..These results indicate that the increased metabolic activity in gonads in adolescence concerns not only dehydroepiandrosterone as the product of the 5-ene metabolic pathway but also its precursors...
  2. ncbi request reprint Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and lipids in men
    J Sulcova
    Institute of Endocrinology, AREKO, Ltd, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 49:685-93. 2000
    ..Using this application protocol, exogenous DHEA neither altered the lipid spectrum, nor did it influence the atherogenic index...
  3. ncbi request reprint An analysis of the relationship between insulin resistance and the activity of steroid C17,20-lyase and 3beta-hydroxysteroid dehydrogenase in ovaries and adrenals in women with polycystic ovary syndrome
    J Vrbíklová
    Institute of Endocrinology, Prague, Czech Republic
    Exp Clin Endocrinol Diabetes 108:455-62. 2000
    ..The authors conclude that insulin resistance and/or hyperinsulinemia is probably not the primary factor responsible for the exaggerated adrenal androgen secretion found in a great number of patients with PCOS...
  4. ncbi request reprint Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men
    J Sulcova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 50:9-18. 2001
    ..The most expressive was the fall of the atherogenic index. We suggest that the gel containing 7-oxo-DHEA might be a suitable drug for improving the composition of the steroid and lipid parameters in elderly men...
  5. ncbi request reprint Sex hormone-binding globulin as a marker of the effect of hormonal treatment in Turner's syndrome
    R Hampl
    Institute of Endocrinology, 119 94 Praha, Czech Republic
    Endocr Regul 35:17-24. 2001
    ..Limited data on SHBG levels in these patients and only scarce reports on other than gonadal steroids in these patients are available so far. The major aim of this study was to find out whether SHBG does respond to GH treatment...
  6. ncbi request reprint Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Gynecol Obstet Invest 58:36-41. 2004
    ..Flutamide is effective in reducing adrenal androgen production in overweight women, but has no effect on lipid spectrum or on insulin resistance...
  7. ncbi request reprint Dehydroepiandrosterone in relation to adiposity, glucose tolerance and lipid spectra in Czech non-diabetic population
    B Bendlova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S67-76. 2008
    ..In this respect, the benefit of DHEA(S) supplementation seems -- at least in terms of its alleged antiobesity and antidiabetogenic effects -- to be more than controversial...
  8. ncbi request reprint Hormonal and psychobehavioral predictors of weight loss in response to a short-term weight reduction program in obese women
    V Hainer
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S17-27. 2008
    ..8 % of the variability in weight loss. Psychobehavioral factors (items of the Eating Inventory, Beck Depression score) did not contribute to weight change induced by a well-controlled short-term weight reduction program...
  9. ncbi request reprint Association of C/T polymorphism in the LRP5 gene with circulating follicle stimulating hormone in Caucasian postmenopausal women
    I Zofkova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 56:735-9. 2007
    ..The mediating role of subtle undetectable variations in estrogen levels is discussed. We did not find any relationship between the LRP-5 genotype and serum LH levels...
  10. ncbi request reprint Neuroactive steroids, their precursors, and polar conjugates during parturition and postpartum in maternal and umbilical blood: 1. Identification and simultaneous determination of pregnanolone isomers
    M Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 75:237-44. 2000
    ..The possible role of the sulfatation of pregnanolone isomers around parturition is discussed...
  11. ncbi request reprint Neuromedin beta: P73T polymorphism in overweight and obese subjects
    J Spálová
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S39-48. 2008
    ..Nevertheless, only female non-carriers showed a significant decrease in the hunger score...
  12. ncbi request reprint Chronic cigarette smoking alters circulating sex hormones and neuroactive steroids in premenopausal women
    M Duskova
    Department of Obstetrics and Gynecology of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
    Physiol Res 61:97-111. 2012
    ..The female smokers had pronouncedly increased serum progestogens but paradoxically suppressed levels of their GABA-ergic metabolites. Further investigation is needed concerning these effects...
  13. ncbi request reprint Postmenopausal serum androstenedione levels are associated with the calcitonin receptor gene polymorphism T1377c. A pilot study
    I Zofkova
    Institute of Endocrinology, Prague, Czech Republic
    J Endocrinol Invest 27:442-4. 2004
    ..05 and p<0.02, respectively, ANCOVA). We postulate that the 3beta-hydroxysteroid dehydrogenase activity is associated with C allele at least in C19 steroids. The data correspond with the functionality of CALCR...
  14. ncbi request reprint The UCP1 gene polymorphism A-3826G in relation to DM2 and body composition in Czech population
    D Sramkova
    Institute of Endocrinology, Prague, Czech Republic
    Exp Clin Endocrinol Diabetes 115:303-7. 2007
    ..The A-3826G polymorphism in the UCP1 gene promoter region was found to be associated with reduced mRNA expression indicating that the polymorphism is of functional importance...
  15. doi request reprint The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men
    H Pospisilova
    Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 132:105-11. 2012
    ....
  16. ncbi request reprint Family history of diabetes mellitus determines insulin sensitivity and beta cell function in polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:547-53. 2008
    ..Thus, women with PCOS with the concomitant family history of DM 2 have lower insulin sensitivity than healthy control women. Insulin resistance observed in these women with PCOS is compensated by increased insulin secretion...
  17. ncbi request reprint The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Eur J Endocrinol 144:619-28. 2001
    ..To evaluate adrenal and ovarian steroidogenesis before and after long-term treatment with metformin in women with polycystic ovary syndrome (PCOS)...
  18. ncbi request reprint Immunoassay of 7-hydroxysteroids: 1. Radioimmunoassay of 7beta-hydroxy dehydroepiandrosterone
    O Lapcik
    Institute of Endocrinology, Praha, Czech Republic
    J Steroid Biochem Mol Biol 67:439-45. 1998
    ..05 +/- 1.02 nmol l(-1), the broad range of values from undetectable levels to 10.3 nmol l(-1) was found in the patients. Serum levels of free 7beta-OH-DHEA in the patients significantly correlated with DHEA and its sulfate...
  19. ncbi request reprint Effect of treatment of hypothyroidism on the plasma concentrations of neuroactive steroids and homocysteine
    M Bicikova
    Institute of Endocrinology, Prague, Czech Republic
    Clin Chem Lab Med 39:753-7. 2001
    ..Steroid concentrations correlated negatively with the level of thyroid antimicrosomal antibodies...
  20. ncbi request reprint Polymorphism of INS VNTR is associated with glutamic acid decarboxylase antibodies and postprandial C-peptide in patients with onset of diabetes after 35 years of age
    M Matejkova-Behanova
    Institute of Endocrinology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 53:187-90. 2004
    ....
  21. ncbi request reprint Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome?
    L Starka
    Institute of Endocrinology, Narodni 8, CZ 116 94 Prague 1, Czech Republic
    Endocr Regul 39:127-31. 2005
    ..The complexity of symptoms and genetic base started up the hypothesis on the existence of male equivalent of PCOS. Precocious loss of hair before 30 years of age was suggested as one of the male symptoms of this syndrome...
  22. ncbi request reprint The Eating Inventory, body adiposity and prevalence of diseases in a quota sample of Czech adults
    V Hainer
    Obesity Management Centre, Institute of Endocrinology, Prague, Czech Republic
    Int J Obes (Lond) 30:830-6. 2006
    ..To study the relationships between the Eating Inventory (EI) factors (restraint, disinhibition and hunger), body adiposity and prevalence of selected diseases in a quota sample of Czech adults...
  23. ncbi request reprint Dehydroepiandrosterone in the type 1 diabetes mellitus
    M Duskova
    Institute of Endocrinology, Prague, Czech Republic
    Endocr Regul 46:67-71. 2012
    ..The aim of the present study was to answer the question whether a comparable change in the aging pattern of the DHEA and its sulphate could be detected in the type 1 diabetes mellitus...
  24. ncbi request reprint Role of intron 5 C/T polymorphism of the calcium sensing receptor gene in the regulation of the serum FSH and LH in post-menopausal women
    I Zofkova
    Institute of Endocrinology, Prague, Czech Republic
    J Endocrinol Invest 28:638-42. 2005
    ..The aim of our study was to analyse relationships between the CaR gene and the circulating FSH and LH in normal post-menopausal women...
  25. ncbi request reprint Changes of plasma obestatin, ghrelin and NPY in anorexia and bulimia nervosa patients before and after a high-carbohydrate breakfast
    D Sedláčková
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 60:165-73. 2011
    ..Different fasting ghrelin and obestatin levels in AN and BN could demonstrate their diverse functions in appetite and eating suppression...
  26. ncbi request reprint Changes of metabolic profile in men treated for androgenetic alopecia with 1 mg finasteride
    M Duskova
    Institute of Endocrinology, Prague, Czech Republic
    Endocr Regul 44:3-8. 2010
    ..It thus seemed reasonable to examine whether finasteride treatment of androgenetic alopecia ameliorates some features of metabolic syndrome frequently seen associated with this condition...
  27. ncbi request reprint Evaluation of hepatic 11 beta-hydroxysteroid dehydrogenase activity by cortisone acetate test in young adults with diabetes mellitus type 1
    K Simunkova
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 60:263-70. 2011
    ....
  28. ncbi request reprint Calcium intake and the outcome of short-term weight management
    K Kabrnová-Hlavatá
    Institute of Endocrinology, Obesity Management Centre, Prague, Czech Republic
    Physiol Res 57:237-45. 2008
    ..Body composition measured by bioimpedance demonstrated that added calcium leads to preservation of fat-free mass. Nevertheless, a greater loss of fat-free mass in the placebo group might be partly due to a greater loss of water...
  29. ncbi request reprint TRH test in patients with diabetes mellitus type 1 and/or autoimmune thyroiditis. Changes in the pituitary-thyroid axis, reverse T3, prolactin and growth hormone levels
    E Orlická
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S109-17. 2008
    ..AT was associated with impairment of TRH stimulated fT3, fT4, fT3/fT4 response and changes in rT3 levels, in spite of preserved TRH-stimulated TSH secretion. GH response in AT patients was also altered...
  30. ncbi request reprint 7-Hydroxydehydroepiandrosterone--a natural antiglucocorticoid and a candidate for steroid replacement therapy?
    R Hampl
    Institute of Endocrinology, Czech Academy of Sciences, Prague, Czech Republic
    Physiol Res 49:S107-12. 2000
    ..Application of 7-oxo-DHEA also led to a significant increase of both 7-hydroxyisomers of DHEA, with 7beta-OH-DHEA being the preferred metabolite the concentration of which was increased more than three times...
  31. ncbi request reprint What may be the markers of the male equivalent of polycystic ovary syndrome?
    M Duskova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 53:287-94. 2004
    ..This frequency corresponds to the prevalence of PCOS in women. There was no significant difference between the two subgroups in the occurrence of allele 3 INS VNTR...
  32. ncbi request reprint Relationship between pituitary-thyroid axis hormones and anthropometric parameters in Czech adult population
    M Dvorakova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S127-34. 2008
    ..The fT3/fT4 ratio, reflecting deiodinase activity, was inversely related to age and positively related to BMI in both genders, while the highly significant negative correlation between CI and fT3/fT4 ratio was specific for women...
  33. ncbi request reprint Simultaneous decrease of plasma obestatin and ghrelin levels after a high-carbohydrate breakfast in healthy women
    D Sedláčková
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S29-37. 2008
    ..05). In conclusion, we demonstrated in healthy young women that plasma obestatin concentrations decrease similarly to ghrelin after a high-carbohydrate breakfast...
  34. ncbi request reprint Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal blood: 2. Time profiles of pregnanolone isomers
    M Hill
    Institute of Endocrinology, Narodni trida 8, CZ 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 78:51-7. 2001
    ..A decrease was also observed in the ratio of 3 alpha/3 beta-isomers and 5 alpha/5 beta-isomers around parturition. The possible physiological consequences of the findings are indicated...
  35. pmc Fatty acid composition of adipose tissue triglycerides after weight loss and weight maintenance: the DIOGENES study
    M Kunesova
    Obesity Management Centre, Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 61:597-607. 2012
    ..Lower oleic acid predicts lower weight decrease. These findings suggest a specific role of monounsaturated fatty acids in weight management and as weight change predictors...
  36. ncbi request reprint Plasma obestatin levels in normal weight, obese and anorectic women
    H Zamrazilová
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S49-55. 2008
    ..Lower plasma obestatin levels in obese women compared to normal weight and anorectic women as well as increased ghrelin to obestatin ratio in anorectic women might play a role in body weight regulation in these pathologies...
  37. ncbi request reprint Change in fatty acid composition of serum lipids in obese females after short-term weight-reducing regimen with the addition of n-3 long chain polyunsaturated fatty acids in comparison to controls
    P Hlavaty
    Obesity Management Centre, Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S57-65. 2008
    ..The results suggest that low doses of n-3 fatty acid enrichment can help to avoid unfavorable changes in fatty acid composition in serum lipids after a short-term weight-reducing regimen...
  38. ncbi request reprint Sulphates of 3beta-hydroxy-5-ene steroids in women with epilepsy
    M Hill
    Institute of Endocrinology, Prague, Czech Republic and Charles University in Prague, First Faculty of Medicine and General University Hospital, Department of Obstetrics and Gynaecology, Prague, Czech Republic
    Prague Med Rep 111:111-26. 2010
    ..10), while primidone decreased DHEAS in both FP and LP (both p=0.05) and did not significantly change the levels of PregS. In conclusion, carbamazepine and primidone therapies significantly suppressed the sulphated steroids in serum...
  39. doi request reprint Long-term changes in prevalence of overweight and obesity in Czech 7-year-old children: evaluation of different cut-off criteria of childhood obesity
    M Kunesova
    Obesity Unit, Institute of Endocrinology, Prague, Czech Republic
    Obes Rev 12:483-91. 2011
    ..Using different body mass index references resulted in marked differences in overweight and obesity prevalence...
  40. ncbi request reprint Higher levels of salivary alpha-amylase predict failure of cessation efforts in male smokers
    M Duskova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 59:765-71. 2010
    ..On the other hand, no advantage was found in predicting the failure to quit in women. The results of our study support previously described gender differences in smoking cessation...
  41. ncbi request reprint Pregnanolone isomers, pregnenolone and their polar conjugates around parturition
    J Klak
    Institute of Endocrinology, Prague, CZ 116 94, Czech Republic
    Physiol Res 52:211-21. 2003
    ..A decrease was also observed in the ratio of 3alpha/3beta-isomers and 5alpha/5beta-isomers around parturition. The possible physiological consequences of the findings are indicated...
  42. doi request reprint Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes
    H Kahleova
    Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    J Diabetes Complications 26:442-9. 2012
    ..The aim of our study was to evaluate the effect of a lifestyle intervention program on β-cell function and to explore the role of gastrointestinal peptides in subjects with T2D...
  43. ncbi request reprint Effects of smoking cessation on hormonal levels in men
    H Hruskovicova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 62:67-73. 2013
    ..The decrease in total testosterone was non-significant. Changes in SHBG and testosterone did not correlate with BMI, presumably due to the direct effect of smoking cessation...
  44. ncbi request reprint Is A163G polymorphism in the osteoprotegerin gene associated with heel velocity of sound in postmenopausal women?
    K Zajickova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S153-7. 2008
    ..The present study replicated in part the previous findings about OPG gene variations and peripheral bone mass in Caucasian women...
  45. ncbi request reprint Reduced progesterone metabolites in human late pregnancy
    M Hill
    Department of Obstetrics and Gynecology of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
    Physiol Res 60:225-41. 2011
    ....
  46. ncbi request reprint Serum concentrations of some neuroactive steroids in women suffering from mixed anxiety-depressive disorder
    M Bicikova
    Institute of Endocrinology, Praha, Czech Republic
    Neurochem Res 25:1623-7. 2000
    ..01) levels in the patients group in the follicular phase. Our results indicate that imbalance in neuroactive steroids may play a negative role in origin and course of psychiatric and neurological disorders...
  47. ncbi request reprint Finasteride treatment and neuroactive steroid formation
    M Duskova
    Institute of Endocrinology, Prague, Czech Republic
    Prague Med Rep 110:222-30. 2009
    ....
  48. ncbi request reprint Is maternal progesterone actually independent of the fetal steroids?
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 59:211-24. 2010
    ....
  49. ncbi request reprint Metabolic and endocrine effects of treatment with peroral or transdermal oestrogens in conjunction with peroral cyproterone acetate in women with polycystic ovary syndrome
    J Vrbikova
    Institute of Endocrinology, Prague, Czech Republic
    Eur J Endocrinol 150:215-23. 2004
    ..To compare the influence of transdermal and peroral oestrogen treatments in conjunction with cyproterone acetate (CPA) on metabolic and hormonal parameters in women with polycystic ovary syndrome (PCOS)...
  50. ncbi request reprint Analysis of relations between serum levels of epitestosterone, estradiol, testosterone, IGF-1 and prostatic specific antigen in men with benign prostatic hyperplasia and carcinoma of the prostate
    M Hill
    Institute of Endocrinology, First Medical School, Charles University, Prague, Czech Republic
    Physiol Res 49:S113-8. 2000
    ..377, p<0.01) in partial correlations. PSA levels were higher in patients with prostate cancer (p<0.00001). Epitestosterone, which is negatively correlating with estradiol and IGF-1, may modulate the development of prostate diseases...
  51. ncbi request reprint Circulating neuroactive C21- and C19-steroids in young men before and after ejaculation
    L Starka
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 55:429-36. 2006
    ..This fact speaks against the hypothesis that a drop in the level of neuroactive steroids, e.g. allopregnanolone may trigger the orgasm-related increase of oxytocin, reported by other authors...
  52. ncbi request reprint Weight change and androgen levels during contraceptive treatment of women affected by polycystic ovary
    J Vrbikova
    Institute of Endocrinology, Prague, 116 94 Czech Republic
    Endocr Regul 40:119-23. 2006
    ....
  53. ncbi request reprint Immunoassay of 7-hydroxysteroids: 2. Radioimmunoassay of 7alpha-hydroxy-dehydroepiandrosterone
    O Lapcik
    Institute of Endocrinology, Národni tr 8, 116 94, Praha, Czech Republic
    J Steroid Biochem Mol Biol 71:231-7. 1999
    ..21 to 6.57 (mean 2.33+/-1.50) nM, while those of the patients from 0 to 5. 99 (mean 1.46+/-1.52) nM. The levels of 7alpha-OH-DHEA in patients significantly correlated with those of DHEA and its sulfate...
  54. ncbi request reprint Comparison of total and salivary cortisol in a low-dose ACTH (Synacthen) test: influence of three-month oral contraceptives administration to healthy women
    K Simunkova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S193-9. 2008
    ..Therefore, salivary cortisol can be used for assessment of adrenal function in women regularly using COC...
  55. ncbi request reprint Lack of melatonin response to acute administration of nifedipine and diltiazem in healthy men
    R Kancheva
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 49:S119-24. 2000
    ..2 ng/l (nifedipine study) and 73.0+/-5.3 ng/l (control study) vs. 75.1+/-5.1 ng/l (diltiazem study). In conclusion, the calcium channel blockers used in this study do not alter the nocturnal melatonin secretory process in healthy men...
  56. ncbi request reprint The effect of epitestosterone on estrogen biosynthesis in vitro
    M Bicikova
    Institute of Endocrinology, Prague, Czech Republic
    Horm Metab Res 32:125-8. 2000
    ..The possible explanation of this relation was addressed, and the influence of epitestosterone on kinetics of estradiol formation in vitro was evaluated...
  57. ncbi request reprint Allopregnanolone, pregnenolone sulfate, and epitestosterone in breast cyst fluid
    M Bicikova
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Prague, Czech Republic
    Steroids 66:55-7. 2001
    ..Pregnenolone-sulfate levels in BCF were about two orders of magnitude higher when compared with the circulation. No differences were found in concentrations of the steroids studied between the types of cysts...
  58. ncbi request reprint Allopregnanolone in women with premenstrual syndrome
    M Bicikova
    Institute of Endocrinology, Praha, Czech Republic
    Horm Metab Res 30:227-30. 1998
    ..Significantly lower levels of both progesterone and allopregnanolone than in controls have been found in PMS patients in the follicular phase only...
  59. ncbi request reprint Immunomodulatory 7-hydroxylated metabolites of dehydroepiandrosterone are present in human semen
    R Hampl
    Institute of Endocrinology, Narodni 8, 116 94, Prague, Czech Republic
    J Steroid Biochem Mol Biol 75:273-6. 2000
    ..Mean concentrations of 7-OH-DHEA as measured by RIA amounted 5.75+/-1.29 and 5.39+/-0.75 nmol/l (mean+/-SEM) for 7alpha- and 7beta-OH-DHEA, respectively...
  60. ncbi request reprint 7-Hydroxydehydroepiandrosterone epimers in human serum and saliva. Comparison of gas chromatography-mass spectrometry and radioimmunoassay
    M Hill
    Institute of Endocrinology, Prague, Czech Republic
    J Chromatogr A 935:297-307. 2001
    ..Besides serum, these steroids were, for the first time, measured in saliva where their concentrations were about five times lower. 7alpha- and 7beta-epimer levels correlated well in both body fluids and they were larger in male...
  61. ncbi request reprint The estrogen receptor alpha gene determines serum androstenedione levels in postmenopausal women
    I Zofkova
    Institute of Endocrinology, Narodni 8, 116 94 1, Prague, Czech Republic
    Steroids 67:815-9. 2002
    ..The pathogenetic role of this association in diseases related to menopause, such as osteoporosis, remains to be determined...
  62. ncbi request reprint Inhibition of rat renal and testicular 11 beta-hydroxysteroid dehydrogenase by some antihypertensive drugs, diuretics, and epitestosterone
    M Bicikova
    Institute of Endocrinology, Prague, Czech Republic
    Horm Metab Res 29:465-8. 1997
    ..min). The results represent further evidence for different substrate specificity of renal and testicular 11 beta-hydroxysteroid dehydrogenase...
  63. ncbi request reprint Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients
    J Skrha
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 59:749-55. 2010
    ..Simple meal test could demonstrate impaired GIP secretion and delayed insulin secretion in Type 2 diabetic patients as compared to obese non-diabetic and non-obese healthy control individuals...
  64. ncbi request reprint The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women
    M Kunesova
    Obesity Management Centre, Institute of Endocrinology, Charles University, Prague 1, Czech Republic
    Physiol Res 55:63-72. 2006
    ..595, p<0.008). The results suggest that long chain n-3 PUFA enhance weight loss in obese females treated by VLCD. Docosahexaenoate (22:6n-3) seems to be the active component...
  65. ncbi request reprint Salivary cortisol in low dose (1 microg) ACTH test in healthy women: comparison with serum cortisol
    K Simunkova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 56:449-53. 2007
    ..5183, p=0.0525); correlations after stimulation were not significant. Low-dose ACTH administration appeared as a sufficient stimulus for increasing salivary cortisol to a range considered as a normal adrenal functional reserve...
  66. ncbi request reprint Melatonin negatively correlates with C-peptide after food intake
    L Starka
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S187-92. 2008
    ..However, the physiological role of melatonin association with food intake in daytime remains in question and should be further investigated...
  67. ncbi request reprint Increase of nocturnal melatonin levels in hemodialyzed patients after parathyroidectomy: a pilot study
    R Kancheva
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S181-5. 2008
    ..In summary, in hemodialyzed patients with hyperparathyroidism, parathyroidectomy significantly increases the nocturnal secretion of melatonin. Relationships between the pineal gland and parathyroid glands have yet to be elucidated...
  68. ncbi request reprint Selected adipokines - plasma concentrations and adipose tissue expressions during 24-hour lipid infusion in healthy men
    J Kopecky
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 59:89-96. 2010
    ..Expressions of TNFalpha, leptin and adiponectin were unaffected. In conclusions, our results indicate that acutely induced hyperlipidemia could influence the secretion of TNFalpha and resistin...