Jiri Patocka

Summary

Affiliation: Faculty of Military Health Sciences
Country: Czech Republic

Publications

  1. ncbi request reprint Anti-inflammatory triterpenoids from mysterious mushroom Ganoderma lucidum and their potential possibility in modern medicine
    J Patocka
    Department of Toxicology, Purkyne Military Medical Academy, Hradec Kralove
    Acta Medica (Hradec Kralove) 42:123-5. 1999
  2. ncbi request reprint Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body
    Jiri Patocka
    Purkyne Military Medical Academy, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 47:215-28. 2004
  3. ncbi request reprint The most important microtubule natural inhibitors
    J Patocka
    Department of Toxicology, Purkyne Military Medical Academy, Hardec Králové
    Acta Medica (Hradec Kralove) 42:3-8. 1999
  4. ncbi request reprint Endothelins and sarafotoxins: peptides of similar structure and different function
    Jiri Patocka
    Purkyne Military Medical Academy, Hradec Kralove, Czech Republic Department of Toxicology
    Acta Medica (Hradec Kralove) 47:157-62. 2004
  5. ncbi request reprint Botulism and bioterrorism: how serious is this problem?
    Jiri Patocka
    University of Defence, Faculty of Military Health Sciences, Department of Toxicology, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 48:23-8. 2005
  6. ncbi request reprint Chemical agents and chemical terrorism
    J Patocka
    Department of Toxicology, Purkyne Military Medical Academy, Hradec Kralove, Czech Republic
    Cent Eur J Public Health 12:S75-7. 2004
  7. ncbi request reprint Inorganic lead toxicology
    Jiri Patocka
    Purkyne Military Medical Academy in Hradec Králové, Department of Toxicology, Czech Republic
    Acta Medica (Hradec Kralove) 46:65-72. 2003
  8. ncbi request reprint [Molecular mechanisms of biological effects of lithium]
    J Patocka
    Katedra toxikologie, Vojenská lékarská akademie, Hradec Kralove, Katedra radiologie, Zdravotnĕ sociální fakulta Jihoceské univerzity, Ceske Budejovice
    Cesk Fysiol 51:122-8. 2002
  9. ncbi request reprint Pharmacological potential of endothelin receptors agonists and antagonists
    Jiri Patocka
    Department of Toxicology, University of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Czech Republic
    Acta Medica (Hradec Kralove) 48:67-73. 2005
  10. ncbi request reprint The toxins of Cyanobacteria
    J Patocka
    Department of Toxicology, Purkyne Military Medical Academy, Hradec Kralove
    Acta Medica (Hradec Kralove) 44:69-75. 2001

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Anti-inflammatory triterpenoids from mysterious mushroom Ganoderma lucidum and their potential possibility in modern medicine
    J Patocka
    Department of Toxicology, Purkyne Military Medical Academy, Hradec Kralove
    Acta Medica (Hradec Kralove) 42:123-5. 1999
    ..Very important of them are highly oxygenated anti-inflammatory triterpenes, which are the aim of this mini-review...
  2. ncbi request reprint Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body
    Jiri Patocka
    Purkyne Military Medical Academy, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 47:215-28. 2004
    ..Understanding the enzyme's chemistry is essential in preventing and/or treating organophosphate and carbamate poisoning as well as designing new medicaments for cholinergic-related diseases like as Alzheimer's disease...
  3. ncbi request reprint The most important microtubule natural inhibitors
    J Patocka
    Department of Toxicology, Purkyne Military Medical Academy, Hardec Králové
    Acta Medica (Hradec Kralove) 42:3-8. 1999
    ..The survey of the most important natural microtubule inhibitors is summarized in this paper...
  4. ncbi request reprint Endothelins and sarafotoxins: peptides of similar structure and different function
    Jiri Patocka
    Purkyne Military Medical Academy, Hradec Kralove, Czech Republic Department of Toxicology
    Acta Medica (Hradec Kralove) 47:157-62. 2004
    ..The current minireview focuses on the chemical and molecular aspects of endothelins and sarafotoxins, and their receptors in physiological and pathophysiological processes...
  5. ncbi request reprint Botulism and bioterrorism: how serious is this problem?
    Jiri Patocka
    University of Defence, Faculty of Military Health Sciences, Department of Toxicology, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 48:23-8. 2005
    ..It can lead to death unless appropriate therapy is promptly initiated. Due to the severity and potency of BTX, its importance as a biological weapon is of major concern to public health officials. Nevertheless, BTX is also medicament...
  6. ncbi request reprint Chemical agents and chemical terrorism
    J Patocka
    Department of Toxicology, Purkyne Military Medical Academy, Hradec Kralove, Czech Republic
    Cent Eur J Public Health 12:S75-7. 2004
    ..High-toxic chemical substances can fall in terrorist hands through wide range of sources. Potentially misused types of chemical compounds are discussed in this article...
  7. ncbi request reprint Inorganic lead toxicology
    Jiri Patocka
    Purkyne Military Medical Academy in Hradec Králové, Department of Toxicology, Czech Republic
    Acta Medica (Hradec Kralove) 46:65-72. 2003
    ..Both occupational and environmental exposures to lead remain a serious problem in many developing and industrializing countries and a public health problem of global dimensions...
  8. ncbi request reprint [Molecular mechanisms of biological effects of lithium]
    J Patocka
    Katedra toxikologie, Vojenská lékarská akademie, Hradec Kralove, Katedra radiologie, Zdravotnĕ sociální fakulta Jihoceské univerzity, Ceske Budejovice
    Cesk Fysiol 51:122-8. 2002
    ..A number of lithium-sensitive enzymes and putative important biomolecules have been proposed as potential targets of lithium action and these mechanisms are discussed in this review...
  9. ncbi request reprint Pharmacological potential of endothelin receptors agonists and antagonists
    Jiri Patocka
    Department of Toxicology, University of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Czech Republic
    Acta Medica (Hradec Kralove) 48:67-73. 2005
    ..The aim of this article is a survey of compounds that affect the endothelin receptors and clinical trials with these agents...
  10. ncbi request reprint The toxins of Cyanobacteria
    J Patocka
    Department of Toxicology, Purkyne Military Medical Academy, Hradec Kralove
    Acta Medica (Hradec Kralove) 44:69-75. 2001
    ..All known cyanotoxins and their chemical and toxicological characteristics are presented in this article...
  11. ncbi request reprint Natural polyamines and their biological consequence in mammals
    J Patocka
    Department of Toxicology, Military Medical Academy, Hradec Kralove
    Acta Medica (Hradec Kralove) 43:119-24. 2000
    ..Inhibitors of polyamine biosynthesis have potential clinical uses as antitumor and antiparasitic agents. The brief summary with regard to their biological consequences in mammals is discussed in this paper...
  12. ncbi request reprint 3-Nitropropionic acid and similar nitrotoxins
    J Patocka
    Department of Toxicology, Purkyne Military Medical Academy, Hradec Kralove
    Acta Medica (Hradec Kralove) 43:9-13. 2000
    ..These nitrotoxins induce neurological degeneration in ruminants and humans. 3-Nitropropionic acid-intoxicated rats serve as the animal model for Huntington's disease...
  13. ncbi request reprint New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications
    Kamil Kuca
    Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, Hradec Kralove, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149:75-82. 2005
    ..None from the currently tested AChE reactivators is able to reactivate AChE inhibited by all nerve agents used and, therefore, the search for new potential broad spectrum AChE reactivators is needed...
  14. ncbi request reprint Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes
    Kamil Kuca
    Purkyne Medical Military Academy, Department of Toxicology, Hradec Kralove, Czech Republic
    Neurotox Res 6:565-70. 2004
    ..Rat brain AChE was used as the appropriate source of the enzyme. Our results confirm that there is no single broad-spectrum oxime suitable for the treatment of poisoning with all highly toxic organophosphorus agents...
  15. doi request reprint The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues
    Gabriela Kunesova
    Department of Toxicology, University of Defense, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
    Peptides 29:1982-7. 2008
    ..These results demonstrate the potential of HN analogues in the modulation of the cholinergic system, which plays an important role in the cognitive deficits associated with AD and other neurodegenerative diseases...
  16. ncbi request reprint Protein biotoxins of military significance
    Jiri Patocka
    Department of Toxicology, University of Defence, Faculty of Military Health Sciences, Czech Republic
    Acta Medica (Hradec Kralove) 49:3-11. 2006
    ..The key to timely identification of such attacks relies on education of primary care physicians, first responders, and public health officials...
  17. ncbi request reprint Reactivation potency of the acetylcholinesterase reactivator obidoxime is limited
    Kamil Kuca
    Center of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 153:259-62. 2009
    ..It is also needed by the fact that clinical findings considering this oxime are controversial...
  18. ncbi request reprint Anthrax vaccines
    Miroslav Splino
    Department of Epidemiology, Military Medical Academy, Hradec Kralove, Czech Republic
    Ann Saudi Med 25:143-9. 2005
    ..Serious adverse reactions occur in about 1% of vaccinations. New second-generation vaccines in current research programs include recombinant live vaccines and recombinant sub-unit vaccines...
  19. ncbi request reprint Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease
    Jiri Patocka
    Center of Advanced Studies, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
    Curr Drug Metab 9:332-5. 2008
    ..By this manner may be explained why the hepatotoxicity of tacrine was observed only in the part of persons and why not every patient with AD responds to the treatment by this drug...
  20. ncbi request reprint Effect of 7-methoxytacrine and L-carnitine on the activity of choline acetyltransferase
    J Bajgar
    Military Medical Academy, Hradec Kralove, Czech Republic
    Gen Physiol Biophys 18:3-6. 1999
    ..Both compounds increased ChAT activity when administered separately. 3-day treatment of CRT followed by administration of 7-MEOTA normalized ChAT activity...
  21. ncbi request reprint Anthrax toxin characterization
    Jiri Patocka
    Department of Toxicology, Purkyne Military Medical Academy, Hradec Kralove
    Acta Medica (Hradec Kralove) 45:3-5. 2002
    ..The third toxin molecule, edema factor (EF), hijacks the signaling system in the body. This disrupts the energy balance of cells and leads to them accumulating fluid and complete destroy of cells...
  22. ncbi request reprint Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium--oximes
    Kamil Kuca
    Department of Toxicology, Military Medical Academy, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
    J Enzyme Inhib Med Chem 19:39-43. 2004
    ....
  23. ncbi request reprint Organic lead toxicology
    Jiri Patocka
    University of South Bohemia, Ceske Budejovice, Faculty of Health and Social Care, Department of Radiology and Toxicology, Czech Republic
    Acta Medica (Hradec Kralove) 51:209-13. 2008
    ....
  24. ncbi request reprint Effect of humanin analogues on experimentally induced impairment of spatial memory in rats
    Gabriela Krejcova
    Department of Toxicology, Purkyne Military Medical Academy, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
    J Pept Sci 10:636-9. 2004
    ..impairment of spatial memory in the multiple T-maze in rats has been evaluated. Both peptides reversed the impairment of spatial memory. These results indicate the potential of humanin analogues in modulation of the cholinergic system...
  25. ncbi request reprint Prophylaxis against anthrax
    Miroslav Splino
    Department of Epidemiology, Purkyne Military Medical Academy, Hradec Kralove
    Acta Medica (Hradec Kralove) 45:85-8. 2002
    ..anthracis spores. The AVA vaccine licensed in the United States, primary vaccination, protective efficacy of the vaccine, and adverse events are characterised. Stress is laid on pre-exposure and post-exposure prophylaxis of anthrax...
  26. ncbi request reprint [Cholinesterases and their importance in the etiology, diagnosis and therapy of Alzheimer's disease]
    J Patocka
    Katedra toxikologie, ,
    Cesk Fysiol 50:4-10. 2001
    ..Both AChE) and BuChE become recently the target for the most frequently used therapy of AD--cholinesterase inhibitors...