Kamil Kuca

Summary

Affiliation: Faculty of Military Health Sciences
Country: Czech Republic

Publications

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    Kuca K, Patocka J, Cabal J, Jun D. Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes. Neurotox Res. 2004;6:565-70 pubmed
    ..Rat brain AChE was used as the appropriate source of the enzyme. Our results confirm that there is no single broad-spectrum oxime suitable for the treatment of poisoning with all highly toxic organophosphorus agents. ..
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    Kuca K, Dohnal V. 1,3-Bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents. Acta Medica (Hradec Kralove). 2004;47:167-9 pubmed
    ..The maximum concentration of pralidoxime was reached at the concentrations 10(-1) M (for cyclosarin) and 10(-3) M (for VX) but these concentrations are not available for the use in vivo. ..
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    Kuca K, Juna D, Musilek K. Structural requirements of acetylcholinesterase reactivators. Mini Rev Med Chem. 2006;6:269-77 pubmed
    ..It is shown that there are several structural fragments possibly involving in the structure of proposed AChE reactivators. Finally, an attempt of a future course of new AChE reactivators development is discussed. ..
  4. Kuca K, Musilek K, Jun D, Pohanka M, Ghosh K, Hrabinova M. Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase. J Enzyme Inhib Med Chem. 2010;25:509-12 pubmed publisher
    ..In the case of cyclosarin- and soman-inhibited AChE, oxime K027 did not reach sufficient reactivation potency. ..
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    Kuca K, Patocka J. Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium--oximes. J Enzyme Inhib Med Chem. 2004;19:39-43 pubmed
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    Kuca K, Cabal J, Kassa J. A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods. Pharmazie. 2004;59:795-8 pubmed
    ..Thus, oxime K033 seems to be a relatively efficacious broad spectrum acetylcholinesterase reactivator and, therefore, could be useful if no information about the type of nerve agent used was available. ..
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    Klimova B, Maresova P, Novotný M, Kuca K. A Global View on Narcolepsy - A Review Study. Mini Rev Med Chem. 2016;: pubmed
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    Kuca K, Jun D, Bajgar J. Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro. Drug Chem Toxicol. 2007;30:31-40 pubmed
    ..Moreover, oxime HI-6 (the most effective one) was not able to reactivate tabun- and soman-inhibited AChE. Due to this fact, it could be designated as a partially broad-spectrum reactivator...
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    Kuca K, Musilek K, Pohanka M, Dohnal V, Patocka J. Reactivation potency of the acetylcholinesterase reactivator obidoxime is limited. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009;153:259-62 pubmed
    ..It is also needed by the fact that clinical findings considering this oxime are controversial...

More Information

Publications16

  1. request reprint
    Kuca K, Cabal J. [In vitro reactivation of acetylcholinesterase inhibition by O-isopropylmethylfluorophosphonate using the bisquarternary oxime, HS-6]. Ceska Slov Farm. 2004;53:93-5 pubmed
    ..The oxime HS-6 was an effective reactivator of sarin-inhibited AChE. It is not as effective as the H-oxime HI-6, but it is better than 2-PAM and obidoxime...
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    Kuca K, Cabal J, Jun D, Hrabinova M. In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings. Drug Chem Toxicol. 2006;29:443-9 pubmed
    ..In most cases, the reactivation bell-shaped curve is obtained. The most potent AChE reactivators are selected and provided for further experiments during our development process...
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    Kuca K, Cabal J, Jun D, Musilek K. In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases. Neurotox Res. 2007;11:101-6 pubmed
    ..A second AChE reactivator, K075, does not attain as great a reactivation potency as K074, although its maximal reactivation (17%) was achieved at relevant concentrations for humans...
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    Kuca K, Cabal J, Jun D, Hrabinova M. Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin. Clin Toxicol (Phila). 2007;45:512-5 pubmed
    ..Moreover, according to the results, we can describe basic structural requirements, which are necessary for the efficacious reactivation process...
  5. Kuca K, Jun D. Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes. J Med Toxicol. 2006;2:141-6 pubmed
    ..Organophosphorus nerve agents inhibit the enzyme, acetylcholinesterase (AChE; EC 3.1.1.7). AChE reactivators (also known as oximes) are generally used for the reactivation of an inhibited enzyme...
  6. Kuca K, Cabal J, Jung Y, Musilek K, Soukup O, Jun D, et al. Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127. Basic Clin Pharmacol Toxicol. 2009;105:207-10 pubmed publisher
    ..Due to this, experiments on human tissue should be conducted after in vitro and in vivo tests on animals to eliminate such important failures of promising oximes...
  7. Kuca K, Musilova L, Palecek J, Cirkva V, Paar M, Musilek K, et al. Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon. Molecules. 2009;14:4915-21 pubmed publisher
    ..In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime...