Jiri Kassa

Summary

Affiliation: Faculty of Military Health Sciences
Country: Czech Republic

Publications

  1. Kassa J, Timperley C, Bird M, Williams R, Green A, Tattersall J. Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice. Toxicology. 2018;408:95-100 pubmed publisher
  2. Kassa J, Korabecny J. Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice. Acta Medica (Hradec Kralove). 2017;60:140-145 pubmed publisher
    ..These findings demonstrate the important influence of the dose of 6-chlorotacine on its prophylactic efficacy in the case of pharmacological pretreatment of soman poisoning in mice. ..
  3. request reprint
    Kassa J, Musilek K, Karasova J, Kuca K, Bajgar J. Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings. Mini Rev Med Chem. 2012;12:24-34 pubmed
  4. request reprint
    Kassa J, Krejèová G. Neuroprotective effects of currently used antidotes in tabun-poisoned rats. Pharmacol Toxicol. 2003;92:258-64 pubmed
  5. request reprint
    Kassa J. [Effect of diazepam on the effectiveness of antidote therapy in eliminating the acute lethal effects of soman in mice]. Cas Lek Cesk. 2001;140:497-9 pubmed
  6. Kassa J, Jun D, Karasova J, Bajgar J, Kuca K. A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats. Chem Biol Interact. 2008;175:425-7 pubmed publisher
  7. request reprint
    Kassa J, Karasova J. A comparison of the potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity in rats. Toxicology. 2007;229:136-44 pubmed
    ..Due to their neuroprotective effects, both newly developed oximes (especially K075) appear to be more suitable oximes for the antidotal treatment of acute tabun poisonings than the oxime HI-6. ..
  8. request reprint
    Kassa J, Karasova J. The evaluation of the neuroprotective effects of bispyridinium oximes in tabun-poisoned rats. J Toxicol Environ Health A. 2007;70:1556-67 pubmed
    ..Due to its neuroprotective effects, trimedoxime may be considered to be more suitable oxime for the antidotal treatment of acute tabun exposure than currently used oximes (obidoxime, HI-6) and the newly synthesized oxime K075. ..
  9. request reprint
    Kassa J, Kuca K, Karasova J, Musilek K. The development of new oximes and the evaluation of their reactivating, therapeutic and neuroprotective efficacy against tabun. Mini Rev Med Chem. 2008;8:1134-43 pubmed
    ..Due to their therapeutic, reactivating and neuroprotective efficacy, all newly synthesized oximes appear to be suitable oximes for the antidotal treatment of acute tabun poisonings. ..

More Information

Publications43

  1. Kassa J, Karasova J, Tesarova S, Kuca K, Musilek K. A comparison of the ability of newly-developed bispyridinium oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) to counteract the acute neurotoxicity of soman in rats. Toxicol Mech Methods. 2010;20:445-51 pubmed publisher
    ..Thus, the oxime K203 does not provide any beneficial effect for the antidotal treatment of acute poisoning with soman and the oxime HI-6 should be still considered to be the best oxime for antidotal treatment of acute soman poisonings. ..
  2. Kassa J, Karasova J, Kuca K, Musilek K. A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice. Drug Chem Toxicol. 2010;33:227-32 pubmed publisher
  3. request reprint
    Kassa J. Therapeutic and neuroprotective efficacy of pharmacological pretreatment and antidotal treatment of acute tabun or soman poisoning with the emphasis on pretreatment drug PANPAL. Arh Hig Rada Toksikol. 2006;57:427-34 pubmed
  4. request reprint
    Kassa J, Bielavský J. A comparison of the efficacy of new monopyridinium oximes with the oxime HI-6 against mevinphos in mice. Acta Medica (Hradec Kralove). 1999;42:9-11 pubmed
    ..4. Use of new monopyridinium oxime 2,5-PAEtM appears to be the improvement in the antidotal treatment of poisoning with organophosphorus insecticide mevinphos in comparison with HI-6. ..
  5. Kassa J, Korabecny J, Nepovimova E. The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice. Acta Medica (Hradec Kralove). 2017;60:37-43 pubmed publisher
    ..These findings demonstrate that pharmacological pretreatment of somanpoisoned mice can be promising and useful in the case of administration of 6-chlorotacrine and partly compound 2. ..
  6. request reprint
    Kassa J, Koupilová M, Herink J, Vachek J. The long-term influence of low-level sarin exposure on behavioral and neurophysiological functions in rats. Acta Medica (Hradec Kralove). 2001;44:21-7 pubmed
  7. Kassa J, Misik J, Karasova J. A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats. Basic Clin Pharmacol Toxicol. 2012;111:333-8 pubmed publisher
  8. request reprint
    Kassa J, Fusek J. The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats. Toxicology. 2000;154:67-73 pubmed
  9. request reprint
    Kassa J, Cabal J. A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods. Toxicology. 1999;132:111-8 pubmed
  10. request reprint
    Kassa J, Krejcova G, Samnaliev I. A comparison of the neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in soman-poisoned rats. Acta Medica (Hradec Kralove). 2003;46:101-7 pubmed
    ..The pharmacological pretreatment containing pyridostigmine and biperiden appears to be more efficacious to eliminate soman-induced neurotoxic sings than PANPAL. ..
  11. Kassa J, Karasova J, Tesarova S, Musilek K, Kuca K, Jung Y. A comparison of neuroprotective efficacy of the oxime K203 and its fluorinated analogue (KR-22836) with obidoxime in Tabun-poisoned rats. Basic Clin Pharmacol Toxicol. 2010;107:861-7 pubmed publisher
    ..Thus, the newly developed fluorinated analogue of K203, called KR-22836, is able to slightly increase the neuroprotective effectiveness of antidotal treatment of acute tabun poisonings compared to K203 and currently available obidoxime...
  12. request reprint
    Kassa J, Kunesova G. The influence of antidotal treatment of low-level tabun exposure on cognitive functions in rats using a water maze. Neurotox Res. 2006;9:39-45 pubmed
    ..Therefore, each low-level nerve agent exposure should be treated by complex antidotal treatment consisting of anticholinergic drug and oxime...
  13. Kassa J, Karasova J, Bajgar J, Kuca K, Musilek K, Kopelikova I. A comparison of the reactivating and therapeutic efficacy of newly developed bispyridinium oximes (K250, K251) with commonly used oximes against tabun in rats and mice. J Enzyme Inhib Med Chem. 2009;24:1040-4 pubmed publisher
  14. Kassa J, Misik J, Hatlapatková J, Zdarova Karasova J, Sepsova V, Caisberger F, et al. The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203. Molecules. 2017;22: pubmed publisher
    ..Therefore, the newly developed oximes are not suitable for the replacement of commonly used oximes (especially trimedoxime) in the treatment of acute tabun poisonings. ..
  15. request reprint
    Kassa J, Jun D, Kuca K. A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats. J Enzyme Inhib Med Chem. 2007;22:297-300 pubmed
  16. request reprint
    Kassa J, Jun D, Kuca K, Bajgar J. Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats. Basic Clin Pharmacol Toxicol. 2007;101:328-32 pubmed
  17. Kassa J, Karasova J, Sepsova V, Caisberger F, Bajgar J. A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice. Int J Toxicol. 2011;30:562-7 pubmed publisher
  18. request reprint
    Kassa J, Karasova J. A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) to counteract soman-induced neurotoxicity in rats. Drug Chem Toxicol. 2007;30:117-31 pubmed
    ..The oxime HI-6 is still the best acetylcholinesterase reactivator for the antidotal treatment of acute poisonings with soman...
  19. request reprint
    Kassa J, Koupilová M. Neuroprotective effects of antidotes in soman-poisoned rats. Acta Medica (Hradec Kralove). 1999;42:127-31 pubmed
  20. Kassa J, Hatlapatková J, Žďárová Karasová J. The Evaluation of the Potency of Newly Developed Oximes (K727, K733) and Trimedoxime to Counteract Acute Neurotoxic Effects of Tabun in Rats. Acta Medica (Hradec Kralove). 2015;58:135-43 pubmed publisher
    ..Therefore, the newly developed oximes are not suitable for the replacement of commonly used oximes such as trimedoxime in the treatment of acute tabun poisonings. ..
  21. request reprint
    Kassa J, Karasova J, Pavlikova R, Caisberger F, Bajgar J. The ability of oxime mixtures to increase the reactivating and therapeutic efficacy of antidotal treatment of cyclosarin poisoning in rats and mice. Acta Medica (Hradec Kralove). 2012;55:27-31 pubmed
    ..Based on the obtained data, we can conclude that the antidotal treatment involving chosen combinations of oximes brings a beneficial effect for its ability to counteract the acute poisoning with cyclosarin...
  22. request reprint
    Kassa J, Kuca K, Cabal J. A comparison of the potency of trimedoxime and other currently available oximes to reactivate tabun-inhibited acetylcholinesterase and eliminate acute toxic effects of tabun. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005;149:419-23 pubmed
    ..The oxime HI-6, so efficacious against soman, does not seem to be sufficiently effective oxime to reactivate tabun-inhibited acetylcholinesterase and to counteract acute lethal effects of tabun...
  23. Kassa J, Karasova J, Sepsova V, Caisberger F. The benefit of combinations of oximes for the reactivating and therapeutic efficacy of antidotal treatment of sarin poisoning in rats and mice. Basic Clin Pharmacol Toxicol. 2011;109:30-4 pubmed publisher
  24. Kassa J, Karasova J, Pavlikova R, Musilek K, Kuca K, Bajgar J, et al. A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicol Mech Methods. 2011;21:241-5 pubmed publisher
  25. Kassa J, Karasova J, Pavlikova R, Misik J, Caisberger F, Bajgar J. The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice. J Appl Toxicol. 2010;30:120-4 pubmed publisher
  26. request reprint
    Kassa J, Karasova J, Musilek K, Kuca K, Jung Y. A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Drug Chem Toxicol. 2008;31:371-81 pubmed
  27. Kassa J, Kunesova G. The benefit of combination of oximes for the neuroprotective efficacy of antidotal treatment of sarin-poisoned rats. Toxicol Mech Methods. 2012;22:260-7 pubmed publisher
    ..Thus, both tested combinations of oximes in combination with atropine bring a small benefit for the neuroprotective efficacy of antidotal treatment of acute sarin poisonings...
  28. request reprint
    Kassa J, Jun D, Kuca K. The reactivating and therapeutic efficacy of oximes to counteract Russian VX poisonings. Int J Toxicol. 2006;25:397-401 pubmed
    ..Thus, the oxime HI-6 seems to be the most suitable oxime for the antidotal treatment of acute poisonings with Russian VX as in the case of VX, sarin, cyclosarin, and soman poisonings...
  29. Kassa J, Misik J, Karasova J. Evaluation of the potency of two novel bispyridinium oximes (K456, K458) in comparison with oxime K203 and trimedoxime to counteract tabun-induced neurotoxicity in rats. Basic Clin Pharmacol Toxicol. 2013;113:201-8 pubmed publisher
  30. Kassa J, Karasova J, Caisberger F, Musilek K, Kuca K, Jung Y. A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice. J Enzyme Inhib Med Chem. 2010;25:480-4 pubmed publisher
  31. Kassa J, Karasova J, Caisberger F, Bajgar J. The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of soman poisoning in rats and mice. Toxicol Mech Methods. 2009;19:547-51 pubmed publisher
  32. request reprint
    Kassa J, Karasova J, Musilek K, Kuca K. An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology. 2008;243:311-6 pubmed
  33. request reprint
    Kassa J, Karasova J, Vasina L. The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats. J Appl Toxicol. 2007;27:621-30 pubmed
    ..Therefore, the oxime HI-6 is still the most suitable oxime for the antidotal treatment of acute poisonings with cyclosarin due to its neuroprotective as well as reactivating efficacy...
  34. Kassa J, Sepsova V, Musilek K, Horova A. The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K456, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice. Toxicol Mech Methods. 2013;23:94-8 pubmed publisher