Research Topics
Genomes and Genes | Jan ZivnySummaryAffiliation: Charles University Location: Praha, Czech Republic Summary: cancer, hematopoietic malignities, experimental cancer therapy, cancer stem cell, clinical proteomics, cell membrane microparticles Publications
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Detail Information
Publications
Cell death signalling pathways in the pathogenesis and therapy of haematologic malignancies: overview of therapeutic approachesP Klener
Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Folia Biol (Praha) 52:119-36. 2006..Some of the agents have recently been approved for therapy, some are under the clinical evaluation in various phases of clinical trials and some are tested under the experimental laboratory conditions...- Reduced erythroid cell and erythropoietin production in response to acute anemia in prion protein-deficient (Prnp-/-) miceJan H Zivny
1st School of Medicine, Charles University, Prague, Czech Republic
Blood Cells Mol Dis 40:302-7. 2008..These observations indicate that PrPc may modulate tissue hypoxia-sensing mechanisms or effect hypoxia target gene expression... 
Déjà vu in proteomics. A hit parade of repeatedly identified differentially expressed proteinsJiri Petrak
Institute of Hematology and Blood Transfusion, Prague, Czech Republic
Proteomics 8:1744-9. 2008..We consider if these commonly observed changes represent common cellular stress responses or are a reflection of the technical limitations of 2-DE...- TRAIL-induced apoptosis of HL60 leukemia cells: two distinct phenotypes of acquired TRAIL resistance that are accompanied with resistance to TNFalpha but not to idarubicin and cytarabinePavel Klener
Department of Pathophysiology, 1st Medical Faculty, Charles University in Prague, Czech Republic
Blood Cells Mol Dis 42:77-84. 2009..We identified distinct pathways for the development of HL60 leukemia cell resistance to apoptosis induction. These findings are relevant for the design of more effective strategies for leukemia therapy... - The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineeringRobert Pytlik
First Department of Medicine, Charles University, Prague, Czech Republic
Biomaterials 30:3415-27. 2009.... - The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARCM Hnátková
Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, First Medical Department Clinical Department of Haematology, Prague, Czech Republic
Prague Med Rep 110:35-41. 2009..The understanding of biological pathways in Hodgkin's lymphoma could be important for monitoring of disease activity and for the development of future targeted therapy... 
Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failureMartina Zivná
Center for Applied Genomics, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic
Am J Hum Genet 85:204-13. 2009..Our findings provide insight into the functionality of renin-angiotensin system and stress the importance of renin analysis in families and individuals with early onset hyperuricemia, anemia, and progressive kidney failure...- Identification of molecular targets for selective elimination of TRAIL-resistant leukemia cells. From spots to in vitro assays using TOP15 chartsJiri Petrak
Charles University in Prague, First Faculty of Medicine, Institute of Pathological Physiology, Prague, Czech Republic
Proteomics 9:5006-15. 2009..In a series of in vitro assays, we confirmed the increased toxicity of etoposide and cisplatin to TRAIL resistant HL-60/P1 cells, and adenosine and vidarabine to HL-60/P2, compared with TRAIL-sensitive HL-60 cells... - The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignanciesJ Zivny
the Institute of Pathological Physiology, Charles University in Prague, First Faculty of Medicine, U nemocnice 5, 128 53 Prague 2, Czech Republic
Curr Pharm Des 16:11-33. 2010.... - More on clinical renal geneticsJean Pierre Grunfeld
Clin J Am Soc Nephrol 5:563-7. 2010 - Cell death signalling pathways in the pathogenesis and therapy of haematologic malignancies: overview of apoptotic pathwaysP Klener
Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Folia Biol (Praha) 52:34-44. 2006..In this part of the review we focus on basic details of the apoptosis pathways, key players of the receptor-mediated apoptosis, and molecules involved in the cross-talk between individual apoptosis pathways and apoptosis regulation... - Alterations of uromodulin biology: a common denominator of the genetically heterogeneous FJHN/MCKD syndromeP Vylet'al
Center for Applied Genomics, Charles University 1st School of Medicine, Prague, Czech Republic
Kidney Int 70:1155-69. 2006..Uromodulin-associated kidney diseases' may be thus a more appropriate term for this syndrome... - TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitorsM Plasilova
Institute of Hematology and Blood Transfusion, Prague, Czech Republic
Leukemia 16:67-73. 2002..To conclude, our data document that TRAIL does not affect normal human hematopoiesis but suppresses the growth of early primary leukemia and myelodysplasia progenitors... - Inhibition of Smad5 in human hematopoietic progenitors blocks erythroid differentiation induced by BMP4Ota Fuchs
Institute of Hematology and Blood Transfusion, Prague, Czech Republic
Blood Cells Mol Dis 28:221-33. 2002..We propose that the BMP4/Smad5 signal transduction pathway activates hematopoietic differentiation programs that may be impaired in anemia manifestations in MDS and AML patients with Smad5 haploinsufficiency... - [Impaired development of uteroplacental circulation]O Sosna
Ceska Gynekol 67:226-9. 2002..SUBJECT OF STUDY: A summary of what is known about development of uteroplacental circulation predispose women to the development of preeclampsia and IUGR but the etiology of preeclampsia is still unknown... - Expression of genes regulating angiogenesis in human circulating hematopoietic cord blood CD34+/CD133+ cellsJiri Pomyje
Department of Pathophysiology, 1st Medical Faculty, Charles University Prague, Czech Republic
Eur J Haematol 70:143-50. 2003..The aim of the study was to determine angiogenesis regulating genes expression in CD34+ cells, their subpopulations, and during their differentiation induced by hematopoietic growth factors... - Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signalingTobias Weber
Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany
Biochemistry 42:4277-91. 2003..These data provide an insight into the molecular mechanism, by which alpha-TOS kills malignant cells, and advocate its testing as a potential anticancer agent or adjuvant... - Diamond blackfan anemia stem cells fail to repopulate erythropoiesis in NOD/SCID miceJan Zivny
Department of Pathophysiology, Charles University, First Medical Faculty, Prague, Czech Republic
Blood Cells Mol Dis 31:93-7. 2003..Therefore, we conclude that disordered DBA erythropoiesis may be a result of defective erythroid-lineage commitment and maintenance of early erythroid progenitors... - [Specific mucosal immunity in the female reproductive tract: general introduction (part 1)]J Zivny
Ustav patologické fyziologie 1 LF UK, Praha
Ceska Gynekol 68:206-9. 2003..Basic mechanisms of mucosal immune system and the unique features of female reproductive tract immune system are reviewed in this article... - [Specific mucosal immunity in the female reproductive tract: protection against infectious diseases and regulation of fertility (part 2)]J Zivny
Ustav patologické fyziologie, 1 LF UK, Praha
Ceska Gynekol 68:254-8. 2003..Specific mechanisms concerning development of mucosal vaccines to sexually transmitted diseases and the immune regulation of fertility are reviewed in this article... - Expression of angiopoietic factors in normal and type-I diabetes human placenta: a pilot studyJan Janota
Institute for the Care of Mother and Child, Podolske nabrezi 157, Praha 4, 140 00, Czech Republic
Eur J Obstet Gynecol Reprod Biol 111:153-6. 2003..Morphological changes of blood vessel wall have been described in placenta from pregnancies complicated by diabetes mellitus type-I... - Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuriaJan Simak
Laboratory of Cellular Hematology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
Br J Haematol 125:804-13. 2004..Analysis of circulating ECMP appears promising to provide useful information on the status of the vascular endothelium in PNH and SCD... - Clinical and molecular characterization of a family with a dominant renin gene mutation and response to treatment with fludrocortisoneA J Bleyer
Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Clin Nephrol 74:411-22. 2010..Mutational analysis revealed a novel heterozygous mutation c.58T > C resulting in the amino acid substitution of cysteine for arginine in the preprorenin signal sequence (p.cys20Arg) occurring in all affected members...