Vladimir Tesar

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. ncbi request reprint [Hypertension in patients with polycystic kidney disease -  incidence, pathogenesis, prognosis, therapy]
    V Tesar
    Klinika nefrologie 1 lékařské fakulty UK a VFN v Praze
    Vnitr Lek 59:496-500. 2013
  2. doi request reprint ANCA-associated renal vasculitis - an update
    Vladimir Tesar
    Department of Nephrology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Contrib Nephrol 181:216-28. 2013
  3. ncbi request reprint Blockade of endothelin receptors attenuates end-organ damage in homozygous hypertensive ren-2 transgenic rats
    Pavel Dvorak
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Kidney Blood Press Res 27:248-58. 2004
  4. doi request reprint Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension
    Zdenka Vanourková
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Vascul Pharmacol 50:194-9. 2009
  5. doi request reprint Effects of combined endothelin A receptor and renin-angiotensin system blockade on the course of end-organ damage in 5/6 nephrectomized Ren-2 hypertensive rats
    Ivana Vaneckova
    Institute of Physiology v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Kidney Blood Press Res 35:382-92. 2012
  6. doi request reprint Genetic predisposition to advanced glycation end products toxicity is related to prognosis of chronic hemodialysis patients
    Marta Kalousova
    Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Kidney Blood Press Res 33:30-6. 2010
  7. doi request reprint Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats
    Zdenka Vernerova
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Vascul Pharmacol 48:165-73. 2008
  8. pmc Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: study in angiotensin II receptor subtype 1A knockout mice
    Ludek Cervenka
    Department for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    J Hypertens 26:1379-89. 2008
  9. doi request reprint The retrospective analysis of 343 Czech patients with IgA nephropathy--one centre experience
    Dita Maixnerova
    Department of Nephrology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Nephrol Dial Transplant 27:1492-8. 2012
  10. pmc Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats
    Zuzana Honetschlägerová
    Department for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    J Hypertens 29:1590-601. 2011

Collaborators

Detail Information

Publications44

  1. ncbi request reprint [Hypertension in patients with polycystic kidney disease -  incidence, pathogenesis, prognosis, therapy]
    V Tesar
    Klinika nefrologie 1 lékařské fakulty UK a VFN v Praze
    Vnitr Lek 59:496-500. 2013
    ..The influence of these drugs on the control of blood pressure, if any, remains uncertain...
  2. doi request reprint ANCA-associated renal vasculitis - an update
    Vladimir Tesar
    Department of Nephrology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Contrib Nephrol 181:216-28. 2013
    ..Rituximab-based maintenance treatment is superior to standard treatment with azathioprine. The use of more targeted treatment will hopefully be translated into a better long-term outcome of AAV patients...
  3. ncbi request reprint Blockade of endothelin receptors attenuates end-organ damage in homozygous hypertensive ren-2 transgenic rats
    Pavel Dvorak
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Kidney Blood Press Res 27:248-58. 2004
    ..45% NaCl) and high-salt (HS, 2% NaCl) intake...
  4. doi request reprint Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension
    Zdenka Vanourková
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Vascul Pharmacol 50:194-9. 2009
    ....
  5. doi request reprint Effects of combined endothelin A receptor and renin-angiotensin system blockade on the course of end-organ damage in 5/6 nephrectomized Ren-2 hypertensive rats
    Ivana Vaneckova
    Institute of Physiology v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Kidney Blood Press Res 35:382-92. 2012
    ..However, no additive cardio- and renoprotective effects of ET(A) and RAS blockade were noted at the end of the study...
  6. doi request reprint Genetic predisposition to advanced glycation end products toxicity is related to prognosis of chronic hemodialysis patients
    Marta Kalousova
    Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Kidney Blood Press Res 33:30-6. 2010
    ..The A419C (E111A) polymorphism of the GLO I gene is associated with vascular disease in hemodialysis (HD) patients and some RAGE gene polymorphisms are implicated in various pathological states...
  7. doi request reprint Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats
    Zdenka Vernerova
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Vascul Pharmacol 48:165-73. 2008
    ....
  8. pmc Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: study in angiotensin II receptor subtype 1A knockout mice
    Ludek Cervenka
    Department for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    J Hypertens 26:1379-89. 2008
    ....
  9. doi request reprint The retrospective analysis of 343 Czech patients with IgA nephropathy--one centre experience
    Dita Maixnerova
    Department of Nephrology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Nephrol Dial Transplant 27:1492-8. 2012
    ..We have assessed the main demographic, clinical and histological data, and the medical treatment of IgAN pts...
  10. pmc Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats
    Zuzana Honetschlägerová
    Department for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    J Hypertens 29:1590-601. 2011
    ....
  11. ncbi request reprint Glycoxidation and inflammation in chronic haemodialysis patients
    Marta Kalousova
    Institute of Medical Biochemistry, Department of Medicine Strahov, First Faculty of Medicine, Charles University and General University Hospital, Katerinska 32, CZ 121 08 Prague 2, Czech Republic
    Nephrol Dial Transplant 18:2577-81. 2003
    ..Although both glycoxidation and inflammation can contribute to severe vascular and cardiovascular complications, the role that these pathogenic mechanisms play in the complex response of the whole organism remains to be elucidated...
  12. pmc Placental growth factor may predict increased left ventricular mass index in patients with mild to moderate chronic kidney disease--a prospective observational study
    Martina Peiskerová
    Department of Nephrology, First Faculty of Medicine, Charles University, Prague, Czech Republic
    BMC Nephrol 14:142. 2013
    ..The aim of our study was to determine the possible association of PlGF and several other CV risk markers to echocardiographic parameters in CKD population...
  13. doi request reprint Placental growth factor, pregnancy-associated plasma protein-A, soluble receptor for advanced glycation end products, extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high mobility group box 1 le
    Oskar Zakiyanov
    Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    BMC Nephrol 14:245. 2013
    ..However, their clinical significance in acute kidney injury (AKI) is unknown. The aim of this cross-sectional study was to determine whether selected biomarkers are changed in AKI patients...
  14. doi request reprint Circulating endothelial progenitor cells in patients with ANCA-associated vasculitis
    Jakub Zavada
    Department of Nephrology, First Faculty of Medicine, Charles University in Prague, General Teaching Hospital, Prague, Czech Republic
    Kidney Blood Press Res 31:247-54. 2008
    ....
  15. ncbi request reprint The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats
    Vera Certíková Chábová
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Kidney Blood Press Res 30:335-46. 2007
    ..Second, the renal functional responses to inhibition of the intrarenal formation of 20-HETE and EETs were investigated...
  16. ncbi request reprint Determinants of circulating matrix metalloproteinase-2 and pregnancy-associated plasma protein-A in patients with chronic kidney disease
    Oskar Zakiyanov
    Department of Nephrology, First Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic
    Clin Lab 58:471-80. 2012
    ..However, the serum determinants of MMP-2 and PAPP-A in CKD are unknown. The aim of the present study is to evaluate the clinical significance of MMP-2 and PAPP-A and their determinants in patients with CKD...
  17. doi request reprint Serum S100A12 (EN-RAGE) levels in patients with decreased renal function and subclinical chronic inflammatory disease
    Oskar Zakiyanov
    Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
    Kidney Blood Press Res 34:457-64. 2011
    ..The aim of the study was to determine S100A12 levels and describe their relationship to inflammatory markers in patients with decreased renal function...
  18. doi request reprint Plasma calprotectin in chronically dialyzed end-stage renal disease patients
    Karin Malickova
    Institute of Clinical Biochemistry, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Inflamm Res 59:299-305. 2010
    ..The current study aimed to evaluate plasma calprotectin levels and clearance end-stage renal disease (ESRD) patients with and without acute infection undergoing chronic hemodialysis (HD)...
  19. doi request reprint Pregnancy-associated plasma protein A (PAPP-A) and soluble receptor for advanced glycation end products (sRAGE)--intra- and inter-individual variability in chronic hemodialysis patients
    Blanka Míková
    Institute of Medical Chemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Scand J Clin Lab Invest 72:296-303. 2012
    ..The aim of our study was to describe their intra- and inter-individual variability...
  20. doi request reprint Pregnancy-associated plasma protein A as an independent mortality predictor in long-term hemodialysis patients
    Marta Kalousova
    Institute of Clinical Biochemistry and Laboratory Diagnostics, Charles University and General University Hospital, Prague, Czech Republic
    Kidney Blood Press Res 35:192-201. 2012
    ..Pregnancy-associated plasma protein A (PAPP-A) is a biomarker related to vascular damage. The aim of the study was to focus on PAPP-A and related parameters and their relationship to the prognosis of long-term hemodialysis (HD) patients...
  21. doi request reprint Changes in levels of matrix metalloproteinase-2 and -9, pregnancy-associated plasma protein-A in patients with various nephropathies
    Oskar Zakiyanov
    Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    J Nephrol 26:502-9. 2013
    ..We compared MMP-2, MMP-9 and PAPP-A levels in patients with GN, with those found in healthy controls...
  22. ncbi request reprint A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients
    Marta Kalousova
    Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
    Ann N Y Acad Sci 1126:268-71. 2008
    ..In summary, in this study we demonstrate for the first time the association of A419C polymorphism of the glyoxalase I gene with sRAGE levels and show the genetic predisposition to vascular complications in HD patients...
  23. doi request reprint Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy
    Barbora Svobodová
    Department of Nephrology, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
    Nephrol Dial Transplant 28:1839-44. 2013
    ....
  24. doi request reprint Intracellular cytokine production in ANCA-associated vasculitis: low levels of interleukin-10 in remission are associated with a higher relapse rate in the long-term follow-up
    Zdenka Hruskova
    Department of Nephrology, 1st Faculty of Medicine and General Teaching Hospital, Charles University, Prague, Czech Republic
    Arch Med Res 40:276-84. 2009
    ..The aim of this study was to assess the intracellular cytokine production in patients with AAV at different stages of the disease, in particular, in relation to the long-term prognosis...
  25. ncbi request reprint Influence of losartan and enalapril on urinary excretion of 8-isoprostane in experimental nephrotic syndrome
    Vladimir Tesar
    Department of Nephrology, 1st Department of Medicine, 1st Medicine Faculty, Charles University, U nemocnice 2, 120 00 Prague 2, Czech Republic
    Med Sci Monit 8:BR69-74. 2002
    ..ACE inhibitors and angiotensin II antagonists may reduce proteinuria, perhaps by decreasing intraglomerular pressure and increasing the selective permeabiity of the glomerular capillary wall...
  26. pmc The coincidence of IgA nephropathy and Fabry disease
    Dita Maixnerova
    Department of Nephrology, Charles University, Prague, Czech Republic
    BMC Nephrol 14:6. 2013
    ..IgA nephropathy (IgAN) is the most common glomerulonephritis, which may also coexist with other diseases. We present two patients with an unusual coincidence of IgAN and Fabry disease (FD)...
  27. doi request reprint Prevalence and risk of hypertension in renal disease--data from the Czech Registry of Renal Biopsies
    Eva Jancova
    Department of Nephrology, General Teaching Hospital and Charles University, 1st Faculty of Medicine, Prague, Czech Republic
    Kidney Blood Press Res 31:135-42. 2008
    ....
  28. doi request reprint Placental growth factor in patients with decreased renal function
    Oskar Zakiyanov
    Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Ren Fail 33:291-7. 2011
    ..The aim of this study was to determine PlGF levels and describe their relationship to renal function and risk factors of atherogenesis in patients with decreased renal function...
  29. doi request reprint Reduced number of endothelial progenitor cells is predictive of early relapse in anti-neutrophil cytoplasmic antibody-associated vasculitis
    Jakub Zavada
    Department of Nephrology, Charles University in Prague, Czech Republic
    Rheumatology (Oxford) 48:1197-201. 2009
    ..We hypothesized that decreased capacity for endothelial regeneration paralleled by low EPC numbers could increase the risk of relapse in patients with AAV...
  30. ncbi request reprint Antiphospholipid antibodies in patients with lupus nephritis
    Lenka Fialova
    Institute for Medical Biochemistry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Ren Fail 25:747-58. 2003
    ..The synthesis of aPL can reflect the spreading of the autoimmune response for several antigens modified on the vessel wall...
  31. ncbi request reprint Pathobiochemistry of nephrotic syndrome
    Vladimir Tesar
    First Department of Medicine, Division of Nephrology, First Faculty of Medicine and University Hospital, Prague, Czech Republic
    Adv Clin Chem 37:173-218. 2003
    ....
  32. doi request reprint Associations of serum levels of advanced glycation end products with nutrition markers and anemia in patients with chronic kidney disease
    Markéta Kratochvilová
    Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Ren Fail 33:131-7. 2011
    ..However, their relation to nutrition, anemia, and micro inflammation is not well characterized. The aim of this study is to determine their relationship in patients with chronic kidney disease (CKD)...
  33. doi request reprint Association of advanced vasculopathy and transforming growth factor-beta1 gene expression with immunoglobulin A nephropathy progression
    Irena Brabcova
    Transplant Laboratory, Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Nephrol Dial Transplant 26:573-9. 2011
    ..The mechanism of IgA nephropathy (IgAN) progression remains ill-defined. In this prospective study, the prognostic role of clinical, histological and molecular markers over a 2-year follow-up was evaluated...
  34. doi request reprint Outcome of thirty patients with ANCA-associated renal vasculitis admitted to the intensive care unit
    Doubravka Frausova
    Department of Nephrology, General Teaching Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic
    Ren Fail 30:890-5. 2008
    ..While active vasculitis is the most frequent reason for ICU admission, the mortality rate is highest in patients with infectious complications...
  35. ncbi request reprint Recent progress in the pathogenesis of nephrotic proteinuria
    Vladimir Tesar
    Department of Nephrology, 1st School of Medicine and University Hospital, Charles University, Prague, Czech Republic
    Crit Rev Clin Lab Sci 45:139-220. 2008
    ....
  36. doi request reprint Treatment of proliferative lupus nephritis: a slowly changing landscape
    Vladimir Tesar
    Department of Nephrology, 1st School of Medicine and General University Hospital, Charles University, U nemocnice 2, 128 08 Prague 2, Czech Republic
    Nat Rev Nephrol 7:96-109. 2011
    ..Treatment of lupus nephritis should be individually tailored to patients, with more aggressive therapy reserved for patients at high risk of renal dysfunction and progression of renal disease...
  37. ncbi request reprint Biosimilars and renal health care in the countries of Central and Eastern Europe
    Vladimir Tesar
    Department of Nephrology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Kidney Blood Press Res 30:2-5. 2007
  38. doi request reprint Study of urinary proteomes in Anderson-Fabry disease
    Lucie Vojtová
    Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Ren Fail 32:1202-9. 2010
    ..The main aim of this work was to investigate possible differences in urine proteins between healthy controls and AFD patients and to identify abnormal proteins as potential biomarkers of disease...
  39. doi request reprint Pregnancy-associated plasma protein A: spotlight on kidney diseases
    Marta Kalousova
    Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Clin Chem Lab Med 50:1183-90. 2012
    ..Various assays for PAPP-A exist and the type of assay used in a study should be considered. This article reviews the data summarizing basic information about PAPP-A with a particular focus on the significance of PAPP-A in renal diseases...
  40. ncbi request reprint The protective effects of erythropoietin on rat glomerular podocytes in culture are modulated by extracellular matrix proteins
    Jan Krtil
    Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Kidney Blood Press Res 38:142-55. 2013
    ..Erythropoietin (EPO) is thought to protect podocytes in vivo. Here, we studied how various types of extracellular matrix (ECM) proteins and EPO affect podocytes in culture...
  41. ncbi request reprint Receptor for advanced glycation end products--soluble form and gene polymorphisms in chronic haemodialysis patients
    Marta Kalousova
    Institute of Clinical Chemistry and Laboratory Diagnostics, Department of Nephrology, 1st Faculty of Medicine and General University Hospital, Charles University, Karlovo nam 32, 121 11 Prague 2, Czech Republic
    Nephrol Dial Transplant 22:2020-6. 2007
    ..The pathological effects mediated via RAGE are physiologically inhibited by soluble RAGE (sRAGE). Our aim was to study sRAGE and RAGE gene polymorphisms in haemodialysis (HD) patients...
  42. ncbi request reprint Mycophenolate mofetil in low doses stabilizes and improves antineutrophil cytoplasmic antibody-associated vasculitis and lupus nephritis
    Marketa Kazderova
    Department of Nephrology, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
    Arch Med Res 39:115-9. 2008
    ..Clinical experience with mycophenolate mofetil (MMF) in glomerulonephritis still remains limited...
  43. ncbi request reprint Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats
    Věra Čertíková Chábová
    Department of Nephrology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Vascul Pharmacol 47:145-59. 2007
    ..Our data suggest that altered production and/or action of CYP-derived metabolites play a permissive role in the development and maintenance of hypertension in TGR by enhancing ANG II-induced vasoconstriction...
  44. doi request reprint Effect of preload reduction by hemodialysis on conventional and novel echocardiographic parameters of left ventricular structure and function
    Tomas Palecek
    2nd Medical Department Clinical Department of Cardiology and Angiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Echocardiography 25:162-8. 2008
    ..Therefore we aimed to investigate the effect of acute preload reduction induced by HD on conventional and novel parameters of LV structure and function...