S Svacina

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. ncbi Treatment of obese diabetics
    Stepan Svacina
    3rd Department ofMedicine, Charles University, 1st Medical Faculty, Katerinská, Prague, Czech Republic
    Adv Exp Med Biol 771:459-64. 2012
  2. ncbi [Hypoglycaemia--a phenomenon over which modern diabetology manages to prevail]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 58:751-4. 2012
  3. ncbi [Incretin therapy and the metabolic syndrome]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 57:417-21. 2011
  4. ncbi [System renin-aldosterone in fat tissue and other organ and tissues]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 54:508-10. 2008
  5. ncbi [Importance of the structure of insulin preparations for clinical practice]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 55:409-11. 2009
  6. ncbi [Diabetic osteopathy: previously disputed but most likely important ailment]
    S Svacina
    IIl interní klinika 1 Iékarské fakulty UKa VFN Praha
    Vnitr Lek 56:736-8. 2010
  7. ncbi [Potential new antidiabetics for the next decade]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 55:429-33. 2009
  8. ncbi [Diabetes mellitus, antidiabetics and bone]
    Stepan Svacina
    Univerzita Karlova v Praze, 1 lékarská fakulta, III interni klinika VFN
    Cas Lek Cesk 149:282-4. 2010
  9. ncbi [Respiratory infections and inhalation insulin therapy]
    S Svacina
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 52:426-8. 2006
  10. ncbi [Metabolic PPAR nuclear receptors and skin]
    S Svacina
    III interní klinika 1 1ékarské fakulty UK a VFN, Praha
    Vnitr Lek 52:451-3. 2006

Collaborators

Detail Information

Publications56

  1. ncbi Treatment of obese diabetics
    Stepan Svacina
    3rd Department ofMedicine, Charles University, 1st Medical Faculty, Katerinská, Prague, Czech Republic
    Adv Exp Med Biol 771:459-64. 2012
    ....
  2. ncbi [Hypoglycaemia--a phenomenon over which modern diabetology manages to prevail]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 58:751-4. 2012
    ..Key words: cardiovascular risk - insulin therapy - incretin therapy - oral antidiabetic medication - insulin analogues...
  3. ncbi [Incretin therapy and the metabolic syndrome]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 57:417-21. 2011
    ..Both groups of drugs are expected to have positive cardiovascular effects, although it is not clear whether these are likely to be direct or indirect, i.e. facilitated by improved compensation of metabolic syndrome components...
  4. ncbi [System renin-aldosterone in fat tissue and other organ and tissues]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 54:508-10. 2008
    ..Between systemic approach to obesity a new phenomenon of organ obesity is coming - adipokines from local fat cells can influence organ and tissue function e.g. in essential hypertension...
  5. ncbi [Importance of the structure of insulin preparations for clinical practice]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 55:409-11. 2009
    ..The necessary effect extension is achieved by similar technological changes, also with so-called incretin mimetics...
  6. ncbi [Diabetic osteopathy: previously disputed but most likely important ailment]
    S Svacina
    IIl interní klinika 1 Iékarské fakulty UKa VFN Praha
    Vnitr Lek 56:736-8. 2010
    ..This risk can be positively and negatively modified by antidiabetic drugs. It is important to find some markers for fracture risk in diabetes. Nowadays only bone densitometry can be used with some limitations to quantify this risk...
  7. ncbi [Potential new antidiabetics for the next decade]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 55:429-33. 2009
    ..In diabetology, antibodies against receptors will be used, too. However, modern pharmacotherapy will undoubtedly come up against the principles of so-called metabolic surgery and other successful technological procedures...
  8. ncbi [Diabetes mellitus, antidiabetics and bone]
    Stepan Svacina
    Univerzita Karlova v Praze, 1 lékarská fakulta, III interni klinika VFN
    Cas Lek Cesk 149:282-4. 2010
    ..Very interesting and also promising is the effect of glucagon like peptide-1 and the new antidiabetic drug class- incretin analogues on bone metabolism...
  9. ncbi [Respiratory infections and inhalation insulin therapy]
    S Svacina
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 52:426-8. 2006
    ..Insulin is more absorbed in smokers. The research of inhalation insulin brought again attention to diabetic pneumopathy. This disease has no clinical importance as has no relation to inhalation insulin therapy...
  10. ncbi [Metabolic PPAR nuclear receptors and skin]
    S Svacina
    III interní klinika 1 1ékarské fakulty UK a VFN, Praha
    Vnitr Lek 52:451-3. 2006
    ..Dermatology will be after internal medicine the second field where influencing of PPAR receptors will be very important...
  11. ncbi [Colorectal cancer and diabetes]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 57:378-80. 2011
    ..The most important current preventive clinical measure is colonoscopy. Type 2 diabetes patients should be considered as a risk group and thus prevention should be targeted at these patients...
  12. ncbi [Side effects of pharmacotherapy on lipid levels]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 53:408-11. 2007
    ..The article provides an overview of some of the drug groups provoking dyslipidemia, as well as an overview of drugs with a positive effect on dyslipidemia...
  13. ncbi [Is there any relation between diabetes therapy and cancer risk?]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 57:760-3. 2011
    ..The large discussion in many publications shows the important role of FDA and EMA. This agencies do not suspend drugs without consistent evaluation of results...
  14. ncbi [Olfaction and gustation in diabetes]
    S Svacina
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 53:483-5. 2007
    ..Pathology of olfaction and gustation can play a role in the pathogenesis of diabetes and its complications. Olfaction and gustation could be also a target of diabetes therapy in the future...
  15. ncbi [Metabolic importance of muscles and the role of sports in diabetic patients]
    S Svacina
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 53:545-7. 2007
    ..Dosing scheme for insulin and diet was published for sporting in diabetes. Most important is individual selfmonitoring and adjustment of therapy during sporting activities...
  16. ncbi [Tumours of kidneys, urinary bladder and prostate in obesity and diabetes]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 54:464-7. 2008
    ..Urinary tract cancers have no relation to type 1 diabetes. We have found 3.9 time higher risk of kidney cancer in Czech diabetic patients...
  17. ncbi Influence of metabolic state and diabetes on the outcome at the end of first year after gastric banding
    K Nedelnikova
    1st Surgical Department of the 1st Medical Faculty, Charles University, Prague, Czech Republic
    Obes Surg 10:372-5. 2000
    ..The influence of metabolic state and the presence of diabetes before surgery on the weight changes following non-adjustable gastric banding, were studied...
  18. ncbi The influence of short-term fasting on serum leptin levels, and selected hormonal and metabolic parameters in morbidly obese and lean females
    M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University and University Hospital, Prague, Czech Republic
    Endocr Res 27:251-60. 2001
    ..The drop of serum leptin levels after 24-h starvation is significantly blunted in obese compared to lean subjects. The reason for the difference is probably the insulin resistance possibly further modified by different DHEA-S levels...
  19. ncbi Serum adipocyte fatty acid binding protein levels in patients with type 2 diabetes mellitus and obesity: the influence of fenofibrate treatment
    M M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 58:93-9. 2009
    ..This combination makes FABP a valuable marker of metabolic disturbances in patients with type 2 diabetes mellitus...
  20. ncbi Cardiac surgery increases serum concentrations of adipocyte fatty acid-binding protein and its mRNA expression in circulating monocytes but not in adipose tissue
    T Kotulak
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 63:83-94. 2014
    ..Our data suggest that circulating A-FABP might be involved in the development of acute perioperative stress response, insulin resistance and hyperglycemia of critically ill irrespectively of the presence of diabetes mellitus. ..
  21. ncbi Glucose metabolism in a patient with insulinoma complicated by hyperosmolar non-ketotic state
    J Skrha
    Department of Internal Medicine 3, Faculty of Medicine, Charles University, Prague, Czechoslovakia
    Diabet Med 7:361-3. 1990
    ..The hyperosmolar state was induced by vomiting and dehydration during an acute urinary tract infection. Impairment of glucose metabolism was confirmed by the finding of reduced tissue sensitivity to insulin during a euglycaemic clamp...
  22. ncbi [Obesity, type 2 diabetes and their quantitative relation]
    S Svacina
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 48:500-6. 2002
    ..Even slight body weight reduction by 5-10%, within the reach of everybody, influences in a fundamental way the incidence and compensation of diabetes as well as other components of the metabolic syndrome...
  23. ncbi The effect of very-low-calorie diet on mRNA expression of inflammation-related genes in subcutaneous adipose tissue and peripheral monocytes of obese patients with type 2 diabetes mellitus
    M Mraz
    Third Department of Medicine, General University Hospital and First Medical Faculty, Charles University, 128 08 Prague 2, Czech Republic
    J Clin Endocrinol Metab 96:E606-13. 2011
    ..Low-grade inflammation links obesity, type 2 diabetes mellitus (T2DM), and cardiovascular diseases...
  24. ncbi Post-exercise changes of beta hydroxybutyrate as a predictor of weight changes
    M Matoulek
    Third Internal Medicine Clinic, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Physiol Res 63:S321-5. 2014
    ..299; p=0.03). Serum BOHB increase after the single exercise may detect individuals with an ability to induce lipolysis in three-month program of physical activity for obese patients. ..
  25. ncbi Our experience with antidepressant treatment in the obese and type 2 diabetics
    S Svacina
    Third Medical Department, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Prague Med Rep 106:291-6. 2005
    ..In diabetics, antidepressants reduce glucose levels, too. Their influence on weight and diabetes compensation is, however, smaller than in "classic" anti-obesity drugs, sibutramine and orlistat...
  26. ncbi Increased circulating and epicardial adipose tissue mRNA expression of fibroblast growth factor-21 after cardiac surgery: possible role in postoperative inflammatory response and insulin resistance
    T Kotulak
    Department of Anesthesia and Resuscitation, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 60:757-67. 2011
    ..Muscle FGF-21 mRNA positively correlated with blood glucose levels at the end of the surgery. Our data suggest a possible role of FGF-21 in the regulation of glucose metabolism and insulin sensitivity in surgery-related stress...
  27. ncbi [Metabolic syndrome and skin diseases]
    S Svacina
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 147:307-10. 2008
    ..Even more important is the fact that physical activity, weight loss and diet treatment can have a common positive effect on both diseases. Also some drugs can influence both diseases together...
  28. ncbi [Metformin as the first line antidiabetic agent]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 56:1225-7. 2010
    ..Since diabetes patients live with increased cardiovascular risk, it is important to continuously remind ourselves of the positive cardiovascular effects of metformin...
  29. ncbi [Obesity treatment in metabolic syndrome patients]
    S Svacina
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 55:622-5. 2009
    ..Bariatric surgery decreases significantly mortality of obese patients with metabolic syndrome. It is likely that mortality reduction following the use of anti-obesity agents will soon be proven as well...
  30. ncbi [The treatment of hyperglycaemia in critically ill patients: comparison of standard protocol and computer algorithm]
    J Kremen
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 53:1269-73. 2007
    ..The aim of our study was comparison of standard protocol of intensive insulin therapy used on cardiac surgery ICU in General University Hospital in Prague and computer algorithm MPC (Model Predictive Control)...
  31. ncbi [Antihyperglycaemic treatment and vascular diseases]
    S Svacina
    III interni klinika 1, lékarské fakulty UK a VFN Praha
    Vnitr Lek 56:313-6. 2010
    ..5. There is no doubt about the importance of hyperglycaemia correction in prevention of cardiovascular diseases in type 1 diabetes patients...
  32. ncbi 60 years of the Third Medical Department of the First Faculty of Medicine and General Teaching Hospital
    S Svacina
    Third Medical Department, First Faculty of Medicine, Charles University in Prague, General Teaching Hospital, Czech Republic
    Prague Med Rep 106:318-20. 2005
  33. ncbi [There is nothing better than impact factor and citation rate]
    S Svacina
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 145:966; discussion 967. 2006
  34. ncbi Coming of Jesuits to Czech lands and the present
    S Svacina
    Third Medical Department, First Faculty of Medicine, Charles University, General Teaching Hospital, Prague, Czech Republic
    Prague Med Rep 107:370-3. 2006
  35. ncbi Two endocrinological anniversaries
    S Svacina
    Third Medical Department Clinical Department of Endocrinology and Metabolism of the First Faculty of Medicine, Charles University in Prague, and General Teaching Hospital, Czech Republic
    Prague Med Rep 105:423-31. 2004
    ..On June 29, 2004, professor Schreiber himself, still full of vigour celebrated his 80th birthday. That day, too, is a significant anniversary in the history of Czech endocrinology...
  36. ncbi [New perspectives in modulation of PPAR nuclear receptors]
    S Svacina
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 143:731-3. 2004
    ..Drugs influencing PPAR will be used in future in dermatology, surgery, obesitology, oncology, gastroenterology and also in neurology and psychiatry...
  37. ncbi [Is there any role for gastric balloon in obesity treatment?]
    S Svacina
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 146:642-6. 2007
    ..This initial balloon-induced weight loss does not treat obesity definitely, but is used as a preoperative preparation for surgical obesity treatment...
  38. ncbi [Nutrigenetics and nutrigenomics]
    S Svacina
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 146:837-9. 2007
    ..In the future both, nutrigenetics a nutrigenomics, will induce many changes in preventive and also in clinical medicine...
  39. ncbi [Gynecologic complications in obesity]
    S Svacina
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 48:1151-4. 2002
    ..The author emphasizes the importance of weight reduction in the treatment of sterility and for the prevention of gynaecological tumours. An increase of body weight must be prevented in gynaecological hormonal treatment and contraception...
  40. ncbi Comparison of lipid lowering effect of sibutramine in patients treated or not treated with statins--3 month follow-up
    S Svacina
    Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Third Medical Department, Prague, Czech Republic
    Prague Med Rep 108:333-8. 2007
    ..We can therefore preliminarily conclude that sibutramine therapy has significant positive effect on the lipid profile even in patients who were started on statins prior to initiation of sibutramine treatment...
  41. ncbi Prolonged oral glucose tolerance test combined with indirect calorimetry and estimation of several substrates and hormones in obese subjects
    J Sonka
    Laboratory for Endocrinology and Metabolism, Ist Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 39:39-47. 1993
    ..The rather stable values of indirect calorimetry indicate that energy metabolism of obese subject works on a low, pre-set level-independently on the supply of some relevant hormones and substrates...
  42. ncbi Comparisin of low energy breakfast based on special egg white spread product with a standard breakfast
    J Housova
    Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Third Medical Department, Department of Endocrinology and Metabolism, Prague, Czech Republic
    Prague Med Rep 109:127-33. 2008
    ..A special spread based on egg white was used (Energy content per 100 g: 319 kJ versus 802 kJ, fat content 1.15 g versus 15 g). Egg white derived products are widely used for weight reduction in Czech Republic...
  43. ncbi Does impedance measure a functional state of the body fat?
    R Větrovská
    Third Department of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
    Physiol Res 63:S309-20. 2014
    ..We hypothesize that BIA methods could also measure some other physiopathological conditions like inflammation, hydration or cell infiltration of fat. ..
  44. ncbi [Gastrointestinal tract cancer and diabetes mellitus]
    S Svacina
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 50:386-91. 2004
    ..Type II diabetes mellitus should be considered as a risk factor especially for colorectal cancer, liver cancer, and pancreas cancer. In type I diabetics no risk of gastrointestinal tract cancers was proved...
  45. ncbi [Gastric banding and diabetes mellitus]
    S Svacina
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 50:371-4. 2004
    ..This important treatment option is still passed by our diabetologists. Gastric banding is not indicated for type I diabetes...
  46. ncbi [Metabolic aspects of the polycystic ovary syndrome]
    S Svacina
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 48:1142-6. 2002
    ..The polycystic ovaries syndrome is nowadays unequivocally an atherogenic syndrome and is a unit very close to Reaven's metabolic syndrome X or is part of this syndrome...
  47. ncbi Second derivative of the finger arterial pressure waveform: an insight into dynamics of the peripheral arterial pressure pulse
    J Simek
    Third Department of Internal Medicine, First School of Medicine, General University Hospital, Charles University, Prague, Czech Republic
    Physiol Res 54:505-13. 2005
    ..001 and 0.021, respectively). Therefore, B/A and C/A provide additional information about simple clinical characteristics and might reflect the structural alteration of the arterial wall in hypertensive subjects...
  48. ncbi [New trends in diabetology]
    S Svacina
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 50:S76-80. 2004
    ..Extreme incidence of diabetes is stimulating new technologies development in diabetology...
  49. ncbi The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women
    M Kunesova
    Obesity Management Centre, Institute of Endocrinology, Charles University, Prague 1, Czech Republic
    Physiol Res 55:63-72. 2006
    ..595, p<0.008). The results suggest that long chain n-3 PUFA enhance weight loss in obese females treated by VLCD. Docosahexaenoate (22:6n-3) seems to be the active component...
  50. ncbi [Monitoring of glucose concentration in critical patients, comparing arterial blood glucose concentrations and interstitial glucose concentration measured by microdialysis technique]
    J Kremen
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 52:777-81. 2006
    ....
  51. ncbi [Regular aerobic physical activity improves the lipid profile in persons with excessive body weight]
    Z Stránská
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 53:404-7. 2007
    ..A significant decrease was found in both HDL-cholesterol, triglycerides and the atherosclerosis index. No significant changes were recorded in the total and LDL-cholesterol level...
  52. ncbi [Pilot study to evaluate blood glucose control by a model predictive control algorithm with variable sampling rate vs. routine glucose management protocol in peri- and postoperative period in cardiac surgery patients]
    T Roubicek
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 146:868-73. 2007
    ..Recent studies have shown that the normalization of glycemia by intensive insulin therapy decreases mortality, length of the hospitalization and number of complications...
  53. ncbi The effects of orlistat treatment interruption on weight and associated metabolic parameters
    K Owen
    Third Medical Department of the First Faculty of Medicine, Charles University in Prague, General Teaching Hospital, Czech Republic
    Prague Med Rep 107:394-400. 2006
    ....
  54. ncbi Levels of adhesion molecules bear a relationship to triglyceride levels in type 2 diabetic subjects with proven silent ischemia
    A Adamikova
    Diabetes Center, WHO Collaborating Center, Bata Hospital, Zlin, Czech Republic
    Int Angiol 27:307-12. 2008
    ..The aim of the study was to examine the levels of adhesion molecules, high-sensitivity C-reactive protein (hs-CRP) and lipid spectrum of type 2 diabetic subjects with proven silent myocardial ischemia...
  55. ncbi [Low birth weight and delayed risk of type 2 diabetes and metabolic syndrome]
    S Svacina
    III interní klinika klinika endokrinologie a metabolismu 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 49:952-5. 2003
    ..Detection of all these phenomena is important in selecting patients in diabetes and cardiovascular risk for preventive intervention...
  56. ncbi [C-reactive protein]
    S Svacina
    Vnitr Lek 52:1004-5. 2006