Research Topics
Species | Alena SkalovaSummaryAffiliation: Charles University Country: Czech Republic Publications
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Publications
Sinonasal tubulopapillary low-grade adenocarcinoma. Histopathological, immunohistochemical and ultrastructural features of poorly recognised entityA Skalova
Medical Faculty Hospital, Charles University, Alej Svobody 80, 323 18 Plzen, Czech Republic
Virchows Arch 443:152-8. 2003....
Pleomorphic adenoma of the salivary glands with intravascular tumor deposits: a diagnostic pitfallAlena Skalova
Department of Pathology, Charles University, Faculty of Medicine in Plzen, Czech Republic
Am J Surg Pathol 36:1674-82. 2012....
HER3 and downstream pathways are involved in colonization of brain metastases from breast cancerLeonard Da Silva
Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
Breast Cancer Res 12:R46. 2010..Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear...- Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glandsA Skalova
Department of Pathology, Medical Faculty, Charles University, Pilsen, Czech Republic
Virchows Arch 434:537-46. 1999..We describe some unusual histological features associated with onococytic metaplasia in benign myoepithelial cell-derived salivary gland tumours, hoping to help to avoid the overdiagnosis of malignancy... - [Cystic hypersecretory carcinoma: rare and potentially aggressive variant of intraductal carcinoma of the breast. Report of five cases]A Skalova
Siklův patologicko anatomický ustav LF UK, Plzen
Ceska Gynekol 70:73-8. 2005..To describe a poorly recognized histological and immunohistochemical features of cystic hypersecretory carcinoma of breast, including the overexpression of HER-2/neu protein and androgen receptors... - [Comment on the new WHO classification of salivary gland tumors]A Skalova
Siklův patologicko anatomický ustav LF UK, Plzen
Cesk Patol 41:60-5. 2005 - Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a markerAlena Skalova
Department of Pathology, Medical Faculty Hospital, Charles University, Plzen, Czech Republic
Am J Surg Pathol 30:939-44. 2006..We therefore conclude that the findings in the present study are further supporting evidence that SPA is a neoplasm, and not just a reactive process... - Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL geneA Skalova
Department of Pathology, Medical Faculty of Charles University, Pilsen, Czech Republic
Pathol Res Pract 204:599-606. 2008..This mutation is a C to T exchange at position 194, resulting in amino acid exchange S65L. No mutation was found in any of the three exons analyzed and in the exon-intron junctions of the VHL gene in the sporadic case... - Acinic cell carcinoma with high-grade transformation: a report of 9 cases with immunohistochemical study and analysis of TP53 and HER-2/neu genesAlena Skalova
Department of Pathology, Charles University in Prague, Faculty of Medicine, 305 99 Pilsen, Czech Republic
Am J Surg Pathol 33:1137-45. 2009..Six of 9 patients (66%) died from tumor dissemination, all with a median overall survival of 4.3 years (range: 1 to 9 y). The high propensity for LN metastases indicates the need for neck dissection at the time of diagnosis... - Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entityAlena Skalova
Department of Pathology, Charles University, Pilsen, Czech Republic
Am J Surg Pathol 34:599-608. 2010..Thus, our results strongly support the concept that MASC and AciCC are different entities... - Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entityAlena Skalova
Department of Pathology, Charles University Prague, Faculty of Medicine in Pilsen, Pilsen, Czech Republic
Am J Surg Pathol 35:1168-76. 2011..Twelve patients are alive with no evidence of recurrent or metastatic disease after treatment, 1 patient died 2 years after surgery without evidence of tumor, and 1 patient is alive with recurrent tumor of the palate... - Cystic hypersecretory carcinoma: rare and poorly recognized variant of intraductal carcinoma of the breast. Report of five casesA Skalova
Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
Histopathology 46:43-9. 2005..To report five cases of a rare variant of intraductal carcinoma of the breast, so-called cystic hypersecretory carcinoma. The clinical and pathological characteristics of the lesion are described, along with a review of the literature... - Salivary duct carcinoma--a highly aggressive salivary gland tumor with HER-2/neu oncoprotein overexpressionA Skalova
Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
Pathol Res Pract 197:621-6. 2001..Thus, our study suggests that anti-HER2/neu therapy with Herceptin is beneficial for patients with aggressive salivary duct carcinoma... - Spindle cell myoepithelial tumours of the parotid gland with extensive lipomatous metaplasia. A report of four cases with immunohistochemical and ultrastructural findingsA Skalova
Sikl s Department of Pathology, Medical Faculty Hospital, Plzen, Czech Republic
Virchows Arch 439:762-7. 2001..A possible pathogenesis is proposed of true metaplastic transformation of myoepithelial cells to adipocytes. This lesion is important to identify correctly, as inadequate surgery can lead to recurrence... - Oncocytic cystadenoma of the parotid gland with tyrosine-rich crystalsA Skalova
Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
Pathol Res Pract 196:849-51. 2000..A case of benign oncocytic cystadenoma with abundant intraluminal tyrosine-rich crystals involving the parotid gland is described... - Sclerosing polycystic adenosis of parotid gland with dysplasia and ductal carcinoma in situ. Report of three cases with immunohistochemical and ultrastructural examinationA Skalova
Department of Pathology, Medical Faculty of Charles University, Plzen, Czech Republic
Virchows Arch 440:29-35. 2002..In addition, all our cases showed foci of dysplasia of the ductal epithelium, which in one case was severe enough to amount to carcinoma in situ. This feature that has not previously been reported in SPA... - Expression of HER-2/neu gene and protein in salivary duct carcinomas of parotid gland as revealed by fluorescence in-situ hybridization and immunohistochemistryA Skalova
Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
Histopathology 42:348-56. 2003..However, correlation between IHC and molecular genetic analysis of HER-2/neu in salivary duct carcinoma has not yet been performed... - [Amplification and overexpression of HER-2/neu in parotid gland salivary duct carcinoma. Immunohistochemical study and fluorescence in situ hybridization]A Skalova
Patologicko anatomický ústav, Lékarská fakulta Univerzity Karlovy, Plzen
Cesk Patol 38:27-34. 2002..There was no difference in outcome of patients with IHC positive-nonamplified and IHC positive-amplified tumours... - [Detection of HER-2/neu in breast carcinoma]A Skalova
Patologicko anatomický ústav LF UK, Bioptická laborator s r o, Plzen
Cas Lek Cesk 142:93-8. 2003..Following these developments, demand for pathologists to evaluating properly HER-2/neu in breast cancer specimens has been rapidly increasing... - Aggressive angiomyxoma presenting as polyp of uterine cavityA Skalova
Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
Pathol Res Pract 196:719-25. 2000..Immunohistochemical and ultrastructural findings support the conclusion that the progenitor cell displays myofibroblastic and fibroblastic features, with a capacity for smooth muscle differentiation... - Malignancy-simulating change in parotid gland oncocytoma following fine needle aspiration. Report of 3 casesA Skalova
Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
Pathol Res Pract 195:399-405. 1999..This report provides another, previously undescribed, example of a diagnostic pitfall that may be observed in histologic tissue specimens removed after FNA of oncocytic tumors... - Cutaneous apocrine mixed tumor with intravascular tumor deposits: a diagnostic pitfallDmitry V Kazakov
Sikl s Department of Pathology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic
Am J Dermatopathol 33:775-9. 2011..At present, its significance is not completely clear. Until proved otherwise in future, we suggest to consider intravascular deposits in cutaneous apocrine mixed tumors as an innocuous phenomenon... - Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD geneDmitry V Kazakov
Sikl s Department of Pathology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic
Hum Pathol 40:1499-503. 2009..Analysis of the CYLD gene revealed polymorphisms. This is the first report of a "dermal analogue tumor" of the salivary gland that resembled a cutaneous spiradenoma and not a cylindroma... - Microglandular adenocarcinoma of the uterus mimicking microglandular cervical hyperplasiaMichal Zamecnik
Sikl's Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic
Ann Diagn Pathol 7:180-6. 2003..Our case shows the difficulties in the diagnosis of this lesion and confirms a low aggressiveness that was observed in all 10 cases described to date... - Epidermolysis bullosa acquisita-like reaction associated with penicillamine therapy for sclerodermatous graft-versus-host diseasePetra Cetkovska
Department of Dermatology, Charles University Hospital, Dr E Benese 13, 305 99 Pilsen, Czech Republic
J Am Acad Dermatol 49:1157-9. 2003..The surprisingly early onset of this eruption in lesions of sclerodermatous graft-versus-host disease might have been due to severe immune alteration... - The importance of prognostic factors in premenopausal women with breast cancerJ Finek
Department of Oncology, University Hospital and Medical Faculty, Pilsen, Czech Republic
Anticancer Res 27:1893-6. 2007..We evaluated individual prognostic factors (age, histology, TNM classification, ER, PR, CA 15-3, CEA, HER2) and their impact on disease-free survival (DFS) and overall survival (OS) during the 5-year follow-up period... - Angiomatoid change in polyps of the nasal and paranasal regions: an underrecognized and commonly misdiagnosed lesion--report of 45 casesLadislav Hadravsky
Department of Pathology, Medical Faculty, Charles University in Prague, Plzen, Czech Republic
Virchows Arch 460:203-9. 2012..APNPRs sometimes cause severe changes of the skeletal bones especially in recurrent lesions. Awareness of the above described features and familiarity with the clinical presentation of APNPRs is the best way to avoid a misdiagnosis... - Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entityAshton Connor
Department of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada
Am J Surg Pathol 36:27-34. 2012..These findings reinforce MASC as a unique low-grade salivary gland tumor entity with morphologic overlap with AciCC, MEC, and cystadenocarcinoma... - Ulcerating Warthin's tumourIvo Starek
ENT Clinic, Medical Faculty Hospital, Olomouc, Czech Republic
Acta Otolaryngol 124:744-6. 2004..The main clinical pitfall of such an inflammatory skin disruption of an otherwise benign Warthin's tumour is that it may be mistaken for an infiltratively growing malignant lesion... - Lipomatous salivary gland tumors: a series of 31 cases spanning their morphologic spectrum with emphasis on sialolipoma and oncocytic lipoadenomaAbbas Agaimy
Institute of Pathology Institute of Diagnostic and Interventional Radiology Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Erlangen Laboratory for Dermatohistology and Oral Pathology, Munich Institute of Pathology, Klinikum Augsburg, Augsburg, Germany Sikl s Department of Pathology, Faculty of Medicine, Charles University, Pilsen, Czech Republic
Am J Surg Pathol 37:128-37. 2013..Oncocytic lipoadenoma is an epithelial-predominant tumor that is distinct from the fat-dominated nononcocytic sialolipoma, but the 2 types seem to merge in some cases... - Metastasizing middle ear carcinoid: an unusual case report, with focus on ultrastructural and immunohistochemical findingsRichard Salzman
ENT Department, Derriford Hospital, Plymouth, UK
Otol Neurotol 33:1418-21. 2012..There are only 4 unequivocal cases of metastasizing middle ear carcinoid previously reported... - Basaloid squamous carcinoma with collagenous spherules and crystalloidsM Zamecnik
Department of Pathology, Slovak Postgraduate Academy of Medicine, Bratislava, Slovak Republic
Ann Diagn Pathol 5:233-9. 2001....