Alena Skalova

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. ncbi request reprint Sinonasal tubulopapillary low-grade adenocarcinoma. Histopathological, immunohistochemical and ultrastructural features of poorly recognised entity
    A Skalova
    Medical Faculty Hospital, Charles University, Alej Svobody 80, 323 18 Plzen, Czech Republic
    Virchows Arch 443:152-8. 2003
  2. pmc Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity
    Alena Skalova
    Sikl s Department of Pathology, Faculty of Medicine in Pilsen, Faculty Hospital, Medical Faculty of Charles University, E Benese 13, 305 99 Plzen, Czech Republic
    Head Neck Pathol 7:S30-6. 2013
  3. ncbi request reprint Human papillomaviruses are not involved in the etiopathogenesis of salivary gland tumors
    Alena Skalova
    Department of Pathology, Charles University in Progue, Faculty of Medicine in Pilsen, Medical Faculty Hospital, Czech Republic
    Cesk Patol 49:72-5. 2013
  4. ncbi request reprint [Pleomorphic adenoma of salivary glands: diagnostic pitfalls and mimickers of malignancy]
    A Skalova
    Siklův ústav patologie, Univerzita Karlova v Praze, Lékarská fakulta v Plzni
    Cesk Patol 48:179-83. 2012
  5. doi request reprint Pleomorphic adenoma of the salivary glands with intravascular tumor deposits: a diagnostic pitfall
    Alena Skalova
    Department of Pathology, Charles University, Faculty of Medicine in Plzen, Czech Republic
    Am J Surg Pathol 36:1674-82. 2012
  6. pmc HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
    Leonard Da Silva
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
    Breast Cancer Res 12:R46. 2010
  7. ncbi request reprint Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands
    A Skalova
    Department of Pathology, Medical Faculty, Charles University, Pilsen, Czech Republic
    Virchows Arch 434:537-46. 1999
  8. ncbi request reprint [Cystic hypersecretory carcinoma: rare and potentially aggressive variant of intraductal carcinoma of the breast. Report of five cases]
    A Skalova
    Siklův patologicko anatomický ustav LF UK, Plzen
    Ceska Gynekol 70:73-8. 2005
  9. ncbi request reprint [Comment on the new WHO classification of salivary gland tumors]
    A Skalova
    Siklův patologicko anatomický ustav LF UK, Plzen
    Cesk Patol 41:60-5. 2005
  10. ncbi request reprint Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker
    Alena Skalova
    Department of Pathology, Medical Faculty Hospital, Charles University, Plzen, Czech Republic
    Am J Surg Pathol 30:939-44. 2006

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Sinonasal tubulopapillary low-grade adenocarcinoma. Histopathological, immunohistochemical and ultrastructural features of poorly recognised entity
    A Skalova
    Medical Faculty Hospital, Charles University, Alej Svobody 80, 323 18 Plzen, Czech Republic
    Virchows Arch 443:152-8. 2003
    ....
  2. pmc Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity
    Alena Skalova
    Sikl s Department of Pathology, Faculty of Medicine in Pilsen, Faculty Hospital, Medical Faculty of Charles University, E Benese 13, 305 99 Plzen, Czech Republic
    Head Neck Pathol 7:S30-6. 2013
    ..However, molecular testing is recommended at this time to arrive at the diagnosis of MASC. ..
  3. ncbi request reprint Human papillomaviruses are not involved in the etiopathogenesis of salivary gland tumors
    Alena Skalova
    Department of Pathology, Charles University in Progue, Faculty of Medicine in Pilsen, Medical Faculty Hospital, Czech Republic
    Cesk Patol 49:72-5. 2013
    ..Little is known, however, about the possible role of HPV in salivary gland tumors...
  4. ncbi request reprint [Pleomorphic adenoma of salivary glands: diagnostic pitfalls and mimickers of malignancy]
    A Skalova
    Siklův ústav patologie, Univerzita Karlova v Praze, Lékarská fakulta v Plzni
    Cesk Patol 48:179-83. 2012
    ..The most common pitfall in diagnosis of pleomorphic adenoma is so called "atypical PA" that must be distinguished from early malignant transformation to in situ-carcinoma ex pleomorphic adenoma...
  5. doi request reprint Pleomorphic adenoma of the salivary glands with intravascular tumor deposits: a diagnostic pitfall
    Alena Skalova
    Department of Pathology, Charles University, Faculty of Medicine in Plzen, Czech Republic
    Am J Surg Pathol 36:1674-82. 2012
    ....
  6. pmc HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
    Leonard Da Silva
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
    Breast Cancer Res 12:R46. 2010
    ..Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear...
  7. ncbi request reprint Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands
    A Skalova
    Department of Pathology, Medical Faculty, Charles University, Pilsen, Czech Republic
    Virchows Arch 434:537-46. 1999
    ..We describe some unusual histological features associated with onococytic metaplasia in benign myoepithelial cell-derived salivary gland tumours, hoping to help to avoid the overdiagnosis of malignancy...
  8. ncbi request reprint [Cystic hypersecretory carcinoma: rare and potentially aggressive variant of intraductal carcinoma of the breast. Report of five cases]
    A Skalova
    Siklův patologicko anatomický ustav LF UK, Plzen
    Ceska Gynekol 70:73-8. 2005
    ..To describe a poorly recognized histological and immunohistochemical features of cystic hypersecretory carcinoma of breast, including the overexpression of HER-2/neu protein and androgen receptors...
  9. ncbi request reprint [Comment on the new WHO classification of salivary gland tumors]
    A Skalova
    Siklův patologicko anatomický ustav LF UK, Plzen
    Cesk Patol 41:60-5. 2005
  10. ncbi request reprint Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker
    Alena Skalova
    Department of Pathology, Medical Faculty Hospital, Charles University, Plzen, Czech Republic
    Am J Surg Pathol 30:939-44. 2006
    ..We therefore conclude that the findings in the present study are further supporting evidence that SPA is a neoplasm, and not just a reactive process...
  11. doi request reprint Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene
    A Skalova
    Department of Pathology, Medical Faculty of Charles University, Pilsen, Czech Republic
    Pathol Res Pract 204:599-606. 2008
    ..This mutation is a C to T exchange at position 194, resulting in amino acid exchange S65L. No mutation was found in any of the three exons analyzed and in the exon-intron junctions of the VHL gene in the sporadic case...
  12. doi request reprint Acinic cell carcinoma with high-grade transformation: a report of 9 cases with immunohistochemical study and analysis of TP53 and HER-2/neu genes
    Alena Skalova
    Department of Pathology, Charles University in Prague, Faculty of Medicine, 305 99 Pilsen, Czech Republic
    Am J Surg Pathol 33:1137-45. 2009
    ..Six of 9 patients (66%) died from tumor dissemination, all with a median overall survival of 4.3 years (range: 1 to 9 y). The high propensity for LN metastases indicates the need for neck dissection at the time of diagnosis...
  13. doi request reprint Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity
    Alena Skalova
    Department of Pathology, Charles University, Pilsen, Czech Republic
    Am J Surg Pathol 34:599-608. 2010
    ..Thus, our results strongly support the concept that MASC and AciCC are different entities...
  14. doi request reprint Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity
    Alena Skalova
    Department of Pathology, Charles University Prague, Faculty of Medicine in Pilsen, Pilsen, Czech Republic
    Am J Surg Pathol 35:1168-76. 2011
    ..Twelve patients are alive with no evidence of recurrent or metastatic disease after treatment, 1 patient died 2 years after surgery without evidence of tumor, and 1 patient is alive with recurrent tumor of the palate...
  15. ncbi request reprint Cystic hypersecretory carcinoma: rare and poorly recognized variant of intraductal carcinoma of the breast. Report of five cases
    A Skalova
    Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
    Histopathology 46:43-9. 2005
    ..To report five cases of a rare variant of intraductal carcinoma of the breast, so-called cystic hypersecretory carcinoma. The clinical and pathological characteristics of the lesion are described, along with a review of the literature...
  16. ncbi request reprint Salivary duct carcinoma--a highly aggressive salivary gland tumor with HER-2/neu oncoprotein overexpression
    A Skalova
    Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
    Pathol Res Pract 197:621-6. 2001
    ..Thus, our study suggests that anti-HER2/neu therapy with Herceptin is beneficial for patients with aggressive salivary duct carcinoma...
  17. ncbi request reprint Expression of HER-2/neu gene and protein in salivary duct carcinomas of parotid gland as revealed by fluorescence in-situ hybridization and immunohistochemistry
    A Skalova
    Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
    Histopathology 42:348-56. 2003
    ..However, correlation between IHC and molecular genetic analysis of HER-2/neu in salivary duct carcinoma has not yet been performed...
  18. ncbi request reprint Spindle cell myoepithelial tumours of the parotid gland with extensive lipomatous metaplasia. A report of four cases with immunohistochemical and ultrastructural findings
    A Skalova
    Sikl s Department of Pathology, Medical Faculty Hospital, Plzen, Czech Republic
    Virchows Arch 439:762-7. 2001
    ..A possible pathogenesis is proposed of true metaplastic transformation of myoepithelial cells to adipocytes. This lesion is important to identify correctly, as inadequate surgery can lead to recurrence...
  19. ncbi request reprint [Amplification and overexpression of HER-2/neu in parotid gland salivary duct carcinoma. Immunohistochemical study and fluorescence in situ hybridization]
    A Skalova
    Patologicko anatomický ústav, Lékarská fakulta Univerzity Karlovy, Plzen
    Cesk Patol 38:27-34. 2002
    ..There was no difference in outcome of patients with IHC positive-nonamplified and IHC positive-amplified tumours...
  20. ncbi request reprint Sclerosing polycystic adenosis of parotid gland with dysplasia and ductal carcinoma in situ. Report of three cases with immunohistochemical and ultrastructural examination
    A Skalova
    Department of Pathology, Medical Faculty of Charles University, Plzen, Czech Republic
    Virchows Arch 440:29-35. 2002
    ..In addition, all our cases showed foci of dysplasia of the ductal epithelium, which in one case was severe enough to amount to carcinoma in situ. This feature that has not previously been reported in SPA...
  21. ncbi request reprint [Detection of HER-2/neu in breast carcinoma]
    A Skalova
    Patologicko anatomický ústav LF UK, Bioptická laborator s r o, Plzen
    Cas Lek Cesk 142:93-8. 2003
    ..Following these developments, demand for pathologists to evaluating properly HER-2/neu in breast cancer specimens has been rapidly increasing...
  22. ncbi request reprint Oncocytic cystadenoma of the parotid gland with tyrosine-rich crystals
    A Skalova
    Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
    Pathol Res Pract 196:849-51. 2000
    ..A case of benign oncocytic cystadenoma with abundant intraluminal tyrosine-rich crystals involving the parotid gland is described...
  23. ncbi request reprint Aggressive angiomyxoma presenting as polyp of uterine cavity
    A Skalova
    Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
    Pathol Res Pract 196:719-25. 2000
    ..Immunohistochemical and ultrastructural findings support the conclusion that the progenitor cell displays myofibroblastic and fibroblastic features, with a capacity for smooth muscle differentiation...
  24. ncbi request reprint Malignancy-simulating change in parotid gland oncocytoma following fine needle aspiration. Report of 3 cases
    A Skalova
    Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic
    Pathol Res Pract 195:399-405. 1999
    ..This report provides another, previously undescribed, example of a diagnostic pitfall that may be observed in histologic tissue specimens removed after FNA of oncocytic tumors...
  25. doi request reprint Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, β-catenin, EGFR, and CCND1 genes
    Alena Skalova
    Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague Bioptic Laboratory Ltd Bioptic Laboratory Ltd, Molecular Pathology Laboratory Department of Maxillofacial Surgery, Faculty of Medicine, Clinic of Dentistry, Plzen The Fingerland Department of Pathology, Faculty of Medicine and University Hospital, Charles University in Prague, Hradec Kralove, Czech Republic Department of Pathology, Medical University of Gdansk, Poland Department of Anatomical Pathology, University of Calgary and Foothills Medical Centre, Calgary, AB, Canada
    Am J Surg Pathol 38:23-33. 2014
    ..Recognizing HG-transformed MASC and testing for ETV6 rearrangement may be of potential value in patient treatment, because the presence of the ETV6-NTRK3 translocation may represent a therapeutic target in MASC. ..
  26. doi request reprint CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands
    Alena Skalova
    Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague Bioptic Laboratory Ltd Bioptic Laboratory Ltd, Molecular Pathology Laboratory Department of Maxillofacial Surgery, Clinic of Dentistry, Faculty of Medicine in Plzen, Plzen, Czech Republic Department of Anatomical Pathology, University of Calgary and Foothills Medical Center, Calgary, Canada Pathology Research Group, N N Alexandrov s Research Center of Oncology and Medical Radiology, Minsk, Republic of Belarus Department of Pathology, Medical University of Gdansk, Gdansk, Poland
    Am J Surg Pathol 37:1743-50. 2013
    ....
  27. doi request reprint Cutaneous apocrine mixed tumor with intravascular tumor deposits: a diagnostic pitfall
    Dmitry V Kazakov
    Sikl s Department of Pathology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic
    Am J Dermatopathol 33:775-9. 2011
    ..At present, its significance is not completely clear. Until proved otherwise in future, we suggest to consider intravascular deposits in cutaneous apocrine mixed tumors as an innocuous phenomenon...
  28. doi request reprint Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene
    Dmitry V Kazakov
    Sikl s Department of Pathology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic
    Hum Pathol 40:1499-503. 2009
    ..Analysis of the CYLD gene revealed polymorphisms. This is the first report of a "dermal analogue tumor" of the salivary gland that resembled a cutaneous spiradenoma and not a cylindroma...
  29. ncbi request reprint Microglandular adenocarcinoma of the uterus mimicking microglandular cervical hyperplasia
    Michal Zamecnik
    Sikl s Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic
    Ann Diagn Pathol 7:180-6. 2003
    ..Our case shows the difficulties in the diagnosis of this lesion and confirms a low aggressiveness that was observed in all 10 cases described to date...
  30. ncbi request reprint Epidermolysis bullosa acquisita-like reaction associated with penicillamine therapy for sclerodermatous graft-versus-host disease
    Petra Cetkovska
    Department of Dermatology, Charles University Hospital, Dr E Benese 13, 305 99 Pilsen, Czech Republic
    J Am Acad Dermatol 49:1157-9. 2003
    ..The surprisingly early onset of this eruption in lesions of sclerodermatous graft-versus-host disease might have been due to severe immune alteration...
  31. ncbi request reprint The importance of prognostic factors in premenopausal women with breast cancer
    J Finek
    Department of Oncology, University Hospital and Medical Faculty, Pilsen, Czech Republic
    Anticancer Res 27:1893-6. 2007
    ..We evaluated individual prognostic factors (age, histology, TNM classification, ER, PR, CA 15-3, CEA, HER2) and their impact on disease-free survival (DFS) and overall survival (OS) during the 5-year follow-up period...
  32. doi request reprint Angiomatoid change in polyps of the nasal and paranasal regions: an underrecognized and commonly misdiagnosed lesion--report of 45 cases
    Ladislav Hadravsky
    Department of Pathology, Medical Faculty, Charles University in Prague, Plzen, Czech Republic
    Virchows Arch 460:203-9. 2012
    ..APNPRs sometimes cause severe changes of the skeletal bones especially in recurrent lesions. Awareness of the above described features and familiarity with the clinical presentation of APNPRs is the best way to avoid a misdiagnosis...
  33. ncbi request reprint Ulcerating Warthin's tumour
    Ivo Starek
    ENT Clinic, Medical Faculty Hospital, Olomouc, Czech Republic
    Acta Otolaryngol 124:744-6. 2004
    ..The main clinical pitfall of such an inflammatory skin disruption of an otherwise benign Warthin's tumour is that it may be mistaken for an infiltratively growing malignant lesion...
  34. doi request reprint Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity
    Ashton Connor
    Department of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada
    Am J Surg Pathol 36:27-34. 2012
    ..These findings reinforce MASC as a unique low-grade salivary gland tumor entity with morphologic overlap with AciCC, MEC, and cystadenocarcinoma...
  35. doi request reprint Lipomatous salivary gland tumors: a series of 31 cases spanning their morphologic spectrum with emphasis on sialolipoma and oncocytic lipoadenoma
    Abbas Agaimy
    Pathologisches Institut, Universitatsklinikum Erlangen, Krankenhausstrae 8 10, 91054 Erlangen, Germany
    Am J Surg Pathol 37:128-37. 2013
    ..Oncocytic lipoadenoma is an epithelial-predominant tumor that is distinct from the fat-dominated nononcocytic sialolipoma, but the 2 types seem to merge in some cases...
  36. doi request reprint Metastasizing middle ear carcinoid: an unusual case report, with focus on ultrastructural and immunohistochemical findings
    Richard Salzman
    ENT Department, Derriford Hospital, Plymouth, UK
    Otol Neurotol 33:1418-21. 2012
    ..There are only 4 unequivocal cases of metastasizing middle ear carcinoid previously reported...
  37. ncbi request reprint Basaloid squamous carcinoma with collagenous spherules and crystalloids
    M Zamecnik
    Department of Pathology, Slovak Postgraduate Academy of Medicine, Bratislava, Slovak Republic
    Ann Diagn Pathol 5:233-9. 2001
    ....