Berta Otová

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. ncbi request reprint Therapeutic effect of heat shock on T-cell lymphoma in inbred Sprague-Dawley rat
    B Otova
    Institute of Biology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Folia Biol (Praha) 45:121-31. 1999
  2. ncbi request reprint Relevant animal model of human lymphoblastic leukaemia/lymphoma--spontaneous T-cell lymphomas in an inbred Sprague-Dawley rat strain (SD/Cub)
    B Otova
    Institute of Biology and Medical Genetics, 1st Faculty of Medicine and General Teaching Hospital, Charles University, Prague, Czech Republic
    Folia Biol (Praha) 48:213-26. 2002
  3. ncbi request reprint [Biological mechanisms of aging]
    B Otova
    Ustav biologie a lékarské genetiky 1 LF UK a VFN, Praha
    Cas Lek Cesk 145:688-94. 2006
  4. ncbi request reprint In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG
    Berta Otová
    Institute of Biology and Medical Genetics, Charles University, Prague, Czech Republic
    Anticancer Res 29:1295-302. 2009
  5. ncbi request reprint Effects of paclitaxel, docetaxel and their combinations on subcutaneous lymphomas in inbred Sprague-Dawley/Cub rats
    Berta Otová
    Institute of Biology and Medical Genetics, 1st Faculty of Medicine and General Teaching Hospital Charles University, 128 00 Prague, Czech Republic
    Eur J Pharm Sci 29:442-50. 2006
  6. ncbi request reprint PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions
    Marie Valeriánová
    Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, 128 00 Prague 2, Czech Republic
    Anticancer Res 23:4933-9. 2003
  7. doi request reprint Second-generation taxanes effectively suppress subcutaneous rat lymphoma: role of disposition, transport, metabolism, in vitro potency and expression of angiogenesis genes
    Berta Otová
    Institute of Biology and Medical Genetics, 1st Faculty of Medicine and General Teaching Hospital Charles University, 128 00, Prague, Czech Republic
    Invest New Drugs 30:991-1002. 2012

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Therapeutic effect of heat shock on T-cell lymphoma in inbred Sprague-Dawley rat
    B Otova
    Institute of Biology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Folia Biol (Praha) 45:121-31. 1999
    ..Contrary to the heat shock, the cold stress did not suppress growth of lymphomas and, furthermore, accelerated the infiltration of parenchymatous organs with lymphoma cells...
  2. ncbi request reprint Relevant animal model of human lymphoblastic leukaemia/lymphoma--spontaneous T-cell lymphomas in an inbred Sprague-Dawley rat strain (SD/Cub)
    B Otova
    Institute of Biology and Medical Genetics, 1st Faculty of Medicine and General Teaching Hospital, Charles University, Prague, Czech Republic
    Folia Biol (Praha) 48:213-26. 2002
    ....
  3. ncbi request reprint [Biological mechanisms of aging]
    B Otova
    Ustav biologie a lékarské genetiky 1 LF UK a VFN, Praha
    Cas Lek Cesk 145:688-94. 2006
    ..Contemporary views on the mechanisms of aging and aging variations--progeria and longevity are presented. Replicative aging, the roles of glycation and free radicals on the genetical determination of progeria and longevity are discussed...
  4. ncbi request reprint In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG
    Berta Otová
    Institute of Biology and Medical Genetics, Charles University, Prague, Czech Republic
    Anticancer Res 29:1295-302. 2009
    ..Findings show that in vivo antitumour efficacy of both antimitotic acyclic nucleoside phosphonates PMEDAP and PMEG consequently affect the angiogenesis in T-cell lymphoma...
  5. ncbi request reprint Effects of paclitaxel, docetaxel and their combinations on subcutaneous lymphomas in inbred Sprague-Dawley/Cub rats
    Berta Otová
    Institute of Biology and Medical Genetics, 1st Faculty of Medicine and General Teaching Hospital Charles University, 128 00 Prague, Czech Republic
    Eur J Pharm Sci 29:442-50. 2006
    ..Thus, docetaxel was effective against T-cell lymphomas and may be a potential anticancer drug in similar indications...
  6. ncbi request reprint PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions
    Marie Valeriánová
    Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, 128 00 Prague 2, Czech Republic
    Anticancer Res 23:4933-9. 2003
    ..While the prevalent effect of cypr-PMEDAP during fetus development is embryolethality, PMEDAP did not induce any embryo-lethal or teratogenic effect...
  7. doi request reprint Second-generation taxanes effectively suppress subcutaneous rat lymphoma: role of disposition, transport, metabolism, in vitro potency and expression of angiogenesis genes
    Berta Otová
    Institute of Biology and Medical Genetics, 1st Faculty of Medicine and General Teaching Hospital Charles University, 128 00, Prague, Czech Republic
    Invest New Drugs 30:991-1002. 2012
    ..In conclusion, SB-T-1214, SB-T-12854 and IDN5109 are good candidates for further study...