Affiliation: Charles University
Country: Czech Republic
Nachtigal P, Vecerova L, Pospisilova N, Micuda S, Brcakova E, Navarro Hernandez E, et al
. Endoglin co-expression with eNOS, SMAD2 and phosphorylated SMAD2/3 in normocholesterolemic and hypercholesterolemic mice: an immunohistochemical study. Histol Histopathol. 2009;24:1499-506 pubmed publisher
..In conclusion, we suggest that endoglin, SMAD2, phosphorylated SMAD2/3 and eNOS may be important in vessel endothelium homeostasis underlying their role in atherogenesis. ..
Nachtigal P, Pospisilova N, Vecerova L, Micuda S, Brcakova E, Pospechova K, et al
. Atorvastatin Increases Endoglin, SMAD2, Phosphorylated SMAD2/3 and eNOS Expression in ApoE/LDLR Double Knockout Mice. J Atheroscler Thromb. 2009;16:265-74 pubmed
..These findings suggest, that endoglin might be interesting marker of endothelial dysfunction and/or atherogenesis which is upregulated by statins implicating potential beneficial role of endoglin and its pathway in atherosclerosis. ..
Rathouska J, Ježková K, Nemeckova I, Zemankova L, Varejckova M, Nachtigal P. Endoglin is not expressed with cell adhesion molecules in aorta during atherogenesis in apoE-deficient mice. Histol Histopathol. 2015;30:233-44 pubmed publisher
..Moreover, endoglin is not localized with cell adhesion molecules involved in atherosclerosis, suggesting it might not participate in leukocyte accumulation in aorta of apoE-deficient mice during atherogenesis. ..
Zemankova L, Varejckova M, Dolezalova E, Fikrová P, Ježková K, Rathouská J, et al
. Atorvastatin-induced endothelial nitric oxide synthase expression in endothelial cells is mediated by endoglin. J Physiol Pharmacol. 2015;66:403-13 pubmed
Sahebkar A, Rathouska J, Simental MendÃa L, Nachtigal P. Statin therapy and plasma cortisol concentrations: A systematic review and meta-analysis of randomized placebo-controlled trials. Pharmacol Res. 2016;103:17-25 pubmed publisher
..Results of this meta-analysis of RCTs suggest a significant elevation in plasma cortisol levels following statin therapy. ..
Vitverova B, Blazickova K, Najmanova I, Vicen M, HyÅ¡pler R, Dolezelova E, et al
. Soluble endoglin and hypercholesterolemia aggravate endothelial and vessel wall dysfunction in mouse aorta. Atherosclerosis. 2018;271:15-25 pubmed publisher
Varejckova M, Gallardo Vara E, Vicen M, Vitverova B, Fikrová P, Dolezelova E, et al
. Soluble endoglin modulates the pro-inflammatory mediators NF-?B and IL-6 in cultured human endothelial cells. Life Sci. 2017;175:52-60 pubmed publisher
..A combined treatment of sEng with other cardiovascular risk factors will be necessary in order to reveal whether sEng is not only a biomarker of cardiovascular diseases, but also a protagonist of endothelial dysfunction. ..
Rathouska J, Fikrová P, Mrkvicova A, Blazickova K, Varejckova M, Dolezelova E, et al
. High soluble endoglin levels do not induce changes in structural parameters of mouse heart. Heart Vessels. 2017;32:1013-1024 pubmed publisher
Nachtigal P, Simunek T, Atkinson J. Pharmacy Practice and Education in the Czech Republic. Pharmacy (Basel). 2017;5: pubmed publisher
..Specialisation is organised in the form of postgraduate, continuing professional development by the Czech Chamber of Pharmacists, and delivered by the Institute of Postgraduate Education for Health Professions. ..