Marek Mraz

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. doi request reprint MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia
    Marek Mraz
    Rebecca and John Moores Cancer Center, University of California San Diego, La Jolla, CA, USA
    Leuk Lymphoma 54:1836-9. 2013
  2. ncbi request reprint [Inhibition of B cell receptor signaling: a first targeted therapeutic approach for chronic lymphocytic leukemia and other B cell lymphomas]
    M Mraz
    Interni hematologicka a onkologicka klinika LF MU a FN Brno
    Klin Onkol 26:179-85. 2013
  3. doi request reprint The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus
    Marek Mraz
    CEITEC, Center of Molecular Medicine, Masaryk University, Brno, Czech Republic
    Leuk Res 37:802-8. 2013
  4. doi request reprint MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia
    Marek Mraz
    Center of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Blood 119:2110-3. 2012
  5. doi request reprint MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtypes
    Marek Mraz
    Center of Molecular Biology and Gene Therapy, Department of Internal Medicine Hematooncology, University Hospital Brno and Medical Faculty MU, Brno, Czech Republic
    Leuk Lymphoma 50:506-9. 2009
  6. pmc ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin
    Veronika Navrkalova
    Department of Molecular Medicine, CEITEC Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Haematologica 98:1124-31. 2013
  7. doi request reprint Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation
    Jan Verner
    Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Exp Hematol 40:899-905.e5. 2012
  8. doi request reprint MicroRNAs regulate p21(Waf1/Cip1) protein expression and the DNA damage response in human embryonic stem cells
    Dasa Dolezalova
    Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3 A1, Brno, Czech Republic
    Stem Cells 30:1362-72. 2012
  9. doi request reprint Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia
    Martin Trbusek
    University Hospital Brno, Department of Internal Medicine Hematooncology, Czech Republic
    J Clin Oncol 29:2703-8. 2011
  10. ncbi request reprint MicroRNA biogenesis, functionality and cancer relevance
    Branislav Kusenda
    Center of Molecular Biology and Gene Therapy, Department of Internal Medicine Hematooncology, University Hospital Brno, Cernopolni 9, 625 00 Brno Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150:205-15. 2006

Collaborators

  • Jiri Mayer
  • Michael Doubek
  • Jana Smardova
  • Petr Kuglik
  • Sarka Pospisilova
  • Martin Trbusek
  • Yvona Brychtova
  • Veronika Navrkalova
  • Sarka Pavlova
  • Ludmila Sebejova
  • Dasa Dolezalova
  • Jitka Malcikova
  • Jan Verner
  • Branislav Kusenda
  • David Potesil
  • Blanka Kubesova
  • Jana Kminkova
  • Veronika Nemethova
  • Jana Zemanova
  • Josef Jaroš
  • Jana Volejnikova
  • Jitka Kabathova
  • Alexandra Tomancová
  • Petr Dvorak
  • Zuzana Holubcová
  • Boris Tichy
  • Vladimir Vinarsky
  • Karla Plevova
  • Tomáš Bárta
  • Marta Krejci
  • Petr Sedlacek
  • Ales Hampl
  • Zbynek Zdrahal
  • Petr Dobes
  • Miluse Svitakova
  • Vladimira Vranova
  • Hana Skuhrova Francova

Detail Information

Publications10

  1. doi request reprint MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia
    Marek Mraz
    Rebecca and John Moores Cancer Center, University of California San Diego, La Jolla, CA, USA
    Leuk Lymphoma 54:1836-9. 2013
    ..How these miRNAs influence cellular activation and/or BCR signaling through the post-transcriptional regulation of critical signaling molecules (e.g. Lyn, Syk, BTK, SHIP-1, SHP1) is a topic of current research...
  2. ncbi request reprint [Inhibition of B cell receptor signaling: a first targeted therapeutic approach for chronic lymphocytic leukemia and other B cell lymphomas]
    M Mraz
    Interni hematologicka a onkologicka klinika LF MU a FN Brno
    Klin Onkol 26:179-85. 2013
    ..Herein, we review the data on BCR pathway deregulation in malignant CLL B  cells, and the results of clinical trials utilizing fosfamatinib, ibrutinib and GS 1101...
  3. doi request reprint The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus
    Marek Mraz
    CEITEC, Center of Molecular Medicine, Masaryk University, Brno, Czech Republic
    Leuk Res 37:802-8. 2013
    ..This demonstrates that this loss of genetic material is likely not pathogenic and in fact is merely a marker of IGL rearrangement...
  4. doi request reprint MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia
    Marek Mraz
    Center of Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Blood 119:2110-3. 2012
    ..This study underscores the importance of miR-650 in CLL biology and normal B-cell physiology...
  5. doi request reprint MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtypes
    Marek Mraz
    Center of Molecular Biology and Gene Therapy, Department of Internal Medicine Hematooncology, University Hospital Brno and Medical Faculty MU, Brno, Czech Republic
    Leuk Lymphoma 50:506-9. 2009
    ..Consequently, these three miRNAs could potentially play important roles in the pathogenesis of aggressive CLL...
  6. pmc ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin
    Veronika Navrkalova
    Department of Molecular Medicine, CEITEC Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Haematologica 98:1124-31. 2013
    ....
  7. doi request reprint Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation
    Jan Verner
    Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Exp Hematol 40:899-905.e5. 2012
    ..This indicates an involvement of similar immune regulatory pathways also in aGVHD. Our data support use of gene expression profiling at aGVHD onset for a prediction of its outcomes...
  8. doi request reprint MicroRNAs regulate p21(Waf1/Cip1) protein expression and the DNA damage response in human embryonic stem cells
    Dasa Dolezalova
    Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3 A1, Brno, Czech Republic
    Stem Cells 30:1362-72. 2012
    ..The described mechanism elucidates the role of miRNAs in regulation of important molecular pathway governing the G1/S transition checkpoint before as well as after DNA damage...
  9. doi request reprint Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia
    Martin Trbusek
    University Hospital Brno, Department of Internal Medicine Hematooncology, Czech Republic
    J Clin Oncol 29:2703-8. 2011
    ..There is a distinct connection between TP53 defects and poor prognosis in chronic lymphocytic leukemia (CLL). It remains unclear whether patients harboring TP53 mutations represent a homogenous prognostic group...
  10. ncbi request reprint MicroRNA biogenesis, functionality and cancer relevance
    Branislav Kusenda
    Center of Molecular Biology and Gene Therapy, Department of Internal Medicine Hematooncology, University Hospital Brno, Cernopolni 9, 625 00 Brno Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150:205-15. 2006
    ..MiRNAs are essential regulators of various processes such as proliferation, differentiation, development, cell death and interaction between virus and host cell...