Zdena Kristofikova

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. doi request reprint Protein τ-mediated effects on rat hippocampal choline transporters CHT1 and τ-amyloid β interactions
    Zdena Kristofikova
    Alzheimer Disease Centre, Prague Psychiatric Centre, Ustavni 91, 181 03, Prague 8, Bohnice, Czech Republic
    Neurochem Res 38:1949-59. 2013
  2. ncbi request reprint Neuroinflammation and complexes of 17β-hydroxysteroid dehydrogenase type 10--amyloid β in Alzheimer's disease
    Zdena Kristofikova
    Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Czech Republic
    Curr Alzheimer Res 10:165-73. 2013
  3. doi request reprint Interactions of amyloid β peptide 1-40 and cerebrosterol
    Zdena Kristofikova
    Alzheimer Disease Centre, Prague Psychiatric Centre, Ustavni 91, 181 03, Prague 8, Bohnice, Czech Republic
    Neurochem Res 37:604-13. 2012
  4. doi request reprint Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia
    Zdena Kristofikova
    Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic
    Neurochem Int 53:118-25. 2008
  5. doi request reprint Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis
    Zdena Kristofikova
    Alzheimer Disease Center, Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic
    Mol Biosyst 5:1174-9. 2009
  6. doi request reprint Lateralization of 17beta-hydroxysteroid dehydrogenase type 10 in hippocampi of demented and psychotic people
    Petra Hovorkova
    Alzheimer Disease Center, Prague Psychiatric Center, Prague, Czech Republic
    Dement Geriatr Cogn Disord 26:193-8. 2008
  7. ncbi request reprint Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers
    Zdena Kristofikova
    Alzheimer Disease Centre, Prague Psychiatric Centre, Ustavni 91, Prague 8 Bohnice 181 03, Czech Republic
    Neurochem Res 33:412-21. 2008
  8. ncbi request reprint Sex-dependent actions of amyloid beta peptides on hippocampal choline carriers of postnatal rats
    Z Kristofikova
    Prague Psychiatric Center, Ustavni 91, Prague 8, Bohnice, 181 03, Prague, Czech Republic
    Neurochem Res 31:351-60. 2006
  9. ncbi request reprint Exposure of postnatal rats to a static magnetic field of 0.14 T influences functional laterality of the hippocampal high-affinity choline uptake system in adulthood; in vitro test with magnetic nanoparticles
    Z Kristofikova
    Prague Psychiatric Centre, Ustavni 91, 181 03, Prague 8, Bohnice, Czech Republic
    Neurochem Res 30:253-62. 2005
  10. ncbi request reprint Age- and sex-dependent laterality of rat hippocampal cholinergic system in relation to animal models of neurodevelopmental and neurodegenerative disorders
    Zdena Kristofikova
    Prague Psychiatric Centre, Prague, Czech Republic
    Neurochem Res 29:671-80. 2004

Detail Information

Publications17

  1. doi request reprint Protein τ-mediated effects on rat hippocampal choline transporters CHT1 and τ-amyloid β interactions
    Zdena Kristofikova
    Alzheimer Disease Centre, Prague Psychiatric Centre, Ustavni 91, 181 03, Prague 8, Bohnice, Czech Republic
    Neurochem Res 38:1949-59. 2013
    ..The developed biosensor will be used to detect Aβ-τ complexes in cerebrospinal fluid in order to evaluate them as prospective biomarkers of Alzheimer's disease. ..
  2. ncbi request reprint Neuroinflammation and complexes of 17β-hydroxysteroid dehydrogenase type 10--amyloid β in Alzheimer's disease
    Zdena Kristofikova
    Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Czech Republic
    Curr Alzheimer Res 10:165-73. 2013
    ..Phospho-τ is currently the best biomarker of Alzheimer's disease...
  3. doi request reprint Interactions of amyloid β peptide 1-40 and cerebrosterol
    Zdena Kristofikova
    Alzheimer Disease Centre, Prague Psychiatric Centre, Ustavni 91, 181 03, Prague 8, Bohnice, Czech Republic
    Neurochem Res 37:604-13. 2012
    ..Using this procedure, globular amyloid β could retain 24(S)hydroxycholesterol and thus contribute to its pathological accumulation in the brains of patients with Alzheimer disease...
  4. doi request reprint Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia
    Zdena Kristofikova
    Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic
    Neurochem Int 53:118-25. 2008
    ..The volumetric asymmetry of the planum temporale as a marker of handedness is not probably simply linked to brain laterality at biochemical level but reflects alterations due to pathological processes...
  5. doi request reprint Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis
    Zdena Kristofikova
    Alzheimer Disease Center, Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic
    Mol Biosyst 5:1174-9. 2009
    ..In patients with multiple sclerosis, our results are the first to demonstrate significant changes in enzyme expression and to suggest possible alterations in amyloid beta peptides...
  6. doi request reprint Lateralization of 17beta-hydroxysteroid dehydrogenase type 10 in hippocampi of demented and psychotic people
    Petra Hovorkova
    Alzheimer Disease Center, Prague Psychiatric Center, Prague, Czech Republic
    Dement Geriatr Cogn Disord 26:193-8. 2008
    ..The multifunctional mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 could play a role in the development of Alzheimer disease via its high-affinity binding to amyloid-beta peptides and its overexpression...
  7. ncbi request reprint Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers
    Zdena Kristofikova
    Alzheimer Disease Centre, Prague Psychiatric Centre, Ustavni 91, Prague 8 Bohnice 181 03, Czech Republic
    Neurochem Res 33:412-21. 2008
    ..Moreover, via Raman spectroscopy we demonstrate for the first time that peptides form a complex with 24-hydroxycholesterol...
  8. ncbi request reprint Sex-dependent actions of amyloid beta peptides on hippocampal choline carriers of postnatal rats
    Z Kristofikova
    Prague Psychiatric Center, Ustavni 91, Prague 8, Bohnice, 181 03, Prague, Czech Republic
    Neurochem Res 31:351-60. 2006
    ..Our study indicates that Abeta could play a role in postnatal sexual differentiation of hippocampal cholinergic system...
  9. ncbi request reprint Exposure of postnatal rats to a static magnetic field of 0.14 T influences functional laterality of the hippocampal high-affinity choline uptake system in adulthood; in vitro test with magnetic nanoparticles
    Z Kristofikova
    Prague Psychiatric Centre, Ustavni 91, 181 03, Prague 8, Bohnice, Czech Republic
    Neurochem Res 30:253-62. 2005
    ....
  10. ncbi request reprint Age- and sex-dependent laterality of rat hippocampal cholinergic system in relation to animal models of neurodevelopmental and neurodegenerative disorders
    Zdena Kristofikova
    Prague Psychiatric Centre, Prague, Czech Republic
    Neurochem Res 29:671-80. 2004
    ..The data demonstrate viral infection-mediated alterations in normal patterns of brain asymmetry and are discussed in relation to animal models of neurodevelopmental and neurodegenerative diseases...
  11. ncbi request reprint Age- and sex-dependent effects of ethanol on hippocampal hemicholinium-3 sensitive choline carriers during postnatal development of rats
    Zdena Kristofikova
    Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Czech Republic
    Neurochem Res 28:397-405. 2003
    ..The direct effects of ethanol on male choline carriers can contribute to the inhibition of acetylcholine synthesis and to sex-dependent neurotoxic effects of alcohol applied in vivo during early and late postnatal period...
  12. doi request reprint Aging and lateralization of the rat brain on a biochemical level
    Zdena Kristofikova
    Prague Psychiatric Centre, Prague, Czech Republic
    Neurochem Res 35:1138-46. 2010
    ..Since lateral analyses are of sufficient sensitivity to reveal subtle links, we recommend using Wistar rather than Long Evans rats in modeling of diseases accompanied by alterations in brain asymmetry...
  13. ncbi request reprint Neuro-immuno-teratogenicity of drugs used in neonatal pharmacotherapy in relation to the ontogenic stage at the time of their administration
    O Benesova
    Prague Psychiatric Center, Prague, Czech Republic
    Gen Physiol Biophys 18:21-7. 1999
    ..e. when the drugs were administered at a higher stage of the ontogenic development simulating neonatal period in humans. This finding may be warning from the clinical point of view for the neonatological practice...
  14. ncbi request reprint Brain maldevelopment and neurobehavioural deviations in adult rats treated neonatally with indomethacin
    O Benesova
    Prague Psychiatric Center, Ustavni 91, 181 03 Prague 8, Czech Republic
    Eur Neuropsychopharmacol 11:367-73. 2001
    ..On the other hand, deviations in adult INDO groups PD:9 and PD:9-10 were characterized by pain hypersensitivity, lower pituitary weight with unchanged TSH content and deficit of monoamine transmission in the hypothalamus...
  15. ncbi request reprint Amyloid beta peptide 1-40 and the function of rat hippocampal hemicholinium-3 sensitive choline carriers: effects of a proteolytic degradation in vitro
    Z Kristofikova
    Prague Psychiatric Centre, Czech Republic
    Neurochem Res 26:203-12. 2001
    ..Stimulation increases the sensitivity of carriers to the interaction with Abeta...
  16. doi request reprint Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer's disease
    Francisco Garcia-Sierra
    Department of Cell Biology, Center of Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico
    Brain Pathol 22:240-50. 2012
    ..It would appear, therefore, that ubiquitin targeting of tau protein occurs at NFTs in the early and intermediate stages of the maturation...
  17. doi request reprint Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease
    Jose J Jarero-Basulto
    From the Department of Cell Biology, Center of Research and Advanced Studies of the National Polytechnic Institute JJJ B, FG S Brain Bank LANSE, Center of Research and Advanced Studies of the National Polytechnic Institute JL M and Department of Neuroscience, Center of Research and Advanced Studies of the National Polytechnic Institute RM, Mexico City, México Laboratory of Biochemistry and Brain Pathophysiology and AD Center, Prague Psychiatric Center, Prague, Czech Republic ZK, DR College of Sciences, University of Texas at San Antonio, San Antonio, Texas GP and Department of Translational Science and Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, Michigan LIB
    J Neuropathol Exp Neurol 72:1145-61. 2013
    ..Our data suggest that generation of this pathologic Asp(421) truncation of tau in long-lasting fibrillary structures may produce further permanent toxicity for neurons in the brains of patients with AD...