Dmitry V Kazakov


Affiliation: Charles University
Country: Czech Republic


  1. request reprint
    Kazakov D, Mentzel T, Erlandson R, Mukensnabl P, Michal M. Clear cell trichoblastoma: a clinicopathological and ultrastructural study of two cases. Am J Dermatopathol. 2006;28:197-201 pubmed
    ..No distinct lipid droplets or glycogen particles were identified. The basaloid cells were joined by scattered small desmosomes. These findings were consistent with trichilemmal differentiation at the bulb...
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    Kazakov D, Mukensnabl P, Michal M. An unusual hamartoma of the folliculosebaceous-apocrine unit: a case report. J Cutan Pathol. 2006;33:365-8 pubmed
    ..Some of the epithelial structures were reminiscent of those seen in tubular apocrine adenoma; others resembled syringomatous elements. We interpreted this unusual lesion as a hamartoma of the folliculosebaceous-apocrine unit. ..
  3. Kazakov D, Schaller J, Vanecek T, Kacerovska D, Michal M. Brooke-Spiegler syndrome: report of a case with a novel mutation in the CYLD gene and different types of somatic mutations in benign and malignant tumors. J Cutan Pathol. 2010;37:886-90 pubmed publisher
    ..2322delA causing a frameshift mutation E774DfsX2. LOH occurred in both BCCs, one trichoepithelioma and one spiradenoma. In the remaining three lesions, the somatic event remained undetected. ..
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    Kazakov D, Michal M. Melanocytic "ball-in-mitts" and "microalveolar structures" and their role in the development of cellular blue nevi. Ann Diagn Pathol. 2007;11:160-75 pubmed
    ..These nevi often show a morphological overlap, and ball-in-mitts and microalveolar structures found in various stages of their development seem to greatly account for this overlap. ..
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    Kazakov D, Bisceglia M, Spagnolo D, Kutzner H, Belousova I, Hes O, et al. Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: a retrospective clinicopathologic study of 18 cases. Am J Surg Pathol. 2007;31:1094-102 pubmed
    ..We conclude that some atypical cytoarchitectural features in apocrine mixed tumors, albeit worrisome, do not indicate a malignant change. ..
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    Kazakov D, Nemcova J, Mikyskova I, Belousova I, Vazmitel M, Michal M. Human papillomavirus in lesions of anogenital mammary-like glands. Int J Gynecol Pathol. 2007;26:475-80 pubmed
    ..These results coupled with those obtained from literature review suggest that HPV plays no causative role in lesions of anogenital MLG. ..
  7. Kazakov D, Thoma Uszynski S, Vanecek T, Kacerovska D, Grossmann P, Michal M. A case of Brooke-Spiegler syndrome with a novel germline deep intronic mutation in the CYLD gene leading to intronic exonization, diverse somatic mutations, and unusual histology. Am J Dermatopathol. 2009;31:664-73 pubmed publisher
    ..A deep intronic mutation resulting in exonization and a somatic sequence mutations causing exon skipping are hitherto unreported genetic mechanisms involving the CYLD gene in patients with Brooke-Spiegler syndrome. ..
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    Kazakov D, Nemcova J, Mikyskova I, Michal M. Absence of Epstein-Barr virus, human papillomavirus, and simian virus 40 in patients of central european origin with lymphoepithelioma-like carcinoma of the skin. Am J Dermatopathol. 2007;29:365-9 pubmed
    ..Because all 10 cases studied proved negative for EBV, HPV, and SV40, these viruses seem to play no causal role in LELC of the skin in patients from Central Europe. ..
  9. Kazakov D, Vittay G, Michal M, Calonje E. High-grade trichoblastic carcinosarcoma. Am J Dermatopathol. 2008;30:62-4 pubmed publisher
    ..This conclusion is reached after analyzing the embryological development of the hair follicle, its normal histology and the morphology of cutaneous adnexal tumors with follicular differentiation. ..

More Information


  1. Kazakov D, Belousova I, Kacerovska D, Sima R, Vanecek T, Vazmitel M, et al. Hyperplasia of hair follicles and other adnexal structures in cutaneous lymphoproliferative disorders: a study of 53 cases, including so-called pseudolymphomatous folliculitis and overt lymphomas. Am J Surg Pathol. 2008;32:1468-78 pubmed publisher
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    Kazakov D, Mukensnabl P, Michal M. Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. Am J Dermatopathol. 2006;28:142-6 pubmed
    ..Rare cases occurring in the sites normally devoid of apocrine glands may represent the eccrine counterpart. ..
  3. Kazakov D. Brooke-Spiegler Syndrome and Phenotypic Variants: An Update. Head Neck Pathol. 2016;10:125-30 pubmed publisher
    ..There appears to be no genotype-phenotype correlations with respect to the severity of the disease, the possibility of malignant transformation, and development of extracutaneous lesions. ..
  4. Farkas K, Deák B, Sánchez L, Martínez A, Corell J, Botella A, et al. The CYLD p.R758X worldwide recurrent nonsense mutation detected in patients with multiple familial trichoepithelioma type 1, Brooke-Spiegler syndrome and familial cylindromatosis represents a mutational hotspot in the gene. BMC Genet. 2016;17:36 pubmed publisher
    ..R758X CYLD mutation. Our results indicate that this position is a mutational hotspot on the gene and that patients carrying the mutation exhibit high phenotypic diversity. ..
  5. Kacerovska D, Michal M, Kuroda N, Tanaka A, Sima R, Denisjuk N, et al. Hybrid peripheral nerve sheath tumors, including a malignant variant in type 1 neurofibromatosis. Am J Dermatopathol. 2013;35:641-9 pubmed publisher
    ..The malignant component showed areas with an epithelioid cell morphology. ..
  6. Kazakov D, Requena L, Kutzner H, Fernandez Figueras M, Kacerovska D, Mentzel T, et al. Morphologic diversity of syringocystadenocarcinoma papilliferum based on a clinicopathologic study of 6 cases and review of the literature. Am J Dermatopathol. 2010;32:340-7 pubmed publisher
    ..Its association with the benign counterpart and ductal changes suggests a transformation that may involve usual ductal hyperplasia-atypical ductal hyperplasia-(ductal) adenocarcinoma in situ-invasive adenocarcinoma pathway...
  7. Kazakov D, Grossmann P, Spagnolo D, Vanecek T, Vazmitel M, Kacerovska D, et al. Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. Am J Dermatopathol. 2010;32:215-21 pubmed publisher
  8. Kazakov D, Spagnolo D, Stewart C, Thompson J, Agaimy A, Magro G, et al. Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal h. Am J Surg Pathol. 2010;34:95-103 pubmed publisher
  9. Kazakov D, Zelger B, Rutten A, Vazmitel M, Spagnolo D, Kacerovska D, et al. Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol. 2009;33:705-19 pubmed publisher
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    Kazakov D, Bisceglia M, Calonje E, Hantschke M, Kutzner H, Mentzel T, et al. Tubular adenoma and syringocystadenoma papilliferum: a reappraisal of their relationship. An interobserver study of a series, by a panel of dermatopathologists. Am J Dermatopathol. 2007;29:256-63 pubmed
  11. Kyrpychova L, Kacerovska D, Vanecek T, Grossmann P, Michal M, Kerl K, et al. Cutaneous hidradenoma: a study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions. Ann Diagn Pathol. 2016;23:8-13 pubmed publisher
    ..In none of the cases was a CRTC3-MAML2 fusion detected. No obvious correlation between the cellular composition and presence of t(11,19) translocation was found. ..
  12. Kazakov D, Spagnolo D, Kacerovska D, Kempf W, Michal M. Cutaneous adenolipoma: extending the spectrum of changes in the lipomatous and epithelial components. Am J Dermatopathol. 2011;33:56-9 pubmed publisher
  13. Konstantinova A, Vanecek T, Martinek P, Kyrpychova L, Spagnolo D, Stewart C, et al. Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. Ann Diagn Pathol. 2017;28:12-18 pubmed publisher
    ..The PI3K-AKT cascade plays a role in tumors arising at both sites. It appears that some histopathologically similar anogenital and breast lesions develop along similar molecular pathways. ..
  14. Kazakov D, Sima R, Vanecek T, Kutzner H, Palmedo G, Kacerovska D, et al. Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors. Am J Dermatopathol. 2009;31:248-55 pubmed publisher
    ..This study broadens the list of cutaneous adnexal tumors harboring CTNNB1 mutations and extends the listing of the mutations occurring in these neoplasms...
  15. Kazakov D, Stewart C, Kacerovska D, Leake R, Kreuzberg B, Chudacek Z, et al. Prostatic-type tissue in the lower female genital tract: a morphologic spectrum, including vaginal tubulosquamous polyp, adenomyomatous hyperplasia of paraurethral Skene glands (female prostate), and ectopic lesion in the vulva. Am J Surg Pathol. 2010;34:950-5 pubmed publisher
    ..All lesions were immunopositive for prostate-specific antigen and/or prostatic acid phosphatase. A brief discussion of the earlier published material is included...
  16. Kazakov D, Vanecek T, Nemcova J, Kacerovska D, Spagnolo D, Mukensnabl P, et al. Spectrum of tumors with follicular differentiation in a patient with the clinical phenotype of multiple familial trichoepitheliomas: a clinicopathological and molecular biological study, including analysis of the CYLD and PTCH genes. Am J Dermatopathol. 2009;31:819-27 pubmed publisher
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    Kazakov D, Bisceglia M, Mukensnabl P, Michal M. Pseudoangiomatous stromal hyperplasia in lesions involving anogenital mammary-like glands. Am J Surg Pathol. 2005;29:1243-6 pubmed
    ..The clinicopathologic features of PASH in the anogenital area seem to be identical to those in the breast. ..
  18. Kazakov D, Ivan D, Kutzner H, Spagnolo D, Grossmann P, Vanecek T, et al. Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. Am J Dermatopathol. 2009;31:236-47 pubmed publisher
    ..Even rarer is the amplification of the Her2/neu gene. Of note is the relatively low frequency of TP53 mutations despite a high rate of p53 protein expression at the immunohistochemical level. ..
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    Kazakov D, Calonje E, Zelger B, Luzar B, Belousova I, Mukensnabl P, et al. Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases. Am J Dermatopathol. 2007;29:242-8 pubmed
    ..The rest of organoid nevus is usually recognized both clinically and microscopically, although large tumors may overgrow and mask the nevus. The tumor seems to be a low-grade carcinoma in terms of clinical behavior...
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    Kazakov D, Michal M. Trichoepithelioma with giant and multinucleated neoplastic epithelial cells. Am J Dermatopathol. 2006;28:63-4 pubmed
    ..CD34 stained the stroma. We believe that the focal presence of pleomorphic giant cells in trichoepithelioma has no clinical or prognostic implications and does not denote its "malignant transformation"...
  21. Kazakov D, Spagnolo D, Kacerovska D, Michal M. Lesions of anogenital mammary-like glands: an update. Adv Anat Pathol. 2011;18:1-28 pubmed publisher
    ..This will enable their recognition, precise classification and should introduce greater uniformity in how they are reported in the literature so that more meaningful clinicopathological comparisons and correlations may be made...