K Jirsova

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. ncbi Morphological and immunocytochemical characterization of snake-like chromatin cells
    K Jirsova
    Department of Ophthalmology, General Teaching Hospital, Charles University, Prague, Czech Republic
    Histol Histopathol 21:355-60. 2006
  2. ncbi Cisplatin-induced apoptosis in cultures of human Schwann cells
    Katerina Jirsova
    Laboratory and Ocular Tissue Bank, Department of Ophthalmology, General Teaching Hospital and Charles University, Prague, Czech Republic
    Neurosci Lett 392:22-6. 2006
  3. doi Mesothelial proteins are expressed in the human cornea
    Katerina Jirsova
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, General Teaching Hospital, Charles University, Prague, Czech Republic
    Exp Eye Res 91:623-9. 2010
  4. ncbi [Collagen in the human cornea--types, location and role]
    K Jirsova
    Laborator biologie a patologie oka, Institut dedicnych metabolických chorob, 1 LF UK a VFN, Praha
    Cesk Slov Oftalmol 64:167-70. 2008
  5. pmc The OV-TL 12/30 clone of anti-cytokeratin 7 antibody as a new marker of corneal conjunctivalization in patients with limbal stem cell deficiency
    Katerina Jirsova
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, Prague, Czech Republic
    Invest Ophthalmol Vis Sci 52:5892-8. 2011
  6. ncbi [The application of the autologous serum eye drops results in significant improvement of the conjunctival status in patients with the dry eye syndrome]
    K Jirsova
    Laborator biologie a patologie oka, Ustav dĕdicných metabolických poruch VFN a 1 LF UK, Praha
    Cesk Slov Oftalmol 64:52-6. 2008
  7. ncbi Presence of snake-like chromatin in epithelial cells of keratoconjunctivitis sicca followed by a large number of micronuclei
    Katerina Jirsova
    Laboratory and Ocular Tissue Bank, Department of Ophthalmology, General Teaching Hospital, Prague, Czech Republic
    Acta Cytol 51:541-6. 2007
  8. ncbi Immunohistochemical characterization of cytokeratins in the abnormal corneal endothelium of posterior polymorphous corneal dystrophy patients
    Katerina Jirsova
    Ocular Tissue Bank, General Teaching Hospital and Charles University, U nemocnice 2, Prague 128 08, Czech Republic
    Exp Eye Res 84:680-6. 2007
  9. ncbi Ocular surface injuries in autoimmune dry eye. The severity of microscopical disturbances goes parallel with the severity of symptoms of dryness
    J Cejkova
    Department of Eye Histochemistry and Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Histol Histopathol 24:1357-65. 2009
  10. ncbi [Immunohistochemical characterization of collagen IV in control corneas and in corneas obtained from patients suffering from posterior polymorphous corneal dystrophy]
    S Merjava
    Laborator biologie a patologie oka, Institut dedicnych metabolických chorob, VFN a 1 LF UK, Praha
    Cesk Slov Oftalmol 64:115-9. 2008

Collaborators

  • P Liskova
  • Radoslav Matej
  • S J Tuft
  • G K Klintworth
  • S Merjava
  • Jitka Cejkova
  • Pavel Studeny
  • Kristyna Brejchova
  • Jana Nejepinska
  • Robert Dobrovolny
  • Martin Filipec
  • Rhian Gwilliam
  • Magdalena Vokrojova
  • Andrej Farkas
  • Kristyna Juklova
  • Jana Ledvinova
  • Josef Kraus
  • Milan Elleder
  • Befekadu Asfaw
  • Helena Poupetova
  • Elizabeth J Huckle
  • Stanislav Kmoch
  • Neil D Ebenezer
  • Panos Deloukas
  • Catherine L Stables
  • Shomi S Bhattacharya
  • Alison J Hardcastle

Detail Information

Publications21

  1. ncbi Morphological and immunocytochemical characterization of snake-like chromatin cells
    K Jirsova
    Department of Ophthalmology, General Teaching Hospital, Charles University, Prague, Czech Republic
    Histol Histopathol 21:355-60. 2006
    ....
  2. ncbi Cisplatin-induced apoptosis in cultures of human Schwann cells
    Katerina Jirsova
    Laboratory and Ocular Tissue Bank, Department of Ophthalmology, General Teaching Hospital and Charles University, Prague, Czech Republic
    Neurosci Lett 392:22-6. 2006
    ..Morphological observation revealed advanced as well as less prominent alterations in the nuclear chromatin. In contrast, the TUNEL method detected only those cells with advanced DNA fragmentation...
  3. doi Mesothelial proteins are expressed in the human cornea
    Katerina Jirsova
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, General Teaching Hospital, Charles University, Prague, Czech Republic
    Exp Eye Res 91:623-9. 2010
    ..The much more pronounced occurrence of calbindin 2 in the corneal epithelium compared to fewer positive endothelial cells explains the higher turnover of epithelial cells compared to the proliferatively inactive endothelium...
  4. ncbi [Collagen in the human cornea--types, location and role]
    K Jirsova
    Laborator biologie a patologie oka, Institut dedicnych metabolických chorob, 1 LF UK a VFN, Praha
    Cesk Slov Oftalmol 64:167-70. 2008
  5. pmc The OV-TL 12/30 clone of anti-cytokeratin 7 antibody as a new marker of corneal conjunctivalization in patients with limbal stem cell deficiency
    Katerina Jirsova
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, Prague, Czech Republic
    Invest Ophthalmol Vis Sci 52:5892-8. 2011
    ....
  6. ncbi [The application of the autologous serum eye drops results in significant improvement of the conjunctival status in patients with the dry eye syndrome]
    K Jirsova
    Laborator biologie a patologie oka, Ustav dĕdicných metabolických poruch VFN a 1 LF UK, Praha
    Cesk Slov Oftalmol 64:52-6. 2008
    ....
  7. ncbi Presence of snake-like chromatin in epithelial cells of keratoconjunctivitis sicca followed by a large number of micronuclei
    Katerina Jirsova
    Laboratory and Ocular Tissue Bank, Department of Ophthalmology, General Teaching Hospital, Prague, Czech Republic
    Acta Cytol 51:541-6. 2007
    ..To evaluate the number of micronuclei in snake-like chromatin (SLC) cells in the conjunctival epithelium of keratoconjunctivitis sicca (KCS) patients. To elucidate possible correlations between SLC cell numbers and KCS intensity...
  8. ncbi Immunohistochemical characterization of cytokeratins in the abnormal corneal endothelium of posterior polymorphous corneal dystrophy patients
    Katerina Jirsova
    Ocular Tissue Bank, General Teaching Hospital and Charles University, U nemocnice 2, Prague 128 08, Czech Republic
    Exp Eye Res 84:680-6. 2007
    ..The wide spectrum of CK expression is most probably not indicative of the transformation of endothelial cells to a distinct epithelial phenotype, but more likely reflects the modified differentiation of metaplastic epithelium...
  9. ncbi Ocular surface injuries in autoimmune dry eye. The severity of microscopical disturbances goes parallel with the severity of symptoms of dryness
    J Cejkova
    Department of Eye Histochemistry and Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Histol Histopathol 24:1357-65. 2009
    ..From the clinical point of view it is important that the level of severity of the above described microscopical disturbances found in conjunctival epithelial cells goes parallel with the level of severity of dry eye symptoms...
  10. ncbi [Immunohistochemical characterization of collagen IV in control corneas and in corneas obtained from patients suffering from posterior polymorphous corneal dystrophy]
    S Merjava
    Laborator biologie a patologie oka, Institut dedicnych metabolických chorob, VFN a 1 LF UK, Praha
    Cesk Slov Oftalmol 64:115-9. 2008
    ..An increase of the staining intensity for the alpha1 and alpha2 chains was observed, especially in the Descemet's membrane and the corneal stroma in samples obtained from the patients compared to the control tissues...
  11. ncbi The role of conjunctival epithelial cell xanthine oxidoreductase/xanthine oxidase in oxidative reactions on the ocular surface of dry eye patients with Sjögren's syndrome
    J Cejkova
    Department of Eye Histochemistry and Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Histol Histopathol 22:997-1003. 2007
    ..It is suggested that reactive oxygen species which are generated by this enzymatic system, contribute to oxidative reactions on the eye surface of patients with ocular manifestations of autoimmune disease (Sjögren's syndrome)...
  12. ncbi Cytokeratins 8 and 18 in adult human corneal endothelium
    Stanislava Merjava
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, General Teaching Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic
    Exp Eye Res 89:426-31. 2009
    ..These results clearly demonstrate that cells of the corneal endothelium express CKs 8 and 18 and share some features with simple epithelia...
  13. ncbi Mucolipidosis IV: report of a case with ocular restricted phenotype caused by leaky splice mutation
    Robert Dobrovolny
    Institute of Inherited Metabolic Diseases, First Medical Faculty and General Faculty Hospital, Charles University, Prague, Czech Republic
    Am J Ophthalmol 143:663-71. 2007
    ..To confirm and define a molecular basis for a case of mucolipidosis type IV (ML IV) with an extremely atypical phenotype pattern...
  14. doi Organ culture, but not hypothermic storage, facilitates the repair of the corneal endothelium following mechanical damage
    Jana Nejepinska
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Acta Ophthalmol 88:413-9. 2010
    ..To evaluate the reparative capacity of the mechanically injured endothelium of corneas stored under organ culture (OC) or hypothermic conditions...
  15. doi Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy
    Stanislava Merjava
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, General Teaching Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic
    Exp Eye Res 88:945-52. 2009
    ..The increased expression of the alpha1, alpha2 collagen IV and alpha1 collagen VIII chains and the change in their localization in DM may contribute to the increased endothelial proliferative capacity observed in PPCD patients...
  16. doi Role of matrix metalloproteinases in recurrent corneal melting
    Kristyna Brejchova
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital Prague, Ke Karlovu 2, 12808 Prague 2, Czech Republic
    Exp Eye Res 90:583-90. 2010
    ....
  17. doi The assessment of pathogenic prions in the brains of eye tissue donors: 2-years experience in the Czech Republic
    Katerina Jirsova
    Ocular Tissue Bank General Teaching Hospital, Charles University, Prague, Czech Republic
    Cornea 29:996-9. 2010
    ..The aim of this study was to assess the presence of pathogenic prions in the brain tissue of eye donors and to evaluate the benefits of 2-year obligatory testing in the Czech Republic...
  18. doi Descemet membrane endothelial keratoplasty with a stromal rim (DMEK-S)
    Pavel Studeny
    Department of Ophthalmology, Sokolov Hospital, Sokolov, Czech Republic
    Br J Ophthalmol 94:909-14. 2010
    ..To describe a novel technique for the preparation and transplantation of posterior corneal lamellae consisting of endothelium and bare Descemet membrane with a stromal supporting rim...
  19. ncbi Posterior polymorphous corneal dystrophy in Czech families maps to chromosome 20 and excludes the VSX1 gene
    Rhian Gwilliam
    Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    Invest Ophthalmol Vis Sci 46:4480-4. 2005
    ..In the Czech Republic, PPCD is one of the most prevalent corneal dystrophies. The purpose of this study was to determine the chromosomal locus of PPCD in two large Czech families, by using linkage analysis...
  20. doi Phenotype associated with the H626P mutation and other changes in the TGFBI gene in Czech families
    Petra Liskova
    Division of Molecular Genetics, Institute of Ophthalmology, UCL, London, UK
    Ophthalmic Res 40:105-8. 2008
    ..To evaluate mutations in the transforming-growth-factor-beta-induced (TGFBI) gene in patients of Czech origin with autosomal dominant corneal dystrophies...
  21. pmc Novel mutations in the ZEB1 gene identified in Czech and British patients with posterior polymorphous corneal dystrophy
    Petra Liskova
    Division of Molecular Genetics, Institute of Ophthalmology, UCL, London, United Kingdom
    Hum Mutat 28:638. 2007
    ..In the remaining six families no disease causing mutations were identified thereby indicating that as yet unidentified gene(s) are likely to be responsible for PPCD...