J Horacek

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. doi request reprint Latent toxoplasmosis reduces gray matter density in schizophrenia but not in controls: voxel-based-morphometry (VBM) study
    Jiri Horacek
    Prague Psychiatric Centre, Faculty of Science of Charles University, Prague, Czech Republic
    World J Biol Psychiatry 13:501-9. 2012
  2. ncbi request reprint The influence of clonidine on oral ketamine-midazolam premedication in intellectually disabled patients indicated for dental procedures: double-blind comparison of two sedation regimes
    Jiri Horacek
    Prague Psychiatric Centre, Prague, Czech Republic
    Neuro Endocrinol Lett 33:380-4. 2012
  3. doi request reprint Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect
    J Horacek
    Prague Psychiatric Centre, Prague, Czech Republic
    Psychol Med 40:1443-51. 2010
  4. ncbi request reprint Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study
    Jiri Horacek
    Centre of Neuropsychiatric Studies, Prague Psychiatric Center, Prague, Czech Republic
    Neuro Endocrinol Lett 27:587-94. 2006
  5. ncbi request reprint The effect of tryptophan depletion on brain activation measured by functional magnetic resonance imaging during the Stroop test in healthy subjects
    J Horacek
    Prague Psychiatric Centre, Ustavni 91, 18100 Prague 8, Czech Republic
    Physiol Res 54:235-44. 2005
  6. ncbi request reprint Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia
    Jiri Horacek
    Prague Psychiatric Centre, Prague, Czech Republic
    CNS Drugs 20:389-409. 2006
  7. ncbi request reprint Effect of low-frequency rTMS on electromagnetic tomography (LORETA) and regional brain metabolism (PET) in schizophrenia patients with auditory hallucinations
    Jiri Horacek
    Prague Psychiatric Center, Prague, Czech Republic
    Neuropsychobiology 55:132-42. 2007
  8. ncbi request reprint Novel antipsychotics and extrapyramidal side effects. Theory and reality
    J Horacek
    Prague Psychiatric Centre and the 3rd Faculty of Medicine of Charles University, Czech Republic
    Pharmacopsychiatry 33:34-42. 2000
  9. ncbi request reprint The relationship between central serotonergic activity and insulin sensitivity in healthy volunteers
    J Horacek
    3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    Psychoneuroendocrinology 24:785-97. 1999
  10. ncbi request reprint Prolactin response to D-fenfluramine challenge test as a predictor of treatment response to haloperidol in acute schizophrenia
    P Mohr
    Prague Psychiatric Center, Praha, 8, Czech Republic
    Schizophr Res 30:91-9. 1998

Collaborators

Detail Information

Publications43

  1. doi request reprint Latent toxoplasmosis reduces gray matter density in schizophrenia but not in controls: voxel-based-morphometry (VBM) study
    Jiri Horacek
    Prague Psychiatric Centre, Faculty of Science of Charles University, Prague, Czech Republic
    World J Biol Psychiatry 13:501-9. 2012
    ..To address the role of latent T. gondii infection in schizophrenia we studied the influence of latent toxoplasmosis on brain morphology...
  2. ncbi request reprint The influence of clonidine on oral ketamine-midazolam premedication in intellectually disabled patients indicated for dental procedures: double-blind comparison of two sedation regimes
    Jiri Horacek
    Prague Psychiatric Centre, Prague, Czech Republic
    Neuro Endocrinol Lett 33:380-4. 2012
    ..The oral administration of sedating drugs can remediate the problems with cooperation and enable the medical procedures to take place. Standard guidelines are lacking for oral sedation of the intellectually disabled...
  3. doi request reprint Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect
    J Horacek
    Prague Psychiatric Centre, Prague, Czech Republic
    Psychol Med 40:1443-51. 2010
    ..Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has a unique rapid antidepressant effect but its influence on theta cordance is unknown...
  4. ncbi request reprint Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study
    Jiri Horacek
    Centre of Neuropsychiatric Studies, Prague Psychiatric Center, Prague, Czech Republic
    Neuro Endocrinol Lett 27:587-94. 2006
    ..Resting brain metabolism was investigated by (18)FDG positron emission tomography (PET) as the probe for the relative regional synaptic strength and density...
  5. ncbi request reprint The effect of tryptophan depletion on brain activation measured by functional magnetic resonance imaging during the Stroop test in healthy subjects
    J Horacek
    Prague Psychiatric Centre, Ustavni 91, 18100 Prague 8, Czech Republic
    Physiol Res 54:235-44. 2005
    ..The present findings allow the postulate that serotonergic medial forebrain and cingulum bundle pathways play a role in the activity of cortical structures involved in Stroop test processing...
  6. ncbi request reprint Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia
    Jiri Horacek
    Prague Psychiatric Centre, Prague, Czech Republic
    CNS Drugs 20:389-409. 2006
    ..This mechanism may normalise glutamatergic dysfunction and structural abnormalities and affect the core pathophysiological substrates for schizophrenia...
  7. ncbi request reprint Effect of low-frequency rTMS on electromagnetic tomography (LORETA) and regional brain metabolism (PET) in schizophrenia patients with auditory hallucinations
    Jiri Horacek
    Prague Psychiatric Center, Prague, Czech Republic
    Neuropsychobiology 55:132-42. 2007
    ..A neuroimaging study elucidating the effect of rTMS in auditory hallucinations has yet to be published...
  8. ncbi request reprint Novel antipsychotics and extrapyramidal side effects. Theory and reality
    J Horacek
    Prague Psychiatric Centre and the 3rd Faculty of Medicine of Charles University, Czech Republic
    Pharmacopsychiatry 33:34-42. 2000
    ..This paper briefly outlines the hypotheses and observations and summarizes the current knowledge of the occurrence of and risk for extrapyramidal side effects with novel antipsychotics...
  9. ncbi request reprint The relationship between central serotonergic activity and insulin sensitivity in healthy volunteers
    J Horacek
    3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    Psychoneuroendocrinology 24:785-97. 1999
    ..The data support the hypothesis of a close connection between 5-HT activity in the brain and peripheral sensitivity to insulin. The possible physiological mechanisms of this connection are discussed...
  10. ncbi request reprint Prolactin response to D-fenfluramine challenge test as a predictor of treatment response to haloperidol in acute schizophrenia
    P Mohr
    Prague Psychiatric Center, Praha, 8, Czech Republic
    Schizophr Res 30:91-9. 1998
    ..The higher responsiveness of the 5-HT system in first episode, non-medicated schizophrenics, was associated with a poorer treatment response to haloperidol, an antidopaminergic neuroleptic...
  11. ncbi request reprint The influence of low-frequency left prefrontal repetitive transcranial magnetic stimulation on memory for words but not for faces
    L Skrdlantova
    Prague Psychiatric Centre, Ustavni 91, 181 00 Prague 8, Czech Republic
    Physiol Res 54:123-8. 2005
    ..As a non-invasive tool, rTMS is useful for cognitive brain mapping and the functional localization of the category specific memory system...
  12. ncbi request reprint Increased sensitivity to the acute effects of MDMA ("ecstasy") in female rats
    T Palenicek
    Laboratory of Biochemistry and Pathophysiology of the Brain, Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Czech Republic
    Physiol Behav 86:546-53. 2005
    ..Increased sensitivity of females to the behavioral effects of MDMA can be explained by increased reactivity of serotonergic and dopaminergic systems...
  13. ncbi request reprint [The dry binders, Vivapur 102, Vivapur 12 and the effect of magnesium stearate on the strength of tablets containing these substances]
    J Mužíková
    Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Kralove
    Ceska Slov Farm 52:176-80. 2003
    ....
  14. ncbi request reprint [Lyme borreliosis--incidence of serum anti-myelin antibodies]
    O Ryskova
    Ustav klinické mikrobiologie, UK Praha, LF Hradec Králové
    Epidemiol Mikrobiol Imunol 51:60-5. 2002
    ....
  15. ncbi request reprint Mescaline effects on rat behavior and its time profile in serum and brain tissue after a single subcutaneous dose
    Tomas Palenicek
    Prague Psychiatric Center, Ustavni 91, 181 03, Prague 8, Bohnice, Czech Republic
    Psychopharmacology (Berl) 196:51-62. 2008
    ..Mescaline attenuates various behavioral parameters in rats; however, no information is available about its pharmacokinetics in rats and its relation to the behavioral changes produced by the drug...
  16. ncbi request reprint An analysis of spontaneous behavior following acute MDMA treatment in male and female rats
    Tomas Palenicek
    Laboratory of Biochemistry and Pathophysiology of the Brain, Prague Psychiatric Centre, Prague, Czech Republic
    Neuro Endocrinol Lett 28:781-8. 2007
    ..This study also confirms that behavioral experiments should focus on more behavioral elements than only on e.g. locomotion and that the observer-based approach still gives the most reliable results...
  17. doi request reprint Models of schizophrenia in humans and animals based on inhibition of NMDA receptors
    Vera Bubenikova-Valesova
    Prague Psychiatric Center, Prague, Czech Republic
    Neurosci Biobehav Rev 32:1014-23. 2008
    ....
  18. ncbi request reprint Dementia in a patient with Fahr's syndrome
    Katerina Konupcíková
    Department of Psychiatry, Charles University in Prague, Faculty of Medicine, Czech Republic
    Neuro Endocrinol Lett 29:431-4. 2008
    ..Extensive brain calcifications together with unevenly distributed perfusion on single photon emission tomography are documented...
  19. doi request reprint LORETA functional imaging in antipsychotic-naive and olanzapine-, clozapine- and risperidone-treated patients with schizophrenia
    Barbora Tislerova
    3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    Neuropsychobiology 58:1-10. 2008
    ..The lack of difference in risperidone patients versus antipsychotic-naive subjects may relate to risperidone's different pharmacodynamic mechanism...
  20. doi request reprint Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition
    Tomas Palenicek
    Prague Psychiatric Center, Ustavni 91, 181 03, Prague 8, Czech Republic
    Prog Neuropsychopharmacol Biol Psychiatry 34:588-96. 2010
    ..On the contrary although LSD disrupted PPI in males and MD female rats, EP females were protected from this disruptive effect. Thus, EP females seem to have a lower sensitivity to LSD behavioural actions...
  21. doi request reprint Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats
    Vera Bubenikova-Valesova
    Department of Brain Pathophysiology and Biochemistry, Prague Psychiatric Centre, Prague, Czech Republic
    Psychopharmacology (Berl) 212:267-76. 2010
    ..Augmentation therapy with serotonin-1A receptor (5-HT1A) partial agonists has been suggested to ameliorate psychotic symptoms in patients with schizophrenia...
  22. ncbi request reprint Trazodone improves the results of cognitive behaviour therapy of primary insomnia in non-depressed patients
    Lucie Zavesicka
    Prague Psychiatric Center, 3rd Faculty of Medicine, Charles University, Ustavni 91, 181 03 Praha 8 Bohnice, Czech Republic
    Neuro Endocrinol Lett 29:895-901. 2008
    ..The present study was undertaken to evaluate the clinical efficacy of CBT, singly and combined with trazodone pharmacotherapy, for primary insomnia...
  23. doi request reprint Medial frontal and dorsal cortical morphometric abnormalities are related to obsessive-compulsive disorder
    Jana Koprivova
    Prague Psychiatric Centre, Prague, Czech Republic
    Neurosci Lett 464:62-6. 2009
    ..The relationships between OCD and clinical variables provide further evidence that frontal, parietal and occipital structures play a role in the disorder...
  24. doi request reprint Expression of the hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study
    Monika Vrajová
    Prague Psychiatric Center, Ustavni 91, 181 03, Prague 8, Czech Republic
    Neurochem Res 35:994-1002. 2010
    ....
  25. ncbi request reprint Language lateralization in monozygotic twins discordant and concordant for schizophrenia. A functional MRI pilot study
    Filip Spaniel
    Psychiatric Center, Ustavní 191, 181 03 Prague 8, Czech Republic
    Eur Psychiatry 22:319-22. 2007
    ..Previous studies have suggested altered structural and functional asymmetry of the brain in schizophrenia...
  26. ncbi request reprint The effect of repetitive transcranial magnetic stimulation (rTMS) add on serotonin reuptake inhibitors in patients with panic disorder: a randomized, double blind sham controlled study
    Jan Prasko
    Psychiatric Centre Prague Charles University, 3rd School of Medicine in Prague, Czech Republic
    Neuro Endocrinol Lett 28:33-8. 2007
    ..Transcranial magnetic stimulation (rTMS) can modulate cortical activity. The goal of our study was to assess whether rTMS would facilitate effect of serotonin reuptake inhibitors in patients with panic disorder...
  27. ncbi request reprint 18FDG PET in hallucinating and non-hallucinating patients
    Miloslav Kopecek
    Prague Psychiatric Centre, 3rd Medical Faculty Prague Charles University, Centre of Neuropsychiatric Studies in Prague, Prague, Czech Republic
    Neuro Endocrinol Lett 28:53-9. 2007
    ..The aim of the study was to detect whether the abnormal regional brain activity correlates with auditory verbal hallucination-proneness (AVH) in a group of patients with schizophrenia and schizophrenia-related psychoses...
  28. ncbi request reprint Magnetic resonance relaxometry in monozygotic twins discordant and concordant for schizophrenia
    Filip Spaniel
    Psychiatric Center Prague, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic
    Eur Psychiatry 20:41-4. 2005
    ..Patients with schizophrenia (n = 11) showed significant prolongation in T1 relaxation times in the globus pallidus (GP) bilaterally (P < 0.005, Bonferroni corrected) when compared to 14 healthy MZ twins...
  29. ncbi request reprint The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating
    Vera Bubenikova
    Prague Psychiatric Center affiliated with the Charles University 3rd Faculty of Medicine and the Center of Neuropsychiatric Studies, 181 03 Prague 8, Czech Republic
    Pharmacol Biochem Behav 80:591-6. 2005
    ..5 and 5 mg/kg) without MK-801 treatment. In summary, the four "atypical" antipsychotics had different efficacies to restore the disrupted PPI by MK-801. Only clozapine and olanzapin restored the MK-801-induced deficits in PPI...
  30. ncbi request reprint The change of regional brain metabolism (18FDG PET) in panic disorder during the treatment with cognitive behavioral therapy or antidepressants
    Jan Prasko
    Prague Psychiatric Centre, 3rd Faculty of Medicine Charles University Prague, Centre of Neuropsychiatric Studies, Prague, Czech Republic
    Neuro Endocrinol Lett 25:340-8. 2004
    ..The goal of our study was to identify brain structures in patients with panic disorder (PD) that show changes in 18FDG PET during the treatment with cognitive behavioral therapy (CBT) or antidepressants...
  31. ncbi request reprint The effect of tryptophan depletion on the action of haloperidol in MK-801-treated rats
    Vera Bubenikova
    Prague Psychiatric Center and Center of Neuropsychiatric Studies, 181 03 Prague 8, Czech Republic
    Eur J Pharmacol 502:109-16. 2004
    ..The effect of the tryptophan-free mixture combined with the classical antipsychotic haloperidol in MK-801-treated rats indicates the possibly important role of the serotonergic system in the action of antipsychotics...
  32. ncbi request reprint The effect of repetitive transcranial magnetic stimulation (rTMS) on symptoms in obsessive compulsive disorder. A randomized, double blind, sham controlled study
    Jan Prasko
    Psychiatric Centre Prague, Czech Republic
    Neuro Endocrinol Lett 27:327-32. 2006
    ..The goal of our study is to assess whether transcranial magnetic stimulation (rTMS) would facilitate the effect of antidepressant in OCD patients...
  33. ncbi request reprint Moclobemide and cognitive behavioral therapy in the treatment of social phobia. A six-month controlled study and 24 months follow up
    Jan Prasko
    Psychiatric Centre Prague, Ustavni 91, 181 03 Prague 8, Czech Republic
    Neuro Endocrinol Lett 27:473-81. 2006
    ..The relapse rate during the 24-month follow up was significantly lower in the group treated with CBT in comparison with the group A. formerly treated with moclobemide alone...
  34. ncbi request reprint Bright light therapy and/or imipramine for inpatients with recurrent non-seasonal depression
    Jan Prasko
    Psychiatric Centre Prague, 3rd Medical Faculty Charles University Prague, Czech Republic
    Neuro Endocrinol Lett 23:109-13. 2002
    ..The aim of a double-blind study was to assess the efficacy of bright light therapy and/or imipramine in the treatment of inpatients suffering with recurrent non-seasonal major depressive disorder...
  35. ncbi request reprint The double-blind sham-controlled study of high-frequency rTMS (20 Hz) for negative symptoms in schizophrenia: negative results
    Tomas Novak
    Psychiatric Centre Prague, Charles University, 3rd School of Medicine in Prague, Czech Republic
    Neuro Endocrinol Lett 27:209-13. 2006
    ..Results from our study did not confirm that HF-rTMS over the left DLPCF affects the negative symptoms of schizophrenia and alternative rTMS approaches are discussed...
  36. ncbi request reprint Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia
    Miloslav Kopecek
    Prague Psychiatric Centre, 3rd Medical Faculty Prague Charles University, Centre of Neuropsychiatric Studies in Prague, Prague, Czech Republic
    Neuro Endocrinol Lett 27:803-6. 2006
    ..Risperidone in antipsychotic doses induces hyperprolactinemia. The aim of this study was to verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics...
  37. ncbi request reprint The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801
    Vera Bubenikova-Valesova
    Prague Psychiatric Center and the Center of Neuropsychiatric Studies, Prague, Czech Republic
    Neuropharmacology 52:1071-8. 2007
    ..In addition, these findings could indicate that activation of the 5-HT(1A) autoreceptor could be effective as a treatment in schizophrenia, but full potent agonism of the receptor could worsen the psychotic symptoms...
  38. ncbi request reprint Hyperprolactinemia after low dose of amisulpride
    Miloslav Kopecek
    Psychiatric Centre Prague, Czech Republic
    Neuro Endocrinol Lett 25:419-22. 2004
    ..Amisulpride in antipsychotic doses can induce hyperprolactinemia. The aim of this study was to prove whether the same is true for low doses of amisulpride...
  39. doi request reprint Differences in onset of disease and severity of psychopathology between toxoplasmosis-related and toxoplasmosis-unrelated schizophrenia
    D Holub
    Medical Faculty Charles University, Hradec Kralove, Czech Republic
    Acta Psychiatr Scand 127:227-38. 2013
    ..Toxoplasmosis is a lifelong parasitic disease that appears to be associated to schizophrenia. However, no distinguishing attributes in Toxoplasma-infected schizophrenia patients have been described as yet...
  40. ncbi request reprint Relation of sex and estrous phase to deficits in prepulse inhibition of the startle response induced by ecstasy (MDMA)
    V Bubenikova
    Prague Psychiatric Center, Prague, Czech Republic
    Behav Pharmacol 16:127-30. 2005
    ..Our result showed that female rats in the proestrous and estrous phases were less sensitive to the disruption of PPI by MDMA...
  41. ncbi request reprint A randomized, double blind comparative study of prophylactic parenteral nutritional support with or without glutamine in autologous stem cell transplantation for hematological malignancies -- three years' follow-up
    A Sykorova
    2nd Department of Internal Medicine, Charles University, Faculty of Medicine and University Hospital, 500 05 Hradec Kralove, Czech Republic
    Neoplasma 52:476-82. 2005
    ..In the three years' follow-up, no clinically useful benefit of prophylactic PN in autologous transplant patients was proven. Also, glutamine supplementation was not helpful, and was even connected with apparently worse long-term outcome...
  42. ncbi request reprint Parallel optimization and genotyping of multiple single-nucleotide polymorphism markers by sample pooling approach using cycling-gradient CE with multiple injections
    Marek Minarik
    Genomac International, Laboratory for Molecular Genetics, Prague, Czech Republic
    Electrophoresis 27:3856-63. 2006
    ..The main advantages include low cost, simple setup and validation of SNP markers...
  43. ncbi request reprint Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer's disease
    Ibrahim Ibrahim
    Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, MR Unit, Prague, Czech Republic
    Neuro Endocrinol Lett 30:39-45. 2009
    ..Fractional anisotropy in the corpus callosum of both groups was also calculated using ROI analysis...