M Haluzik

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. ncbi request reprint [Pathophysiological background for incretin therapy: is it capable of more than we think?]
    M Haluzik
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 57:897-902. 2011
  2. ncbi request reprint Three months of regular aerobic exercise in patients with obesity improve systemic subclinical inflammation without major influence on blood pressure and endocrine production of subcutaneous fat
    P Trachta
    Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Physiol Res 63:S299-308. 2014
  3. ncbi request reprint Serum concentrations and subcutaneous adipose tissue mRNA expression of omentin in morbid obesity and type 2 diabetes mellitus: the effect of very-low-calorie diet, physical activity and laparoscopic sleeve gastrectomy
    M Urbanova
    Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Physiol Res 63:207-18. 2014
  4. pmc The use of continuous glucose monitoring combined with computer-based eMPC algorithm for tight glucose control in cardiosurgical ICU
    Petr Kopecky
    Department of Anaesthesia, Resuscitation and Intensive Medicine, 1st Faculty of Medicine and General University Hospital, Charles University in Prague, U nemocnice 2, 128 08 Prague 2, Czech Republic
    Biomed Res Int 2013:186439. 2013
  5. ncbi request reprint Cardiac surgery increases serum concentrations of adipocyte fatty acid-binding protein and its mRNA expression in circulating monocytes but not in adipose tissue
    T Kotulak
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 63:83-94. 2014
  6. doi request reprint Laparoscopic sleeve gastrectomy differentially affects serum concentrations of FGF-19 and FGF-21 in morbidly obese subjects
    D Haluzikova
    3rd Department of Medicine, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Obesity (Silver Spring) 21:1335-42. 2013
  7. ncbi request reprint Adiponectin and its potential in the treatment of obesity, diabetes and insulin resistance
    Martin Haluzik
    Charles University, Third Department of Medicine, First Faculty of Medicine, Prague, Czech Republic
    Curr Opin Investig Drugs 6:988-93. 2005
  8. ncbi request reprint Adipocytokines and cancer
    D Housa
    Third Department of Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 00 Prague 2, Czech Republic
    Physiol Res 55:233-44. 2006
  9. ncbi request reprint The influence of very-low-calorie-diet on serum leptin, soluble leptin receptor, adiponectin and resistin levels in obese women
    K Anderlova
    Third Department of Medicine and 1 Faculty of Medicine, Charles University, U Nemocnice 1, 128 00 Prague 2 Czech Republic
    Physiol Res 55:277-83. 2006
  10. ncbi request reprint PPAR-alpha and insulin sensitivity
    M M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University and University Hospital, U Nemocnice 1, 128 08, Praha 2, Czech Republic
    Physiol Res 55:115-22. 2006

Detail Information

Publications83

  1. ncbi request reprint [Pathophysiological background for incretin therapy: is it capable of more than we think?]
    M Haluzik
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 57:897-902. 2011
    ..The aim of this review is to summarize both metabolic and extrapancreatic effects of incretin-based therapies and to outline perspectives of potential wider use of this treatment approach...
  2. ncbi request reprint Three months of regular aerobic exercise in patients with obesity improve systemic subclinical inflammation without major influence on blood pressure and endocrine production of subcutaneous fat
    P Trachta
    Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Physiol Res 63:S299-308. 2014
    ..We conclude that three months of regular exercise decrease systemic subclinical inflammation with only minor influence on the blood pressure and the endocrine function of subcutaneous fat. ..
  3. ncbi request reprint Serum concentrations and subcutaneous adipose tissue mRNA expression of omentin in morbid obesity and type 2 diabetes mellitus: the effect of very-low-calorie diet, physical activity and laparoscopic sleeve gastrectomy
    M Urbanova
    Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Physiol Res 63:207-18. 2014
    ..The increase in circulating omentin levels and the decrease in omentin mRNA expression in SCAT of obese women after LSG might contribute to surgery-induced metabolic improvements and sustained reduction of body weight. ..
  4. pmc The use of continuous glucose monitoring combined with computer-based eMPC algorithm for tight glucose control in cardiosurgical ICU
    Petr Kopecky
    Department of Anaesthesia, Resuscitation and Intensive Medicine, 1st Faculty of Medicine and General University Hospital, Charles University in Prague, U nemocnice 2, 128 08 Prague 2, Czech Republic
    Biomed Res Int 2013:186439. 2013
    ..In postcardiac surgery patients, we assessed the performance of a system for intensive intravenous insulin therapy using continuous glucose monitoring (CGM) and enhanced model predictive control (eMPC) algorithm...
  5. ncbi request reprint Cardiac surgery increases serum concentrations of adipocyte fatty acid-binding protein and its mRNA expression in circulating monocytes but not in adipose tissue
    T Kotulak
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 63:83-94. 2014
    ..Our data suggest that circulating A-FABP might be involved in the development of acute perioperative stress response, insulin resistance and hyperglycemia of critically ill irrespectively of the presence of diabetes mellitus. ..
  6. doi request reprint Laparoscopic sleeve gastrectomy differentially affects serum concentrations of FGF-19 and FGF-21 in morbidly obese subjects
    D Haluzikova
    3rd Department of Medicine, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Obesity (Silver Spring) 21:1335-42. 2013
    ..The aim of the study was to assess the effects of laparoscopic sleeve gastrectomy (LSG) on serum concentrations of FGF-19 and FGF-21 along with circulating bile acids and other relevant hormonal and biochemical parameters...
  7. ncbi request reprint Adiponectin and its potential in the treatment of obesity, diabetes and insulin resistance
    Martin Haluzik
    Charles University, Third Department of Medicine, First Faculty of Medicine, Prague, Czech Republic
    Curr Opin Investig Drugs 6:988-93. 2005
    ..Current experimental and clinical data regarding adiponectin physiology and pathophysiology are detailed in this review...
  8. ncbi request reprint Adipocytokines and cancer
    D Housa
    Third Department of Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 00 Prague 2, Czech Republic
    Physiol Res 55:233-44. 2006
    ..Further studies are necessary to decide whether obesity-induced endocrine dysfunction of adipose tissue can directly influence carcinogenesis in different tissues and organs...
  9. ncbi request reprint The influence of very-low-calorie-diet on serum leptin, soluble leptin receptor, adiponectin and resistin levels in obese women
    K Anderlova
    Third Department of Medicine and 1 Faculty of Medicine, Charles University, U Nemocnice 1, 128 00 Prague 2 Czech Republic
    Physiol Res 55:277-83. 2006
    ..Therefore, other mechanisms rather than changes in the endocrine function of the adipose tissue are probably involved in the VLCD-induced improvement of insulin sensitivity...
  10. ncbi request reprint PPAR-alpha and insulin sensitivity
    M M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University and University Hospital, U Nemocnice 1, 128 08, Praha 2, Czech Republic
    Physiol Res 55:115-22. 2006
    ..Further clinical studies using more potent PPAR-alpha agonists on a larger population need to be performed to evaluate the possible role of PPAR- alpha in the regulation of insulin sensitivity in humans...
  11. ncbi request reprint The role of resistin in obesity-induced insulin resistance
    Martin Haluzik
    Charles University, Third Department of Medicine, First Faculty of Medicine, Prague, Czech Republic
    Curr Opin Investig Drugs 7:306-11. 2006
    ..Current experimental and clinical data concerning resistin physiology and pathophysiology, and its possible role in the development of insulin resistance and atherosclerosis are detailed in this review...
  12. ncbi request reprint Improvement of insulin sensitivity after peroxisome proliferator-activated receptor-alpha agonist treatment is accompanied by paradoxical increase of circulating resistin levels
    M M Haluzik
    Third Department of Medicine, First Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic
    Endocrinology 147:4517-24. 2006
    ..This effect could be partially explained by increased AdipoR1 expression in adipose tissue after fenofibrate treatment...
  13. ncbi request reprint [Peroxisome proliferator activated receptors (PPAR) and insulin sensitivity: experimental studies]
    M M Haluzik
    Katedra chemie Prírodovedecké fakulty Ostravské univerzity, Ostrava
    Cesk Fysiol 55:163-8. 2006
    ..Here we summarize the experimental studies focusing on the role of PPAR-alpha in the regulation of insulin sensitivity and discuss possible mechanisms involved...
  14. ncbi request reprint [Adipose tissue hormones]
    M Haluzik
    III interní klinika 1 lékarské fakulty UKa VFN Praha
    Vnitr Lek 56:1028-34. 2010
    ..It also describes its possible role in the ethiopathogenesis of insulin resistance, atherosclerosis and other obesity-related pathologies...
  15. pmc Association of macrophage inhibitory cytokine-1 with nutritional status, body composition and bone mineral density in patients with anorexia nervosa: the influence of partial realimentation
    Ivana Dostalova
    3rd Department of Medicine, 1st Faculty of Medicine, Charles University and General University Hospital, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Nutr Metab (Lond) 7:34. 2010
    ..However, its possible role in the etiopathogenesis of nutritional disorders of other etiology such as anorexia nervosa (AN) is currently unknown...
  16. ncbi request reprint [Treatment of type 2 diabetes mellitus with GLP-1 agonists]
    M Haluzik
    II interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 57:411-5. 2011
    ..We will focus mostly on the two drugs that are currently available in Czech Republic--exenatide and liraglutide...
  17. ncbi request reprint Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice
    Martin Haluzik
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 145:3258-64. 2004
    ....
  18. ncbi request reprint Adiponectin and its role in the obesity-induced insulin resistance and related complications
    M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08, Praha 2, Czech Republic
    Physiol Res 53:123-9. 2004
    ..The aim of this review is to summarize the current knowledge about the physiology and pathophysiology of adiponectin and to discuss its potential in the treatment of insulin resistance and atherosclerosis...
  19. ncbi request reprint The influence of methylene blue and L-NAME on the development of streptozotocin-induced diabetes in rats
    M Haluzik
    IIIrd Department of Medicine, 1st Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Sb Lek 100:213-7. 1999
    ..The precise mechanism of this effect is not clear. We failed to demonstrate clear effect of methylene blue and/or L-NAME on oxidative stress development in diabetic rats...
  20. ncbi request reprint Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa
    Jitka Housova
    Third Department of Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08, Prague 2, Czech Republic
    J Clin Endocrinol Metab 90:1366-70. 2005
    ..We suggest that increased adiponectin levels reflect decreased body fat content in AN patients. In contrast, circulating resistin levels do not appear to be closely related to the nutritional status...
  21. ncbi request reprint The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications
    M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 49:S37-42. 2000
    ..Further clarification of the role of nitric oxide in streptozotocin-induced diabetes development could have important clinical implications...
  22. ncbi request reprint Serum leptin concentrations in patients with combined hyperlipidemia: relationship to serum lipids and lipoproteins
    M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 48:363-8. 1999
    ..We conclude that serum leptin concentrations in patients with combined hyperlipidemia as well as in healthy control subjects reflect the body fat content and have no significant relation to serum lipids or lipoproteins...
  23. ncbi request reprint Serum leptin levels in patients with hyperlipidemias
    M Haluzik
    3rd Medical Department, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Nutrition 16:429-33. 2000
    ..We conclude that serum leptin levels in patients with hyperlipidemias do not significantly differ from those healthy control subjects matched by age and body mass index...
  24. ncbi request reprint Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies
    Martin Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Endocrinology 145:1662-7. 2004
    ....
  25. ncbi request reprint [The effect of an NO-synthase inhibitor, methylene blue, on the function of certain endocrine glands]
    M Haluzik
    III interní klinika 1 lékarské fakulty Univerzity karlovy, Praha, Czech Republic
    Sb Lek 98:267-76. 1997
    ..The possible mechanism of its influence with potential role of nitric oxide in the modulation of regulating pathways in these endocrine glands is discussed...
  26. ncbi request reprint Treatment with the NO-synthase inhibitor, methylene blue, moderates the decrease in serum leptin concentration in streptozotocin-induced diabetes
    M Haluzik
    3 Medical Department, 1 Faculty of Medicine, Prague, Czech Republic
    Endocr Res 25:163-71. 1999
    ..We conclude that the drop of serum leptin levels in diabetic rats is probably mainly due to streptozotocin-induced insulin deficiency, which is partially attenuated by NO-synthase inhibitor treatment...
  27. ncbi request reprint Relationship of serum leptin levels and selected nutritional parameters in patients with protein-caloric malnutrition
    M Haluzik
    3 Medical Department, 1 Faculty of Medicine, Charles University, Prague, Czech Republic
    Nutrition 15:829-33. 1999
    ....
  28. ncbi request reprint Influence of PPAR-alpha agonist fenofibrate on insulin sensitivity and selected adipose tissue-derived hormones in obese women with type 2 diabetes
    K Anderlova
    Third Department of Medicine, First Faculty of Medicine, Charles University, Praha, Czech Republic
    Physiol Res 56:579-86. 2007
    ..The lack of insulin-sensitizing effects of fenofibrate in humans relative to rodents could be due to a generally lower PPAR-alpha expression in human liver and muscle...
  29. ncbi request reprint Serum adipocyte fatty acid binding protein levels in patients with type 2 diabetes mellitus and obesity: the influence of fenofibrate treatment
    M M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 58:93-9. 2009
    ..This combination makes FABP a valuable marker of metabolic disturbances in patients with type 2 diabetes mellitus...
  30. ncbi request reprint Serum preadipocyte factor-1 concentrations in females with obesity and type 2 diabetes mellitus: the influence of very low calorie diet, acute hyperinsulinemia, and fenofibrate treatment
    P Kavalkova
    Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic
    Horm Metab Res 45:820-6. 2013
    ..The decrease of Pref-1 levels after VLCD may be involved in the improvement of metabolic status and the amelioration of insulin resistance in T2DM patients. ..
  31. ncbi request reprint The influence of obesity and different fat depots on adipose tissue gene expression and protein levels of cell adhesion molecules
    L Bosanska
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 59:79-88. 2010
    ..Increased adhesion molecules production in visceral fat may provide a novel direct link between visceral adiposity and increased risk of cardiovascular complications...
  32. ncbi request reprint Adiponectin and resistin gene polymorphisms in patients with anorexia nervosa and obesity and its influence on metabolic phenotype
    J Krizova
    Third Department of Medicine, First Medical Faculty, Charles University, Prague, Czech Republic
    Physiol Res 57:539-46. 2008
    ..We conclude that polymorphisms in adiponectin and resistin genes can contribute to metabolic phenotype of patients with obesity and anorexia nervosa...
  33. doi request reprint Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity
    M Mraz
    Third Department of Medicine, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
    Clin Endocrinol (Oxf) 71:369-75. 2009
    ....
  34. ncbi request reprint Preadipocyte factor-1 concentrations in patients with anorexia nervosa: the influence of partial realimentation
    P Kavalkova
    Third Department of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 61:153-9. 2012
    ..05). We conclude that alterations in Pref-1 are not involved in the ethiopathogenesis of anorexia nervosa but its changes after partial realimentation could be involved in the regulation of adipose tissue expansion after realimentation...
  35. ncbi request reprint Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome
    V Durovcová
    Third Department of Medicine, First Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic
    Physiol Res 59:415-22. 2010
    ..In contrast neither obesity nor hypercortisolism significantly affected FGF19 concentrations...
  36. ncbi request reprint Serum concentrations of adipocyte fatty acid binding protein in patients with anorexia nervosa
    D Haluzikova
    Department of Sports Medicine, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
    Physiol Res 58:577-81. 2009
    ..We conclude that, in contrast to patients with obesity where FAPB is a prominent marker of metabolic alterations, chronic malnutrition in AN does not significantly affect its serum levels...
  37. ncbi request reprint Serum concentrations of fibroblast growth factor 19 in patients with obesity and type 2 diabetes mellitus: the influence of acute hyperinsulinemia, very-low calorie diet and PPAR-α agonist treatment
    M Mraz
    Third Department of Medicine, General University Hospital and First Medical Faculty, Charles University, Prague, Czech Republic
    Physiol Res 60:627-36. 2011
    ..58+/-26.2 vs. 107.47+/-25.0 pg/ml, p<0.05). We conclude that FGF-19 levels in our study were at least partially dependent upon nutritional status, but were not related to parameters of glucose metabolism or insulin sensitivity...
  38. ncbi request reprint Increased circulating and epicardial adipose tissue mRNA expression of fibroblast growth factor-21 after cardiac surgery: possible role in postoperative inflammatory response and insulin resistance
    T Kotulak
    Department of Anesthesia and Resuscitation, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 60:757-67. 2011
    ..Muscle FGF-21 mRNA positively correlated with blood glucose levels at the end of the surgery. Our data suggest a possible role of FGF-21 in the regulation of glucose metabolism and insulin sensitivity in surgery-related stress...
  39. doi request reprint The effect of very-low-calorie diet on mRNA expression of inflammation-related genes in subcutaneous adipose tissue and peripheral monocytes of obese patients with type 2 diabetes mellitus
    M Mraz
    Third Department of Medicine, General University Hospital and First Medical Faculty, Charles University, 128 08 Prague 2, Czech Republic
    J Clin Endocrinol Metab 96:E606-13. 2011
    ..Low-grade inflammation links obesity, type 2 diabetes mellitus (T2DM), and cardiovascular diseases...
  40. doi request reprint Serum concentrations and tissue expression of components of insulin-like growth factor-axis in females with type 2 diabetes mellitus and obesity: the influence of very-low-calorie diet
    V Tousková
    Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University, Prague 2, Czech Republic
    Mol Cell Endocrinol 361:172-8. 2012
    ..Increased SCAT and circulating IGFBP-2 and IGFBP-3 in PM might participate in metabolic improvements after VLCD...
  41. doi request reprint Changes in energy metabolism in pheochromocytoma
    O Petrak
    Third Department of Medicine, General University Hospital, Prague 2, Czech Republic
    J Clin Endocrinol Metab 98:1651-8. 2013
    ..Catecholamine overproduction in pheochromocytoma affects basal metabolism, resulting in weight loss despite normal food intake...
  42. ncbi request reprint Plasma concentrations of adipocyte fatty acid binding protein in patients with Cushing's syndrome
    V Durovcová
    Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Physiol Res 59:963-71. 2010
    ..We suggest that increased FABP-4 concentrations in CS patients are rather due to their excessive fat accumulation and related metabolic abnormalities than due to a direct effect of cortisol on FABP-4 production...
  43. ncbi request reprint Serum leptin levels in diabetic patients on hemodialysis: the relationship to parameters of diabetes metabolic control
    M Haluzik
    Department of Medicine, Faculty of Medicine, Charles University and University Hospital, Prague, Czech Republic
    Endocr Res 26:303-17. 2000
    ..The body fat content and body mass index are the strongest predictors of serum leptin levels, while parameters of long term diabetes metabolic control play probably only minor direct role in its regulation...
  44. ncbi request reprint Plasma levels of active and total ghrelin in renal failure: a relationship with GH/IGF-I axis
    Z Jarkovska
    Third Department of Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Growth Horm IGF Res 15:369-76. 2005
    ..We did not prove clearly significant relationship between ghrelin serum levels and parameters of GH/IGF-I axis in study subjects...
  45. ncbi request reprint Hepcidin expression in adipose tissue increases during cardiac surgery
    M Vokurka
    Institute of Pathological Physiology, Center of Experimental Hematology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Physiol Res 59:393-400. 2010
    ..We suggest that acute inflammatory changes could affect the regulation of hepcidin expression in subcutaneous adipose tissue and thus possibly contribute to inflammation-induced systemic changes of iron metabolism...
  46. ncbi request reprint Effect of PPAR-gamma agonist treatment on markers of endothelial dysfunction in patients with type 2 diabetes mellitus
    R Dolezalova
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 56:741-8. 2007
    ..We conclude that 5-month rosiglitazone treatment significantly reduced several markers of endothelial dysfunction. This effect could be at least in part attributable to marked increase of circulating adiponectin levels...
  47. ncbi request reprint The influence of short-term fasting on serum leptin levels, and selected hormonal and metabolic parameters in morbidly obese and lean females
    M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University and University Hospital, Prague, Czech Republic
    Endocr Res 27:251-60. 2001
    ..The drop of serum leptin levels after 24-h starvation is significantly blunted in obese compared to lean subjects. The reason for the difference is probably the insulin resistance possibly further modified by different DHEA-S levels...
  48. ncbi request reprint Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment
    J Housova
    Third Department of Medicine, First Faculty of Medicine and University Hospital, U Nemocnice 1, 128 08, Prague 2, Czech Republic
    Physiol Res 54:73-8. 2005
    ..These alterations appear to be relatively independent of nutritional status and insulin sensitivity...
  49. doi request reprint The Peptidic GHS-R antagonist [D-Lys(3)]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity
    L Maletinska
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Mol Cell Endocrinol 343:55-62. 2011
    ..Our data suggest that ghrelin antagonists could be especially beneficial in individuals with common obesity combined with estrogen deficiency...
  50. ncbi request reprint Serum visfatin levels in patients with anorexia nervosa and bulimia nervosa
    I Dostalova
    Third Department of Medicine, First Faculty of Medicine, Prague, Czech Republic
    Physiol Res 58:903-7. 2009
    ..We conclude that circulating visfatin levels are not affected by the presence of chronic malnutrition in AN or binge/purge eating behavior in BN...
  51. ncbi request reprint Ghrelin agonist JMV 1843 increases food intake, body weight and expression of orexigenic neuropeptides in mice
    M Holubova
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 62:435-44. 2013
    ..Our data suggest that JMV 1843 could have possible future uses in the treatment of cachexia. ..
  52. ncbi request reprint Increased angiotensinogen production in epicardial adipose tissue during cardiac surgery: possible role in a postoperative insulin resistance
    T Roubicek
    Third Department of Medicine, First Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic
    Physiol Res 57:911-7. 2008
    ..Our study suggests that increased angiotensinogen production in epicardial adipose tissue may contribute to the development of postoperative insulin resistance...
  53. ncbi request reprint The effect of pheochromocytoma treatment on subclinical inflammation and endocrine function of adipose tissue
    L Bosanska
    Third Department of Medicine, First Faculty of Medicine, Charles University, Praha, Czech Republic
    Physiol Res 58:319-25. 2009
    ..We failed to demonstrate an involvement of the changes in circulating leptin, adiponectin or resistin levels in this process...
  54. ncbi request reprint The influence of nitric oxide synthase inhibitor L-NAME on bones of male rats with streptozotocin-induced diabetes
    P D Broulik
    Third Medical Department, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 21 Prague 2, Czech Republic
    Physiol Res 52:729-34. 2003
    ..Inhibition of NO neither increased osteoclastic activity (TRAP) nor induced osteopenia in L-NAME-treated rats. This suggests a possibility that NO is not involved in the pathogenesis of diabetic osteopenia...
  55. ncbi request reprint Plasma levels of total and active ghrelin in acromegaly and growth hormone deficiency
    Z Jarkovska
    Third Department of Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Physiol Res 55:175-81. 2006
    ..In conclusion, all groups of the tested subjects showed similar plasma levels of total and active ghrelin. In acromegaly and growth hormone deficiency plasma ghrelin does not seem to be significantly affected by changes in GH secretion...
  56. doi request reprint Laparoscopic sleeve gastrectomy ameliorates mRNA expression of inflammation-related genes in subcutaneous adipose tissue but not in peripheral monocytes of obese patients
    P Trachta
    Third Department of Medicine, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Mol Cell Endocrinol 383:96-102. 2014
    ..The sustained proinflammatory and chemotactic profile in PM even 2 years after LSG may contribute to partial persistence of metabolic complications in obese patients after metabolic surgery...
  57. ncbi request reprint Soluble leptin receptor levels in patients with chronic renal failure
    J Krizova
    Third Medical Department, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 52:347-51. 2003
    ..The physiological consequences of this finding require further investigation...
  58. ncbi request reprint Leptin as an acute phase reactant after non-adjustable laparoscopic gastric banding
    P Maruna
    Institute of Pathological Physiology, 3rd Internal Dept, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Obes Surg 11:609-14. 2001
    ..We compared plasma leptin changes with 4 proinflammatory cytokines and BMI...
  59. ncbi request reprint Simultaneous decrease of plasma obestatin and ghrelin levels after a high-carbohydrate breakfast in healthy women
    D Sedláčková
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S29-37. 2008
    ..05). In conclusion, we demonstrated in healthy young women that plasma obestatin concentrations decrease similarly to ghrelin after a high-carbohydrate breakfast...
  60. ncbi request reprint Serum resistin levels in benign prostate hyperplasia and non-metastatic prostate cancer: possible role in cancer progression
    D Housa
    Department of Pathology, Third Faculty of Medicine, Charles University in Prague, Czech Republic
    Neoplasma 55:442-6. 2008
    ..We conclude that serum resistin levels do not significantly differ between patients with benign prostate hyperplasia and prostate cancer, but there is a trend towards decrease in resistin serum levels in advanced cancer cases...
  61. doi request reprint Estradiol supplementation helps overcome central leptin resistance of ovariectomized mice on a high fat diet
    R Matysková
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Horm Metab Res 42:182-6. 2010
    ....
  62. ncbi request reprint Estrogenic effect of estradiol-sulfamate on the male rat anterior pituitary
    J Nedvidkova
    Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 67:359-62. 1998
    ..Thus, our data support the concept that the ES has a lesser estrogenic effect on the AP function...
  63. doi request reprint The endocrine profile of subcutaneous and visceral adipose tissue of obese patients
    M Dolinkova
    3rd Department of Medicine, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
    Mol Cell Endocrinol 291:63-70. 2008
    ..We conclude that both SAT and VAT exhibit alterations in the expression of specific genes possibly contributing to proinflammatory and insulin resistance state and consequently to metabolic complications of obesity...
  64. ncbi request reprint Novel adipokine fibroblast growth factor 21 is increased in rheumatoid arthritis
    H Hulejová
    Institute of Rheumatology, Prague, Czech Republic
    Physiol Res 61:489-94. 2012
    ..This work shows that patients with seropositive RA have increased levels of FGF-21. The results suggest that FGF-21 is related to BMI but not disease activity or lipid profiles in patients with RA...
  65. doi request reprint Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus
    P Kleiblova
    Institute of Biochemistry and Experimental Oncology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Mol Cell Endocrinol 314:150-6. 2010
    ....
  66. ncbi request reprint Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes
    H Kim
    Molecular and Cellular Physiology Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Room 8D12, Bethesda, MD 20892 1758, USA
    Diabetologia 47:2215-25. 2004
    ..The aim of this study was to examine the effects of thiazolidinediones on the MKR mouse model of type 2 diabetes...
  67. ncbi request reprint Plasma ghrelin levels in patients with end-stage renal disease
    Z Jarkovska
    Third Department of Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Physiol Res 54:403-8. 2005
    ..05). In conclusion, patients with ESRD have higher ghrelin concentrations, which might be caused by a decreased excretion/metabolism of ghrelin in the kidney during renal failure...
  68. ncbi request reprint Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus
    I Dostalova
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 58:1-7. 2009
    ....
  69. ncbi request reprint The regulation of adenohypophyseal prolactin secretion: effect of triiodothyronine and methylene blue on estrogenized rat adenohypophysis
    J Nedvidkova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 49:S27-35. 2000
    ....
  70. ncbi request reprint Genetic polymorphisms as a risk factor for anorexia nervosa
    S Sulek
    Department of Paediatrics and Adolescent Medicine, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
    Prague Med Rep 108:215-25. 2007
    ..g. serotonin, ghrelin, catechol-O-methyl transferase, neuropeptide Y, brain-derived neurotrophic factor and adipokines...
  71. ncbi request reprint The role of ghrelin in the regulation of food intake in patients with obesity and anorexia nervosa
    I Dostalova
    Third Department of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 58:159-70. 2009
    ..The aim of this review is to summarize the current knowledge about the physiology and pathophysiology of ghrelin and to discuss its potential in the prevention and/or treatment of obesity and anorexia nervosa...
  72. ncbi request reprint The influence of hormonal changes during menstrual cycle on serum adiponectin concentrations in healthy women
    P Kleiblova
    Department of Obstetrics and Gynecology, General University Hospital, First Faculty of Medicine, Prague, Czech Republic
    Physiol Res 55:661-6. 2006
    ..Therefore, the differences in insulin sensitivity in various phases of the menstrual cycle are not due to changes of circulating adiponectin levels...
  73. ncbi request reprint Increased lipolysis of subcutaneous abdominal adipose tissue and altered noradrenergic activity in patients with Cushing's syndrome: an in-vivo microdialysis study
    M Krsek
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 55:421-8. 2006
    ..This finding together with non-significantly increased local catecholamine concentrations in these patients suggests a possible link between increased lipolysis and catecholaminergic activity in subcutaneous adipose tissue...
  74. ncbi request reprint Serum leptin levels in septic men correlate well with C-reactive protein (CRP) and TNF-alpha but not with BMI
    P Maruna
    Institute of Pathological Physiology, Third Internal Department, Charles University, Prague, Czech Republic
    Physiol Res 50:589-94. 2001
    ..The significant correlation between leptin and CRP and leptin and alpha-1-antitrypsin indicates that leptin can participate in APP synthesis regulation during a systemic inflammatory response...
  75. ncbi request reprint Adiponectin as a potential marker of prostate cancer progression: studies in organ-confined and locally advanced prostate cancer
    D Housa
    Third Department of Internal Medicine, First Faculty of Medicine and General Faculty Hospital Prague, U nemocnice 2, Prague, Czech Republic
    Physiol Res 57:451-8. 2008
    ..Serum adiponectin levels are higher in locally advanced relative to organ-confined prostate cancer and may thus serve as an auxiliary marker providing further improvement for discrimination between pT2 and pT3 stages...
  76. ncbi request reprint Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity
    M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    J Hum Hypertens 16:41-5. 2002
    ..Leptin is a protein hormone produced predominantly by adipocytes that plays a role in food intake regulation and a series of other physiological processes including blood pressure regulation...
  77. ncbi request reprint Effect of PPAR-γ agonist rosiglitazone on bone mineral density and serum adipokines in C57BL/6 male mice
    P D Broulik
    Third Department of Medicine Department of Endocrinology and Metabolism, Charles University in Prague, Czech Republic
    Folia Biol (Praha) 57:133-8. 2011
    ..The levels of adipokines do not play any role...
  78. ncbi request reprint [Polymorphisms of adiponectin and resistin genes in patients with obesity and anorexia nervosa]
    M Dolinkova
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 145:562-6. 2006
    ....
  79. ncbi request reprint [The treatment of hyperglycaemia in critically ill patients: comparison of standard protocol and computer algorithm]
    J Kremen
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 53:1269-73. 2007
    ..The aim of our study was comparison of standard protocol of intensive insulin therapy used on cardiac surgery ICU in General University Hospital in Prague and computer algorithm MPC (Model Predictive Control)...
  80. ncbi request reprint [Monitoring of glucose concentration in critical patients, comparing arterial blood glucose concentrations and interstitial glucose concentration measured by microdialysis technique]
    J Kremen
    III interní klinika 1 lékarské fakulty UK a VFN, Praha
    Vnitr Lek 52:777-81. 2006
    ....
  81. ncbi request reprint [Adiponectin and atherosclerosis]
    D Haluzikova
    II interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 53:359-63. 2007
    ....
  82. pmc Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum
    L Senolt
    Institute of Rheumatology, 1st Medical Faculty, Charles University, Na Slupi 4, 12850 Prague 2, Czech Republic, and University Hospital Giessen, Department of Internal Medicine and Rheumatology, Germany
    Ann Rheum Dis 66:458-63. 2007
    ..Resistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents. In humans, proinflammatory properties of resistin are superior to its insulin resistance-inducing effects...