Research Topics
| J FlegrSummaryAffiliation: Charles University Country: Czech Republic Publications
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Publications
How and why Toxoplasma makes us crazyJaroslav Flegr
Faculty of Science, Charles University in Prague, Prague 128 44, Czech Republic
Trends Parasitol 29:156-63. 2013....
Microevolutionary, macroevolutionary, ecological and taxonomical implications of punctuational theories of adaptive evolutionJaroslav Flegr
Jaroslav Flegr, Department of Philosophy and History of Science, Faculty of Science, Charles University in Prague, Vinicna 7, CZ 12844, Praha 2, Czech Republic
Biol Direct 8:1. 2013..The punctuational theories offer many new predictions that need to be tested, but also provide explanations for a much broader spectrum of known biological phenomena than classical gradualistic evolutionary theories...
Influence of latent Toxoplasma infection on human personality, physiology and morphology: pros and cons of the Toxoplasma-human model in studying the manipulation hypothesisJaroslav Flegr
Faculty of Science, Charles University, Department of Philosophy and History of Science, Prague, Czech Republic
J Exp Biol 216:127-33. 2013....
Rhesus factor modulation of effects of smoking and age on psychomotor performance, intelligence, personality profile, and health in Czech soldiersJaroslav Flegr
Faculty of Science, Charles University in Prague, Prague, Czech Republic
PLoS ONE 7:e49478. 2012..It is not known, however, whether the RhD phenotype modifies exclusively the response of the body to toxoplasmosis or whether it also influences effects of other factors...
The relation of cortisol and sex hormone levels to results of psychological, performance, IQ and memory tests in military men and womenJaroslav Flegr
Faculty of Science, Charles University in Prague, Biology Dept, Prague, Czech Republic
Neuro Endocrinol Lett 33:224-35. 2012..Cortisol, along with other hormones of hypothalamo-pituitary-adrenal axis, belongs to one of the main factors influencing psychological and pathognomic factors, intelligence, and memory...
Fatal attraction phenomenon in humans: cat odour attractiveness increased for toxoplasma-infected men while decreased for infected womenJaroslav Flegr
Department of Biology, Charles University, Prague, Czech Republic
PLoS Negl Trop Dis 5:e1389. 2011..While most behavioural effects of toxoplasmosis were confirmed also in humans, neither the fatal attraction phenomenon nor any toxoplasmosis-associated changes in olfactory functions have been searched for in them...
Probable neuroimmunological link between Toxoplasma and cytomegalovirus infections and personality changes in the human hostMartina Novotna
Department of Parasitology, Charles University, Vinicna 7, Prague 128 44, Czech Republic
BMC Infect Dis 5:54. 2005....
Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosisSárka Kaňková
Department of Parasitology, Charles University in Prague, Faculty of Science, Vinicna 7, CZ 128 44 Praha 2, Czech Republic
BMC Infect Dis 7:114. 2007..The purpose of this study was to confirm that women with latent toxoplasmosis have developmentally younger fetuses at estimated pregnancy week 16 and to test four exclusive hypotheses that could explain the observed data...
Effects of toxoplasma on human behaviorJaroslav Flegr
Departmeent of Parasitology, Faculty of Science, Charles University, Vinicna 7, CZ 128 44 Praha 2, Czech Republic
Schizophr Bull 33:757-60. 2007..Other studies have demonstrated reduced psychomotor performance in affected individuals. Possible mechanisms by which T. gondii may affect human behavior include its effect on dopamine and on testosterone...
Sex-dependent toxoplasmosis-associated differences in testosterone concentration in humansJ Flegr
Department of Parasitology, Faculty of Sciences, Charles University, Vinicna 7, 128 44 Prague 2, Czech Republic
Parasitology 135:427-31. 2008..The opposite direction of the testosterone shift in men compared to women can explain the observed gender specificity of behavioural shifts in Toxoplasma-infected subjects...
Brief Communication: Latent toxoplasmosis and salivary testosterone concentration--important confounding factors in second to fourth digit ratio studiesJaroslav Flegr
Department of Philosophy and History of Sciences, Faculty of Sciences, Charles University, 128 44 Prague 2, Czech Republic
Am J Phys Anthropol 137:479-84. 2008....
Neurophysiological effect of the Rh factor. Protective role of the RhD molecule against Toxoplasma-induced impairment of reaction times in womenJaroslav Flegr
Department of Philosophy and History of Natural Science, Charles University, Vinicna 7, Prague 128 44, Czech Republic
Neuro Endocrinol Lett 29:475-81. 2008..No phenotypic effect of RhD protein, except its role in hemolytic disease of newborns and protective role against Toxoplasma-induced impairment of reaction times in men, has been described...
Influence of latent 'asymptomatic' toxoplasmosis on body weight of pregnant womenJaroslav Flegr
Department of Parasitology, Charles University, Prague, Czech Republic
Folia Parasitol (Praha) 52:199-204. 2005..The prevalence of latent toxoplasmosis is extremely high. Therefore, even its mild symptoms such as the decreased body weight in Toxoplasma-positive pregnant women might in fact indicate an unrecognized serious public health problem...
Increased incidence of traffic accidents in Toxoplasma-infected military drivers and protective effect RhD molecule revealed by a large-scale prospective cohort studyJaroslav Flegr
Department of Philosophy, Faculty of Science, Charles University, Prague, Czech Republic
BMC Infect Dis 9:72. 2009..In the present study we searched for increased incidence of traffic accidents and for protective effect of RhD positivity in 3890 military drivers...
A possible role of intracellular isoelectric focusing in the evolution of eukaryotic cells and multicellular organismsJaroslav Flegr
Department of Philosophy and History of Science, Charles University, Vinicna 7, 128 44, Praha 2, Czech Republic
J Mol Evol 69:444-51. 2009....
Testosterone and cortisol levels in university students reflect actual rather than estimated number of wrong answers on written examJaroslav Flegr
Faculty of Science, Charles University in Prague, Vinicna 7, Praha, Czech Republic
Neuro Endocrinol Lett 31:577-81. 2010..It is possible that the complicated patterns in humans result from the methods limitations--measurement of hormone concentrations in simulated competitive events or sport instead in real-life situations...
Elastic, not plastic species: frozen plasticity theory and the origin of adaptive evolution in sexually reproducing organismsJaroslav Flegr
Department of Philosophy and History of Science, Charles University, Vinicna 7, CZ 128 44 Praha 2, Czech Republic
Biol Direct 5:2. 2010..Two models, the selfish gene theory and frozen plasticity theory were suggested to explain evolution of adaptive traits in sexual organisms in past 30 years...
Potential immunomodulatory effects of latent toxoplasmosis in humansJaroslav Flegr
Biology Departments, Charles University in Prague, Czech Republic
BMC Infect Dis 11:274. 2011..For example, the immunosuppression hypothesis explains the higher probability of the birth of male offspring observed in Toxoplasma-positive humans and mice by the protection of the (more immunogenic) male embryos against abortion...
Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case-control studyJaroslav Flegr
Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
BMC Infect Dis 2:11. 2002..It is not know, however, whether the changes observed in laboratory influence the performance of subjects in real-life situations...
Was Lysenko (partly) right? Michurinist biology in the view of modern plant physiology and geneticsJaroslav Flegr
Department of Parasitology and Hydrobiology, Faculty of Science, Charles University, Vinicna 7, Prague 2, CZ 128 44 Czech Republic
Riv Biol 95:258-72. 2002..e., by a theory of frozen plasticity...
Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii Dopamine, a missing link between schizophrenia and toxoplasmosis?Jaroslav Flegr
Department of Parasitology, Charles University, Vinicna 7, 128 44, Prague, Czech Republic
Biol Psychol 63:253-68. 2003..003) and lower probability of achieving a higher education (P(2)<0.0000). Decrease of NS suggests that the increase of dopamine in brain of infected subjects can represent a missing link between toxoplasmosis and schizophrenia...
Body height, body mass index, waist-hip ratio, fluctuating asymmetry and second to fourth digit ratio in subjects with latent toxoplasmosisJ Flegr
Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
Parasitology 130:621-8. 2005....
Toxoplasma and reaction time: role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphismM Novotna
Department of Parasitology, Charles University, Prague 128 44, Czech Republic
Parasitology 135:1253-61. 2008..Moreover, an unequal prevalence of toxoplasmosis in different countries could explain pronounced differences in frequencies of RhD-negative phenotype in geographically distinct populations...
New and old risk-factors for Toxoplasma gondii infection: prospective cross-sectional study among military personnel in the Czech RepublicP Kolbekova
Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
Clin Microbiol Infect 13:1012-7. 2007..28), B (OR 1.33) or AB (OR 1.43) vs. O. These results suggested that horizontal toxoplasmosis transmission in the Czech Republic may occur through consumption of raw meat, contact with cat faeces and farming...
Influence of latent toxoplasmosis on the secondary sex ratio in miceS Kaňková
Department of Parasitology, Faculty of Science, Charles University in Prague, Vinicna 7, CZ 128 44 Prague 2, Czech Republic
Parasitology 134:1709-17. 2007....
Influence of chronic toxoplasmosis on some human personality factorsJ Flegr
Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
Folia Parasitol (Praha) 41:122-6. 1994....
Decrease of psychomotor performance in subjects with latent 'asymptomatic' toxoplasmosisJ Havlicek
Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
Parasitology 122:515-20. 2001....
Changes in the personality profile of young women with latent toxoplasmosisJ Flegr
Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
Folia Parasitol (Praha) 46:22-8. 1999..The difference in several other factors (desurgency/surgency, alaxia/protension, naiveté/shrewdness, and self-sentiment integration) concerned changes in the variances, rather than the mean values of the factors...
Increased pregnancy weight gain in women with latent toxoplasmosis and RhD-positivity protection against this effectS Kaňková
Department of Parasitology, Faculty of Science, Charles University in Prague, Vinicna 7, CZ 12844 Prague 2, Czech Republic
Parasitology 137:1773-9. 2010..RhD-positive subjects are protected against toxoplasmosis-associated impairment of psychomotor performance. Here we searched for RhD-positivity-associated maternal protection against the effects of toxoplasmosis...
Women infected with parasite Toxoplasma have more sonsS Kaňková
Department of Parasitology, Charles University, Vinicna 7, 128 44, Prague 2, Czech Republic
Naturwissenschaften 94:122-7. 2007..In light of the high prevalence of latent toxoplasmosis in most countries, the impact of toxoplasmosis on the human population might be considerable...
The role of dopamine in Toxoplasma-induced behavioural alterations in mice: an ethological and ethopharmacological studyA Skallová
Department of Parasitology, Faculty of Science, Charles University, Vinicna 7, Prague 128 44, Czech Republic
Parasitology 133:525-35. 2006..These results suggest an association between Toxoplasma gondii infection and changes in the dopaminergic neuromodulatory system...
Poorer results of mice with latent toxoplasmosis in learning tests: impaired learning processes or the novelty discrimination mechanism?H Hodkova
Department of Parasitology, Charles University, Vinicna 7, Prague 128 44, Czech Republic
Parasitology 134:1329-37. 2007....
Concordance between genetic relatedness and phenotypic similarities of Trichomonas vaginalis strainsV Hampl
Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
BMC Evol Biol 1:11. 2001..Furthermore, the distribution of endobionts such as mycoplasmas or Trichomonas vaginalis virus (TVV) in the T. vaginalis metapopulation is poorly characterised...
Correlation of duration of latent Toxoplasma gondii infection with personality changes in womenJ Flegr
Department of Parasitology, Charles University, Prague, Czech
Biol Psychol 53:57-68. 2000..The same evidence questions the view that women with a particular personality profile are more prone to acquisition of T. gondii infection...
Correlation between aerobic and anaerobic resistance to metronidazole in trichomonads: application of a new computer program for permutation testsJ Flegr
Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
Parasitol Res 84:590-2. 1998..natur.cuni.cz/flegr/PROGRAMS/+ ++TREEPT.ZIP and http://www.karlin. mff.cuni.cz/-zaboj/treept...
Decreased level of novelty seeking in blood donors infected with ToxoplasmaAnna Skallová
Department of Parasitology, Charles University, Vinicna 7, Prague 128 44, Czech Republic
Neuro Endocrinol Lett 26:480-6. 2005..However, it is also possible that the observed effect was caused by association of both novelty seeking and Toxoplasma infection with a third factor, e.g. size of place of residence...
Construction and bootstrap analysis of DNA fingerprinting-based phylogenetic trees with the freeware program FreeTree: application to trichomonad parasitesV Hampl
Department of Parasitology, Faculty of Sciences, Charles University, Prague 2, Czech Republic
Int J Syst Evol Microbiol 51:731-5. 2001..The FreeTree program makes such analysis possible...
Higher perceived dominance in Toxoplasma infected men--a new evidence for role of increased level of testosterone in toxoplasmosis-associated changes in human behaviorHana Hodková
Department of Parasitology, Charles University, Vinièná 7, Prague 128 44, Czech Republic
Neuro Endocrinol Lett 28:110-4. 2007..009) and masculine (p=0.052). These results support the idea that the higher level of testosterone could be responsible for at least some of the toxoplasmosis-associated shifts in human and animal behavior...
Pattern of money allocation in experimental games supports the stress hypothesis of gender differences in Toxoplasma gondii-induced behavioural changesJitka Lindová
Department of Philosophy and History of Science, Faculty of Science, Charles University, Vinicna 7, 128 44 Prague, Czech Republic
Folia Parasitol (Praha) 57:136-42. 2010..016), but both genders appeared less generous when infected in the Dictator Game modified to minimize social connotation (p = 0.048)...
Differences in the 2nd to 4th digit length ratio in humans reflect shifts along the common allometric lineLukáš Kratochvíl
Department of Ecology, Faculty of Science, Charles University in Prague, Vinicna 7, 128 44 Praha 2, Czech Republic
Biol Lett 5:643-6. 2009..We conclude that previously published results on the 2D : 4D ratio are biased by its covariation with finger length. We strongly recommend regression-based approaches for comparisons of hand shape among different groups...
Differences in onset of disease and severity of psychopathology between toxoplasmosis-related and toxoplasmosis-unrelated schizophreniaD Holub
Medical Faculty Charles University, Hradec Kralove, Czech Republic
Acta Psychiatr Scand 127:227-38. 2013..Toxoplasmosis is a lifelong parasitic disease that appears to be associated to schizophrenia. However, no distinguishing attributes in Toxoplasma-infected schizophrenia patients have been described as yet...
Dominance, submissivity (and homosexuality) in general population: testing of evolutionary hypothesis of sadomasochism by Internet-trap-methodEva Jozifkova
Department of Anthropology and Human Genetics, Faculty of Science, Charles University in Prague, Czech Republic
Neuro Endocrinol Lett 27:711-8. 2006..CONCLUSIONS: Large number of people who chose unequal sexual partner suggests that hierarchical status plays important role in human mating system...
The influence of RhD phenotype on toxoplasmosis- and age-associated changes in personality profile of blood donorsJaroslav Flegr
Biology Section, Faculty of Science, Charles University, Vinicna 7, 128 44 Prague, Czech Republic
Folia Parasitol (Praha) 57:143-50. 2010..Moreover, our results indicate that RhD phenotype might influence not only the effect of toxoplasmosis but also the effect of aging on specific personality traits...
Comparison of european Trichobilharzia species based on ITS1 and ITS2 sequencesJ Dvorak
Department of Parasitology, Charles University, Prague, Czech Republic
Parasitology 124:307-13. 2002..franki is more related to the nasal T. regenti, than to the visceral T. szidati. The newly designed primer, which is specific for T. regenti, might be used as a tool for diagnosis of this potential pathogen...
Tetratrichomonads from the oral cavity and respiratory tract of humansK Kutisova
Department of Parasitology, Faculty of Science, Charles University in Prague, , Prague 2, 128 44, Czech Republic
Parasitology 131:309-19. 2005..Consistent differences between 'bronchial' and 'oral' groups were confirmed by analysis of ITS1-5.8S rRNA-ITS2 sequences. Our results have revealed novel trichomonad species of the human oral cavity and bronchi...
Gender differences in behavioural changes induced by latent toxoplasmosisJitka Lindová
Department of Parasitology, Faculty of Science, Charles University, Vinicna 7, 128 44, Praha 2, Czech Republic
Int J Parasitol 36:1485-92. 2006..In the composite behavioural variable Mistrust (analogue to factor L), the pattern was affected by environment (rural versus urban). Possible interpretations of the gender differences are discussed...
Women's preference for dominant male odour: effects of menstrual cycle and relationship statusJan Havlicek
Department of Anthropology, Faculty of Humanities, Charles University, Husnikova 2075, 155 00 Prague, Czech Republic
Biol Lett 1:256-9. 2005..In accordance with the theory of mixed mating strategies, this preference varies with relationship status, being much stronger in fertile women in stable relationships than in fertile single women...
Inference of the phylogenetic position of oxymonads based on nine genes: support for metamonada and excavataVladimir Hampl
Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
Mol Biol Evol 22:2508-18. 2005....
