Zdenek Fisar

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. ncbi Effect of cannabinoids on platelet serotonin uptake
    Marie Velenovská
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Addict Biol 12:158-66. 2007
  2. pmc Plasma cortisol in Alzheimer's disease with or without depressive symptoms
    Martina Zverova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Med Sci Monit 19:681-9. 2013
  3. doi Cannabinoids and monoamine neurotransmission with focus on monoamine oxidase
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Prog Neuropsychopharmacol Biol Psychiatry 38:68-77. 2012
  4. ncbi Binding of imipramine to phospholipid bilayers using radioligand binding assay
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Gen Physiol Biophys 23:77-99. 2004
  5. ncbi [Biochemical mechanisms of action of antidepressants]
    Zdenek Fisar
    Univerzita Karlova v Praze, 1 lékarská fakulta, Psychiatrická klinika VFN
    Cas Lek Cesk 150:531-40. 2011
  6. ncbi Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 12808 Prague, Czech Republic
    Neuro Endocrinol Lett 31:645-56. 2010
  7. doi In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Toxicol Lett 201:176-80. 2011
  8. ncbi Intracellular signalling pathways and mood disorders
    Z Fisar
    Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Department of Psychiatry, Prague, Czech Republic
    Folia Biol (Praha) 56:135-48. 2010
  9. ncbi Inhibition of monoamine oxidase activity by cannabinoids
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00, Prague 2, Czech Republic
    Naunyn Schmiedebergs Arch Pharmacol 381:563-72. 2010
  10. ncbi Phytocannabinoids and endocannabinoids
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University in Prague, Ke Karlovu 11, 128 01 Prague 2, Czech Republic
    Curr Drug Abuse Rev 2:51-75. 2009

Collaborators

Detail Information

Publications30

  1. ncbi Effect of cannabinoids on platelet serotonin uptake
    Marie Velenovská
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Addict Biol 12:158-66. 2007
    ..A hypothesis was supported that lowered serotonin uptake may reflect a gender-related differences in effects of psychoactive cannabinoids...
  2. pmc Plasma cortisol in Alzheimer's disease with or without depressive symptoms
    Martina Zverova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Med Sci Monit 19:681-9. 2013
    ..The aim of this study was to investigate the association of plasma cortisol concentration with AD in presence or absence of comorbid depressive symptoms...
  3. doi Cannabinoids and monoamine neurotransmission with focus on monoamine oxidase
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Prog Neuropsychopharmacol Biol Psychiatry 38:68-77. 2012
    ..Basic information is summarized in the paper about mechanisms of action of cannabinoids on monoaminergic systems, with a view to inhibition of monoamine oxidase...
  4. ncbi Binding of imipramine to phospholipid bilayers using radioligand binding assay
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Gen Physiol Biophys 23:77-99. 2004
    ..These results support the hypothesis suggesting that the lipid part of biological membranes plays a role in the mechanism of antidepressant action...
  5. ncbi [Biochemical mechanisms of action of antidepressants]
    Zdenek Fisar
    Univerzita Karlova v Praze, 1 lékarská fakulta, Psychiatrická klinika VFN
    Cas Lek Cesk 150:531-40. 2011
    ..Knowledge about biological markers of mood disorders and predictors of efficiency of pharmacotherapy is included also in relation to importance, potentialities and perspectives in the development of new antidepressants...
  6. ncbi Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 12808 Prague, Czech Republic
    Neuro Endocrinol Lett 31:645-56. 2010
    ..We investigated systematically in vitro effects of pharmacologically different antidepressants and mood stabilizers on MAO activity...
  7. doi In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Toxicol Lett 201:176-80. 2011
    ..Because oximes concentrations effective for MAO inhibition could not be achieved in vivo at the cerebral level, we suppose that oximes investigated do not interfere with brain MAO at therapeutically relevant concentrations...
  8. ncbi Intracellular signalling pathways and mood disorders
    Z Fisar
    Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Department of Psychiatry, Prague, Czech Republic
    Folia Biol (Praha) 56:135-48. 2010
    ....
  9. ncbi Inhibition of monoamine oxidase activity by cannabinoids
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00, Prague 2, Czech Republic
    Naunyn Schmiedebergs Arch Pharmacol 381:563-72. 2010
    ..Decrease of MAO activity may play a role in some effects of cannabinoids on serotonergic, noradrenergic, and dopaminergic neurotransmission...
  10. ncbi Phytocannabinoids and endocannabinoids
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University in Prague, Ke Karlovu 11, 128 01 Prague 2, Czech Republic
    Curr Drug Abuse Rev 2:51-75. 2009
    ....
  11. ncbi Cannabinoids and atherosclerosis
    Zdenek Fisar
    Charles University in Prague, First Faculty of Medicine, Department of Psychiatry, Prague, Czech Republic
    Prague Med Rep 110:5-12. 2009
    ..Basic information about function and role of the endocannabinoid system is summarized in the paper; possible therapeutic action of cannabinoids, effects on atherosclerosis specially, is described at the close...
  12. ncbi Platelet serotonin uptake in drug-naïve depressive patients before and after treatment with citalopram
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University in Prague, Ke Karlovu 11, 128 01 Prague 2, Czech Republic
    Psychiatry Res 161:185-94. 2008
    ..The initial severity of depression was significantly negatively correlated with V(max), which supported a hypothesis that the initial severity of depressive disorder could be related to the lower V(max)...
  13. ncbi Effect of pharmacologically selective antidepressants on serotonin uptake in rat platelets
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Gen Physiol Biophys 24:113-28. 2005
    ..An increase in limiting membrane permeability for 5-HT could be included in the common adaptive effect of the long-term administration of antidepressants that differ in pharmacologic selectivity...
  14. ncbi Interactions between tricyclic antidepressants and phospholipid bilayer membranes
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Gen Physiol Biophys 24:161-80. 2005
    ..The data supports the hypothesis under which TCAs could have effect on affective disorders partially via binding to the lipid part of the membrane and following changes of lipid-protein interactions...
  15. ncbi Effect of long-term administration of antidepressants on the lipid composition of brain plasma membranes
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Gen Physiol Biophys 24:221-36. 2005
    ..Hypothesis was supported that changes in brain neurotransmission produced by antidepressants could be, at least partially, associated with adaptive changes in membrane cholesterol and phospholipids...
  16. ncbi Distribution of antidepressants between plasma and red blood cells
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Neuro Endocrinol Lett 27:307-13. 2006
    ..The distribution of different antidepressants between plasma and red blood cells (RBCs) or between water and erythrocyte membranes (ghosts) has not been sufficiently compared so far...
  17. ncbi Depression, antidepressants, and peripheral blood components
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Neuro Endocrinol Lett 29:17-28. 2008
    ....
  18. ncbi In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain
    Jana Hroudova
    Department of Psychiatry, 1st Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Neuro Endocrinol Lett 32:259-63. 2011
    ..Various types of oximes reactivate AChE and are commonly used as antidotes against organophosphates (pesticides, nerve agents)...
  19. doi Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties
    Jan Korabecny
    Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
    Bioorg Med Chem Lett 21:6563-6. 2011
    ..In this Letter, the synthesis, biological activity and molecular modelling of elimination by-product isolated during synthesis of 7-MEOTA based bis-alkylene linked compound is described...
  20. ncbi Plasma homocysteine in Alzheimer's disease with or without co-morbid depressive symptoms
    Eva Kitzlerova
    Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague and General Teaching Hospital, Czech Republic
    Neuro Endocrinol Lett 35:42-9. 2014
    ..This study was designed to detect an association between plasma homocysteine and AD with or without co-morbid depressive symptoms...
  21. ncbi Mitochondrial respiration in blood platelets of depressive patients
    Jana Hroudova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 121 08 Prague 2, Czech Republic Electronic address
    Mitochondrion 13:795-800. 2013
    ..The hypothesis that decreased mitochondrial respiratory rate participate in pathophysiology of depression was supported. ..
  22. ncbi Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers
    Jana Hroudova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Neuro Endocrinol Lett 31:336-42. 2010
    ..We investigated in vitro effects of pharmacologically different antidepressants and mood stabilizers on mitochondrial enzymes to discover, which mitochondrial functions could be involved in pathophysiology of mood disorders...
  23. doi Connectivity between mitochondrial functions and psychiatric disorders
    Jana Hroudova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Psychiatry Clin Neurosci 65:130-41. 2011
    ....
  24. ncbi In vitro inhibition of mitochondrial respiratory rate by antidepressants
    Jana Hroudova
    Department of Psychiatry, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague, Czech Republic
    Toxicol Lett 213:345-52. 2012
    ..Our findings suggest that mood stabilizers do not interfere with brain mitochondrial respiration, whereas direct mitochondrial targeting is involved in mechanisms of action of pharmacologically different antidepressants...
  25. doi GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression
    Jan Pláteník
    Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Katerinska 32, 121 08 Prague 2, Czech Republic
    Prog Neuropsychopharmacol Biol Psychiatry 50:83-93. 2014
    ....
  26. doi Can chiroptical spectroscopy be used for the analysis of blood plasma?
    Michal Tatarkovič
    Department of Analytical Chemistry, Institute of Chemical Technology, Prague, Czech Republic
    Chirality 24:951-5. 2012
    ..Therefore, these methods can potentially be useful for following research in the development of new, noninvasive, and reliable screening methods of clinical diagnostics...
  27. doi Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment
    Jan Korabecny
    Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
    Molecules 15:8804-12. 2010
    ..Its inhibitory ability towards cholinesterases was determined and compared to tacrine (THA) and 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA). The assessment of IC50 values revealed 1 as a weak inhibitor of both tested enzymes...
  28. ncbi Cholesterol-lowering therapy evokes time-limited changes in serotonergic transmission
    Jan Vevera
    Psychiatric Clinic, First Faculty of Medicine of Charles University, Ke Karlovu 11, 120 00 Prague, Czech Republic
    Psychiatry Res 133:197-203. 2005
    ..A significant increase in SERT activity was detected only during the first month of simvastatin therapy. This finding suggests that within this period some patients could be vulnerable to depression, violence, or suicide...
  29. pmc Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease
    Jana Hroudova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Biomed Res Int 2014:175062. 2014
    ..Also, damaged function of electron transport chain complexes and interactions between pathological proteins and mitochondria are described for AD particularly and marginally for PD and HD. ..
  30. doi Core/shell nanofibers with embedded liposomes as a drug delivery system
    Andrea Míčková
    Department of Biophysics, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Biomacromolecules 13:952-62. 2012
    ..In conclusion, intact liposomes incorporated into nanofibers by coaxial electrospinning are very promising as a drug delivery system...