O Cinek

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. doi request reprint The incidence of type 1 diabetes in young Czech children stopped rising
    Ondrej Cinek
    Department of Paediatrics, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
    Pediatr Diabetes 13:559-63. 2012
  2. pmc Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1
    Ondrej Cinek
    2nd Faculty of Medicine, Department of Paediatrics, Charles University in Prague and University Hospital Motol, Prague, The Czech Republic
    PLoS ONE 7:e48409. 2012
  3. doi request reprint Heterogeneity in the systems of pediatric diabetes care across the European Union
    Ondrej Cinek
    University Hospital Motol, Prague, Czech Republic Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Pediatr Diabetes 13:5-14. 2012
  4. pmc The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease
    Ondrej Hradsky
    Department of Pediatrics, University Hospital Motol and Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    BMC Med Genet 11:91. 2010
  5. pmc Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)
    Trine W Boesgaard
    Steno Diabetes Centre and Hagedorn Research Institute, Gentofte, Denmark
    BMC Med Genet 11:42. 2010
  6. ncbi request reprint Longitudinal observation of enterovirus and adenovirus in stool samples from Norwegian infants with the highest genetic risk of type 1 diabetes
    O Cinek
    Motol University Hospital, Charles University Prague, V Uvalu 85, CZ 150 06 Praha 5, The Czech Republic
    J Clin Virol 35:33-40. 2006
  7. ncbi request reprint [Childhood diabetes in the Czech Republic: a steady increase in incidence]
    O Cinek
    Ceský registr detského diabetu, Praha
    Cas Lek Cesk 144:266-71; discussion 271-2. 2005
  8. ncbi request reprint NEUROD polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech children
    Ondrej Cinek
    Second Department of Paediatrics, Second Faculty of Medicine, Charles University, V Uvalu 84, Prague 5 CZ 150 06, Czech Republic
    Diabetes Res Clin Pract 60:49-56. 2003
  9. ncbi request reprint No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations
    Ondrej Cinek
    University Hospital Motol, The 2nd Medical School, Charles University, Prague, Czech Republic
    Diabetes Res Clin Pract 76:297-303. 2007
  10. doi request reprint Epidemiology of childhood type 1 diabetes mellitus: lessons from Central and Eastern European data
    Ondrej Cinek
    Department of Pediatrics, The Second Medical Faculty, Charles University, Prague, Czech Republic
    Horm Res Paediatr 76:52-6. 2011

Collaborators

Detail Information

Publications50

  1. doi request reprint The incidence of type 1 diabetes in young Czech children stopped rising
    Ondrej Cinek
    Department of Paediatrics, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
    Pediatr Diabetes 13:559-63. 2012
    ..The aim was to assess trends in incidence of pediatric type 1 diabetes (T1D) using data recorded by the population-based Czech Childhood Diabetes Register over 1989-2009...
  2. pmc Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1
    Ondrej Cinek
    2nd Faculty of Medicine, Department of Paediatrics, Charles University in Prague and University Hospital Motol, Prague, The Czech Republic
    PLoS ONE 7:e48409. 2012
    ..We therefore investigated whether the polymorphisms are associated with differences in the frequency of enterovirus RNA in blood...
  3. doi request reprint Heterogeneity in the systems of pediatric diabetes care across the European Union
    Ondrej Cinek
    University Hospital Motol, Prague, Czech Republic Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Pediatr Diabetes 13:5-14. 2012
    ..It is known that the systems of pediatric diabetes care differ across the member states of the European Union (EU). The aim of this project was to characterize some of the main differences among the national systems...
  4. pmc The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease
    Ondrej Hradsky
    Department of Pediatrics, University Hospital Motol and Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    BMC Med Genet 11:91. 2010
    ..The aim of this study was to assess the association in the Czech population, using a set of markers shown to associate with other diseases...
  5. pmc Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)
    Trine W Boesgaard
    Steno Diabetes Centre and Hagedorn Research Institute, Gentofte, Denmark
    BMC Med Genet 11:42. 2010
    ..Insulin gene (INS) mutations have recently been described as a common cause of permanent neonatal diabetes (PNDM) and a rare cause of diabetes diagnosed in childhood or adulthood...
  6. ncbi request reprint Longitudinal observation of enterovirus and adenovirus in stool samples from Norwegian infants with the highest genetic risk of type 1 diabetes
    O Cinek
    Motol University Hospital, Charles University Prague, V Uvalu 85, CZ 150 06 Praha 5, The Czech Republic
    J Clin Virol 35:33-40. 2006
    ..Data on occurrence and course of the infections in infancy are therefore important for designing effective approaches towards study of the association...
  7. ncbi request reprint [Childhood diabetes in the Czech Republic: a steady increase in incidence]
    O Cinek
    Ceský registr detského diabetu, Praha
    Cas Lek Cesk 144:266-71; discussion 271-2. 2005
    ..The aim of the study was to assess the incidence and prevalence of type 1 diabetes in Czech children aged 0-15 years over the period 1989-2003...
  8. ncbi request reprint NEUROD polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech children
    Ondrej Cinek
    Second Department of Paediatrics, Second Faculty of Medicine, Charles University, V Uvalu 84, Prague 5 CZ 150 06, Czech Republic
    Diabetes Res Clin Pract 60:49-56. 2003
    ..No association was observed for the Pro197His mutation which was carried by 5.3% cases and 5.9% controls. Our results confirm that the NEUROD Ala45Thr polymorphism is associated with childhood-onset Type 1 DM...
  9. ncbi request reprint No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations
    Ondrej Cinek
    University Hospital Motol, The 2nd Medical School, Charles University, Prague, Czech Republic
    Diabetes Res Clin Pract 76:297-303. 2007
    ..The minor (susceptibility) allele is absent in Asian populations, but a recent study suggested an independent involvement of another polymorphism located within the promoter -1123 nucleotides relative to the translational start site...
  10. doi request reprint Epidemiology of childhood type 1 diabetes mellitus: lessons from Central and Eastern European data
    Ondrej Cinek
    Department of Pediatrics, The Second Medical Faculty, Charles University, Prague, Czech Republic
    Horm Res Paediatr 76:52-6. 2011
    ..However, studies performed in Central and Eastern Europe have not revealed any unique patterns of associations with putative risk factors...
  11. ncbi request reprint [Association of insulin gene variants with type 1 diabetes mellitus in Czech population]
    O Cinek
    Pediatrická klinika 2 LF UK a FNM, Praha
    Cas Lek Cesk 143:318-22. 2004
    ..The objective of the study was to quantify the association of insulin gene variants with type 1 diabetes mellitus (TIDM) in the Czech population...
  12. ncbi request reprint Association of single nucleotide polymorphisms within cytokine genes with juvenile idiopathic arthritis in the Czech population
    Ondrej Cinek
    Department of Paediatrics, Motol University Hospital, Prague, Czech Republic
    J Rheumatol 31:1206-10. 2004
    ..To examine the possible association of juvenile idiopathic arthritis (JIA) with polymorphisms within cytokine genes in the Czech population...
  13. ncbi request reprint Continuing increase in incidence of childhood-onset type 1 diabetes in the Czech Republic 1990-2001
    Ondrej Cinek
    2nd Department of Paediatrics, Motol University Hospital, V Uvalu 84, 15006, Prague 5, The Czech Republic
    Eur J Pediatr 162:428-9. 2003
  14. ncbi request reprint Type 1 diabetes mellitus in Czech children diagnosed in 1990-1997: a significant increase in incidence and male predominance in the age group 0-4 years. Collaborators of the Czech Childhood Diabetes Registry
    O Cinek
    2nd Department of Paediatrics, 2nd Medical School, Charles University, Prague, Czech Republic
    Diabet Med 17:64-9. 2000
    ..To overview total, age-and sex-specific incidence rates of type 1 diabetes mellitus and their trends in Czech children 0-14 years of age in the period of 1990-1997...
  15. ncbi request reprint The CTLA4 +49 A/G dimorphism is not associated with type 1 diabetes in Czech children
    O Cinek
    2nd Department of Paediatrics, 2nd Medical School, Charles University, Prague, Czech Republic
    Eur J Immunogenet 29:219-22. 2002
    ..This may be another piece of evidence against the +49 A/G transition as the aetiological polymorphism within the CTLA4 gene...
  16. ncbi request reprint [Prediction of insulin-dependent diabetes mellitus in children of first-degree relatives of diabetic patients]
    O Cinek
    Ustav klinické biochemie a patobiochemie FNM, Praha
    Cas Lek Cesk 140:492-6. 2001
    ..Our study was aimed at prediction of IDDM in a cohort of children having a first-degree relative with IDDM...
  17. ncbi request reprint HLA-DQ polymorphisms modify the risk of thyroid autoimmunity in children with type 1 diabetes mellitus
    Z Sumnik
    2nd Department of Pediatrics, 2nd Medical School, Charles University, Prague, Czech Republic
    J Pediatr Endocrinol Metab 16:851-8. 2003
    ..PATIENTS AND METLHODS: Screening for TAI was performed in 285 children with DM1 by measuring autoantibodies against thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg). HLA-DQA1 and -DQB1 were genotyped using PCR-SSP...
  18. ncbi request reprint Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 and TNF -308A
    Zdenek Sumnik
    Motol University Hospital, Charles University Prague, V Uvalu 84, CZ 150 06, Prague, The Czech Republic
    Diabetes Care 29:858-63. 2006
    ....
  19. ncbi request reprint Polymorphism of INS VNTR is associated with glutamic acid decarboxylase antibodies and postprandial C-peptide in patients with onset of diabetes after 35 years of age
    M Matejkova-Behanova
    Institute of Endocrinology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 53:187-90. 2004
    ....
  20. ncbi request reprint HLA-DQA1*05-DQB1*0201 positivity predisposes to coeliac disease in Czech diabetic children
    Z Sumnik
    2nd Department of Paediatrics of the 2nd Medical School, Charles University, Prague, Czech Republic
    Acta Paediatr 89:1426-30. 2000
    ..1, CI 95% 1.1-15), being found more frequently in diabetic children with CD (80%) than in diabetic children without CD (49%)...
  21. ncbi request reprint Higher maternal age at delivery, and lower birth orders are associated with increased risk of childhood type 1 diabetes mellitus
    Z Sumnik
    Department of Paediatrics, 2nd Medical School, Charles University, V Uvalu 84, Prague 5, The Czech Republic
    Exp Clin Endocrinol Diabetes 112:294-7. 2004
    ..We detected no independent effect of maternal education, either. Our study provides further evidence that the risk of Type 1 diabetes in the offspring increases with higher maternal age at delivery and lower birth order...
  22. ncbi request reprint Thyroid autoimmunity in children with coexisting type 1 diabetes mellitus and celiac disease: a multicenter study
    Z Sumnik
    Department of Pediatrics, 2nd Faculty of Medicine, Prague, Czech Republic
    J Pediatr Endocrinol Metab 19:517-22. 2006
    ..Children with type 1 diabetes mellitus (DM1) are more prone to developing thyroid autoimmunity (TAI); TAI also occurs more frequently in patients with celiac disease (CD)...
  23. doi request reprint Variants of CARD15, TNFA and PTPN22 and susceptibility to Crohn's disease in the Czech population: high frequency of the CARD15 1007fs
    O Hradsky
    Department of Pediatrics, University Hospital Motol, Prague, Czech Republic
    Tissue Antigens 71:538-47. 2008
    ..In conclusion, we report a high frequency of the minor allele of the CARD15 1007fs polymorphism in the Czech population and a strong effect of this allele on the age at disease onset...
  24. ncbi request reprint Pregnancy in a woman suffering from type 1 diabetes associated with Addison's disease and Hashimoto's thyroiditis (fully developed Autoimmune Polyglandular Syndrome Type 2)
    K Stechova
    2nd Department of Paediatrics, University Hospital Motol in Prague, V Uvalu 84, Prague 5, Czech Republic
    Exp Clin Endocrinol Diabetes 112:333-7. 2004
    ..Interdisciplinary approach and very careful observation of the mother as well as of the child enabled successful outcome of this highly risky pregnancy...
  25. ncbi request reprint [Type I diabetes mellitus and associated autoimmune diseases in the first-degree relatives of diabetic children: questionnaire based study]
    H Malcova
    Pediatrická klinika 2 LF UK a FNM, Praha
    Cas Lek Cesk 143:625-9. 2004
    ..The shared genetic background may play a role in the disease pathogenesis. The aim of our study was to assess the prevalence of T1DM and other autoimmune disorders in the first-degree relatives of diabetic children...
  26. ncbi request reprint Widespread clone of Burkholderia cenocepacia in cystic fibrosis patients in the Czech Republic
    Pavel Drevinek
    Paediatric Department, Charles University 2nd Medical School, Prague, Czech Republic
    J Med Microbiol 54:655-9. 2005
    ..cepacia epidemic strain marker, PCR negativity for the cable pilin subunit gene and close genetic relatedness to the epidemic strain of RAPD 01 type previously identified in Canada...
  27. doi request reprint Association of IL23R p.381Gln and ATG16L1 p.197Ala with Crohn disease in the Czech population
    Petra Dusatkova
    Department of Pediatrics, University Hospital Motol, and Second Faculty of Medicine, Charles University in Prague, Czech Republic
    J Pediatr Gastroenterol Nutr 49:405-10. 2009
    ..Ala197Thr, rs2241880) with Crohn disease (CD) was identified by whole genome association studies, and subsequently confirmed by other works. The aim of this study was to assess this association in the Czech population...
  28. ncbi request reprint [EBV quantification in children after allogeneic hematopoietic stem cell transplantation]
    P Hubacek
    Klinika dĕtské hematologie a onkologie 2, LF UK a FNM, Praha
    Cas Lek Cesk 145:301-6. 2006
    ..The aims of the study were to retrospectively characterise the viral loads in four patients who died of this complication, and to test possible risk factors for EBV reactivation in a prospectively observed cohort of children after AHSCT...
  29. doi request reprint Partial remission with cyclosporine A in a patient with nephrotic syndrome due to NPHS2 mutation
    Michal Malina
    Department of Pediatrics, Second Faculty of Medicine, Charles University Prague, Prague 5, Czech Republic
    Pediatr Nephrol 24:2051-3. 2009
    ..However, its long-term effect and safety in children with hereditary forms of nephrotic syndrome have yet to be investigated...
  30. doi request reprint HHV-6 DNA throughout the tissues of two stem cell transplant patients with chromosomally integrated HHV-6 and fatal CMV pneumonitis
    Petr Hubacek
    Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine and Motol University Hospital, Charles University, Prague, The Czech Republic
    Br J Haematol 145:394-8. 2009
    ..In individuals with chromosomal integration, HHV-6 DNA is found in every tissue of recipient origin indicating inheritance through the germ line...
  31. doi request reprint Prevalence of HHV-6 integrated chromosomally among children treated for acute lymphoblastic or myeloid leukemia in the Czech Republic
    Petr Hubacek
    Department of Paediatric Haematology and Oncology, Motol University Hospital, Prague, Czech Republic
    J Med Virol 81:258-63. 2009
    ..Where high levels of HHV-6 DNA are present, CI-HHV-6 should be confirmed as soon as possible so that potentially toxic but ineffective antiviral treatment can be stopped...
  32. pmc Direct culture-independent Strain typing of Burkholderia cepacia complex in sputum samples from patients with cystic fibrosis
    Pavel Drevinek
    Department of Pediatrics, 2nd Medical School, Charles University, V Uvalu 84, 150 06 Prague, Czech Republic
    J Clin Microbiol 48:1888-91. 2010
    ..The redesigned nested-PCR MLST format was successfully used to accurately identify strains in 23 sputum samples, of which 8 were culture negative...
  33. ncbi request reprint High prevalence of coeliac disease in siblings of children with type 1 diabetes
    Zdenek Sumnik
    Department of Paediatrics, 2nd Faculty of Medicine, V Uvalu 84, 150 06 Prague 5, Czech Republic
    Eur J Pediatr 164:9-12. 2005
    ..The HLA-DQ2 polymorphism was more frequent among siblings with EMA (seven of nine) than in siblings without EMA (33%), corrected P = 0.031...
  34. doi request reprint Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet
    Petr Hubacek
    Motol University Hospital, Prague, Czech Republic
    Pediatr Transplant 13:919-22. 2009
    ..To our best knowledge, this is the first reported case of successful CMV treatment with a combination of CDV and FCV...
  35. pmc Direct PCR detection of Burkholderia cepacia complex and identification of its genomovars by using sputum as source of DNA
    Pavel Drevinek
    2nd Department of Pediatrics, 2nd Medical School of Charles University, Prague, Czech Republic
    J Clin Microbiol 40:3485-8. 2002
    ..The product of the first PCR round is also used to identify the genomovar of the pathogen. The protocol achieves high sensitivity and specificity with simple interpretation of genomovar status...
  36. ncbi request reprint Absence of breast-feeding is associated with the risk of type 1 diabetes: a case-control study in a population with rapidly increasing incidence
    Hana Malcova
    Department of Paediatrics, Motol University Hospital, Charles University, V Uvalu 84, 150 06 rague 5, Czech Republic
    Eur J Pediatr 165:114-9. 2006
    ..Short breast-feeding period and short attendance to day care is associated with the risk of T1DM in Czech children...
  37. ncbi request reprint Association of insulin gene VNTR polymorphism with polycystic ovary syndrome
    Marketa Vankova
    Institute of Endocrinology, Prague, Czech Republic
    Ann N Y Acad Sci 967:558-65. 2002
    ....
  38. doi request reprint Boys with haemophilia have low trabecular bone mineral density and sarcopenia, but normal bone strength at the radius
    O Soucek
    Department of Paediatrics, University Hospital Motol, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Haemophilia 18:222-8. 2012
    ..Bone strength measured at the diaphysis of the radius is not impaired in boys with haemophilia. The finding of the decreased trabecular bone density can be most likely attributed to their sarcopenia...
  39. ncbi request reprint Interferon-gamma and cortisol levels in cerebrospinal fluid and its relationship to the etiology of aseptic meningoencephalitis
    M Holub
    Third Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University, Teaching Hospital Na Bulovce, Prague, Czech Republic
    Prague Med Rep 107:343-53. 2006
    ..The results indicate that the prevailing intrathecal immune reaction during AM is shifted to a Th1-like response, whereas anti-inflammatory response in the brain is executed by the effect of cortisol...
  40. ncbi request reprint Failure of multiple antivirals to affect high HHV-6 DNAaemia resulting from viral chromosomal integration in case of severe aplastic anaemia
    P Hubacek
    Department of Paediatric Haematology and Oncology, Motol University Hospital, Prague, The Czech Republic
    Haematologica 92:e98-e100. 2007
    ..After one year of steady high HHV6 DNA load in blood, viral chromosomal integration was proved by demonstrating the viral DNA in hair follicles. This condition appeared to be unconnected with, and to have no effect, on the original SAA...
  41. ncbi request reprint Anti-GAD65 reactive peripheral blood mononuclear cells in the pathogenesis of cystic fibrosis related diabetes mellitus
    Katerina Stechova
    Department of Paediatrics, 2nd Medical Faculty of Charles University and University Hospital Motol in Prague, V Uvalu 84, Prague 5, Motol, 15006, Czech Republic
    Autoimmunity 38:319-23. 2005
    ..In our pilot study we addressed if autoreactive mononuclear cells are present also in peripheral blood of patients with other specific forms of diabetes as cystic fibrosis related diabetes (CFRD)...
  42. ncbi request reprint High genotypic diversity of Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis in the Czech Republic
    Sarka Vosahlikova
    Department of Paediatrics, 2nd Medical School, Charles University in Prague, Uvalu 84, 15006 Prague 5, Czech Republic
    Res Microbiol 158:324-9. 2007
    ..The absence of highly epidemic P. aeruginosa strains may result from infection control measures taken upon recognition of the epidemic B. cenocepacia...
  43. doi request reprint Autosomal inheritance of diabetes in two families characterized by obesity and a novel H241Q mutation in NEUROD1
    Lucie Gonsorcíkova
    Department of Paediatrics, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Pediatr Diabetes 9:367-72. 2008
    ....
  44. ncbi request reprint Genomovar distribution of the Burkholderia cepacia complex differs significantly between Czech and Slovak patients with cystic fibrosis
    Pavel Drevinek
    J Med Microbiol 52:603-4. 2003
  45. ncbi request reprint Genetic association of type 1 diabetes in an Azerbaijanian population: the HLA-DQ, -DRB1*04, the insulin gene, and CTLA4
    Gunduz Ahmedov
    Azerbaijan Medical University, Str K Ragimov 11, Baku, Azerbaijan Republic
    Pediatr Diabetes 7:88-93. 2006
    ..Little is known on the genetic susceptibility to type 1 diabetes mellitus (T1DM) in the nations of the former Soviet part of south-west Asia...
  46. ncbi request reprint Asymptomatic circulation of HEV71 in Norway
    Elisabet Witsø
    Norwegian Institute of Public Health, Oslo, Norway
    Virus Res 123:19-29. 2007
    ..Complete sequencing of this strain, HEV71 804/NO/03, revealed differences in the 5'UTR and polymerase with respect to more pathogenic genotypes that may explain its reduced neurovirulence...
  47. doi request reprint Longitudinal observation of parechovirus in stool samples from Norwegian infants
    German Tapia
    Norwegian Institute of Public Health, Oslo, Norway
    J Med Virol 80:1835-42. 2008
    ..There was no significant association between infections and the following symptoms: coughing, sneezing, fever, diarrhea or vomiting. In conclusion, human parechovirus infects frequently infants at an early age without causing disease...
  48. ncbi request reprint Incidence of HHV7 in donors and recipients of allogeneic hematopoietic stem cell transplantation
    Petr Hubacek
    Pediatr Blood Cancer 50:935; author reply 936. 2008
  49. ncbi request reprint Islet autoantibody development during follow-up of high-risk children from the general Norwegian population from three months of age: design and early results from the MIDIA study
    Lars C Stene
    Division of Epidemiology, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    J Autoimmun 29:44-51. 2007
    ..5-12.4%). Thus, persistent islet autoimmunity is not uncommon in the first year of life in children from the general population carrying the high-risk HLA genotype, and may develop as early as at 6 months of age...
  50. pmc High prevalence of human enterovirus a infections in natural circulation of human enteroviruses
    Elisabet Witsø
    Norwegian Institute of Public Health, Oslo, Norway
    J Clin Microbiol 44:4095-100. 2006
    ..5%), CAV4 (8.9%), E18 (8.9%), and CBV3 (7.3%). These findings suggest that the prevalence of HEV infections in general, and HEV-A infections in particular, has been underestimated in epidemiological studies based on virus culture...