Josef Zicha

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. ncbi request reprint Hypertensive response to chronic NG-nitro-L-arginine methyl ester (L-NAME) treatment is similar in immature and adult Wistar rats
    Josef Zicha
    Centre for Experimental Cardiovascular Research, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Clin Sci (Lond) 105:483-9. 2003
  2. ncbi request reprint Involvement of BK(Ca) and K(V) potassium channels in cAMP-induced vasodilatation: their insufficient function in genetic hypertension
    M Pintérová
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 63:275-85. 2014
  3. ncbi request reprint Nifedipine-sensitive blood pressure component in hypertensive models characterized by high activity of either sympathetic nervous system or renin-angiotensin system
    J Zicha
    Institute of Physiology AS CR, Prague, Czech Republic
    Physiol Res 63:13-26. 2014
  4. ncbi request reprint The interaction of calcium entry and calcium sensitization in the control of vascular tone and blood pressure of normotensive and hypertensive rats
    J Zicha
    Department of Experimental Hypertension, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 63:S19-27. 2014
  5. ncbi request reprint The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats
    M Bencze
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 62:471-8. 2013
  6. ncbi request reprint Age-dependent salt hypertension in Dahl rats: fifty years of research
    J Zicha
    Centre for Cardiovascular Research, Prague, Czech Republic
    Physiol Res 61:S35-87. 2012
  7. doi request reprint Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats
    J Zicha
    Center for Experimental Cardiovascular Research, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Acta Physiol (Oxf) 205:124-32. 2012
  8. ncbi request reprint Abnormalities of membrane function and lipid metabolism in hypertension: a review
    J Zicha
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Am J Hypertens 12:315-31. 1999
  9. ncbi request reprint Antihypertensive mechanisms of chronic captopril or N-acetylcysteine treatment in L-NAME hypertensive rats
    Josef Zicha
    Institute of Physiology AS CR and Cardiovascular Research Center, Prague, Czech Republic
    Hypertens Res 29:1021-7. 2006
  10. ncbi request reprint Neurogenic pulmonary edema induced by spinal cord injury in spontaneously hypertensive and Dahl salt hypertensive rats
    J Sedy
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 60:975-9. 2011

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Hypertensive response to chronic NG-nitro-L-arginine methyl ester (L-NAME) treatment is similar in immature and adult Wistar rats
    Josef Zicha
    Centre for Experimental Cardiovascular Research, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Clin Sci (Lond) 105:483-9. 2003
    ..This suggests that the altered NO bioavailability (but not the generally exaggerated reactivity to hypertensive stimuli) is the cause of exaggerated hypertensive response observed in immature rats exposed to excess salt intake...
  2. ncbi request reprint Involvement of BK(Ca) and K(V) potassium channels in cAMP-induced vasodilatation: their insufficient function in genetic hypertension
    M Pintérová
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 63:275-85. 2014
    ..In conclusion, K(+) channels seem to have higher activity in SHR, but their vasodilator action cannot match sufficiently the augmented vasoconstriction in this hypertensive strain. ..
  3. ncbi request reprint Nifedipine-sensitive blood pressure component in hypertensive models characterized by high activity of either sympathetic nervous system or renin-angiotensin system
    J Zicha
    Institute of Physiology AS CR, Prague, Czech Republic
    Physiol Res 63:13-26. 2014
    ..In conclusions, BP response to nifedipine is proportional to the vasoconstrictor activity exerted by both SNS and RAS, indicating a key importance of these two pressor systems for actual L-VDCC opening necessary for BP maintenance. ..
  4. ncbi request reprint The interaction of calcium entry and calcium sensitization in the control of vascular tone and blood pressure of normotensive and hypertensive rats
    J Zicha
    Department of Experimental Hypertension, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 63:S19-27. 2014
    ....
  5. ncbi request reprint The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats
    M Bencze
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 62:471-8. 2013
    ..Major BP reduction (namely in SHR) due to a complete SNS absence is a major drawback of ketamine-xylazine anesthesia. ..
  6. ncbi request reprint Age-dependent salt hypertension in Dahl rats: fifty years of research
    J Zicha
    Centre for Cardiovascular Research, Prague, Czech Republic
    Physiol Res 61:S35-87. 2012
    ..On the contrary, moderate salt hypertension in adult Dahl rats is attenuated by superoxide scavenging or endothelin-A receptor blockade which do not affect salt hypertension development in young animals...
  7. doi request reprint Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats
    J Zicha
    Center for Experimental Cardiovascular Research, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Acta Physiol (Oxf) 205:124-32. 2012
    ..Therefore, we compared ET-1 role in the development or the maintenance of salt hypertension induced in young (4-week-old) or adult (12-week-old) Dahl rats...
  8. ncbi request reprint Abnormalities of membrane function and lipid metabolism in hypertension: a review
    J Zicha
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Am J Hypertens 12:315-31. 1999
    ..Future studies of functional membrane alterations in hypertension or dyslipidemia will therefore require the detailed determination of membrane lipid composition and the measurement of microviscosity in particular membrane domains...
  9. ncbi request reprint Antihypertensive mechanisms of chronic captopril or N-acetylcysteine treatment in L-NAME hypertensive rats
    Josef Zicha
    Institute of Physiology AS CR and Cardiovascular Research Center, Prague, Czech Republic
    Hypertens Res 29:1021-7. 2006
    ..Chronic captopril treatment prevented L-NAME hypertension by lowering of sympathetic tone, whereas chronic NAC treatment attenuated L-NAME hypertension by reduction in the vasodilator deficit due to enhanced NO-dependent vasodilation...
  10. ncbi request reprint Neurogenic pulmonary edema induced by spinal cord injury in spontaneously hypertensive and Dahl salt hypertensive rats
    J Sedy
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 60:975-9. 2011
    ..It is evident that a moderate impairment of baroreflex sensitivity, which was demonstrated in salt hypertensive Dahl rats, does not exert sufficient protective effects against NPE development...
  11. ncbi request reprint Late blood pressure reduction in SHR subjected to transient captopril treatment in youth: possible mechanisms
    J Zicha
    Institute of Physiology AS CR, v v i, Videnska 1083, Prague 4, Czech Republic
    Physiol Res 57:495-8. 2008
    ..The magnitude of nifedipine-sensitive component of sympathetic vasoconstriction is decisive for BP maintenance not only in untreated SHR but also in SHR during active captopril treatment by or after its withdrawal...
  12. ncbi request reprint Influence of pertussis toxin pretreatment on the development of L-NAME-induced hypertension
    J Zicha
    Institute of Physiology Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Physiol Res 58:751-5. 2009
    ..Our data suggest that the sympathetic vasoconstriction is essential for the development of established NO-deficient hypertension...
  13. doi request reprint Preventive dietary potassium supplementation in young salt-sensitive Dahl rats attenuates development of salt hypertension by decreasing sympathetic vasoconstriction
    J Zicha
    Cardiovascular Research Center, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Acta Physiol (Oxf) 202:29-38. 2011
    ....
  14. ncbi request reprint Altered Na+-K+ pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to Atp1a1 gene
    J Zicha
    Institute of Physiology, Academy of Sciences of the Czech Republic, Center for Experimental Research of Cardiovascular Diseases, CZ 142 20 Prague, Czech Republic
    Physiol Genomics 6:99-104. 2001
    ..In conclusion, abnormal cholesterol metabolism but not the Atp1a1 gene locus might represent an important factor for both high BP and altered Na(+)-K(+) pump function in salt-hypertensive Dahl rats...
  15. ncbi request reprint Relative deficiency of nitric oxide-dependent vasodilation in salt-hypertensive Dahl rats: the possible role of superoxide anions
    J Zicha
    Institute of Physiology, Academy of Sciences of the Czech Republic, and Center for Experimental Research of Cardiovascular Diseases, Prague
    J Hypertens 19:247-54. 2001
    ....
  16. ncbi request reprint Membrane microviscosity, blood pressure and cytosolic pH in Dahl rats: the influence of plasma lipids
    J Zicha
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    J Hypertens 17:785-92. 1999
    ..To determine the relationships between blood pressure, membrane microviscosity, plasma lipids and cytosolic pH in Dahl rats susceptible or resistant to salt hypertension...
  17. ncbi request reprint Ontogenetic aspects of hypertension development: analysis in the rat
    J Zicha
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Rev 79:1227-82. 1999
    ..The critical periods (developmental windows) should be respected in the future pharmacological or gene therapy of human hypertension...
  18. doi request reprint The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats: the effect of preventive interventions
    Jiri Sedy
    Institute of Experimental Medicine and Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Am J Physiol Regul Integr Comp Physiol 297:R1111-7. 2009
    ..In conclusion, nitric oxide has a partial protective effect on NPE development because it attenuates sympathetic vasoconstriction and consequent baroreflex-induced bradycardia following spinal cord injury...
  19. ncbi request reprint The altered balance between sympathetic nervous system and nitric oxide in salt hypertensive Dahl rats: ontogenetic and F2 hybrid studies
    Zdena Dobesová
    Institute of Physiology, Academy of Sciences of the Czech Republic, and Center for Experimental Research of Cardiovascular Diseases, Prague, Czech Republic
    J Hypertens 20:945-55. 2002
    ....
  20. ncbi request reprint Vasoactive systems in L-NAME hypertension: the role of inducible nitric oxide synthase
    Olga Pechanova
    Center for Experimental Cardiovascular Research, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Hypertens 22:167-73. 2004
    ..Furthermore, we studied the extent of nitric oxide (NO) synthesis inhibition and the participation of remaining NO in the counterbalance of pressor systems, with a special reference to inducible nitric oxide synthase (iNOS)...
  21. ncbi request reprint Erythrocyte ion transport and membrane lipid composition in young and adult rats with NO-deficient hypertension
    Martina Vokurkova
    Center for Experimental Cardiovascular Research, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Life Sci 73:1637-44. 2003
    ..Our results exclude the important participation of classical sodium transport abnormalities in the pathogenesis of this NO-deficient form of experimental hypertension...
  22. ncbi request reprint Ca2+ sensitization and Ca2+ entry in the control of blood pressure and adrenergic vasoconstriction in conscious Wistar-Kyoto and spontaneously hypertensive rats
    Michal Behuliak
    aInstitute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic bInstitute of Pharmacology, Faculty of Medicine, Comenius University, Bratislava, Slovakia Michal Behuliak and Mária Pintérová contributed equally to the writing of this article
    J Hypertens 31:2025-35. 2013
    ..However, the changes of calcium sensitization mediated by RhoA/Rho kinase pathway are less understood...
  23. ncbi request reprint Chronic N-acetylcysteine administration prevents development of hypertension in N(omega)-nitro-L-arginine methyl ester-treated rats: the role of reactive oxygen species
    Hana Rauchová
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Hypertens Res 28:475-82. 2005
    ..Since chronic NAC treatment had better preventive than therapeutic effects, it seems that reactive oxygen species play a more important role in the induction than in the maintenance of L-NAME hypertension...
  24. ncbi request reprint Membrane ion transport in erythrocytes of salt hypertensive Dahl rats and their F2 hybrids: the importance of cholesterol
    Martina Vokurkova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Center for Experimental Research of Cardiovascular Diseases, Prague, Czech Republic
    Hypertens Res 26:397-404. 2003
    ..18 and 0.21, p<0.05). Our results support the idea that abnormal lipid metabolism and/or altered Na+,K(+)-ATPase function play an important role in the pathogenesis of salt hypertension in salt-sensitive Dahl rats...
  25. doi request reprint Hemodynamic characterization of recombinant inbred strains: twenty years later
    Jaroslav Kunes
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Hypertens Res 31:1659-68. 2008
    ..Our study confirms the validity of RI strains for the further genetic and physiological research of hypertension...
  26. ncbi request reprint Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery
    Silvia Liskova
    Center of Cardiovascular Research and Institute of Physiology, Academy of Sciences of Czech Republic, Prague, Czech Republic
    Eur J Pharmacol 667:265-70. 2011
    ..We conclude that EDCF contribution to norepinephrine-induced contraction of conduit arteries is similarly enhanced in adult hypertensive and aged normotensive rats...
  27. doi request reprint Influence of calcium-dependent potassium channel blockade and nitric oxide inhibition on norepinephrine-induced contractions in two forms of genetic hypertension
    Silvia Liskova
    Center of Cardiovascular Research and Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Am Soc Hypertens 4:128-34. 2010
    ....
  28. ncbi request reprint Altered balance of main vasopressor and vasodepressor systems in rats with genetic hypertension and hypertriglyceridaemia
    Jaroslav Kunes
    Institute of Physiology, Academy of Sciences of the Czech Republic, and Center for Experimental Research of Cardiovascular Diseases, CZ 142 20 Prague, Czech Republic
    Clin Sci (Lond) 102:269-77. 2002
    ..The altered balance between enhanced SNS-dependent vasoconstriction and unchanged NO-dependent vasodilation ('relative NO deficiency' in rats with high BP) might result in BP elevation in this form of genetic hypertension...
  29. ncbi request reprint The participation of brain NO synthase in blood pressure control of adult spontaneously hypertensive rats
    Silvie Hojna
    Institute of Physiology AS CR, Charles University, Videnska 1083, 142 20, Prague 4, Czech Republic
    Mol Cell Biochem 297:21-9. 2007
    ..Our data do not support the hypothesis that altered brain NO formation contributes to sympathetic hyperactivity and high BP of adult SHR with established hypertension...
  30. ncbi request reprint Relationships between membrane lipids and ion transport in red blood cells of Dahl rats
    Martina Vokurkova
    Institute of Physiology, Academy of Sciences of the Czech Republic and Cardiovascular Research Center, Prague, Czech Republic
    Life Sci 77:1452-64. 2005
    ....
  31. ncbi request reprint Effect of acute hyperglycemia on erythrocyte membrane ion transport in offspring of hypertensive parents
    Gabriela Suchankova
    Diabetes Center, Institute for Clinical and Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic
    J Hypertens 21:1325-30. 2003
    ..The aims of this study were to assess RBC ion transport activities under basal conditions and to test the in vivo effect of acute hyperglycemia on RBC ion transport in the offspring of hypertensive parents (OHP) and healthy controls (C)...
  32. ncbi request reprint Abnormal Igf2 gene in Prague hereditary hypertriglyceridemic rats: its relation to blood pressure and plasma lipids
    Michaela Kadlecová
    Institute of Physiology, Academy of Sciences of the Czech Republic and Cardiovascular Research Center, Prague 4, Czech Republic
    Mol Cell Biochem 314:37-43. 2008
    ..It remains to determine how these abnormalities could be involved in BP regulation by particular vasoactive systems...
  33. doi request reprint Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin
    Mária Pintérová
    Cardiovascular Research Center and Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Hypertens 28:969-78. 2010
    ....
  34. doi request reprint The effects of repeated delivery of angiotensin II AT(1) receptor antisense on distinct vasoactive systems in Ren-2 transgenic rats: young vs. adult animals
    Ivana Vaneckova
    Institute of Physiology v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Hypertens Res 35:761-8. 2012
    ..The contribution of the RAS to BP maintenance is highly important only in homozygous TGRs, whereas it is surpassed by SNS in heterozygous TGR...
  35. ncbi request reprint Vasodilator efficiency of endogenous prostanoids, Ca²⁺-activated K⁺ channels and nitric oxide in rats with spontaneous, salt-dependent or NO-deficient hypertension
    Michal Behuliak
    CRC and Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Hypertens Res 34:968-75. 2011
    ..Thus, the overall activity of vasodilator systems failed to compensate for augmented sympathetic vasoconstriction in hypertensive animals...
  36. doi request reprint The role of sympathetic nervous system in the development of neurogenic pulmonary edema in spinal cord-injured rats
    Jiri Sedy
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Appl Physiol (1985) 112:1-8. 2012
    ....
  37. ncbi request reprint Sexual dimorphism of 11beta-hydroxysteroid dehydrogenase in hypertensive and normotensive rats
    Karla Mazancova
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Hypertens Res 26:333-8. 2003
    ..3) The reduced 11betaHSD activity in the aorta of hypertensive SS/Jr compared to SR/Jr rats suggests that this enzyme might play a role in the pathogenesis of salt-sensitive hypertension in Dahl rats...
  38. doi request reprint Local metabolism of glucocorticoids in Prague hereditary hypertriglyceridemic rats--effect of hypertriglyceridemia and gender
    Petra Klusonova
    Department of Epithelial Physiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Steroids 76:1252-9. 2011
    ..No dramatic changes were found in the mRNA expression of H6PDH and GR. Our data provide evidence that the relationship between hypertriglyceridemia and glucocorticoid action is complex and gender specific...
  39. ncbi request reprint Gender-dependent difference in cell calcium handling in VSMC isolated from SHR: the effect of angiotensin II
    Jana Loukotová
    Institute of Physiology, Academy of Sciences of the Czech Republic and Center for Experimental Research of Cardiovascular Diseases, Prague, Czech Republic
    J Hypertens 20:2213-9. 2002
    ..To further evaluate this gender-dependent difference by studying the role of thapsigargin-sensitive intracellular calcium stores and calcium influx in VSMC isolated from male and female SHR...
  40. doi request reprint Atropine may prevent the development of neurogenic pulmonary edema
    Jiri Sedy
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Med Hypotheses 73:42-4. 2009
    ..v. immediately after the maintenance of the living functions, intubation and ability to monitor patient...
  41. ncbi request reprint Low concentration of isoflurane promotes the development of neurogenic pulmonary edema in spinal cord injured rats
    Jiri Sedy
    Institute of Experimental Medicine, ASCR, Prague, Czech Republic
    J Neurotrauma 24:1487-501. 2007
    ..The optimal concentration of anesthesia for performing a spinal cord compression lesion is 2.5-3% isoflurane in air...
  42. pmc Contribution of Ca(2+)-Dependent Cl(-) Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing
    Silvia Liskova
    Institute of Physiology, Academy of Sciences of the Czech Republic, 14220 Prague 4, Czech Republic Institute of Pharmacology, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Biomed Res Int 2014:289361. 2014
    ..Ca(2+)-dependent Cl(-) channels are important for maintenance of normal vascular tone while their inactivation/closing might be a pathological mechanism. ..
  43. ncbi request reprint Erythrocyte membrane ion transport in offspring of hypertensive parents: effect of acute hyperinsulinemia and relation to insulin action
    Gabriela Suchankova
    Institute for Clinical and Experimental Medicine, and Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Ann N Y Acad Sci 967:352-62. 2002
    ..Acute hyperinsulinemia did not modify any ion transport parameter studied, although negative correlation was observed between insulin action and membrane leaks...
  44. ncbi request reprint Developmental windows and environment as important factors in the expression of genetic information: a cardiovascular physiologist's view
    Jaroslav Kunes
    Cardiovascular Research Centre and Institute of Physiology, AS CR, Videnska 1083, 142 20 Prague 4, Czech Republic
    Clin Sci (Lond) 111:295-305. 2006
    ..This should help to elucidate the mechanisms underlying cardiovascular diseases (including hypertension) and to develop strategies to prevent the development of such diseases...
  45. ncbi request reprint Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems
    Takahiro Ueno
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, 3850 Rue Saint Urbain, Montreal, Quebec, Canada
    J Mol Med (Berl) 81:51-60. 2003
    ..This pharmocogenetic approach enabled us to determine the main causative acute BP regulatory systems and should lead to better selection of suitable antihypertensive drugs for individual patients...
  46. ncbi request reprint Rat model of familial combined hyperlipidemia as a result of comparative mapping
    Takahiro Ueno
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Physiol Genomics 17:38-47. 2004
    ..These data suggest the close relationship between dyslipidemia in HTG rats and human FCHL, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants...
  47. ncbi request reprint Vasorelaxant activity of some oxime derivatives
    Filip Jaros
    Chair of Biochemistry, Faculty of Sciences, Charles University, Czech Republic
    Eur J Pharmacol 575:122-6. 2007
    ..Substances with hydrophilic character (formamidoxime, acetohydroxamic acid, formaldoxime) were effective, whereas less hydrophilic substance (acetaldoxime) or slightly hydrophobic one (acetone oxime) were ineffective...
  48. ncbi request reprint The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension
    Olga Pechanova
    Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Eur J Pharmacol 561:129-36. 2007
    ..The observed antihypertensive effect of melatonin is thus mediated by additional mechanisms independent of NO pathway...
  49. ncbi request reprint Effect of maturation on renal Na+/K+-atpase and its susceptibility to nitric oxide-deficient hypertension in rats
    Veronika Javorková
    Institute for Heart Research, Department of Biochemistry, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Clin Exp Pharmacol Physiol 34:617-23. 2007
    ..However, maturation increased the susceptibility of renal Na(+)/K(+)-ATPase to the harmful effects of L-NAME...
  50. doi request reprint Regression of L-NAME-induced hypertension: the role of nitric oxide and endothelium-derived constricting factor
    Ludovit Paulis
    Institute of Pathophysiology, School of Natural Sciences, Comenius University, Bratislava, Slovak Republic
    Hypertens Res 31:793-803. 2008
    ..However, persisting arterial structural alterations and enhanced EDCF formation may decelerate blood pressure reduction even after the restoration of NO synthase activity...
  51. ncbi request reprint Effect of chronic N-acetylcysteine treatment on the development of spontaneous hypertension
    Olga Pechanova
    Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovak Republic
    Clin Sci (Lond) 110:235-42. 2006
    ..In adult SHRs with established hypertension, however, the secondary alterations (such as pronounced structural remodelling of resistance vessels) might attenuate the therapeutic effect of NAC...