L Vyklicky

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. ncbi request reprint Reducing agent dithiothreitol facilitates activity of the capsaicin receptor VR-1
    L Vyklicky
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Neuroscience 111:435-41. 2002
  2. ncbi request reprint The effects of excessive heat on heat-activated membrane currents in cultured dorsal root ganglia neurons from neonatal rat
    A Lyfenko
    Institute of Physiology, Academy of Sciences of Czech Republic, 142 20 4, Vijdenska 1083, Prague, Czech Republic
    Pain 95:207-14. 2002
  3. doi request reprint Temperature dependence of N-methyl-D-aspartate receptor channels and N-methyl-D-aspartate receptor excitatory postsynaptic currents
    M Korinek
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Neuroscience 165:736-48. 2010
  4. doi request reprint Pregnenolone sulfate modulation of N-methyl-D-aspartate receptors is phosphorylation dependent
    M Petrovic
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska, Prague 4, Czech Republic
    Neuroscience 160:616-28. 2009
  5. ncbi request reprint Temperature dependence of NR1/NR2B NMDA receptor channels
    O Cais
    Institute of Physiology, Academy of Sciences of the Czech Republic v v i, Videnska 1083, 142 20 Prague 4, Czech Republic
    Neuroscience 151:428-38. 2008
  6. ncbi request reprint Procaine excites nociceptors in cultures from dorsal root ganglion of the rat
    V Vlachova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Neurosci Lett 263:49-52. 1999
  7. pmc Temperature coefficient of membrane currents induced by noxious heat in sensory neurones in the rat
    L Vyklicky
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    J Physiol 517:181-92. 1999
  8. ncbi request reprint Activation and modulation of ligand-gated ion channels
    J Krusek
    Departent of Cellular Neurophysiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 53:S103-13. 2004
  9. ncbi request reprint Suramin affects capsaicin responses and capsaicin-noxious heat interactions in rat dorsal root ganglia neurones
    V Vlachova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Physiol Res 51:193-8. 2002
  10. ncbi request reprint Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin
    L Vyklicky
    Department of Cellular Neurophysiology, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 57:S59-68. 2008

Collaborators

  • M Petrovic
  • R K Orkand
  • M Kress
  • J Krusek
  • M Sedlacek
  • V Vlachova
  • M Horak
  • O Cais
  • E Adamusová
  • M Korinek
  • H Chodounska
  • I Dittert
  • A Lyfenko
  • K Novakova-Tousova
  • K Vlcek
  • R Turecek
  • E Kudova
  • V Vyklický
  • J Benedikt
  • J Teisinger
  • K Susankova
  • A Samad
  • P W Reeh
  • Z Vitásková

Detail Information

Publications18

  1. ncbi request reprint Reducing agent dithiothreitol facilitates activity of the capsaicin receptor VR-1
    L Vyklicky
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Neuroscience 111:435-41. 2002
    ..We suggest that the ratio between free sulfhydryl groups and disulfide bonds of the cysteine residues of VR1 pre-sets sensitivity of primary nociceptors to algogens and may represent a new target for treating some pain states in humans...
  2. ncbi request reprint The effects of excessive heat on heat-activated membrane currents in cultured dorsal root ganglia neurons from neonatal rat
    A Lyfenko
    Institute of Physiology, Academy of Sciences of Czech Republic, 142 20 4, Vijdenska 1083, Prague, Czech Republic
    Pain 95:207-14. 2002
    ..This may explain the sensitization of nociceptors after heat injury...
  3. doi request reprint Temperature dependence of N-methyl-D-aspartate receptor channels and N-methyl-D-aspartate receptor excitatory postsynaptic currents
    M Korinek
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Neuroscience 165:736-48. 2010
    ..We conclude that the temperature dependences of native and recombinant NMDAR are different; in addition, we contribute to a better understanding of the molecular mechanism that controls the time course of NMDAR-mediated EPSCs...
  4. doi request reprint Pregnenolone sulfate modulation of N-methyl-D-aspartate receptors is phosphorylation dependent
    M Petrovic
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska, Prague 4, Czech Republic
    Neuroscience 160:616-28. 2009
    ..These results suggest that the effect of PS on NMDARs is controlled by cellular mechanisms that are mediated by dephosphorylation/phosphorylation pathways...
  5. ncbi request reprint Temperature dependence of NR1/NR2B NMDA receptor channels
    O Cais
    Institute of Physiology, Academy of Sciences of the Czech Republic v v i, Videnska 1083, 142 20 Prague 4, Czech Republic
    Neuroscience 151:428-38. 2008
    ....
  6. ncbi request reprint Procaine excites nociceptors in cultures from dorsal root ganglion of the rat
    V Vlachova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Neurosci Lett 263:49-52. 1999
    ..2 mV (SEM, n = 9) suggesting that the current is carried by cations including Ca2+. This procaine effect may offer an explanation for toxic consequence of the clinical use of local anesthetics...
  7. pmc Temperature coefficient of membrane currents induced by noxious heat in sensory neurones in the rat
    L Vyklicky
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    J Physiol 517:181-92. 1999
    ..The liberated components activate distinct cationic channels to generate Iheat. Their affinity to form the complex at low temperatures irreversibly decreases after one exposure to excessive heat...
  8. ncbi request reprint Activation and modulation of ligand-gated ion channels
    J Krusek
    Departent of Cellular Neurophysiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 53:S103-13. 2004
    ....
  9. ncbi request reprint Suramin affects capsaicin responses and capsaicin-noxious heat interactions in rat dorsal root ganglia neurones
    V Vlachova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Physiol Res 51:193-8. 2002
    ....
  10. ncbi request reprint Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin
    L Vyklicky
    Department of Cellular Neurophysiology, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 57:S59-68. 2008
    ..We provide a possible explanation for a high incidence of adverse effects of topical capsaicin and point to a need for more accurate clinical criteria for employing it as a reliable remedy...
  11. ncbi request reprint Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission
    M Sedlacek
    Institute of Physiology, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    Physiol Res 57:S49-57. 2008
    ..These neurosteroids also affect AMPA receptors-mediated synaptic transmission, however, in a rather indirect way, through presynaptically located targets of action...
  12. ncbi request reprint Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization
    K Novakova-Tousova
    Department of Cellular Neurophysiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Neuroscience 149:144-54. 2007
    ....
  13. pmc The effects of capsaicin and acidity on currents generated by noxious heat in cultured neonatal rat dorsal root ganglion neurones
    V Vlachova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
    J Physiol 533:717-28. 2001
    ..6. The results indicate a novel class of capsaicin-sensitive cells, in which capsaicin evokes no or very small inward current but nevertheless increases sensitivity to noxious heat...
  14. ncbi request reprint Morphology and physiology of lamina I neurons of the caudal part of the trigeminal nucleus
    M Sedlacek
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142, 20 Prague 4, Czech Republic
    Neuroscience 147:325-33. 2007
    ....
  15. ncbi request reprint Subtype-dependence of N-methyl-D-aspartate receptor modulation by pregnenolone sulfate
    M Horak
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Neuroscience 137:93-102. 2006
    ..These data provide insight into the mechanisms by which pregnenolone sulfate and related sulfated neurosteroids modulate activity of N-methyl-D-aspartate receptor channels...
  16. ncbi request reprint Pregnenolone sulfate activates NMDA receptor channels
    E Adamusová
    Institute of Physiology AS CR, Prague, Czech Republic
    Physiol Res 62:731-6. 2013
    ..We conclude that PS is an endogenous NMDA agonist that activates the GluN1/GluN2A-B receptors. ..
  17. ncbi request reprint Physiology and pathology of NMDA receptors
    M Petrovic
    Department of Cellular Neurophysiology of the Institute of Physiology of the Academy of Sciences CR, Czech Republic
    Prague Med Rep 106:113-36. 2005
    ..The aim of our review is to summarize the recent data about the structural and functional properties of NMDA receptors and their role in long-term potentiation and excitotoxicity...
  18. ncbi request reprint Intracellular spermine decreases open probability of N-methyl-D-aspartate receptor channels
    R Turecek
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Neuroscience 125:879-87. 2004
    ..Spermine-induced tonic change in the open probability of NMDA receptor channels may play a role in mechanisms underlying short-term changes in the synaptic efficacy...