Ludmila Tuckova

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. ncbi request reprint Activation of macrophages by food antigens: enhancing effect of gluten on nitric oxide and cytokine production
    L Tuckova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague
    J Leukoc Biol 67:312-8. 2000
  2. ncbi request reprint Activation of macrophages by gliadin fragments: isolation and characterization of active peptide
    Ludmila Tuckova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Leukoc Biol 71:625-31. 2002
  3. ncbi request reprint Gliadin peptides activate blood monocytes from patients with celiac disease
    Jana Cinova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Clin Immunol 27:201-9. 2007
  4. ncbi request reprint Gliadin fragments induce phenotypic and functional maturation of human dendritic cells
    Lenka Palova-Jelinkova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague
    J Immunol 175:7038-45. 2005
  5. ncbi request reprint Involvement of innate immunity in the development of inflammatory and autoimmune diseases
    Helena Tlaskalova-Hogenova
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 1st Faculty of Medicine, Charles University, Víde ská 1083, Prague 4, Czech Republic
    Ann N Y Acad Sci 1051:787-98. 2005
  6. ncbi request reprint Monitoring of in vitro deamidation of gliadin peptic fragment by mass spectrometry may reflect one of the molecular mechanisms taking place in celiac disease development
    Petr Novak
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
    J Mass Spectrom 37:507-11. 2002
  7. doi request reprint The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases
    Helena Tlaskalova-Hogenova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    Cell Mol Immunol 8:110-20. 2011
  8. pmc Role of intestinal bacteria in gliadin-induced changes in intestinal mucosa: study in germ-free rats
    Jana Cinova
    Department of Immunology, Institute of Microbiology v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS ONE 6:e16169. 2011
  9. doi request reprint Similarity of fine specificity of IgA anti-gliadin antibodies between patients with celiac disease and humanized α1KI mice
    Daniel Sanchez
    Department of Immunology, Institute of Microbiology, v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Agric Food Chem 59:3092-100. 2011
  10. doi request reprint Identification of rice proteins recognized by the IgE antibodies of patients with food allergies
    Jaroslav Golias
    Institute of Microbiology, Department of Immunology and Gnotobiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Agric Food Chem 61:8851-60. 2013

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Activation of macrophages by food antigens: enhancing effect of gluten on nitric oxide and cytokine production
    L Tuckova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague
    J Leukoc Biol 67:312-8. 2000
    ..Increased NO level could consequently participate in the development of mucosal lesions in the gut of celiac patients...
  2. ncbi request reprint Activation of macrophages by gliadin fragments: isolation and characterization of active peptide
    Ludmila Tuckova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Leukoc Biol 71:625-31. 2002
    ..In contrast, C-terminally shortened peptides had a lower ability to stimulate macrophages than the native form...
  3. ncbi request reprint Gliadin peptides activate blood monocytes from patients with celiac disease
    Jana Cinova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Clin Immunol 27:201-9. 2007
    ..Thus, gliadin activation of HLA-DQ2(+) monocytes leading to chemokine and proinflammatory cytokine production may contribute to the host innate immune response in celiac disease...
  4. ncbi request reprint Gliadin fragments induce phenotypic and functional maturation of human dendritic cells
    Lenka Palova-Jelinkova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague
    J Immunol 175:7038-45. 2005
    ....
  5. ncbi request reprint Involvement of innate immunity in the development of inflammatory and autoimmune diseases
    Helena Tlaskalova-Hogenova
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 1st Faculty of Medicine, Charles University, Víde ská 1083, Prague 4, Czech Republic
    Ann N Y Acad Sci 1051:787-98. 2005
    ..Activation of innate immunity cells by food proteins or components from gut microbiota thus could participate in the impairment of intestinal mucosa and the development of intestinal and/or systemic inflammation...
  6. ncbi request reprint Monitoring of in vitro deamidation of gliadin peptic fragment by mass spectrometry may reflect one of the molecular mechanisms taking place in celiac disease development
    Petr Novak
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
    J Mass Spectrom 37:507-11. 2002
    ..Two sites of glutamine deamidation in this peptide were localized by high-resolution scanning in MS/MS mode in an ion trap. A single deamidation in the parent peptide led to the complete loss of its stimulatory effect on macrophages...
  7. doi request reprint The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases
    Helena Tlaskalova-Hogenova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    Cell Mol Immunol 8:110-20. 2011
    ..g., probiotics and prebiotics) whose administration may aid in disease prevention and treatment...
  8. pmc Role of intestinal bacteria in gliadin-induced changes in intestinal mucosa: study in germ-free rats
    Jana Cinova
    Department of Immunology, Institute of Microbiology v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS ONE 6:e16169. 2011
    ..We aimed to study the effects of gliadin and various intestinal bacterial strains on mucosal barrier integrity, gliadin translocation, and cytokine production...
  9. doi request reprint Similarity of fine specificity of IgA anti-gliadin antibodies between patients with celiac disease and humanized α1KI mice
    Daniel Sanchez
    Department of Immunology, Institute of Microbiology, v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Agric Food Chem 59:3092-100. 2011
    ....
  10. doi request reprint Identification of rice proteins recognized by the IgE antibodies of patients with food allergies
    Jaroslav Golias
    Institute of Microbiology, Department of Immunology and Gnotobiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Agric Food Chem 61:8851-60. 2013
    ..Furthermore, we would suggest that in patients with high IgE reactivity to wheat and rice components, the IgE immunoblot and skin prick test with boiled rice proteins could be beneficial before diet recommendation. ..
  11. ncbi request reprint Epitopes of calreticulin recognised by IgA autoantibodies from patients with hepatic and coeliac disease
    Daniel Sanchez
    Department of Immunology, Institute of Microbiology, Czech Academy of Sciences, 142204 Prague, Czech Republic
    J Autoimmun 21:383-92. 2003
    ..Identification of disease specific CRT epitopes contributes to clarification of autoreactivity against this molecule...
  12. pmc Heat-induced structural changes affect OVA-antigen processing and reduce allergic response in mouse model of food allergy
    Jaroslav Golias
    Department of Immunology and Gnotobiology, Institute of Microbiology, v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS ONE 7:e37156. 2012
    ..The egg protein ovalbumin (OVA) belongs to six most frequent food allergens. We investigated how thermal processing influences its ability to induce allergic symptoms and immune responses in mouse model of food allergy...
  13. pmc Pepsin digest of wheat gliadin fraction increases production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB signaling pathway and an NLRP3 inflammasome activation
    Lenka Palova-Jelinkova
    Institute of Microbiology, Department of Immunology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS ONE 8:e62426. 2013
    ..Thus, innate immune pathways, such as TLR2/4/MyD88/TRIF/MAPK/NF-κB and an NLRP3 inflammasome activation are involved in wheat proteins signaling and may play an important role in the pathogenesis of CD...
  14. ncbi request reprint Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaB
    Lenka Jelínková
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    FEBS Lett 571:81-5. 2004
    ..We propose that gliadin-induced activation of monocytes/macrophages can participate in mechanisms leading to the impairment of intestinal mucosa in coeliac patients...
  15. doi request reprint Proteomic analysis of wheat proteins recognized by IgE antibodies of allergic patients
    Petr Sotkovský
    Department of Immunology and Gnotobiology, Institute of Microbiology v v i, Czech Academy of Sciences, Prague, Czech Republic
    Proteomics 8:1677-91. 2008
    ..Our findings contribute to the identification of wheat allergens aimed to increase the specificity of serum IgE and cell activation diagnostic assays...
  16. ncbi request reprint Cytokine profiling in human colostrum and milk by protein array
    Miloslav Kverka
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Clin Chem 53:955-62. 2007
    ..Human colostrum and milk contain components that influence development. Our aim was to use a protein array to determine the cytokine profile of human lacteal secretions and changes that occur during the early postpartum period...
  17. doi request reprint Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?
    Lenka Frol'ová
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Videnska 1083, Prague 4 142 20, Czech Republic
    Inflamm Res 58:503-12. 2009
    ..It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease...
  18. doi request reprint Gliadin fragments promote migration of dendritic cells
    Barbara Chladkova
    Laboratory of Specific Cellular Immunity, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Cell Mol Med 15:938-48. 2011
    ....
  19. ncbi request reprint Experimentally induced gluten enteropathy and protective effect of epidermal growth factor in artificially fed neonatal rats
    Renata Stepankova
    Laboratory of Electron Microscopy, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague
    J Pediatr Gastroenterol Nutr 36:96-104. 2003
    ....
  20. ncbi request reprint Characterization, molecular cloning and localization of calreticulin in Eisenia fetida earthworms
    Marcela Silerová
    Department of Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
    Gene 397:169-77. 2007
    ..Moreover, a high calreticulin expression was measured in the muscular pharynx...
  21. ncbi request reprint Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases
    Helena Tlaskalova-Hogenova
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Immunol Lett 93:97-108. 2004
    ..Regulation of microflora composition (e.g. by probiotics and prebiotics) offers the possibility to influence the development of mucosal and systemic immunity but it can play a role also in prevention and treatment of some diseases...
  22. ncbi request reprint The prevalence of coeliac disease in Libyan children with type 1 diabetes mellitus
    Abdelhakim Ashabani
    Department of Immunology and Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, Videnska, Prague, Czech Republic
    Diabetes Metab Res Rev 19:69-75. 2003
    ..There are no data on the prevalence of CD in the Libyan population and Libyan DM patients. The aim of this study was to test the occurrence of CD-related markers in a group of Libyan children with DM...
  23. ncbi request reprint Mucosal immunity: its role in defense and allergy
    Helena Tlaskalova-Hogenova
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Science of the Czech Republic, Prague, Czech Republic
    Int Arch Allergy Immunol 128:77-89. 2002
    ....