Research Topics
Species | P SvobodaSummaryAffiliation: Academy of Sciences of the Czech Republic Country: Czech Republic Publications
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Detail Information
Publications
Ontogenetic development of GABA(B)-receptor signaling cascade in plasma membranes isolated from rat brain cortex; the number of GABA(B)-receptors is high already shortly after the birthD Kagan
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Physiol Res 61:629-35. 2012..The further development was reflected in a decrease of [(3)H]CGP54626 binding as the B(max) values of 1.38+/-0.05 and 0.93+/-0.04 pmol · mg(-1) were determined in PM isolated from 13- and 90-days old rats, respectively...- Biochemistry of transmembrane signaling mediated by trimeric G proteinsP Svoboda
Department of Membrane Receptors, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Physiol Res 53:S141-52. 2004..This review provides general information about the basic principles of G protein-regulated transmembrane signaling as well as about our contribution to the current progress in the field... - Hormone-induced subcellular redistribution of trimeric G proteinsP Svoboda
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
Cell Mol Life Sci 59:501-12. 2002..e., beside receptor-based mechanisms) to dampen the hormone or neurotransmitter response after sustained (long-term) exposure... - Subcellular redistribution of trimeric G-proteins--potential mechanism of desensitization of hormone response: internalization, solubilization, down-regulationZ Drastichova
Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
Physiol Res 57:S1-10. 2008..We have also mentioned sodium plus potassium dependent adenosine triphosphatase (Na, K-ATPase) and 3H-ouabain binding as useful reference standard of plasma membrane purity in the brain... - Membrane-Bound and cytosolic forms of heterotrimeric G proteins in young and adult rat myocardium: influence of neonatal hypo- and hyperthyroidismJ Novotny
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
J Cell Biochem 82:215-24. 2001..Alterations in the membrane-cytosol balance of G protein subunits associated with maturation or induced by altered thyroid status indicate physiological importance of cytosolic forms of these proteins in the rat myocardium... - The influence of monovalent cations on trimeric G protein G(i)1α activity in HEK293 cells stably expressing DOR-G(i)1α (Cys(351)-Ile(351)) fusion proteinM Vosahlikova
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Physiol Res 60:541-7. 2011.... - Subcellular shifts of trimeric G-proteins following activation of baker's yeast by glucoseA Kotyk
Department of Membrane Transport, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czechia
Folia Microbiol (Praha) 46:391-6. 2001..The question remains open as to the functional significance of the internalized forms of the G-proteins as these remain sequestered from the plasma membrane well after glucose has been consumed... - The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresisD Durchankova
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Physiol Res 57:195-203. 2008..Our data therefore rather indicate tight/persisting binding of G(q)alpha/G(11)alpha proteins to the membrane... - Maturation of rat brain is accompanied by differential expression of the long and short splice variants of G(s)alpha protein: identification of cytosolic forms of G(s)alphaI Ihnatovych
Department of Developmental Epileptology and Biochemistry of Membrane Receptors, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska, Prague, Czech Republic
J Neurochem 79:88-97. 2001..The number of beta-adrenoceptors increased sharply during early post-natal development but only slightly in adulthood, and both GTP- and isoproterenol-stimulated adenylate cyclase activity reached peak values around PD12... - Proteomic identification of the wt-p53-regulated tumor cell secretomeF W Khwaja
Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Oncogene 25:7650-61. 2006..Evidence for p53-controlled post-translational modifications on nine secreted proteins was also found. These findings will enhance our understanding of wt-p53 modulated interactions of the tumor with its environment... - Agonist-induced transfer of the alpha subunits of the guanine-nucleotide-binding regulatory proteins Gq and G11 and of muscarinic m1 acetylcholine receptors from plasma membranes to a light-vesicular membrane fractionP Svoboda
Department of Biochemistry, University of Glasgow, Scotland
Eur J Biochem 224:455-62. 1994..The second step is represented by an agonist-specific down-regulation pathway. Both the Hm1 receptor and Gq alpha/G11 alpha appear to follow similar sequestration and down-regulation patterns...