Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic
- Tomalova B, Sirova M, Rossmann P, Pola R, Strohalm J, Chytil P, et al. The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia. J Control Release. 2016;223:1-10 pubmed publisher..On the other hand, the treatment of leukaemia requires a drug conjugate with a long circulation half-life. This would provide an active drug, whilst slowly degrading to excretable fragments. ..
- Sirova M, Strohalm J, Chytil P, Lidický O, Tomala J, Rihova B, et al. The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel. J Control Release. 2017;246:1-11 pubmed publisher....