P Rossner

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. doi request reprint Immunochemical detection of oxidatively damaged DNA
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, Videnska 1083, 142 20 Prague, Czech Republic
    Free Radic Res 46:492-522. 2012
  2. doi request reprint Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine values determined by a modified ELISA improves agreement with HPLC-MS/MS
    Pavel Rossner
    Department of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, Prague 142 20, Czech Republic Electronic address
    Biochem Biophys Res Commun 440:725-30. 2013
  3. pmc Nucleotide excision repair is not induced in human embryonic lung fibroblasts treated with environmental pollutants
    Pavel Rossner
    Department of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, Prague, Czech Republic
    PLoS ONE 8:e69197. 2013
  4. doi request reprint Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II: chromosomal aberrations and oxidative stress
    Pavel Rossner
    Department of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, Videnska 1083, 142 20 Prague, Czech Republic
    Mutagenesis 28:97-106. 2013
  5. doi request reprint Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I: bulky DNA adducts
    Pavel Rossner
    Institute of Experimental Medicine AS CR, Videnska 1083, 142 20 Prague 4, Czech Republic
    Mutagenesis 28:89-95. 2013
  6. doi request reprint An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, v v i, Videnska 1083, 142 20 Prague, Czech Republic
    Toxicol Lett 198:312-6. 2010
  7. ncbi request reprint OGG1 polymorphisms and breast cancer risk
    Pavel Rossner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Cancer Epidemiol Biomarkers Prev 15:811-5. 2006
  8. pmc Mutations in p53, p53 protein overexpression and breast cancer survival
    Pavel Rossner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Cell Mol Med 13:3847-57. 2009
  9. doi request reprint Oxidative stress and chromosomal aberrations in an environmentally exposed population
    Pavel Rossner
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    Mutat Res 707:34-41. 2011
  10. ncbi request reprint Air pollution by carcinogenic PAHs and plasma levels of p53 and p21(WAF1) proteins
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, AS CR and Health Institute of Central Bohemia, Prague, Czech Republic
    Mutat Res 620:34-40. 2007

Detail Information

Publications41

  1. doi request reprint Immunochemical detection of oxidatively damaged DNA
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, Videnska 1083, 142 20 Prague, Czech Republic
    Free Radic Res 46:492-522. 2012
    ..Oxidative damage observed in these organisms resulted from disease, exposure to environmental pollutants or from in vitro treatment with various chemical and physical factors...
  2. doi request reprint Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine values determined by a modified ELISA improves agreement with HPLC-MS/MS
    Pavel Rossner
    Department of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, Prague 142 20, Czech Republic Electronic address
    Biochem Biophys Res Commun 440:725-30. 2013
    ..This represents a significant advance for the ELISA, and encouraging its use in more studies adding to our knowledge of the role of this biomarker of oxidative stress in health and disease...
  3. pmc Nucleotide excision repair is not induced in human embryonic lung fibroblasts treated with environmental pollutants
    Pavel Rossner
    Department of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, Prague, Czech Republic
    PLoS ONE 8:e69197. 2013
    ..In summary, our results indicate that the tested compounds induced low levels of DNA damage and affected the expression of NER genes; however, nucleotide excision repair was not induced. ..
  4. doi request reprint Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II: chromosomal aberrations and oxidative stress
    Pavel Rossner
    Department of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, Videnska 1083, 142 20 Prague, Czech Republic
    Mutagenesis 28:97-106. 2013
    ..5 in both regions. A positive relationship was observed between lipid peroxidation and air pollution; protein oxidation seems to be positively affected by PM2.5 in both regions...
  5. doi request reprint Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I: bulky DNA adducts
    Pavel Rossner
    Institute of Experimental Medicine AS CR, Videnska 1083, 142 20 Prague 4, Czech Republic
    Mutagenesis 28:89-95. 2013
    ..5 significantly increased levels of B[a]P-like DNA adducts in the Ostrava subjects, but not in subjects from Prague...
  6. doi request reprint An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, v v i, Videnska 1083, 142 20 Prague, Czech Republic
    Toxicol Lett 198:312-6. 2010
    ..523, p=0.08). In conclusion, we showed that organic extracts of PM were able to induce oxidative damage to DNA in vitro; this ability was increased after S9 metabolic activation of EOM and with decreasing sizes of PM...
  7. ncbi request reprint OGG1 polymorphisms and breast cancer risk
    Pavel Rossner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Cancer Epidemiol Biomarkers Prev 15:811-5. 2006
    ..In addition, data on functionality of these polymorphisms are crucial to understand if these modest differences are important...
  8. pmc Mutations in p53, p53 protein overexpression and breast cancer survival
    Pavel Rossner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Cell Mol Med 13:3847-57. 2009
    ....
  9. doi request reprint Oxidative stress and chromosomal aberrations in an environmentally exposed population
    Pavel Rossner
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    Mutat Res 707:34-41. 2011
    ..In summary, our results indicate that the exposure to environmental pollutants affects urinary excretion of 8-oxodG, lipid peroxidation and the frequency of chromosomal aberrations...
  10. ncbi request reprint Air pollution by carcinogenic PAHs and plasma levels of p53 and p21(WAF1) proteins
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, AS CR and Health Institute of Central Bohemia, Prague, Czech Republic
    Mutat Res 620:34-40. 2007
    ..In conclusion our results suggest that p53 and p21(WAF1) proteins plasma levels may be useful biomarkers of c-PAHs environmental exposure...
  11. ncbi request reprint Plasma protein carbonyl levels and breast cancer risk
    Pavel Rossner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Cell Mol Med 11:1138-48. 2007
    ..8, 95% CI = 1.2-2.6) compared to women with levels below the median for both markers of oxidative stress. In summary, our results suggest that increased plasma protein carbonyl levels may be associated with breast cancer risk...
  12. doi request reprint Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, Videnska 1083, 142 20 Prague, Czech Republic
    Mutat Res 713:76-82. 2011
    ....
  13. doi request reprint Seasonal variability of oxidative stress markers in city bus drivers. Part II. Oxidative damage to lipids and proteins
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, AS CR vvi, Videnska 1083, Prague, Czech Republic
    Mutat Res 642:21-7. 2008
    ..Lipid peroxidation was positively correlated with c-PAHs and PM exposure; protein oxidation correlated negatively and was highest in summer suggesting another factor(s) affecting protein carbonyl levels...
  14. doi request reprint Seasonal variability of oxidative stress markers in city bus drivers. Part I. Oxidative damage to DNA
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, AS CR vvi, Videnska 1083, Prague 4, Czech Republic
    Mutat Res 642:14-20. 2008
    ..5 and PM10 levels, measured by stationary monitors during a 3-day period before urine collection, as the only factors significantly affecting 8-oxodG levels, while the levels of c-PAHs had no significant influence...
  15. doi request reprint Biomarkers of exposure to tobacco smoke and environmental pollutants in mothers and their transplacental transfer to the foetus. Part II. Oxidative damage
    P Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, AS CR, Prague 4, Czech Republic
    Mutat Res 669:20-6. 2009
    ..Our results showed higher lipid peroxidation in newborns than in mothers, close correlation of analyzed oxidative stress markers between newborns and mothers, and a relationship between oxidative stress and induction of DNA adducts...
  16. doi request reprint Biomarkers of exposure to tobacco smoke and environmental pollutants in mothers and their transplacental transfer to the foetus. Part I: bulky DNA adducts
    J Topinka
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, AS CR, Prague 4, Czech Republic
    Mutat Res 669:13-9. 2009
    ..We found a correlation between adduct levels in the blood of mothers and newborns...
  17. pmc Biomarker studies in northern Bohemia
    B Binkova
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Environ Health Perspect 104:591-7. 1996
    ..These results show the importance of considering all potential factors that may affect the biomarkers being analyzed...
  18. ncbi request reprint Spontaneous level of chromosomal aberrations in peripheral blood lymphocytes of control individuals of the Czech Republic population
    P Rossner
    Laboratory of Genetic Toxicology, National Institute of Public Health, Prague, Czech Republic
    Toxicol Lett 96:137-42. 1998
    ..C.) with age. We found 1.10% AB.C. (N = 551) in newborns; 0.71% AB.C. (N = 105) in the group 5-6 yr; 1.20% (N = 1,734) in the group 7-15 yr; 1.25% AB.C. (N = 239) in the group 16-19 yr and 1.59% (N = 2,801) in the group 20-63 yr...
  19. doi request reprint The impact of air pollution on the levels of micronuclei measured by automated image analysis
    A Rossnerova
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic
    Mutat Res 669:42-7. 2009
    ..Our work is the first human biomonitoring study focused on the measurement of MN by automated image analysis for assessing chromosomal damage as a result of environmental mutagen exposure...
  20. ncbi request reprint Adverse reproductive outcomes from exposure to environmental mutagens
    R J Sram
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia, c o Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20, Prague, Czech Republic
    Mutat Res 428:203-15. 1999
    ..Pregnancy outcome and semen studies imply that relatively low air pollution (higher than 40 microg PM10/m(3)) can significantly increase the adverse reproductive outcomes affecting both genders...
  21. ncbi request reprint Chromosomal aberrations, sister-chromatid exchanges, cells with high frequency of SCE, micronuclei and comet assay parameters in 1, 3-butadiene-exposed workers
    R J Sram
    Laboratory of Genetic Ecotoxicology, c o Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Videnska 1083, 142 20, Prague, Czech Republic
    Mutat Res 419:145-54. 1998
    ..GSTM1 genotype affected chromosomal aberrations in exposed group, while GSTT1 genotype affected chromosomal aberrations in controls. No effect of GSTM1 or GSTT1 genotypes was observed on any other biomarkers used...
  22. doi request reprint Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms
    Yana Bagryantseva
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine v v i, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Praha 4, Czech Republic
    Toxicol Lett 199:60-8. 2010
    ..In contrast, GSTM1 null variant seemed to protect DNA integrity...
  23. doi request reprint Frequency of chromosomal aberrations in Prague mothers and their newborns
    A Rossnerova
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, AS CR, v v i, 142 20 Prague 4, Czech Republic
    Mutat Res 699:29-34. 2010
    ..The mother's age affected the level of aberrations in newborns: the group of children born to older mothers (31-40 years) had significantly increased F(G)/100 levels...
  24. ncbi request reprint Chromosomal aberrations by fluorescence in situ hybridization (FISH)--Biomarker of exposure to carcinogenic PAHs
    Olena Beskid
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, v v i, and Health Institute of Central Bohemia, Prague, Czech Republic
    Mutat Res 620:62-70. 2007
    ..According to the original hypothesis it is expected that the most important group of chemicals responsible for the biological activity of air pollution represent c-PAHs...
  25. ncbi request reprint Oxidative and nitrosative stress markers in bus drivers
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR and Health Institute of Central Bohemia, Videnska 1083, 142 20 Prague, Czech Republic
    Mutat Res 617:23-32. 2007
    ..32, p<0.001). Both oxidative and nitrosative stress markers positively correlated with PM2.5 and PM10 exposure. In conclusion, our study indicates that exposure to PM2.5 and PM10 results in increased oxidative and nitrosative stress...
  26. ncbi request reprint The effect of dibenzo[a,1]pyrene and benzo[a]pyrene on human diploid lung fibroblasts: the induction of DNA adducts, expression of p53 and p21(WAF1) proteins and cell cycle distribution
    B Binkova
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia, c o Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Mutat Res 471:57-70. 2000
    ..Whether the S phase delay observed in our study is beneficial for the survival of the cells remains to be further established...
  27. ncbi request reprint The use of YG bacterial tester strains for the monitoring of drinking water mutagenicity
    M Cerna
    National Institute of Public Health, Centre of Environmental Health, Prague, Czech Republic
    Toxicol Lett 96:335-9. 1998
    ..However, to identify the chemical contaminants in drinking water responsible for the mutagenicity further studies are required...
  28. ncbi request reprint Chromosomal aberrations in peripheral lymphocytes of children as biomarkers of environmental exposure and life style
    P Rossner
    Laboratory of Genetic Toxicology, National Institute of Public Health, Prague, Czech Republic
    Toxicol Lett 134:79-85. 2002
    ..Based on our experience, we believe that monitoring the spontaneous level of chromosomal aberrations in children over 5 year periods may be used to examine the general changes in environmental pollution in larger geographic areas...
  29. ncbi request reprint Mutagenicity monitoring of airborne particulate matter (PM10) in the Czech Republic
    M Cerna
    National Institute of Public Health, Center of Environmental Health, Srobarova 48, CZ 100 42, Prague, Czech Republic
    Mutat Res 444:373-86. 1999
    ..For routine ambient air mutagenicity monitoring, the use of YG1041 tester strain without metabolic activation and the plate incorporation test are to be recommended...
  30. ncbi request reprint Possible genetic damage in the Czech nuclear power plant workers
    Radim J Sram
    Laboratory of Genetic Ecotoxicology, Health Institute of Central Bohemia and Institute of Experimental Medicine AS CR, Videnska 1083, 142 20 Praha 4, Czech Republic
    Mutat Res 593:50-63. 2006
    ..No association between the dose of irradiation and the level of chromosomal aberrations in any nuclear power plant was detected either by the conventional cytogenetic analysis or by FISH...
  31. ncbi request reprint Cytogenetic analysis using fluorescence in situ hybridization (FISH) to evaluate occupational exposure to carcinogens
    Radim J Sram
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR and Health Institute of Central Bohemia, 142 20 Prague 4, Czech Republic
    Toxicol Lett 149:335-44. 2004
    ..72+/-1.57 versus 1.25+/-1.11, P<0.05). The method of FISH with whole chromosome painting seems to be more sensitive to detect chromosomal injury by occupational exposure to carcinogens than conventional method...
  32. ncbi request reprint Relationship between urinary 15-F2t-isoprostane and 8-oxodeoxyguanosine levels and breast cancer risk
    Pavel Rossner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 15:639-44. 2006
    ..In summary, our results suggest that urinary markers of lipid peroxidation and oxidative DNA damage may be associated with breast cancer risk...
  33. ncbi request reprint Environmental exposure to carcinogenic polycyclic aromatic hydrocarbons--the interpretation of cytogenetic analysis by FISH
    Radim J Sram
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, v v i, and Health Institute of Central Bohemia, Videnska 1083, 142 20 Prague 4, Czech Republic
    Toxicol Lett 172:12-20. 2007
    ..This is the first study reporting that translocations induced by c-PAHs in peripheral lymphocytes last only several weeks...
  34. doi request reprint An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts
    Jan Topinka
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    Toxicol Lett 198:304-11. 2010
    ..001). It may be concluded that the analysis of total DNA adducts induced in an acellular assay with/without metabolic activation represents a relatively simple method to assess the genotoxic potential of various complex mixtures...
  35. ncbi request reprint Chromosomal aberration frequencies determined by conventional methods: Parallel increases over time in the region of a petrochemical industry and throughout the Czech Republic
    Radim J Sram
    Institute of Experimental Medicine ASCR and Health Institute of Central Bohemia, Laboratory of Genetic Ecotoxicology, Videnska 1083, 142 20 Prague 4, Czech Republic
    Chem Biol Interact 166:239-44. 2007
    ..This substantial increase in %AB.C. values in 2000 and 2004, therefore, has occurred throughout the CR and is probably unrelated to chemicals uniquely present at the petrochemical industry site...
  36. pmc Risk of cancer in an occupationally exposed cohort with increased level of chromosomal aberrations
    Z Smerhovsky
    The National Institute of Public Health, Prague, Czech Republic
    Environ Health Perspect 109:41-5. 2001
    ..000). In contrast, the collected data are inadequate for a critical evaluation of the association with exposure to other chemicals...
  37. pmc Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer
    Pavel Rossner
    Department of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, and Health Institute of Central Bohemia, Videnska 1083, 142 20 Prague 4, Czech Republic
    Environ Health Perspect 113:517-20. 2005
    ..This study contributes to validation of CA as a predictive marker of cancer risk, in particular, of stomach cancer; the association between CA frequency and cancer risk might be limited to chromosome-type aberrations...
  38. doi request reprint Urinary 8-oxodeoxyguanosine levels in children exposed to air pollutants
    Vlasta Svecova
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, v v i, Videnska 1083, 142 20 Prague 4, Czech Republic
    Mutat Res 662:37-43. 2009
    ..The obtained results indicate that 8-oxodG is a sensitive biomarker for measuring the exposure of children to air pollution...
  39. ncbi request reprint Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients
    Yu Jing Zhang
    Department of Environmental Health Science, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Int J Cancer 119:985-91. 2006
    ..These data suggest that genetic, epigenetic and environmental exposure biomarkers in plasma may help in estimating the risk for the development of HCC...
  40. ncbi request reprint Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: female-male comparisons
    Richard J Albertini
    BioMosaics, Inc, 665 Spear Street, Burlington, VT 05401, USA
    Chem Biol Interact 166:63-77. 2007
    ..However, as in the first, differences in the metabolic detoxification of BD as reflected in relative amounts of the M1 and M2 urinary metabolites were associated with genotypes, this time both GST and EH...
  41. pmc Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 29:1178-83. 2008
    ..These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type...