M Pravenec

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. request reprint
    Silhavy J, Mlejnek P, Simakova M, Vaneckova I, Behuliak M, Kuda O, et al. Acute toxic effects of telmisartan in spontaneously hypertensive rats fed a high fructose diet. Physiol Res. 2018;: pubmed
    ..These results are consistent with the possibility that in some circumstances, SHR are predisposed to telmisartan toxicity possibly because of a genetically determined disturbance in telmisartan metabolism. ..
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    Silhavy J, Krijt J, Sokolova J, Zidek V, Mlejnek P, Simakova M, et al. Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats. Physiol Res. 2018;67:657-662 pubmed
    ..These results strongly suggest that, in addition to Folr1, the Folh1 gene also plays an important role in folate and sulfur amino acid levels and affects glucose and lipid metabolism in the rat. ..
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    Pravenec M, Leung K, Zidek V, Mlejnek P, Simakova M, Silhavy J, et al. Genetically determined folate deficiency is associated with abnormal hepatic folate profiles in the spontaneously hypertensive rat. Physiol Res. 2018;67:417-422 pubmed
  4. Houstek J, Vrbacky M, Hejzlarová K, Zidek V, Landa V, Silhavy J, et al. Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction. Physiol Genomics. 2014;46:671-8 pubmed publisher
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    Trnovská J, Šilhavý J, Zídek V, Šimáková M, Mlejnek P, Landa V, et al. Gender-related effects on substrate utilization and metabolic adaptation in hairless spontaneously hypertensive rat. Physiol Res. 2015;64:51-60 pubmed
    ..They are consistent with the hypothesis that increased glucose and palmitate utilization in BAT and muscle is associated with higher sensitivity of adipose and muscle tissues to insulin action. ..
  6. Pravenec M, Kurtz T. Recent advances in genetics of the spontaneously hypertensive rat. Curr Hypertens Rep. 2010;12:5-9 pubmed publisher
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    Landa V, Zidek V, Mlejnek P, Simakova M, Silhavy J, Trnovska J, et al. Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats. Physiol Res. 2014;63:587-90 pubmed
    ..5.9+/-0.1 mmol/l, P<0.005) and reduced insulin levels (1.78+/-0.33 vs. 2.73+/-0.37 nmol/l, P<0.05) in transgenic rats. These results provide evidence for important role of SREBP-2 in regulation of lipid and glucose metabolism. ..
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    Pravenec M, Zidek V, Landa V, Mlejnek P, Silhavy J, Simakova M, et al. Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity. Physiol Res. 2017;66:917-924 pubmed
    ..In summary, these results demonstrate important role of Wars2 gene in regulating BAT function and consequently lipid and glucose metabolism. ..
  9. Heinig M, Colomé Tatché M, Taudt A, Rintisch C, Schafer S, Pravenec M, et al. histoneHMM: Differential analysis of histone modifications with broad genomic footprints. BMC Bioinformatics. 2015;16:60 pubmed publisher
    ..This makeshistoneHMM an attractive choice for the differential analysis of ChIP-seq data. Software is available from http://histonehmm.molgen.mpg.de . ..

More Information

Publications23

  1. Liska F, Landa V, Zidek V, Mlejnek P, Silhavy J, Simakova M, et al. Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat. Hypertension. 2017;69:1084-1091 pubmed publisher
    ..These results provide evidence for an important role of Plzf in regulation of metabolic and cardiac traits in the rat and suggest a cross talk between cell cycle regulators, metabolism, cardiac hypertrophy, and fibrosis. ..
  2. Pravenec M, Mlejnek P, Zidek V, Landa V, Simakova M, Silhavy J, et al. Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue. Physiol Genomics. 2016;48:420-7 pubmed publisher
    ..These results provide evidence that autocrine effects of resistin attenuate differentiation and activity of BAT and thus may play a role in the pathogenesis of insulin resistance in the rat. ..
  3. Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, et al. Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol. 2009;7:70 pubmed publisher
  4. Pravenec M, Kožich V, Krijt J, Sokolová J, Zídek V, Landa V, et al. Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome. Hypertension. 2016;67:335-41 pubmed publisher
  5. Pravenec M, Landa V, Zidek V, Mlejnek P, Silhavy J, Mir S, et al. Effects of transgenic expression of dopamine beta hydroxylase (Dbh) gene on blood pressure in spontaneously hypertensive rats. Physiol Res. 2016;65:1039-1044 pubmed
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    Šilhavý J, Zídek V, Landa V, Šimáková M, Mlejnek P, Oliyarnyk O, et al. Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein. Physiol Res. 2015;64:295-301 pubmed
    ..These findings provide evidence that, in the presence of high CRP levels, rosuvastatin exhibits significant anti-inflammatory, anti-oxidative, and renoprotective effects. ..
  7. Pravenec M, Zidek V, Landa V, Simakova M, Mlejnek P, Silhavy J, et al. Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis. Physiol Genomics. 2011;43:372-9 pubmed publisher
    ..These results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue. ..
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    Pravenec M, Kren V, Szpirer C, Szpirer J. Assignment of the cellular retinol binding protein 1 (Rbp1) and hepatic lipase (Lipc) genes to rat chromosome 8. Folia Biol (Praha). 1997;43:97-9 pubmed
    ..The current findings extend homologies between rat chromosome 8, mouse chromosome 9, and human chromosomes 3q and 15q. ..
  9. Pravenec M, Kajiya T, Zidek V, Landa V, Mlejnek P, Simakova M, et al. Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome. Hypertension. 2011;57:731-7 pubmed publisher
    ..These findings are consistent with the hypothesis that increased CRP is more than just a marker of inflammation and can directly promote multiple features of the metabolic syndrome. ..
  10. Pravenec M, Saba L, Zidek V, Landa V, Mlejnek P, Silhavy J, et al. Systems Genetic Analysis of Brown Adipose Tissue Function. Physiol Genomics. 2017;:physiolgenomics.00091.2017 pubmed publisher
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    Pravenec M, Kazdova L, Landa V, Zidek V, Mlejnek P, Jansa P, et al. Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat. J Biol Chem. 2003;278:45209-15 pubmed
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    Pravenec M, Zidek V, Musilova A, Vorlicek J, Kren V, St Lezin E, et al. Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat. J Hypertens. 2001;19:1061-4 pubmed
    ..The objective of the current study was to directly test for the presence of a blood pressure QTL on rat chromosome 2...
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    Pravenec M, Zidek V, Musilova A, Kren V, Bila V, Di Nicolantonio R. Chromosomal mapping of a major quantitative trait locus regulating compensatory renal growth in the rat. J Am Soc Nephrol. 2000;11:1261-5 pubmed
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    Pravenec M, Landa V, Zidek V, Musilova A, Kazdova L, Qi N, et al. Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension. Physiol Res. 2003;52:681-8 pubmed