M Pravenec

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. ncbi request reprint Recent progress in the genetics of spontaneously hypertensive rats
    M Pravenec
    Department of Genetics of Model Diseases, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 63:S1-8. 2014
  2. pmc Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel
    Marieke Simonis
    Genome Biology Group, Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Genome Biol 13:r31. 2012
  3. pmc Folate deficiency is associated with oxidative stress, increased blood pressure, and insulin resistance in spontaneously hypertensive rats
    Michal Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Am J Hypertens 26:135-40. 2013
  4. pmc Genetical genomic determinants of alcohol consumption in rats and humans
    Boris Tabakoff
    Department of Pharmacology, University of Colorado, Denver, Aurora, CO, USA
    BMC Biol 7:70. 2009
  5. ncbi request reprint Linkage mapping of the interleukin 1beta converting enzyme (Il1bc) and the glutamate receptor subunit KA1 (Grik4) genes to rat chromosome 8
    M Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Folia Biol (Praha) 44:107-9. 1998
  6. pmc Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome
    Michal Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    Hypertension 57:731-7. 2011
  7. pmc Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis
    Michal Pravenec
    Institute of Physiology, Czech Academy of Sciences, 14220 Prague 4, Czech Republic
    Physiol Genomics 43:372-9. 2011
  8. ncbi request reprint Genetic analysis of metabolic defects in the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, 12800 Prague, Czech Republic
    Mamm Genome 13:253-8. 2002
  9. pmc Recent advances in genetics of the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
    Curr Hypertens Rep 12:5-9. 2010
  10. doi request reprint Long-term pioglitazone treatment enhances lipolysis in rat adipose tissue
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Int J Obes (Lond) 32:1848-53. 2008

Detail Information

Publications77

  1. ncbi request reprint Recent progress in the genetics of spontaneously hypertensive rats
    M Pravenec
    Department of Genetics of Model Diseases, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 63:S1-8. 2014
    ....
  2. pmc Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel
    Marieke Simonis
    Genome Biology Group, Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Genome Biol 13:r31. 2012
    ..Recombinant inbred panels are powerful tools to study the cis and trans effects of genetic variation on molecular phenotypes such as gene expression...
  3. pmc Folate deficiency is associated with oxidative stress, increased blood pressure, and insulin resistance in spontaneously hypertensive rats
    Michal Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Am J Hypertens 26:135-40. 2013
    ..In the current study, we analyzed the role of folate deficiency in pathogenesis of the metabolic syndrome in the spontaneously hypertensive rat (SHR)...
  4. pmc Genetical genomic determinants of alcohol consumption in rats and humans
    Boris Tabakoff
    Department of Pharmacology, University of Colorado, Denver, Aurora, CO, USA
    BMC Biol 7:70. 2009
    ....
  5. ncbi request reprint Linkage mapping of the interleukin 1beta converting enzyme (Il1bc) and the glutamate receptor subunit KA1 (Grik4) genes to rat chromosome 8
    M Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Folia Biol (Praha) 44:107-9. 1998
    ..The current results demonstrate that rat chromosome 8 is largely homologous to mouse chromosome 9...
  6. pmc Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome
    Michal Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    Hypertension 57:731-7. 2011
    ..These findings are consistent with the hypothesis that increased CRP is more than just a marker of inflammation and can directly promote multiple features of the metabolic syndrome...
  7. pmc Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis
    Michal Pravenec
    Institute of Physiology, Czech Academy of Sciences, 14220 Prague 4, Czech Republic
    Physiol Genomics 43:372-9. 2011
    ..These results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue...
  8. ncbi request reprint Genetic analysis of metabolic defects in the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, 12800 Prague, Czech Republic
    Mamm Genome 13:253-8. 2002
    ..These findings suggest that closely linked genes on Chr 19, or perhaps even a single gene with pleiotropic effects, influence the clustering of metabolic disturbances in the SHR-BN model...
  9. pmc Recent advances in genetics of the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
    Curr Hypertens Rep 12:5-9. 2010
    ....
  10. doi request reprint Long-term pioglitazone treatment enhances lipolysis in rat adipose tissue
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Int J Obes (Lond) 32:1848-53. 2008
    ....
  11. ncbi request reprint Genetic isolation of quantitative trait loci for blood pressure development and renal mass on chromosome 5 in the spontaneously hypertensive rat
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Physiol Res 52:285-9. 2003
    ..The findings of the current study demonstrate that gene(s) with major effects on blood pressure and renal mass exist in the differential segment of chromosome 5 trapped within the new SHR.BN congenic strain...
  12. ncbi request reprint Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Physiology, Czech Academy of Sciences and The Center for Integrated Genomics, Prague 14220, Czech Republic
    J Biol Chem 278:45209-15. 2003
    ....
  13. ncbi request reprint Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences and Center for Applied Genomics, Prague, Czech Republic
    Int J Obes (Lond) 30:1157-9. 2006
    ..To investigate the mechanism by which fat-specific transgenic expression of resistin affects fatty acid metabolism in the spontaneously hypertensive rat (SHR)...
  14. ncbi request reprint Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension
    M Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Physiol Res 52:681-8. 2003
    ....
  15. ncbi request reprint Genetic analysis of complex cardiovascular traits in the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic
    Exp Physiol 90:273-6. 2005
    ..In the present review, a genetic analysis of cardiovascular phenotypes studied at several levels of complexity in rat recombinant inbred strains is described...
  16. ncbi request reprint Genetic analysis of "metabolic syndrome" in the spontaneously hypertensive rat
    M Pravenec
    Department of Genetics of Model Diseases, Institute of Physiology, Academy of Sciences of the Czech Republic and Center for Integrated Genomics, Prague, Czech Republic
    Physiol Res 53:S15-22. 2004
    ....
  17. ncbi request reprint Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat
    M Pravenec
    Institute of Physiology and Center for Integrated Genomics, Czech Academy of Sciences, Prague, Czech Republic
    J Hypertens 19:1061-4. 2001
    ..The objective of the current study was to directly test for the presence of a blood pressure QTL on rat chromosome 2...
  18. doi request reprint Insight into the genetics of hypertension, a core component of the metabolic syndrome
    Michal Pravenec
    aInstitute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Curr Opin Clin Nutr Metab Care 11:393-7. 2008
    ..To provide insight into genetics of essential hypertension, including discussion of methods used both in human and animal experimental studies and interpretation of results...
  19. ncbi request reprint Assignment of the cellular retinol binding protein 1 (Rbp1) and hepatic lipase (Lipc) genes to rat chromosome 8
    M Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Folia Biol (Praha) 43:97-9. 1997
    ..The current findings extend homologies between rat chromosome 8, mouse chromosome 9, and human chromosomes 3q and 15q...
  20. ncbi request reprint Genetic analysis of cardiovascular risk factor clustering in spontaneous hypertension
    M Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Folia Biol (Praha) 46:233-40. 2000
    ....
  21. ncbi request reprint Chromosomal mapping of a major quantitative trait locus regulating compensatory renal growth in the rat
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences, Czech Republic
    J Am Soc Nephrol 11:1261-5. 2000
    ....
  22. ncbi request reprint HXB/Ipcv and BXH/Cub recombinant inbred strains of the rat: strain distribution patterns of 632 alleles
    M Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Folia Biol (Praha) 45:203-15. 1999
    ..The RI strains were phenotyped in multiple hemodynamic and metabolic traits. In the current study, we describe strain distribution patterns of 632 genetic markers...
  23. ncbi request reprint Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Mamm Genome 12:295-8. 2001
    ....
  24. ncbi request reprint Long-term pioglitazone treatment augments insulin sensitivity and PKC-epsilon and PKC-theta activation in skeletal muscles in sucrose fed rats
    I Markova
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Physiol Res 59:509-16. 2010
    ....
  25. ncbi request reprint A genetic linkage map of the rat derived from recombinant inbred strains
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences, Prague
    Mamm Genome 7:117-27. 1996
    ....
  26. ncbi request reprint Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR
    V Kren
    Institute of Biology and Medical Genetics, First Medical Faculty, Charles University, Prague, Czech Republic
    Hypertension 37:1147-52. 2001
    ..Thus, genetic variation in genes on the Y chromosome may contribute to variation in blood pressure and lipid levels and may influence the risk for cardiovascular disease...
  27. ncbi request reprint Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Nat Genet 27:156-8. 2001
    ..Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension...
  28. ncbi request reprint Autocrine effects of visfatin on hepatocyte sensitivity to insulin action
    V Skop
    Institute of Chemical Technology, Department of Biochemistry and Microbiology, Prague, Czech Republic
    Physiol Res 59:615-8. 2010
    ..6+/-0.2 vs. 2.2+/-0.5 nnmol/g/2 h, P=0.02). These results provide evidence that visfatin exhibits important autocrine effects on sensitivity of liver cells to insulin action possibly through its effects on NAD biosynthesis...
  29. ncbi request reprint Linkage mapping of the Fos cellular oncogene (Fos) to rat chromosome 6 and its possible role in the regulation of compensatory renal growth
    M Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Folia Biol (Praha) 44:151-3. 1998
    ..Despite relatively wide confidence intervals for mapping QTLs with modest effects in a small population of RI strains, this finding probably excludes the Fos as a positional candidate for CRG...
  30. pmc Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    J Clin Invest 96:1973-8. 1995
    ....
  31. pmc Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat
    V Kren
    Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic
    J Clin Invest 99:577-81. 1997
    ..BN-Lx rats...
  32. ncbi request reprint Mapping of quantitative trait loci for seminal vesicle mass and litter size to rat chromosome 8
    V Zidek
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    J Reprod Fertil 116:329-33. 1999
    ....
  33. ncbi request reprint Chromosome assignment of Cd36 transgenes in two rat SHR lines by FISH and linkage mapping of transgenic insert in the SHR-TG19 line
    F Liska
    Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, Albertov 4, Prague 2, 128 00, Czech Republic
    Folia Biol (Praha) 48:139-44. 2002
    ..Within the close neighbourhood of the inserted Cd36 transgene, there are several genes known to be expressed in kidney, and so the influence of some regulatory sequences enhancing kidney expression of the Cd36 transgene can be envisaged...
  34. ncbi request reprint Genetic dissection of testicular weight in the mouse with the BXD recombinant inbred strains
    V Zidek
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Mamm Genome 9:503-5. 1998
    ..9). This QTL region was designated Twq1 and associated with over 75% of genetic variability...
  35. ncbi request reprint The CD36 protein functions as an immunogenic domain of the RT8 alloantigen
    P Mlejnek
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Eur J Immunogenet 30:325-7. 2003
    ....
  36. ncbi request reprint Quantitative trait loci for compensatory renal hypertrophy in the mouse
    V Zidek
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Biochem Biophys Res Commun 248:473-5. 1998
    ..4) and is responsible for approximately 52% of genetic variation in CRH. This marker maps near Ace, Gh, and Ngfr positional candidate genes...
  37. doi request reprint Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat
    Michelle D Johnson
    Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic
    Hypertension 54:639-45. 2009
    ..Candidate genes identified in these studies merit further investigation as potentially causative hypertension genes in SHR and human hypertension...
  38. ncbi request reprint Genetic relationship between placental and fetal weights and markers of the metabolic syndrome in rat recombinant inbred strains
    Martina Buresova
    Institute of Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Genomics 26:226-31. 2006
    ..54, P = 0.006) in adult rats. Our results suggest that predisposition toward a thrifty phenotype associated with decreased placental weight and restricted fetal growth is in part genetically determined...
  39. ncbi request reprint Recombinant inbred and congenic strains of the rat for genetic analysis of limb morphogenesis
    V Kren
    Department of Biology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Folia Biol (Praha) 42:159-66. 1996
    ..5 to 0.6). The verification of all these findings is in progress by means of double congenic strains which, in addition to the Lx gene, carry differential chromosome segments with putative modifiers...
  40. ncbi request reprint CD36 regulates fatty acid composition and sensitivity to insulin in 3T3-L1 adipocytes
    K Kontrová
    Department of Biochemistry and Microbiology, Institute of Chemical Technology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 56:493-6. 2007
    ..02+/-0.1 vs. 8.42+/-0.26 pmol.10(-3) cells, P=0.001). These findings provide evidence that CD36 regulates FA composition thereby affecting sensitivity to insulin action in 3T3-L1 adipocytes...
  41. ncbi request reprint Genetics of Cd36 and the hypertension metabolic syndrome
    Michal Pravenec
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic and the Department of Laboratory Medicine, University of California, San Francisco, CA
    Semin Nephrol 22:148-53. 2002
    ..These findings show that a primary defect in fatty acid transport can promote disordered carbohydrate metabolism in the SHR and show the power of advanced genome technologies for identifying QTL at the molecular level...
  42. ncbi request reprint Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Hypertension 51:148-53. 2008
    ....
  43. doi request reprint Use of rat genomics for investigating the metabolic syndrome
    Michal Pravenec
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Methods Mol Biol 597:415-26. 2010
    ..Owing to recent progress in the development of rat genomic resources, the pace of QTL identification and discovery of new disease mechanisms can be expected to accelerate in the near future...
  44. ncbi request reprint Selected adipokines - plasma concentrations and adipose tissue expressions during 24-hour lipid infusion in healthy men
    J Kopecky
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 59:89-96. 2010
    ..Expressions of TNFalpha, leptin and adiponectin were unaffected. In conclusions, our results indicate that acutely induced hyperlipidemia could influence the secretion of TNFalpha and resistin...
  45. doi request reprint Hemodynamic characterization of recombinant inbred strains: twenty years later
    Jaroslav Kunes
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Hypertens Res 31:1659-68. 2008
    ..Our study confirms the validity of RI strains for the further genetic and physiological research of hypertension...
  46. ncbi request reprint Genome scanning of the HXB/BXH sets of recombinant inbred strains of the rat for quantitative trait loci associated with conditioned taste aversion
    Edita Bielavska
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Behav Genet 32:51-6. 2002
    ..3%) and the SHR-2 (SHR.BN-D2Rat171/D2Arb24) congenic strain (13.1+/-4.4%, p < .01) that are genetically identical except for a segment of chromosome 2 that was transferred onto the genetic background of the SHR from the BN strain...
  47. ncbi request reprint In situ hybridization of a rat cDNA probe for glutathione S-transferase gene Ya subunit (GST Ya) to rat chromosome 8
    M Sladká
    Institute of Biology, 1st Medical Faculty, Charles University, Praha
    Folia Biol (Praha) 38:84-9. 1992
  48. doi request reprint Effect of telmisartan on selected adipokines, insulin sensitivity, and substrate utilization during insulin-stimulated conditions in patients with metabolic syndrome and impaired fasting glucose
    Petr Wohl
    Diabetes Center, Institute for Clinical and Experimental Medicine, Vídenská 1958 4, Prague, Czech Republic
    Eur J Endocrinol 163:573-83. 2010
    ..This study evaluated the effect of telmisartan on insulin sensitivity, substrate utilization, selected plasma adipokines and their expressions in subcutaneous adipose tissue (SAT) in metabolic syndrome...
  49. pmc Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains
    Michal Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic
    Genome Res 17:1319-26. 2007
    ....
  50. ncbi request reprint Molecular genetics of experimental hypertension and the metabolic syndrome: from gene pathways to new therapies
    Michal Pravenec
    Institute of Physiology and Center for Applied Genomics, Czech Academy of Sciences, Prague, Czech Republic
    Hypertension 49:941-52. 2007
    ....
  51. ncbi request reprint Gene expression profiling in hypertension research: a critical perspective
    Michal Pravenec
    Institute of Physiology, Czech Academy of Sciences and The Center for Integrated Genomics, Prague, Czech Republic
    Hypertension 41:3-8. 2003
    ..In this review, we offer a critical perspective on the use of gene expression profiling in hypertension research and discuss some emerging strategies for taking this technology beyond the limits of correlational and descriptive studies...
  52. doi request reprint Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
    Michal Pravenec
    Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic
    Nat Genet 40:952-4. 2008
    ....
  53. doi request reprint Generation of rat "supersonic" congenic/conplastic strains using superovulation and embryo transfer
    Vladimir Landa
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Methods Mol Biol 597:267-75. 2010
    ..Both strategies could also be combined. In the current chapter, a method for derivation of "supersonic" congenic/conplastic rat strains is described...
  54. doi request reprint Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis
    Hana Malinska
    Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Mol Cell Biochem 335:119-25. 2010
    ....
  55. ncbi request reprint Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone
    Nianning Qi
    Department of Laboratory Medicine, University of California, San Francisco, 94143, USA
    J Biol Chem 277:48501-7. 2002
    ..These findings provide direct pharmacogenetic evidence that in the SHR model, Cd36 is a key determinant of the insulin-sensitizing actions of a thiazolidinedione ligand of peroxisome proliferator-activated receptor gamma...
  56. ncbi request reprint TA repeat variation, Npr1 expression, and blood pressure: impact of the Ace locus
    Johanne Tremblay
    Laboratory of Cellular Biology of Hypertension, Centre de Recherche du Centre Hospitalier de l Université de Montréal Hôtel Dieu, Montreal, Quebec, Canada
    Hypertension 41:16-24. 2003
    ..In conclusion, the longer TA repeat unit in the promoter of Npr1 of SHR, in tandem with a putative cGMP responsive element, regulates the transcription of the Npr1 gene with consequences on diastolic blood pressure...
  57. ncbi request reprint Heart rate and blood pressure quantitative trait loci for the airpuff startle reaction
    Rebecca L Jaworski
    Department of Pharmacology, University of California at San Diego, 92093 0636, USA
    Hypertension 39:348-52. 2002
    ..Furthermore, we have established the utility of this experimental paradigm to identify loci responsible for cardiovascular regulation during stress in genetic hypertensive models...
  58. ncbi request reprint Identification and chromosomal localization of ecogenetic components of electrolyte excretion
    Pierre Dumas
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Universite de Montreal, Montreal, Quebec, Canada
    J Hypertens 20:209-17. 2002
    ..To determine to what extent urinary excretion of blood pressure-modulating electrolytes is genetically determined, and to identify their chromosomal localization...
  59. ncbi request reprint Genetic map of AFLP markers in the rat (Rattus norvegicus) derived from the H x B/Ipcv and B x H/Cub sets of recombinant inbred strains
    Anita C M Bonné
    Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Graduate School of Animal Health, Utrecht University, Utrecht, The Netherlands
    Biochem Genet 41:77-89. 2003
    ..These results substantiate the value of the AFLP technology in increasing marker density in genetic maps...
  60. ncbi request reprint Segment of rat chromosome 20 regulates diet-induced augmentations in adiposity, glucose intolerance, and blood pressure
    Zdenka Pausova
    Laboratory of Functional Genomics, Centre de Recherche, CHUM Hôtel Die, 3850 St Urbain St, Montreal, Quebec H2W 1T7, Canada
    Hypertension 41:1047-55. 2003
    ....
  61. ncbi request reprint A new framework marker-based linkage map and SDPs for the rat HXB/BXH strain set
    Martin Jirout
    Department of Pharmacology 0636, University of California San Diego, La Jolla, California 92093 0636, USA
    Mamm Genome 14:537-46. 2003
    ..The new genotypic information obtained also permitted further genetic characterization of the RI strain set including strain independence, genetic similarity among the individual strains, and non-syntenic associations between loci...
  62. ncbi request reprint Liver copper content of rats hypo- or hyperresponsive to dietary cholesterol
    Ingeborg de Wolf
    Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Graduate School of Animal Health, Utrecht University, Utrecht, The Netherlands
    J Trace Elem Med Biol 17:177-82. 2003
    ..The decrease of liver copper concentration after the high fat, high cholesterol diet is probably not caused by a decrease in whole hepatic copper content, but rather due to dietary-induced hepatomegaly...
  63. ncbi request reprint A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model
    Birgit Meyer
    Gene Mapping Center, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Differentiation 72:541-7. 2004
    ..Further studies on the skin histology in affected rats demonstrated features consistent with a lanceolate hair mutation, providing further support for the crucial role of desmoglein 4 in hair shaft differentiation...
  64. ncbi request reprint Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
    Norbert Hubner
    Max Delbruck Center for Molecular Medicine, Berlin Buch 13125, Germany
    Nat Genet 37:243-53. 2005
    ....
  65. ncbi request reprint CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages
    Samir N Patel
    Department of Medicine, University of Toronto, Ontario, Canada
    J Infect Dis 189:204-13. 2004
    ..These studies support the use of these rodent models to examine PE-CD36 interactions...
  66. ncbi request reprint A new transgenic rat model of hepatic steatosis and the metabolic syndrome
    Nathan R Qi
    Department of Laboratory Medicine, University of California, San Francisco, USA
    Hypertension 45:1004-11. 2005
    ....
  67. ncbi request reprint Telmisartan but not valsartan increases caloric expenditure and protects against weight gain and hepatic steatosis
    Ken Sugimoto
    Department of Laboratory Medicine, University of California, San Francisco, CA 94107, USA
    Hypertension 47:1003-9. 2006
    ....
  68. ncbi request reprint Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
    Stephen C Benson
    Department of Biological Sciences, California State University, Hayward, USA
    Hypertension 43:993-1002. 2004
    ....
  69. doi request reprint Progress and prospects in rat genetics: a community view
    Timothy J Aitman
    Medical Research Council Clinical Sciences Centre and Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Genet 40:516-22. 2008
    ..Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research...
  70. doi request reprint Distribution and functional impact of DNA copy number variation in the rat
    Victor Guryev
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Nat Genet 40:538-45. 2008
    ..These characteristics make the rat an excellent model for studying phenotypic effects of structural variation in relation to human complex traits and disease...
  71. pmc Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass
    Enrico Petretto
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Nat Genet 40:546-52. 2008
    ..Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis...
  72. doi request reprint SNP and haplotype mapping for genetic analysis in the rat
    Kathrin Saar
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strae 10, 13125 Berlin, Germany
    Nat Genet 40:560-6. 2008
    ..We provide a detailed SNP map and demonstrate its utility for mapping of quantitative trait loci. This community resource is openly available and augments the genetic tools for this workhorse of physiological studies...
  73. ncbi request reprint Salt preference of congenic strains derived from the spontaneously hypertensive rat
    Robert Di Nicolantonio
    Department of Physiology, University of Melbourne, Victoria, Melbourne 3010, Australia
    Physiol Behav 80:617-22. 2004
    ..Evidence was also found for the existence of a region on chromosome 8, which influences fluid intake in the SHR. The causative genes involved in these effects however remain to be determined...
  74. pmc Heritability and tissue specificity of expression quantitative trait loci
    Enrico Petretto
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom
    PLoS Genet 2:e172. 2006
    ..We delineate the effects of genetic architecture on variation in gene expression and show the sensitivity of this experimental design to tissue sampling variability in large-scale eQTL studies...
  75. ncbi request reprint Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat
    Anita Bonne
    Department of Laboratory Animal Science, Faculty of Veterinary Science, Utrecht University, P O Box 80166, 3508 TD Utrecht, The Netherlands
    Mol Biol Rep 30:173-6. 2003
    ..The intronless Fabp6 segment, which might be a pseudogene of Fabp6, was localized on rat chromosome 15...
  76. ncbi request reprint The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
  77. doi request reprint Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-gamma dependent pathway
    Ken Sugimoto
    Department of Laboratory Medicine, University of California, San Francisco, CA, USA
    J Hypertens 26:1209-15. 2008
    ..As muscle fatty acid oxidation is a major determinant of energy expenditure, we investigated the effects of telmisartan on skeletal muscle fatty acid oxidation in a rat model of the metabolic syndrome...