H Kubova

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. doi request reprint Are morphologic and functional consequences of status epilepticus in infant rats progressive?
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
    Neuroscience 235:232-49. 2013
  2. doi request reprint New insight on the mechanisms of epileptogenesis in the developing brain
    Hana Kubova
    Department of Developmental Epileptology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Adv Tech Stand Neurosurg 39:3-44. 2012
  3. ncbi request reprint Partial agonist of benzodiazepine receptors Ro 19-8022 elicits withdrawal symptoms after short-term administration in immature rats
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 61:319-23. 2012
  4. ncbi request reprint Non-NMDA receptor antagonist GYKI 52466 suppresses cortical afterdischarges in immature rats
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska, Prague
    Eur J Pharmacol 333:17-26. 1997
  5. doi request reprint Hypoxia-induced changes of seizure susceptibility in immature rats are modified by vigabatrin
    Hana Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epileptic Disord 9:S36-43. 2007
  6. ncbi request reprint Outcome of status epilepticus in immature rats varies according to the paraldehyde treatment
    Hana Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epilepsia 46:38-42. 2005
  7. ncbi request reprint Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis
    Hana Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Vídeòská 1083, Prague 4, CZ 142 20, Czech Republic
    Eur J Neurosci 19:3255-65. 2004
  8. doi request reprint Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats
    Hana Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epilepsia 51:469-72. 2010
  9. ncbi request reprint Dynamic changes of status epilepticus-induced neuronal degeneration in the mediodorsal nucleus of the thalamus during postnatal development of the rat
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, CZ 142 20, Czech Republic
    Epilepsia 43:54-60. 2002
  10. ncbi request reprint Does status epilepticus influence the motor development of immature rats?
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Epilepsia 41:S64-9. 2000

Collaborators

Detail Information

Publications49

  1. doi request reprint Are morphologic and functional consequences of status epilepticus in infant rats progressive?
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
    Neuroscience 235:232-49. 2013
    ..In P12 rats, morphologic damage also tended to progress over time. Performance of animals in the Morris water maze correlated with the severity of damage, but not with seizure parameters...
  2. doi request reprint New insight on the mechanisms of epileptogenesis in the developing brain
    Hana Kubova
    Department of Developmental Epileptology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Adv Tech Stand Neurosurg 39:3-44. 2012
    ....
  3. ncbi request reprint Partial agonist of benzodiazepine receptors Ro 19-8022 elicits withdrawal symptoms after short-term administration in immature rats
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 61:319-23. 2012
    ..No signs of hypersensitivity were seen at 4-day interval. There is a difference between immature and adult brain in an appearance of withdrawal symptom after administration of the partial agonist of benzodiazepine receptors Ro 19-8022...
  4. ncbi request reprint Non-NMDA receptor antagonist GYKI 52466 suppresses cortical afterdischarges in immature rats
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska, Prague
    Eur J Pharmacol 333:17-26. 1997
    ..This effect was not influenced by a benzodiazepine antagonist flumazenil. On the contrary, the anticonvulsant action of GYKI 52466 was partly blocked by flumazenil, indicating thus multiple mechanisms of action of GYKI 52466...
  5. doi request reprint Hypoxia-induced changes of seizure susceptibility in immature rats are modified by vigabatrin
    Hana Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epileptic Disord 9:S36-43. 2007
    ..Our data suggest that hypobaric hypoxia transiently increases seizure susceptibility. This effect is partially abolished by vigabatrin administered after hypoxia exposure...
  6. ncbi request reprint Outcome of status epilepticus in immature rats varies according to the paraldehyde treatment
    Hana Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epilepsia 46:38-42. 2005
    ..To test effects of paraldehyde on behavioral outcome of status epilepticus (SE) in developing rats...
  7. ncbi request reprint Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis
    Hana Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Vídeòská 1083, Prague 4, CZ 142 20, Czech Republic
    Eur J Neurosci 19:3255-65. 2004
    ..The present findings indicate that SE is harmful to the immature brain as early as P12, which might be compared with early infancy in humans...
  8. doi request reprint Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats
    Hana Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epilepsia 51:469-72. 2010
    ..Neither drug decreased NMDA-induced mortality, which occurred within approximately 15 min after NMDA administration and reached almost 100% in all groups...
  9. ncbi request reprint Dynamic changes of status epilepticus-induced neuronal degeneration in the mediodorsal nucleus of the thalamus during postnatal development of the rat
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, CZ 142 20, Czech Republic
    Epilepsia 43:54-60. 2002
    ..This study was designed to describe age-related changes of SE-induced neuronal degeneration in this part of the brain...
  10. ncbi request reprint Does status epilepticus influence the motor development of immature rats?
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Epilepsia 41:S64-9. 2000
    ..To study the effect of severe status epilepticus (SE) on the motor development of rats...
  11. ncbi request reprint Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, CZ 142 20, Czech Republic
    J Neurosci 21:3593-9. 2001
    ....
  12. ncbi request reprint Changes in NADPH-diaphorase positivity induced by status epilepticus in allocortical structures of the immature rat brain
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska
    Brain Res Bull 48:39-47. 1999
    ....
  13. ncbi request reprint The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Naunyn Schmiedebergs Arch Pharmacol 360:565-74. 1999
    ..It did not compromise the motor system, but in some tests motivation was probably lost...
  14. ncbi request reprint Midazolam suppresses spike-and-wave rhythm accompanying three different models of epileptic seizures
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Physiol Res 48:491-500. 1999
    ..A spread of epileptic activity into brain structures other than the thalamocortical system determines the type of epileptic seizures...
  15. ncbi request reprint Are acute changes after status epilepticus in immature rats persistent?
    L Suchomelova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Physiol Res 51:185-92. 2002
    ..EEG, behavioral and morphological changes induced by status epilepticus in developing rats persisted for 6 days after the status. They markedly differed according to the age of animals...
  16. ncbi request reprint Single systemic dose of vigabatrin induces early proconvulsant and later anticonvulsant effect in rats
    A Stuchlik
    Department of Neurophysiology of Memory, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    Neurosci Lett 312:37-40. 2001
    ..The biphasic effect of VGB was demonstrated, the initial proconvulsant effect might be due to a different onset of VGB action in individual brain structures, but an additional mechanism of action cannot be excluded...
  17. ncbi request reprint Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats?
    R Haugvicova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 51:363-70. 2002
    ..The anticonvulsant action of vigabatrin, which could be demonstrated mainly against generalized tonic-clonic seizures, varies markedly during development...
  18. ncbi request reprint Two different anticonvulsant actions of tiagabine in developing rats
    R Haugvicova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epilepsia 41:1375-81. 2000
    ..Our goal was to study the anticonvulsant action of tiagabine (TGB) at different levels of brain maturation in rats...
  19. ncbi request reprint Interaction of excitatory amino acid agonists with cortical afterdischarges in developing rats
    P Mares
    Institute of Physiology, Academy of Sciences, Videnska 1083, CZ 14220 Prague 4, Czech Republic
    Epilepsia 43:61-7. 2002
    ..To determine the role of excitatory amino acids (EAAs) in genesis of two types of epileptic afterdischarges...
  20. ncbi request reprint Long-term changes of activity of cortical neurons after status epilepticus induced at early developmental stages in rats
    J Doczi
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Neurosci Lett 352:125-8. 2003
    ..Similar change in SE12 animals did not reach the level of statistical significance. Status epilepticus at an early developmental stage may result in a long-lasting change in functions of surviving cortical neurons...
  21. ncbi request reprint Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats
    R Haugvicova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    J Pharm Pharmacol 54:1011-5. 2002
    ..We concluded that our model is useful for testing anticonvulsant effects. Results with three antiepileptic drugs correspond with their efficacy against myoclonic seizures in man...
  22. ncbi request reprint Changes of cortical epileptic afterdischarges under the influence of convulsant drugs
    H Koryntová
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Brain Res Bull 58:49-54. 2002
    ..Our results indicate various mechanisms and diverse role of the two inhibitory systems in generation of evaluated phenomena...
  23. doi request reprint Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats
    A Mikulecká
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epilepsy Behav 20:12-9. 2011
    ..Anxiolytic-like effects of these drugs were still present at the time when animals exhibited rebound proconvulsant effects...
  24. ncbi request reprint What is the role of neurotransmitter systems in cortical seizures?
    P Mares
    Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 57:S111-20. 2008
    ..All three neurotransmitter systems probably participate in mechanisms of generation, maintenance and arrest of cortical seizures...
  25. doi request reprint Changes of cortical epileptic afterdischarges after status epilepticus in immature rats
    Grygoriy Tsenov
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 14220 Prague 4, Czech Republic
    Epilepsy Res 78:178-85. 2008
    ..P12 group then exhibited a transient increase in duration of ADs 6 days after SE. Our results did not prove a higher cortical excitability after SE in either age group. On the contrary, there were some signs of a decreased excitability...
  26. ncbi request reprint Motor performance and behavior of immature rats are not compromised by a high dose of topiramate
    Mariam Alaverdashvili
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 14220 Prague 4, Czech Republic
    Epilepsy Behav 7:222-30. 2005
    ..A single high dose of TPM resulted only in transient changes in motor performance. A possible anxiolytic effect observed in 25-day-old rats should be studied...
  27. ncbi request reprint Excitatory aminoacids and epileptic seizures in immature brain
    P Mares
    Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 53:S115-24. 2004
    ..In contrast, glutamate metabotropic receptor antagonist MPEP did not exhibit any serious side effects in rat pups...
  28. ncbi request reprint Intrahippocampal injection of endothelin-1 in immature rats results in neuronal death, development of epilepsy and behavioral abnormalities later in life
    Adéla Mátéffyová
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, CZ 142 20, Czech Republic
    Eur J Neurosci 24:351-60. 2006
    ..Our results document that early intrahippocampal injection of ET-1 results in lesion development and both immediate seizures and chronic epilepsy in either age group. Cognitive impairment occurred only in rats with ET-1 injection at P12...
  29. ncbi request reprint Long-term behavioral and morphological consequences of nonconvulsive status epilepticus in rats
    Pavel Krsek
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
    Epilepsy Behav 5:180-91. 2004
    ..Despite relatively inconspicuous manifestations, NCSE may represent a risk for long-term deficits...
  30. ncbi request reprint Effects of a free radical scavenger N-tert-butyl-alpha-phenylnitrone (PBN) on short-term recovery of immature rats after status epilepticus
    J Rejchrtová
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    Physiol Res 54:215-27. 2005
    ..In contrast, administration of PBN aggravated neuronal injury in the hippocampus in P12 rats. Administration of PBN to intact rats did not induce neurodegeneration in either age group...
  31. ncbi request reprint An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci
    P Mares
    Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences, Prague, Czech Republic
    Physiol Res 61:325-9. 2012
    ..GABA-B receptor antagonist did not influence purely cortical epileptic phenomenon but it is proconvulsant in ictal activity generated with participation of subcortical structures...
  32. ncbi request reprint Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent
    R Druga
    Institute of Physiology, Academy of Sciences of the Czech Republic, CZ 142 20 Prague 4, Czech Republic
    Physiol Res 52:251-64. 2003
    ..Parvalbumin (PV) immunocytochemistry revealed a significant decrease in the number of PV-immunoreactive neurons in the rostral piriform cortex and in the dorsal claustrum in animals surviving for two months...
  33. ncbi request reprint Convulsant action of systemically administered glutamate and bicuculline methiodide in immature rats
    P Mares
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20 4, Prague, Czech Republic
    Epilepsy Res 42:183-9. 2000
    ....
  34. doi request reprint Effects of lamotrigine on cortically-elicited phenomena in adult rats: differences between acute application and late consequences of early postnatal administration
    Grygoryi Tsenov
    Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20, Prague 4, Czech Republic
    Brain Res 1258:65-70. 2009
    ..Our results demonstrated a specific anticonvulsant effect as a delayed consequence of early-life administration of LTG; it differed from effects of acute administration of LTG to adult rats...
  35. ncbi request reprint Lamotrigine does not impair motor performance and spontaneous behavior in developing rats
    Anna Mikulecká
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epilepsy Behav 5:464-71. 2004
    ..Lamotrigine administered repeatedly at early developmental stages did not change motor abilities and behavior in an open field...
  36. ncbi request reprint Modulation of adenylyl cyclase activity by baclofen in the developing rat brain: difference between cortex, thalamus and hippocampus
    Lucie Hejnova
    Department of Biochemistry of Membrane Receptors, Institute of Physiology, Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic
    Neurosci Lett 330:9-12. 2002
    ..The stimulatory effect of baclofen in hippocampus may be explained by engagement of Gbetagamma subunits...
  37. ncbi request reprint Intrahippocampal injection of endothelin-1: a new model of ischemia-induced seizures in immature rats
    Grygoriy Tsenov
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epilepsia 48:7-13. 2007
    ..Seizure severity correlated positively with severity of the damage in both age groups. Our study presents focal injection of ET-1 into the brain as a new and practical model of ischemia-induced seizures in immature rats...
  38. ncbi request reprint Changes in cytochrome oxidase in the piriform cortex after status epilepticus in adult rats
    Jakub Otahal
    Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epilepsia 46:89-93. 2005
    ..The present research studied activity of the cytochrome oxidase separately in the rostral and caudal parts of the piriform cortex after lithium chloride-pilocarpine-induced SE in adult rats...
  39. ncbi request reprint Effect of endothelin-1 on the excitability of rat cortical and hippocampal slices in vitro
    R Konopková
    Department of Developmental Epileptology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 61:215-9. 2012
    ..Our data suggest that acute seizures after intrahippocampal application of ET-1 in rats are likely caused by ischemia rather than by a direct action of ET-1 on brain tissue...
  40. ncbi request reprint Anticonvulsant action of a new analogue of allopregnanolone in immature rats
    P Mares
    Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 59:305-8. 2010
    ..Very short duration of anticonvulsant action of HPOP demonstrated in 12-day-old animals indicates that this drug might be used only in acute treatment in epileptology...
  41. doi request reprint Metabotropic glutamate receptors as a target for anticonvulsant and anxiolytic action in immature rats
    Pavel Mares
    Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences, Prague, Czech Republic
    Epilepsia 51:24-6. 2010
    ..The three antagonists possess age-dependent anticonvulsant as well as anxiolytic action, with minimal negative side effects...
  42. doi request reprint Effects of a GABA-B receptor agonist baclofen on cortical epileptic afterdischarges in rats
    Pavel Mares
    Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epileptic Disord 9:S44-51. 2007
    ..Failure of baclofen to exhibit an expected anticonvulsant activity might be due to a complexity of GABA-B inhibitory system (pre- as well as postsynaptic localization of GABA-B receptors)...
  43. ncbi request reprint Effect of free radical spin trap N-tert-butyl-alpha-phenylnitrone (PBN) on seizures induced in immature rats by homocysteic acid
    Jaroslava Folbergrová
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    Exp Neurol 201:105-19. 2006
    ..Free radical scavenger PBN had a clear-cut protective effect, evident as the improved recovery of brain energy status and as a partial, but significant, attenuation of neuronal degeneration associated with this model of seizures...
  44. ncbi request reprint Changes of cortical interhemispheric responses after status epilepticus in immature rats
    Pavel Mares
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epilepsia 46:31-7. 2005
    ..To study cortical excitability after status epilepticus induced in two age groups of immature rats...
  45. ncbi request reprint Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate
    Jaroslava Folbergrová
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Exp Neurol 192:420-36. 2005
    ..The present findings support the possibility that group II mGluRs are a promising target for a novel approach to treating epilepsy...
  46. ncbi request reprint Degenerative neuronal changes in the rat thalamus induced by status epilepticus at different developmental stages
    Rastislav Druga
    Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of Czech Republic, Videnska 1083, Prague 4, Czech Republic
    Epilepsy Res 63:43-65. 2005
    ..The pattern of thalamic damage is age-specific; its extent and severity increases with age...
  47. ncbi request reprint Unequal development of thresholds for various phenomena induced by cortical stimulation in rats
    Pavel Mares
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20 4, Prague, Czech Republic
    Epilepsy Res 49:35-43. 2002
    ..Our data represent a background for pharmacological studies and indicate the development of cortical excitability and of connections between the thalamocortical system and limbic structures...
  48. doi request reprint Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors
    E Szczurowska
    Department of Developmental Epileptology, Institute of Physiology CAS, Videnska 1083, 124 20 Prague 4, Czech Republic National Institute of Mental Health, Topolova 748, 250 67 Klecany, Czech Republic Electronic address
    Exp Neurol 283:97-109. 2016
    ..Interestingly, LiCl in combination with paraldehyde can also strongly alter the normal ontogeny of GRIA2A mRNA as well as GluA2 subunit protein expression. ..
  49. ncbi request reprint Transient changes of cortical interhemispheric responses after repeated caffeine administration in immature rats
    J Tchekalarova
    Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
    Physiol Res 60:961-9. 2011
    ..In spite of transient nature of changes they can reflect delayed or more probably modified brain development...