F Kolar

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. ncbi request reprint Brief daily episode of normoxia inhibits cardioprotection conferred by chronic continuous hypoxia. Role of oxidative stress and BKCa channels
    Jan Neckar
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    Curr Pharm Des 19:6880-9. 2013
  2. pmc Prolonged morphine administration alters protein expression in the rat myocardium
    Zdenka Drastichova
    Department of Physiology, Charles University, Prague
    J Biomed Sci 18:89. 2011
  3. ncbi request reprint Role of oxidative stress in PKC-delta upregulation and cardioprotection induced by chronic intermittent hypoxia
    Frantisek Kolar
    Inst of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Am J Physiol Heart Circ Physiol 292:H224-30. 2007
  4. ncbi request reprint Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia
    F Kolar
    Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, and Center for Experimental Cardiovascular Research, Prague, Czech Republic
    Physiol Res 53:S3-13. 2004
  5. ncbi request reprint MCC-134, a blocker of mitochondrial and opener of sarcolemmal ATP-sensitive K+ channels, abrogates cardioprotective effects of chronic hypoxia
    F Kolar
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Physiol Res 54:467-71. 2005
  6. ncbi request reprint Transient upregulation of protein kinase C in pressure-overloaded neonatal rat myocardium
    B Hamplova
    Charles University, Faculty of Science, Department of Cell Biology, Prague, Czech Republic
    Physiol Res 59:25-33. 2010
  7. ncbi request reprint Cardioprotective effect of chronic hypoxia is blunted by concomitant hypercapnia
    J Neckar
    Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic
    Physiol Res 52:171-5. 2003
  8. ncbi request reprint Ontogenetic development of cardiac tolerance to oxygen deprivation - possible mechanisms
    B Ostadal
    Center for Cardiovascular Research, Prague, Czech Republic
    Physiol Res 58:S1-12. 2009
  9. ncbi request reprint Role of ATP-sensitive K(+)-channels in antiarrhythmic and cardioprotective action of adaptation to intermittent hypobaric hypoxia
    F Kolar
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Bull Exp Biol Med 145:418-21. 2008
  10. ncbi request reprint Effect of acute and chronic simvastatin treatment on post-ischemic contractile dysfunction in isolated rat heart
    O Szarszoi
    Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 57:793-6. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Brief daily episode of normoxia inhibits cardioprotection conferred by chronic continuous hypoxia. Role of oxidative stress and BKCa channels
    Jan Neckar
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    Curr Pharm Des 19:6880-9. 2013
    ..The results suggest that CCH is cardioprotective and brief daily reoxygenation blunts its salutary effects, possibly by a mechanism involving oxidative stress and attenuation of the activation of mitochondrial BKCa channels. ..
  2. pmc Prolonged morphine administration alters protein expression in the rat myocardium
    Zdenka Drastichova
    Department of Physiology, Charles University, Prague
    J Biomed Sci 18:89. 2011
    ..However, there is lack of information about its effect on protein expression in the heart. Therefore, here we aimed to identify the presumed alterations in rat myocardial protein levels after prolonged morphine treatment...
  3. ncbi request reprint Role of oxidative stress in PKC-delta upregulation and cardioprotection induced by chronic intermittent hypoxia
    Frantisek Kolar
    Inst of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Am J Physiol Heart Circ Physiol 292:H224-30. 2007
    ..The infarct size-limiting mechanism of CIH seems to involve the PKC-delta-dependent pathway but apparently not the increased capacity of major antioxidant enzymes...
  4. ncbi request reprint Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia
    F Kolar
    Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, and Center for Experimental Cardiovascular Research, Prague, Czech Republic
    Physiol Res 53:S3-13. 2004
    ..This review summarizes current limited evidence for the involvement of ATP-sensitive potassium channels, reactive oxygen species, nitric oxide and various protein kinases in cardioprotective effects of chronic hypoxia...
  5. ncbi request reprint MCC-134, a blocker of mitochondrial and opener of sarcolemmal ATP-sensitive K+ channels, abrogates cardioprotective effects of chronic hypoxia
    F Kolar
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Physiol Res 54:467-71. 2005
    ..These results support the view that the opening of mitoKATP channels but not sarcKATP channels plays a crucial role in the mechanism by which chronic hypoxia improves cardiac tolerance to ischemia/reperfusion injury...
  6. ncbi request reprint Transient upregulation of protein kinase C in pressure-overloaded neonatal rat myocardium
    B Hamplova
    Charles University, Faculty of Science, Department of Cell Biology, Prague, Czech Republic
    Physiol Res 59:25-33. 2010
    ..It is concluded that PKCalpha, PKCdelta and PKCepsilon undergo transient upregulation associated with the accelerated cardiac growth induced by pressure overload imposed in the very early postnatal period...
  7. ncbi request reprint Cardioprotective effect of chronic hypoxia is blunted by concomitant hypercapnia
    J Neckar
    Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic
    Physiol Res 52:171-5. 2003
    ..8+/-2.4 %; P<0.05). It is concluded that increased CO(2) levels in the inspired air suppress the development of the chronic hypoxia-induced cardioprotective mechanism, possibly by interacting with ROS signalling pathways...
  8. ncbi request reprint Ontogenetic development of cardiac tolerance to oxygen deprivation - possible mechanisms
    B Ostadal
    Center for Cardiovascular Research, Prague, Czech Republic
    Physiol Res 58:S1-12. 2009
    ..These results suggest that the developmental approach offers new possibilities in the studies of pathogenesis, prevention and therapy of critical cardiovascular diseases...
  9. ncbi request reprint Role of ATP-sensitive K(+)-channels in antiarrhythmic and cardioprotective action of adaptation to intermittent hypobaric hypoxia
    F Kolar
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Bull Exp Biol Med 145:418-21. 2008
    ..We found that the cardioprotective and antiarrhythmic effects of adaptation to an altitude of 7000 m and the antiarrhythmic effect of 5000-m adaptation were mediated via activation of K(ATP) channels...
  10. ncbi request reprint Effect of acute and chronic simvastatin treatment on post-ischemic contractile dysfunction in isolated rat heart
    O Szarszoi
    Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 57:793-6. 2008
    ..This supports the idea of possible cardioprotective effect of statin administration in the first-line therapy of the acute coronary syndrome...
  11. ncbi request reprint N-acetylcysteine treatment prevents the up-regulation of MnSOD in chronically hypoxic rat hearts
    P Balková
    Department of Cell Biology, Charles University, Faculty of Science, Prague, Czech Republic
    Physiol Res 60:467-74. 2011
    ..The negative correlation between MnSOD activity and myocardial infarct size suggests that MnSOD can contribute to the improved ischemic tolerance of CIH hearts...
  12. ncbi request reprint Myocardial infarct size-limiting effect of chronic hypoxia persists for five weeks of normoxic recovery
    J Neckar
    Institute of Physiology, Academy of Sciences of the Czech Republic, Centre for Experimental Cardiovascular Research, Prague, Czech Republic
    Physiol Res 53:621-8. 2004
    ..Whereas the increased tolerance to lethal myocardial injury persists for at least 5 weeks after the termination of hypoxia, the antiarrhythmic protection rapidly vanishes, being replaced with transient proarrhythmic effect...
  13. ncbi request reprint The effect of the ultrashort beta-blocker esmolol on cardiac function recovery: an experimental study
    J Pirk
    Institute for Clinical and Experimental Medicine Institut klinické a experimentální medicíny, Prague, Czech Republic
    Eur J Cardiothorac Surg 15:199-203. 1999
    ..This is an experimental work designed to determine, using the isolated perfused rat heart, the effect of the ultra-short acting beta-blocker esmolol on cardiac arrest and cardiac function recovery following esmolol withdrawal...
  14. ncbi request reprint Effects of melatonin on ischemia and reperfusion injury of the rat heart
    O Szarszoi
    Institute of Physiology, Academy of Sciences of the Czech Republic and Centre of Experimental Cardiovascular Research, Prague
    Cardiovasc Drugs Ther 15:251-7. 2001
    ..It appears unlikely that melatonin is cardioprotective at physiological concentrations...
  15. ncbi request reprint Suppression of ischemic and reperfusion ventricular arrhythmias by inhalational anesthetic-induced preconditioning in the rat heart
    H Riha
    Centre for Cardiovascular Research, Prague, Czech Republic
    Physiol Res 60:709-14. 2011
    ..In conclusion, we have shown that preconditioning with isoflurane confers profound protection against myocardial ischemia- and reperfusion-induced arrhythmias and lethal myocardial injury...
  16. ncbi request reprint Acute but not chronic tempol treatment increases ischemic and reperfusion ventricular arrhythmias in open-chest rats
    J Neckar
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 57:653-6. 2008
    ..Acute tempol-treated rats exhibited a tendency to decrease infarct size (P = 0.087). The mechanism of proarrhythmic tempol action during ischemia and reperfusion remains to be elucidated...
  17. ncbi request reprint Myocardial phospholipid remodeling under different types of load imposed during early postnatal development
    F Novak
    Department of Cell Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
    Physiol Res 58:S13-32. 2009
    ..It is evident that PL remodeling may significantly influence both normal and pathological postnatal development of myocardium...
  18. ncbi request reprint P446Myocardial ischemic tolerance and expression of selected genes in spontaneously hypertensive rats adapted to chronic continuous hypoxia
    D Kolar
    Charles University of Prague, Department of Physiology, Prague, Czech Republic
    Cardiovasc Res 103:S82. 2014
    ..We also analyzed the expression levels of selected genes of energy metabolism, antioxidant systems and signalling pathways...
  19. ncbi request reprint Age-dependent influence of a moderate altitude (1,350 m) on the rat cardiopulmonary system
    F Kolar
    Institute of Physiology, Czechoslovak Academy of Sciences, Prague
    Physiol Bohemoslov 37:443-50. 1988
    ..The results show that even a moderate altitude influences the cardiopulmonary system of the rat in a manner characteristic of the effect of chronic hypoxic hypoxia...
  20. ncbi request reprint Cardiac adaptation to chronic high-altitude hypoxia: beneficial and adverse effects
    B Ostadal
    Centre for Cardiovascular Research, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Respir Physiol Neurobiol 158:224-36. 2007
    ..Moreover, interspecies and age differences in the cardiac sensitivity to hypoxia-induced effects in various experimental models were emphasized...
  21. ncbi request reprint Short-term fasting reduces the extent of myocardial infarction and incidence of reperfusion arrhythmias in rats
    M Snorek
    Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 61:567-74. 2012
    ..Further studies are needed to find out whether these beneficial effects can be linked to altered mitochondrial redox state resulting from increased ketogenesis...
  22. ncbi request reprint Pressure overload selectively increases n-3 PUFA in myocardial phospholipids during early postnatal period
    F Novak
    Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic
    Physiol Res 61:S155-63. 2012
    ....
  23. ncbi request reprint P161Two cardioprotective regimens of chronic intermittent hypoxia differ in activation of antioxidant systems
    D Kasparová
    Charles University of Prague, Faculty of Science, Department of Physiology, Prague, Czech Republic
    Cardiovasc Res 103:S28. 2014
    ..Reactive oxygen species formed during hypoxic exposures play an important role in the induction of protective cardiac phenotype...
  24. ncbi request reprint P432Expression and activity of mitochondrial creatine kinase and hexokinase are enhanced in the left ventricle of rats adaptated to chronic intermittent hypoxia
    J Zurmanova
    Charles University of Prague, Department of Physiology, Prague, Czech Republic
    Cardiovasc Res 103:S79-80. 2014
    ..Besides the mtCKs, there are two cytosolic CK isoforms (CKM and CKB) present in cardiomyocytes that help to maintain energy homeostasis...
  25. ncbi request reprint P658Adaptation to continuous normobaric hypoxia affects mitochondrial enzymes in spontaneously hypertensive rat hearts
    M Kalous
    Charles University of Prague, Prague, Czech Republic
    Cardiovasc Res 103:S120. 2014
    ..This strain is characterized with a selective replacement of the mitochondrial genome of SHR with more ischemic tolerant Brown Norway (BN) strain...
  26. ncbi request reprint Tolerance to acute ischemia in adult male and female spontaneously hypertensive rats
    J Besik
    Centre for Cardiovascular Research, Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 56:267-74. 2007
    ..It may be concluded that the hearts of female SHR are more resistant to ischemia/reperfusion injury as compared with male SHR. This fact could have important clinical implications for the treatment of cardiovascular disease in women...