P Jezek

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. ncbi request reprint A structure-activity study of fatty acid interaction with mitochondrial uncoupling protein
    P Jezek
    Institute of Physiology, Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague
    FEBS Lett 408:166-70. 1997
  2. ncbi request reprint Mitochondrial uncoupling proteins--facts and fantasies
    P Jezek
    Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 53:S199-211. 2004
  3. ncbi request reprint Existence of uncoupling protein-2 antigen in isolated mitochondria from various tissues
    P Jezek
    Department of Membrane Transport Biophysics, Institute of Physiology, Prague, Czech Republic
    FEBS Lett 455:79-82. 1999
  4. ncbi request reprint Inactive fatty acids are unable to flip-flop across the lipid bilayer
    P Jezek
    Institute of Physiology, Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague
    FEBS Lett 408:161-5. 1997
  5. ncbi request reprint Reconstituted plant uncoupling mitochondrial protein allows for proton translocation via fatty acid cycling mechanism
    P Jezek
    Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences, 14220 Prague 4, Czech Republic
    J Biol Chem 272:24272-8. 1997
  6. ncbi request reprint Fatty acid cycling mechanism and mitochondrial uncoupling proteins
    P Jezek
    Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague
    Biochim Biophys Acta 1365:319-27. 1998
  7. ncbi request reprint Tryptophan fluorescence of mitochondrial uncoupling protein
    P Jezek
    Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Gen Physiol Biophys 17:157-78. 1998
  8. ncbi request reprint Mammalian mitochondrial uncoupling proteins
    P Jezek
    Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Int J Biochem Cell Biol 30:1163-8. 1998
  9. ncbi request reprint Specific sequence of motifs of mitochondrial uncoupling proteins
    P Jezek
    Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    IUBMB Life 49:63-70. 2000
  10. ncbi request reprint Fatty acid interaction with mitochondrial uncoupling proteins
    P Jezek
    Institute of Physiology, Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague
    J Bioenerg Biomembr 31:457-66. 1999

Collaborators

  • K D Garlid
  • A E Vercesi
  • R Kramer
  • J A Vicente
  • L A Tartaglia
  • M Jaburek
  • L Alan
  • J Zelenka
  • J Jezek
  • J Borecky
  • E Valouskova
  • M Zackova
  • J Kubrycht
  • H Engstová
  • P Hanak
  • J Tauber
  • F Saudek
  • K Zacharovova
  • Z Berkova
  • T Spacek
  • J Santorová
  • M Modriansky
  • K Smolkova
  • P Soucek
  • M Varecha
  • H Chaimovich
  • M Ruzicka
  • P B de Andrade
  • J Hanus
  • A Meinhardt
  • P Arruda
  • A D Costa
  • I G Maia

Detail Information

Publications22

  1. ncbi request reprint A structure-activity study of fatty acid interaction with mitochondrial uncoupling protein
    P Jezek
    Institute of Physiology, Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague
    FEBS Lett 408:166-70. 1997
    ..The findings support the existence of FA cycling mechanism...
  2. ncbi request reprint Mitochondrial uncoupling proteins--facts and fantasies
    P Jezek
    Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 53:S199-211. 2004
    ..Moreover, reaction products of lipoperoxidation such as cleaved hydroperoxy-fatty acids and hydroxy-fatty acid can activate UCP2 and promote feedback down-regulation of mitochondrial ROS production...
  3. ncbi request reprint Existence of uncoupling protein-2 antigen in isolated mitochondria from various tissues
    P Jezek
    Department of Membrane Transport Biophysics, Institute of Physiology, Prague, Czech Republic
    FEBS Lett 455:79-82. 1999
    ..It has been concluded that UCP2 is expressed in these tissues (UCP3 in skeletal muscle); however their existence in mitochondria had not previously been demonstrated...
  4. ncbi request reprint Inactive fatty acids are unable to flip-flop across the lipid bilayer
    P Jezek
    Institute of Physiology, Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague
    FEBS Lett 408:161-5. 1997
    ..A phenomenon of shielding, where an additional alkyl chain or non-polar group can restore the flip-flop activity, is described...
  5. ncbi request reprint Reconstituted plant uncoupling mitochondrial protein allows for proton translocation via fatty acid cycling mechanism
    P Jezek
    Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences, 14220 Prague 4, Czech Republic
    J Biol Chem 272:24272-8. 1997
    ..Exponential flux-voltage characteristics were also studied. We suggest that regulated uncoupling in plant mitochondria may be important during fruit ripening, senescence, and seed dormancy...
  6. ncbi request reprint Fatty acid cycling mechanism and mitochondrial uncoupling proteins
    P Jezek
    Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague
    Biochim Biophys Acta 1365:319-27. 1998
    ..PUMP is supposed to act in the termination of synthetic processes in mature fruits and during the climacteric respiratory rise...
  7. ncbi request reprint Tryptophan fluorescence of mitochondrial uncoupling protein
    P Jezek
    Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Gen Physiol Biophys 17:157-78. 1998
    ..03 without changes in emission spectra, while slightly shifting absorption to red and increasing tyrosine exposure to water...
  8. ncbi request reprint Mammalian mitochondrial uncoupling proteins
    P Jezek
    Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Int J Biochem Cell Biol 30:1163-8. 1998
    ..UCP-1 mediates a purine-nucleotide-sensitive uniport of monovalent unipolar anions, including fatty acids, that lead to fatty acid cycling and uncoupling. UCP-2 and UCP-3 are expected to share a similar mechanism...
  9. ncbi request reprint Specific sequence of motifs of mitochondrial uncoupling proteins
    P Jezek
    Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    IUBMB Life 49:63-70. 2000
    ..These UCP signatures are thought to be involved in fatty acid anion binding and translocation...
  10. ncbi request reprint Fatty acid interaction with mitochondrial uncoupling proteins
    P Jezek
    Institute of Physiology, Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague
    J Bioenerg Biomembr 31:457-66. 1999
    ..The fatty acid cycling mechanism is predicted, as well for the recently discovered uncoupling proteins, UCP2 and UCP3...
  11. ncbi request reprint Functional reconstitution of Arabidopsis thaliana plant uncoupling mitochondrial protein (AtPUMP1) expressed in Escherichia coli
    J Borecky
    Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    FEBS Lett 505:240-4. 2001
    ..This work brings the functional and genetic approaches together for the first time, providing strong support that AtPUMP1 is truly an UCP...
  12. ncbi request reprint Interaction of mitochondrial phosphate carrier with fatty acids and hydrophobic phosphate analogs
    M Zackova
    Institute of Physiology, Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Videnska 1083, 14220, Prague 4, Czech Republic
    Int J Biochem Cell Biol 32:499-508. 2000
    ..This domain allows for FA anion uniport via the phosphate carrier and consequently, FA cycling that should lead to uncoupling in mitochondria. This might be considered as a side function of this carrier...
  13. ncbi request reprint Occurrence of plant-uncoupling mitochondrial protein (PUMP) in diverse organs and tissues of several plants
    P Jezek
    Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences, Prague, Czech Republic
    J Bioenerg Biomembr 32:549-61. 2000
    ..3) PUMP was not detected in mushrooms. We conclude that PUMP is likely present in the mitochondria of organs and tissues of all higher plants...
  14. ncbi request reprint Sulfhydryl groups of the uncoupling protein of brown adipose tissue mitochondria. Distinction between sulfhydryl groups of the H+ channel and the nucleotide binding site
    P Jezek
    Institute of Physiology, Czechoslovak Academy of Sciences, Prague
    Eur J Biochem 183:89-95. 1989
    ..Since N2PhSO2 also affects the GDP binding site, these results demonstrate that the N2PhSO2-reactive residue is not identical with the SHB...
  15. ncbi request reprint Natural and azido fatty acids inhibit phosphate transport and activate fatty acid anion uniport mediated by the mitochondrial phosphate carrier
    H Engstová
    Institute of Physiology, Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague CZ 14220, Czech Republic
    J Biol Chem 276:4683-91. 2001
    ..Hence, the demonstrated PIC interaction with monovalent long-chain FA anions, but with divalent phosphonates of short chain only, indicates a pattern distinct from that valid for the mitochondrial uncoupling protein-1...
  16. ncbi request reprint Possible basic and specific functions of plant uncoupling proteins (pUCP)
    P Jezek
    Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Biosci Rep 21:237-45. 2001
    ..g., during seed germination or in roots. The existence of these specific roles is suggested by the immunochemical and functional localization of pUCP in mitochondria of fruits, seeds and roots of various plant species...
  17. ncbi request reprint Mitochondrial phospholipase A2 activated by reactive oxygen species in heart mitochondria induces mild uncoupling
    J Jezek
    Department of Membrane Transport Biophysics, No 75, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 59:737-47. 2010
    ..In conclusion, ROS-induced function of cardiac mt-iPLA2 may stand on a pro-survival side of ischemia-reperfusion injury...
  18. ncbi request reprint Mitochondrial uncoupling proteins and phylogenesis--UCP4 as the ancestral uncoupling protein
    P Hanak
    Department of Membrane Transport Biophysics, No 375, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 14220, Prague, Czech Republic
    FEBS Lett 495:137-41. 2001
    ..This suggests that UCP4 represents the ancestral UCP from which other mammalian and plant UCPs diverged. Speculations on UCP4 participation in apoptosis are thus supported by its early phylogenetic occurrence...
  19. doi request reprint Assessment of mitochondrial DNA as an indicator of islet quality: an example in Goto Kakizaki rats
    L Alan
    Department No 75, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Transplant Proc 43:3281-4. 2011
    ..Among the remaining β-cells, oxidative phosphorylation (OXPHOS) and consequently glucose-stimulated insulin secretion (GSIS) are impaired, perhaps owing to a deficit in mitochondrial DNA (mtDNA). We sought to identify this abnormality...
  20. ncbi request reprint Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling
    M Jaburek
    Department of Biochemistry and Molecular Biology, Oregon Graduate Institute of Science and Technology, Portland, Oregon 97006, USA
    J Biol Chem 276:31897-905. 2001
    ..Thus, UCP1, like other members of its gene family, translocates anions and does not translocate protons...
  21. ncbi request reprint Sequence similarities of protein kinase substrates and inhibitors with immunoglobulins and model immunoglobulin homologue: cell adhesion molecule from the living fossil sponge Geodia cydonium. Mapping of coherent database similarities and implications for
    J Kubrycht
    Center of Occupational Diseases, National Institute of Public Health, 100 42 Prague, Czechia
    Folia Microbiol (Praha) 49:219-46. 2004
    ..1) we looked for: (i) peptide similarities present in the context of Ig domains or related structures in a large range of species from Archaea to Vertebrata, and (ii) some special nucleotide similarities...
  22. ncbi request reprint Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells
    E Valouskova
    Institute of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic
    Gen Physiol Biophys 27:92-100. 2008
    ..We hypothesize that CIDEa is sequestered in mitochondria while transfer of this potentially dangerous protein from mitochondria into nucleus intensifies or even initiates apoptosis...