Miroslav Dostal

Summary

Affiliation: Institute of Experimental Medicine CAS
Location: Prague, Czech Republic
Summary:
Research Scientist

Curent fields : ecotoxicology, ambient air pollution, children health, epidemiology

In the past: embryology, teratology, developmental toxicity,
embryotoxicity, developmental immunotoxicology,flow cytometry

Publications

  1. ncbi Environmental tobacco smoke exposure in children in two districts of the Czech Republic
    Miroslav Dostal
    Institute of Experimental Medicine AS CR, Prague, Czech Republic
    Int J Hyg Environ Health 211:318-25. 2008
  2. ncbi Childhood morbidity and air pollution in the Teplice program
    M Dostal
    Institute of Exp Medicine, Academy of Sciences, Prague, Czech Republic
    Cas Lek Cesk 140:658-61. 2001
  3. ncbi Air pollution and distributions of lymphocyte immunophenotypes in cord and maternal blood at delivery
    Irva Hertz-Picciotto
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Epidemiology 13:172-83. 2002
  4. ncbi [Environmental pollution and childhood morbidity]
    M Dostal
    Ustav experimentální medicíny AV CR, Praha
    Cas Lek Cesk 140:529-32. 2001
  5. ncbi The distribution of major lymphocyte subsets in cord blood is associated with its pH
    M Dostal
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, Czech Academy of Sciences and Regional Institute of Hygiene of Central Bohemia, 142 20, Prague, Czech Republic
    Clin Biochem 34:119-24. 2001
  6. ncbi The effect of dibenzo[a,1]pyrene and benzo[a]pyrene on human diploid lung fibroblasts: the induction of DNA adducts, expression of p53 and p21(WAF1) proteins and cell cycle distribution
    B Binkova
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia, c o Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Mutat Res 471:57-70. 2000
  7. ncbi [Parameters of cellular immunity in maternal and umbilical cord blood in relation to air pollution. Preliminary results of a pregnancy outcomes study]
    M Dostal
    Laborator genetické ekotoxikologie KHS Stredoceského kraje, Praha
    Cas Lek Cesk 139:183-8. 2000
  8. ncbi HVRII of mtDNA in cord blood cells of newborn children and in their saliva 10 years later
    J Schmuczerova
    Department of Developmental Genotoxicology, Institute of Experimental Medicine AS CR, Prague, Czech Republic
    Folia Biol (Praha) 57:26-9. 2011
  9. ncbi Cell-cycle alterations within chick embryonic anlagen after cyclophosphamide treatment
    L Heringová
    Department of Histology and Embryology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    Teratog Carcinog Mutagen 18:63-72. 1998
  10. ncbi [Clinico-teratologic counseling and the Teratology Information Service]
    D Stejskal
    Oddĕlení lékarské genetiky GENNET, v o s, Praha
    Ceska Gynekol 63:19-22. 1998

Collaborators

Detail Information

Publications66

  1. ncbi Environmental tobacco smoke exposure in children in two districts of the Czech Republic
    Miroslav Dostal
    Institute of Experimental Medicine AS CR, Prague, Czech Republic
    Int J Hyg Environ Health 211:318-25. 2008
    ..6% vs. 27.8%). Our results suggest that in the Czech Republic, children under 5 years of age are significantly exposed to tobacco smoke and that more effective regulatory measures are needed to decrease the prevalence of smoking...
  2. ncbi Childhood morbidity and air pollution in the Teplice program
    M Dostal
    Institute of Exp Medicine, Academy of Sciences, Prague, Czech Republic
    Cas Lek Cesk 140:658-61. 2001
    ..Comparisons were made between children living in Teplice district, known for its high air pollution, and children living in Practice, a district with consistently lower particulate and SO2 exposures...
  3. ncbi Air pollution and distributions of lymphocyte immunophenotypes in cord and maternal blood at delivery
    Irva Hertz-Picciotto
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Epidemiology 13:172-83. 2002
    ..Heavy air pollution may affect the immune system in pregnant women and/or fetuses, reflecting an acute and/or chronic effect, although unmeasured confounders could also play a role...
  4. ncbi [Environmental pollution and childhood morbidity]
    M Dostal
    Ustav experimentální medicíny AV CR, Praha
    Cas Lek Cesk 140:529-32. 2001
    ..Comparisons were drawn between children living in district Teplice, known for its high air pollution, and those living in Practice, the district with consistently lower particulate and SO2 exposures...
  5. ncbi The distribution of major lymphocyte subsets in cord blood is associated with its pH
    M Dostal
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, Czech Academy of Sciences and Regional Institute of Hygiene of Central Bohemia, 142 20, Prague, Czech Republic
    Clin Biochem 34:119-24. 2001
    ..To assess in venous cord blood the distribution of major lymphocyte subsets according to pH and medications used during labor...
  6. ncbi The effect of dibenzo[a,1]pyrene and benzo[a]pyrene on human diploid lung fibroblasts: the induction of DNA adducts, expression of p53 and p21(WAF1) proteins and cell cycle distribution
    B Binkova
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia, c o Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Mutat Res 471:57-70. 2000
    ..Whether the S phase delay observed in our study is beneficial for the survival of the cells remains to be further established...
  7. ncbi [Parameters of cellular immunity in maternal and umbilical cord blood in relation to air pollution. Preliminary results of a pregnancy outcomes study]
    M Dostal
    Laborator genetické ekotoxikologie KHS Stredoceského kraje, Praha
    Cas Lek Cesk 139:183-8. 2000
    ..Selected parameters of cell mediated and humoral immunity in maternal and umbilical samples after delivery were assayed...
  8. ncbi HVRII of mtDNA in cord blood cells of newborn children and in their saliva 10 years later
    J Schmuczerova
    Department of Developmental Genotoxicology, Institute of Experimental Medicine AS CR, Prague, Czech Republic
    Folia Biol (Praha) 57:26-9. 2011
    ....
  9. ncbi Cell-cycle alterations within chick embryonic anlagen after cyclophosphamide treatment
    L Heringová
    Department of Histology and Embryology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    Teratog Carcinog Mutagen 18:63-72. 1998
    ..The results are consistent with the idea that the dose-dependent shift in malformation spectra is causally associated with the dose-dependent and organ-specific depression of mitotic activity...
  10. ncbi [Clinico-teratologic counseling and the Teratology Information Service]
    D Stejskal
    Oddĕlení lékarské genetiky GENNET, v o s, Praha
    Ceska Gynekol 63:19-22. 1998
    ..5 days and 30 days at exposure to sex hormones. Specific features of clinical-teratological counselling and the role of the Czech Teratologic Information Service are described...
  11. ncbi Perinatal hypoxia suppresses immune response of adult rats
    M Vizek
    Institute of Pathophysiology, Second Medical Faculty, Charles University, Prague
    Physiol Res 42:201-4. 1993
    ..These results demonstrate that perinatal hypoxia has an important effect on the immune system of the rat...
  12. ncbi Early postnatal diazepam treatment of rats and neuroimmunocompetence in adulthood and senescence
    O Benesova
    Psychiatric Center, Prague, Czech Republic
    Ann N Y Acad Sci 717:89-101. 1994
    ..Significant depression of immune response in D rats persisting for the whole life may be considered as a serious risk of neonatal D treatment...
  13. ncbi [Perinatal pharmacotherapy and the risk of functional teratogenic defects]
    O Benesova
    Psychiatrické centrum, Praha
    Cesk Fysiol 44:11-4. 1995
    ..The evaluation of functional teratogenic risk in three drugs used in the treatment of risk pregnancies and risk neonates (dexamethazone, fenoterol, diazepam) is presented...
  14. ncbi Treatment of pregnant mice with antibiotics modulates the humoral response of the offspring: role of prenatal and postnatal factors
    M Dostal
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Praha
    Int J Immunopharmacol 16:1035-42. 1994
    ..The results suggest that the immune response of the offspring was modulated by both the prenatally and postnatally acting factors, the latter being mediated by effects of antibiotics on the maternal organism...
  15. ncbi Cleft palate induced with cyclophosphamide in the mouse embryo
    M Dostal
    Folia Morphol (Praha) 30:315-21. 1982
  16. ncbi [Comparison of procalcitonin, interleukin-6 and C-reactive protein in the differential diagnosis of patients with sepsis syndrome in intensive care units]
    M Prucha
    Oddelení klinické biochemie, hematologie a imunologie Nemocnice Na Homolce, Praha
    Vnitr Lek 49:541-7. 2003
    ..In the last years, new parameters have played an important role in this area--C-reactive protein, Interleukin-6 and procalcitonin...
  17. ncbi Cell-cycle alterations underlie cyclophosphamide-induced teratogenesis in the chick embryo
    L Heringová
    Charles University, 3rd Faculty of Medicine, Center of Biomedical Studies, Prague, Czech Republic
    Birth Defects Res A Clin Mol Teratol 67:438-43. 2003
    ..We investigate quantitatively the relationship between the embryotoxic effect of CP and the disturbance of the cell-cycle using flow cytometry...
  18. ncbi Levels of apolipoprotein A-II in cerebrospinal fluid in patients with neuroborreliosis are associated with lipophagocytosis
    L Táborský
    Department of Clinical Biochemistry, Hospital Homolka, 150 30 Prague, Czechia
    Folia Microbiol (Praha) 48:849-55. 2003
    ..The levels of apolipoprotein B were increased only in samples with lymphocytic pleocytosis and Qalb > 7.4. The presence of lipophages in the CSF was significantly associated with the CSF concentration of apolipoprotein A-II...
  19. ncbi Indoor coal use and early childhood growth
    Rakesh Ghosh
    Department of Public Health Sciences, University of California, Davis, Davis, CA 95616, USA
    Arch Pediatr Adolesc Med 165:492-7. 2011
    ..To examine whether indoor coal combustion for heating, which releases pollutants into the air, affects early childhood growth...
  20. ncbi Genetic, biochemical, and environmental factors associated with pregnancy outcomes in newborns from the Czech Republic
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Environ Health Perspect 119:265-71. 2011
    ..Oxidative damage to placental DNA can result in negative pregnancy outcomes, including intrauterine growth restriction (IUGR) and low birth weight (LBW)...
  21. ncbi Air pollution exposure during critical time periods in gestation and alterations in cord blood lymphocyte distribution: a cohort of livebirths
    Caroline E W Herr
    Department of Public Health Sciences, University of California, Davis, USA
    Environ Health 9:46. 2010
    ..This study investigates the association between cord blood lymphocyte proportions and maternal exposure to air pollution during each gestational month...
  22. ncbi Comparison of the health of Roma and non-Roma children living in the district of Teplice
    Miroslav Dostal
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Int J Public Health 55:435-41. 2010
    ..To compare the morbidity of 66 Roma and 466 non-Roma children born and living in a diffused type of habitation in the district of Teplice...
  23. ncbi Urinary 8-oxodeoxyguanosine levels in children exposed to air pollutants
    Vlasta Svecova
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, v v i, Videnska 1083, 142 20 Prague 4, Czech Republic
    Mutat Res 662:37-43. 2009
    ..The obtained results indicate that 8-oxodG is a sensitive biomarker for measuring the exposure of children to air pollution...
  24. ncbi Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development
    Irva Hertz-Picciotto
    Center for Children s Environmental Health and Department of Public Health Sciences, University of California, Davis, CA 95616, USA
    Basic Clin Pharmacol Toxicol 102:146-54. 2008
    ....
  25. ncbi Early childhood lower respiratory illness and air pollution
    Irva Hertz-Picciotto
    Department of Public Health Sciences, University of California, Davis, California 95616, USA
    Environ Health Perspect 115:1510-8. 2007
    ..Few studies of air pollutants address morbidity in preschool children. In this study we evaluated bronchitis in children from two Czech districts: Teplice, with high ambient air pollution, and Prachatice, characterized by lower exposures...
  26. ncbi The DNA repair gene XPD/ERCC2 polymorphisms Arg156Arg (exon 6) and Lys751Gln (exon 23) are closely associated
    Jan Topinka
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Toxicol Lett 172:85-9. 2007
    ....
  27. ncbi Coal home heating and environmental tobacco smoke in relation to lower respiratory illness in Czech children, from birth to 3 years of age
    Rebecca J Baker
    Department of Epidemiology, School of Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 114:1126-32. 2006
    ..Relevance: Few studies have described effects of coal heating fuel on children's health in a Western country. Breast-feeding may attenuate adverse effects of prenatal and childhood exposures to combustion products...
  28. ncbi Cytogenetic effects in children and mothers exposed to air pollution assessed by the frequency of micronuclei and fluorescence in situ hybridization (FISH): a family pilot study in the Czech Republic
    Marie Pedersen
    Institute of Public Health, Department of Environmental and Occupational Health, University of Copenhagen, DK-1014 K Copenhagen, Denmark
    Mutat Res 608:112-20. 2006
    ....
  29. ncbi [Parental smoking and exposure of pre-school children to tobacco smoke]
    M Dostal
    Ustav experimentální medicíny AV CR a Zdravotní ustav Stredoceského kraje, Praha
    Cas Lek Cesk 145:313-8; discussion 319-21. 2006
    ..During studies on the health of children aged 3 or 4.5 years in Teplice and Prachatice districts of the Czech Republic, we focused also on the extent of smoking in the families and exposure of children to environmental tobacco smoke...
  30. ncbi Air pollution and lymphocyte phenotype proportions in cord blood
    Irva Hertz-Picciotto
    Department of Public Health Sciences, University of California, Davis, California, USA
    Environ Health Perspect 113:1391-8. 2005
    ..7% (95% CI, 0.4 to 3.0%). Associations were similar but slightly weaker for PM2.5. Ambient air pollution may influence the relative distribution of lymphocyte immunophenotypes of the fetus...
  31. ncbi [Immunological monitoring of sepsis using flow cytometry--quantitation of monocyte HLA-DR expression and granulocyte CD64 expression]
    L Sedlackova
    Oddelení klinické biochemie, hematologie a imunologie, Nemocnice Na Homolce, Praha
    Epidemiol Mikrobiol Imunol 54:54-61. 2005
    ..e. acquired immunodeficiency. The level of monocyte HLA-DR expression reflects the functional status of monocytes as antigen-presenting cells and granulocyte CD64 expression is also indicative of infectious inflammation...
  32. ncbi [Comparison of the effectiveness of various methods of testing drugs for embryotoxicity]
    V F Puchkov
    Arkh Anat Gistol Embriol 80:104-10. 1981
    ..Advantages and disadvantages of every method applied were discussed...
  33. ncbi Teratogenic interactions of repeated doses of cortisone
    M Dostal
    Folia Morphol (Praha) 32:27-33. 1984
  34. ncbi Teratogenic interactions of consecutively administered cortisone and cyclophosphamide
    M Dostal
    Folia Morphol (Praha) 33:201-8. 1985
  35. ncbi Cyclophosphamide-induced cleft palate: effects of single and consecutive administration
    M Dostal
    Folia Morphol (Praha) 33:103-10. 1985
  36. ncbi Embryotoxicity of cortisone combined with vitamin E
    M Dostal
    Folia Morphol (Praha) 34:132-40. 1986
  37. ncbi Further studies on protective effects of vitamins in cyclophosphamide-induced cleft palate
    M Dostal
    Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague
    Int J Oral Maxillofac Surg 19:308-11. 1990
    ..The data provided offer no explanation for the claimed beneficial effects of vitamins for preventing the occurrence of orofacial clefts in patients at risk...
  38. ncbi Developmental toxicity of cadmium in mice. II. Immunotoxic effects
    D Soukupová
    Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague
    Funct Dev Morphol 1:31-6. 1991
    ..It is concluded that in mice the maternal exposure to a single dose of cadmium results in postnatally manifested deviations of immune functions of their offsprings...
  39. ncbi Effects of antibiotics on the developing immune system
    M Dostal
    Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague
    Bratisl Lek Listy 92:589-93. 1991
    ..fig. 6, ref. 27.)..
  40. ncbi Developmental toxicity of cadmium in mice. I. Embryotoxic effects
    D Soukupová
    Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague
    Funct Dev Morphol 1:3-9. 1991
    ..0 mg CdCl2 administered on the 12th day of pregnancy. Reduction of the thymus weight was a constant effect of treatment with the higher doses of cadmium from the 9th to the 14th day of pregnancy...
  41. ncbi Abnormal delayed-type hypersensitivity in mice born to females treated with vitamin A during pregnancy
    M Dostal
    Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague
    Funct Dev Morphol 2:157-62. 1992
    ..The effects were correlated to the sex and body weight of the offspring, the highest DTH being observed in the female offspring with a low body weight...
  42. ncbi Horizontalization of the palatine processes in the mouse embryo
    M Dostal
    Folia Morphol (Praha) 23:104-8. 1975
  43. ncbi Inhibitory effect of corticoids on the proliferative pattern in mouse palatal processes
    R Jelinek
    Teratology 11:193-8. 1975
    ....
  44. ncbi Growth and position of the mandible during secondary palate closure in the mouse
    M Dostal
    Folia Morphol (Praha) 24:349-58. 1976
  45. ncbi The kinetics of 1,2-3H-cortisol after intra-amniotic administration
    M Dostal
    Folia Biol (Praha) 23:283-90. 1977
    ..and did no longer change substantially. Total radioactivity in the amniotic fluid, after an initial acute fall, corresponded to 16.4% of injected dose from 20 min. to 2 hours after drug administration...
  46. ncbi Embryotoxicity of transplacentally and intraamniotically administered 6-azauridine in mice
    M Dostal
    Teratology 19:143-8. 1979
    ..The value of the intraamniotic technique for establishing the direct embryotoxic effect is discussed...
  47. ncbi Critical period of cleft palate induced by small doses of cortisone
    M Dostal
    Folia Morphol (Praha) 27:141-5. 1979
  48. ncbi The morphogenesis of cleft palate induced by exogenous factors. II. Induction of cleft by cortisone in randombred mice
    M Dostal
    Acta Chir Plast 12:206-8. 1970
  49. ncbi Methods of intraamnial application in mammal germs
    M Dostal
    Acta Chir Plast 12:250. 1970
  50. ncbi The course of palate closure in embryos of different mouse strains
    M Dostal
    Acta Chir Plast 15:23-8. 1973
  51. ncbi Morphogenesis of cleft palate induced by exogenous factors. 3. Intraamniotic application of hydrocortisone in mice
    M Dostal
    Teratology 4:63-8. 1971
  52. ncbi Influence of cortisone on the size of the lateral ventricles in the mouse foetus
    R Jelinek
    Folia Morphol (Praha) 18:138-48. 1970
  53. ncbi Development of vascularization of the secondary palate of the mouse embryo
    Z Rychter
    Folia Morphol (Praha) 19:273-89. 1971
  54. ncbi Morphogenesis of cleft palate induced by exogenous factors. IV. Comparison of the effect of hydrocortisone administered to the pregnant female with direct injection into the amniotic sac of the mouse embryo
    M Dostal
    Folia Morphol (Praha) 19:214-22. 1971
  55. ncbi On the method of evaluating the development of an embryonic component in experimental teratology
    R Jelinek
    Folia Morphol (Praha) 20:130-3. 1972
  56. ncbi [Spatial changes during the horizontalization of palatine shelves]
    M Dostal
    Rozhl Chir 53:171-7. 1974
  57. ncbi Sensitivity of embryos and intraspecies differences in mice in response to prenatal administration of corticoids
    M Dostal
    Teratology 8:245-52. 1973
  58. ncbi Effect of some nonspecific factors accompanying intraamniotic injection in mouse foetus
    M Dostal
    Folia Morphol (Praha) 21:97-101. 1973
  59. ncbi Corticoid-induced cleft palate as a model system for the distinction of maternal and foetal genomes interacting with exogenous teratogen
    M Dostal
    Folia Biol (Praha) 19:153-6. 1973
  60. ncbi Morphogenesis of cleft palate induced by exogenous factors VII. Mitotic activity during formation of the mouse secondary palate
    R Jelinek
    Folia Morphol (Praha) 22:94-101. 1974
  61. ncbi [Significance of extraembryonic factors in experimental teratogenesis]
    R Jelinek
    Cesk Pediatr 29:625-9. 1974
  62. ncbi Cleft palate and normal development of the secondary palate in the rodent embryo
    M Dostal
    Folia Morphol (Praha) 22:28-32. 1974
  63. ncbi The role of mitotic activity in the formation of the secondary palate
    R Jelinek
    Acta Chir Plast 15:216-22. 1973
  64. ncbi Influence of cleft palate on growth of the maxilla in mouse embryos
    M Peterka
    Cleft Palate J 14:206-10. 1977
    ..Final expansion of the maxilla was the same in all experimental groups...
  65. ncbi Effects of 1,2-dibromoethane on haematopoiesis in the chick embryo
    Z Dusek
    Department of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Xenobiotica 33:443-58. 2003
    ..5. The early chick embryo provides a suitable alternative to mammalian models for investigation of long-term effects of xenobiotics on haematopoiesis...
  66. ncbi Genetic variability of HVRII mtDNA in cord blood and respiratory morbidity in children
    J Schmuczerova
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v v i, Videnska 1083, 142 20 Prague 4, Czech Republic
    Mutat Res 666:1-7. 2009
    ..46, p=0.030, 95% CI 1.04-2.06). The results indicate that genetic polymorphisms in mtDNA may be an important factor not only for various types of cancers and neurodegenerative diseases, but also for respiratory morbidity in children...