Triantafyllos Stylianopoulos

Summary

Affiliation: University of Cyprus
Country: Cyprus

Publications

  1. doi request reprint Design considerations for nanotherapeutics in oncology
    Triantafyllos Stylianopoulos
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus Electronic address
    Nanomedicine 11:1893-907. 2015
  2. doi request reprint Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
    Triantafyllos Stylianopoulos
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678, Nicosia, Cyprus
    Ann Biomed Eng 43:2291-300. 2015
  3. pmc Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    Cancer Res 73:3833-41. 2013
  4. pmc Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678, Nicosia, Cyprus
    Ann Biomed Eng 41:68-77. 2013
  5. doi request reprint Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus
    J Biomed Mater Res B Appl Biomater 100:2222-30. 2012
  6. doi request reprint Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
    Athanassios P Pirentis
    a Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus and
    Connect Tissue Res 56:345-54. 2015
  7. pmc Combining two strategies to improve perfusion and drug delivery in solid tumors
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678 Nicosia, Cyprus
    Proc Natl Acad Sci U S A 110:18632-7. 2013
  8. pmc Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors
    Chrysovalantis Voutouri
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    PLoS ONE 9:e104717. 2014
  9. pmc Multistage nanoparticles for improved delivery into tumor tissue
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    Methods Enzymol 508:109-30. 2012
  10. doi request reprint Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
    Fotios Mpekris
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, P O Box 20537, 1678, Nicosia, Cyprus
    Biomech Model Mechanobiol 14:1391-402. 2015

Collaborators

  • Dai Fukumura
  • Panagiotis Papageorgis
  • Fotios Mpekris
  • Athanassios P Pirentis
  • Chrysovalantis Voutouri
  • Stelios Angeli
  • Christiana Polydorou
  • Andreani D Odysseos

Detail Information

Publications11

  1. doi request reprint Design considerations for nanotherapeutics in oncology
    Triantafyllos Stylianopoulos
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus Electronic address
    Nanomedicine 11:1893-907. 2015
    ..Finally, we suggest specific design strategies that should optimize delivery to most solid tumors and discuss under what conditions active targeting would be beneficial...
  2. doi request reprint Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
    Triantafyllos Stylianopoulos
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678, Nicosia, Cyprus
    Ann Biomed Eng 43:2291-300. 2015
    ..Furthermore, our results suggest that smaller nanoparticles achieve better treatment outcome. ..
  3. pmc Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    Cancer Res 73:3833-41. 2013
    ..Crucially, fluid pressure does not cause vessel compression of tumor vessels...
  4. pmc Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678, Nicosia, Cyprus
    Ann Biomed Eng 41:68-77. 2013
    ..Our model provides important guidelines for the optimal design of nanoparticle formulation for delivery to solid tumors...
  5. doi request reprint Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus
    J Biomed Mater Res B Appl Biomater 100:2222-30. 2012
    ..In conclusion, polymer concentration, fiber alignment, and solvent have significant impact on the mechanical and fluid transport properties of electrospun cellulose acetate fiber meshes...
  6. doi request reprint Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
    Athanassios P Pirentis
    a Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus and
    Connect Tissue Res 56:345-54. 2015
    ..This prediction is consistent with long-standing observations of tumor encapsulation and histologic sections that we performed, and it further corroborates the expansive growth hypothesis for the capsule formation. ..
  7. pmc Combining two strategies to improve perfusion and drug delivery in solid tumors
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678 Nicosia, Cyprus
    Proc Natl Acad Sci U S A 110:18632-7. 2013
    ..g., pancreatic ductal adenocarcinomas). In the case of tumors with hyperpermeable and compressed vessels (e.g., subset of mammary carcinomas), the two strategies need to be combined for improved treatment outcomes. ..
  8. pmc Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors
    Chrysovalantis Voutouri
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    PLoS ONE 9:e104717. 2014
    ....
  9. pmc Multistage nanoparticles for improved delivery into tumor tissue
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    Methods Enzymol 508:109-30. 2012
    ..Finally, we provide detailed experimental methods for the characterization of such nanoparticles...
  10. doi request reprint Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
    Fotios Mpekris
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, P O Box 20537, 1678, Nicosia, Cyprus
    Biomech Model Mechanobiol 14:1391-402. 2015
    ..Finally, we demonstrated the applicability of our model to actual geometries, employing a breast tumor model derived from MR images. ..
  11. pmc Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review)
    Panagiotis Papageorgis
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus
    Int J Oncol 46:933-43. 2015
    ..These findings provide new insights towards the significance of targeting TGFβ pathway to enhance personalized tumor treatment...